Harmonizome 3.0

erb-b2 receptor tyrosine kinase 4

This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

From NURSA Protein Complexes

proteins in the BL3038 (ERBB4) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the erbb4-erbb4 complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

From GO Biological Process Annotations 2023

genes participating in the ERBB4-ERBB4 signaling pathway biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2025

genes participating in the ERBB4-ERBB4 signaling pathway biological process from the curated GO Biological Process Annotations 2025 dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025

proteins co-occuring with the ERBB4-ERBB4 complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.

From Biocarta Pathways

proteins participating in the g-secretase mediated erbb4 signaling pathway pathway from the Biocarta Pathways dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the erbb4-egfr complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the erbb4-erbb3 complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term erbb4 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From KEA Substrates of Kinases

substrates of the kinase ERBB4 from the curated KEA Substrates of Kinases dataset.

From NURSA Protein Complexes

proteins in the BL3041 (ERBB4) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for ERBB4 from the Pathway Commons Protein-Protein Interactions dataset.

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase ERBB4 from the curated PhosphoSitePlus Substrates of Kinases dataset.

From PID Pathways

proteins participating in the ErbB4 signaling events pathway from the PID Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Downregulation of ERBB4 signaling pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the PI3K events in ERBB4 signaling pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the SHC1 events in ERBB4 signaling pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Nuclear signaling by ERBB4 pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Signaling by ERBB4 pathway from the Reactome Pathways dataset.

From GO Biological Process Annotations 2023

genes participating in the ERBB2-ERBB4 signaling pathway biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the ERBB4 signaling pathway biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the negative regulation of ERBB4 signaling pathway biological process from the curated GO Biological Process Annotations 2023 dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the ERBB4 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From Reactome Pathways 2024

proteins participating in the Downregulation of ERBB4 signaling pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Nuclear signaling by ERBB4 pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the PI3K events in ERBB4 signaling pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the SHC1 events in ERBB4 signaling pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Signaling by ERBB4 pathway from the Reactome Pathways 2024 dataset.

From GO Biological Process Annotations 2025

genes participating in the ERBB2-ERBB4 signaling pathway biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Biological Process Annotations 2025

genes participating in the ERBB4 signaling pathway biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Biological Process Annotations 2025

genes participating in the negative regulation of ERBB4 signaling pathway biological process from the curated GO Biological Process Annotations 2025 dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025

proteins co-occuring with the ERBB4-ERBB3 complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025

proteins co-occuring with the ERBB4-EGFR complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025

proteins co-occuring with the ERBB4:ERBB2 complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the ERBB4 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.