Harmonizome 3.0

epidermal growth factor

This gene encodes a member of the epidermal growth factor superfamily. The encoded preproprotein is proteolytically processed to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding with high affinity to the cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term egf in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Guide to Pharmacology Protein Ligands of Receptors

receptors of the EGF ligand (protein) from the curated Guide to Pharmacology Protein Ligands of Receptors dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for EGF from the Pathway Commons Protein-Protein Interactions dataset.

From Phosphosite Textmining Biological Term Annotations

proteins co-occuring with the biological term egf in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the EGF gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From DGIdb Drug Targets 2026

interacting proteins for the EGF drug from theDGIdb Drug Targets 2026 dataset.

From Biocarta Pathways

proteins participating in the egf signaling pathway pathway from the Biocarta Pathways dataset.

From Biocarta Pathways

proteins participating in the cbl mediated ligand-induced downregulation of egf receptors pathway pathway from the Biocarta Pathways dataset.

From Biocarta Pathways

proteins participating in the role of egf receptor transactivation by gpcrs in cardiac hypertrophy pathway from the Biocarta Pathways dataset.

From CORUM Protein Complexes

proteins in the CIN85-CBL-SH3GL2-EGFR complex, EGF stimulated protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Ksr1 complex (Ksr1, Mek, 14-3-3, Mapk), EGF stimulated protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Ksr1-Mek-Braf-Erk complex, EGF induced protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the RAF1-RAS complex, EGF induced protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Shc-Grb2-mSos1 complex, EGF stimulated protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Egfr-Grb2-mSos1 complex, EGF stimulated protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Ksr1-Mek-Braf complex, EGF induced protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the RIN1-STAM2-EGFR complex, EGF stimulated protein complex from the CORUM Protein Complexes dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the EGF-like domain, extracellular protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the EGF-like calcium-binding, conserved site protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the EGF-like, laminin protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the EGF-like repeat and discoidin I-like domain-containing protein 3 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Complement Clr-like EGF domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the EGF-like calcium-binding domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tyrosine protein kinase, EGF/ERB/XmrK receptor protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Thrombomodulin-like, EGF-like protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the EGF-containing fibulin-like extracellular matrix protein 2 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the EGF domain, merozoite surface protein 1-like protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Follistatin/Osteonectin EGF domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the von Willebrand factor C and EGF domain-containing protein protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the EGF-like, conserved site protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the EGF-type aspartate/asparagine hydroxylation site protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From PANTHER Pathways

proteins participating in the EGF receptor signaling pathway pathway from the PANTHER Pathways dataset.

From Phosphosite Textmining Biological Term Annotations

proteins co-occuring with the biological term egf-induced in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

From PID Pathways

proteins participating in the EGF receptor (ErbB1) signaling pathway pathway from the PID Pathways dataset.

From WikiPathways Pathways 2014

proteins participating in the EGF/EGFR Signaling Pathway(Homo sapiens) pathway from the WikiPathways Pathways 2014 dataset.

From LINCS L1000 CMAP Chemical Perturbation Consensus Signatures

genes differentially expressed following the EGF-816 small molecule perturbation from the LINCS L1000 CMAP Chemical Perturbation Consensus Signatures dataset.

From WikiPathways Pathways 2024

proteins participating in the EGF EGFR signaling pathway from the WikiPathways Pathways 2024 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the HB-EGF drug from theDGIdb Drug Targets 2026 dataset.