Harmonizome 3.0

cyclin-dependent kinase 5

This gene encodes a proline-directed serine/threonine kinase that is a member of the cyclin-dependent kinase family of proteins. Unlike other members of the family, the protein encoded by this gene does not directly control cell cycle regulation. Instead the protein, which is predominantly expressed at high levels in mammalian postmitotic central nervous system neurons, functions in diverse processes such as synaptic plasticity and neuronal migration through phosphorylation of proteins required for cytoskeletal organization, endocytosis and exocytosis, and apoptosis. In humans, an allelic variant of the gene that results in undetectable levels of the protein has been associated with lethal autosomal recessive lissencephaly-7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdk5 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Hub Proteins Protein-Protein Interactions

interacting proteins for hub protein CDK5 from the curated Hub Proteins Protein-Protein Interactions dataset.

From KEA Substrates of Kinases

substrates of the kinase CDK5 from the curated KEA Substrates of Kinases dataset.

From NURSA Protein-Protein Interactions

interacting proteins for CDK5 from the NURSA Protein-Protein Interactions dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for CDK5 from the Pathway Commons Protein-Protein Interactions dataset.

From Phosphosite Textmining Biological Term Annotations

proteins co-occuring with the biological term cdk5 in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase CDK5 from the curated PhosphoSitePlus Substrates of Kinases dataset.

From Kinase Library Serine Threonine Kinome Atlas

substrates of the kinase CDK5 from the Kinase Library Serine Threonine Kinome Atlas dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the CDK5 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From CORUM Protein Complexes

proteins in the Cdk5/p35 complex (Cdk5-Cdk5r1 complex) protein complex from the CORUM Protein Complexes dataset.

From Biocarta Pathways

proteins participating in the deregulation of cdk5 in alzheimers disease pathway from the Biocarta Pathways dataset.

From Biocarta Pathways

proteins participating in the phosphorylation of mek1 by cdk5/p35 down regulates the map kinase pathway pathway from the Biocarta Pathways dataset.

From Biocarta Pathways

proteins participating in the regulation of ck1/cdk5 by type 1 glutamate receptors pathway from the Biocarta Pathways dataset.

From CORUM Protein Complexes

proteins in the Cdk5-c-Abl-Cables complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Cdk5-Cdk5r1-Pctk1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Cell cycle kinase complex CDK5 protein complex from the CORUM Protein Complexes dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the CDK5 and ABL1 enzyme substrate 1/2 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From Reactome Pathways 2024

proteins participating in the Activated NTRK2 signals through CDK5 pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models pathway from the Reactome Pathways 2024 dataset.