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FCGR3A GeneFc fragment of IgG, low affinity IIIa, receptor (CD16a) This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other responses, including antibody dependent cellular mediated cytotoxicity and antibody dependent enhancement of virus infections. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene are associated with immunodeficiency 20, and have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2020] |
FCGR3A-mediated phagocytosis Gene Setproteins participating in the FCGR3A-mediated phagocytosis pathway from the Reactome Pathways 2024 dataset. |
fcgr3a Gene SetFrom GeneRIF Biological Term Annotations genes co-occuring with the biological term fcgr3a in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. |
FCGR3A Gene SetFrom Pathway Commons Protein-Protein Interactions interacting proteins for FCGR3A from the Pathway Commons Protein-Protein Interactions dataset. |
FCGR3A Gene SetFrom LINCS L1000 CMAP CRISPR Knockout Consensus Signatures genes differentially expressed following the FCGR3A gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. |
phagocytosis Gene SetFrom GeneRIF Biological Term Annotations genes co-occuring with the biological term phagocytosis in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. |
modulation of phagocytosis in other organism involved in symbiotic interaction Gene SetFrom GO Biological Process Annotations 2015 genes participating in the modulation of phagocytosis in other organism involved in symbiotic interaction biological process from the curated GO Biological Process Annotations 2015 dataset. |
immune response-regulating cell surface receptor signaling pathway involved in phagocytosis Gene SetFrom GO Biological Process Annotations 2015 genes participating in the immune response-regulating cell surface receptor signaling pathway involved in phagocytosis biological process from the curated GO Biological Process Annotations 2015 dataset. |
positive regulation of phagocytosis, engulfment Gene SetFrom GO Biological Process Annotations 2015 genes participating in the positive regulation of phagocytosis, engulfment biological process from the curated GO Biological Process Annotations 2015 dataset. |
negative regulation of phagocytosis Gene SetFrom GO Biological Process Annotations 2015 genes participating in the negative regulation of phagocytosis biological process from the curated GO Biological Process Annotations 2015 dataset. |
entry of symbiont into host cell by promotion of host phagocytosis Gene SetFrom GO Biological Process Annotations 2015 genes participating in the entry of symbiont into host cell by promotion of host phagocytosis biological process from the curated GO Biological Process Annotations 2015 dataset. |
regulation of phagocytosis, engulfment Gene SetFrom GO Biological Process Annotations 2015 genes participating in the regulation of phagocytosis, engulfment biological process from the curated GO Biological Process Annotations 2015 dataset. |
phagocytosis Gene SetFrom GO Biological Process Annotations 2015 genes participating in the phagocytosis biological process from the curated GO Biological Process Annotations 2015 dataset. |
negative regulation of phagocytosis, engulfment Gene SetFrom GO Biological Process Annotations 2015 genes participating in the negative regulation of phagocytosis, engulfment biological process from the curated GO Biological Process Annotations 2015 dataset. |
respiratory burst after phagocytosis Gene SetFrom GO Biological Process Annotations 2015 genes participating in the respiratory burst after phagocytosis biological process from the curated GO Biological Process Annotations 2015 dataset. |
phagocytosis, recognition Gene SetFrom GO Biological Process Annotations 2015 genes participating in the phagocytosis, recognition biological process from the curated GO Biological Process Annotations 2015 dataset. |
phagocytosis, engulfment Gene SetFrom GO Biological Process Annotations 2015 genes participating in the phagocytosis, engulfment biological process from the curated GO Biological Process Annotations 2015 dataset. |
positive regulation by symbiont of host phagocytosis Gene SetFrom GO Biological Process Annotations 2015 genes participating in the positive regulation by symbiont of host phagocytosis biological process from the curated GO Biological Process Annotations 2015 dataset. |
positive regulation by organism of phagocytosis in other organism involved in symbiotic interaction Gene SetFrom GO Biological Process Annotations 2015 genes participating in the positive regulation by organism of phagocytosis in other organism involved in symbiotic interaction biological process from the curated GO Biological Process Annotations 2015 dataset. |
regulation of phagocytosis Gene SetFrom GO Biological Process Annotations 2015 genes participating in the regulation of phagocytosis biological process from the curated GO Biological Process Annotations 2015 dataset. |
fc-gamma receptor signaling pathway involved in phagocytosis Gene SetFrom GO Biological Process Annotations 2015 genes participating in the fc-gamma receptor signaling pathway involved in phagocytosis biological process from the curated GO Biological Process Annotations 2015 dataset. |
positive regulation of phagocytosis Gene SetFrom GO Biological Process Annotations 2015 genes participating in the positive regulation of phagocytosis biological process from the curated GO Biological Process Annotations 2015 dataset. |
entry of organism into cell of other organism by promotion of phagocytosis in other organism involved in symbiotic interaction Gene SetFrom GO Biological Process Annotations 2015 genes participating in the entry of organism into cell of other organism by promotion of phagocytosis in other organism involved in symbiotic interaction biological process from the curated GO Biological Process Annotations 2015 dataset. |
modulation by symbiont of host phagocytosis Gene SetFrom GO Biological Process Annotations 2015 genes participating in the modulation by symbiont of host phagocytosis biological process from the curated GO Biological Process Annotations 2015 dataset. |
abnormal sertoli cell phagocytosis Gene SetFrom MPO Gene-Phenotype Associations gene mutations causing the abnormal sertoli cell phagocytosis phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset. |
impaired macrophage phagocytosis Gene SetFrom MPO Gene-Phenotype Associations gene mutations causing the impaired macrophage phagocytosis phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset. |
increased sertoli cell phagocytosis Gene SetFrom MPO Gene-Phenotype Associations gene mutations causing the increased sertoli cell phagocytosis phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset. |
impaired neutrophil phagocytosis Gene SetFrom MPO Gene-Phenotype Associations gene mutations causing the impaired neutrophil phagocytosis phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset. |
decreased sertoli cell phagocytosis Gene SetFrom MPO Gene-Phenotype Associations gene mutations causing the decreased sertoli cell phagocytosis phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset. |
Role of phospholipids in phagocytosis Gene Setproteins participating in the Role of phospholipids in phagocytosis pathway from the Reactome Pathways dataset. |
Fcgamma receptor (FCGR) dependent phagocytosis Gene Setproteins participating in the Fcgamma receptor (FCGR) dependent phagocytosis pathway from the Reactome Pathways dataset. |
Response of Mtb to phagocytosis Gene Setproteins participating in the Response of Mtb to phagocytosis pathway from the Reactome Pathways dataset. |
Fc-gamma receptor signaling pathway involved in phagocytosis Gene SetFrom GO Biological Process Annotations 2023 genes participating in the Fc-gamma receptor signaling pathway involved in phagocytosis biological process from the curated GO Biological Process Annotations 2023 dataset. |
phagocytosis Gene SetFrom GO Biological Process Annotations 2023 genes participating in the phagocytosis biological process from the curated GO Biological Process Annotations 2023 dataset. |
positive regulation of phagocytosis Gene SetFrom GO Biological Process Annotations 2023 genes participating in the positive regulation of phagocytosis biological process from the curated GO Biological Process Annotations 2023 dataset. |
negative regulation of phagocytosis Gene SetFrom GO Biological Process Annotations 2023 genes participating in the negative regulation of phagocytosis biological process from the curated GO Biological Process Annotations 2023 dataset. |
regulation of phagocytosis Gene SetFrom GO Biological Process Annotations 2023 genes participating in the regulation of phagocytosis biological process from the curated GO Biological Process Annotations 2023 dataset. |
positive regulation of phagocytosis, engulfment Gene SetFrom GO Biological Process Annotations 2023 genes participating in the positive regulation of phagocytosis, engulfment biological process from the curated GO Biological Process Annotations 2023 dataset. |
phagocytosis, engulfment Gene SetFrom GO Biological Process Annotations 2023 genes participating in the phagocytosis, engulfment biological process from the curated GO Biological Process Annotations 2023 dataset. |
positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis Gene SetFrom GO Biological Process Annotations 2023 genes participating in the positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis biological process from the curated GO Biological Process Annotations 2023 dataset. |
respiratory burst after phagocytosis Gene SetFrom GO Biological Process Annotations 2023 genes participating in the respiratory burst after phagocytosis biological process from the curated GO Biological Process Annotations 2023 dataset. |
negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis Gene SetFrom GO Biological Process Annotations 2023 genes participating in the negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis biological process from the curated GO Biological Process Annotations 2023 dataset. |
negative regulation of phagocytosis, engulfment Gene SetFrom GO Biological Process Annotations 2023 genes participating in the negative regulation of phagocytosis, engulfment biological process from the curated GO Biological Process Annotations 2023 dataset. |
cytoskeletal rearrangement involved in phagocytosis, engulfment Gene SetFrom GO Biological Process Annotations 2023 genes participating in the cytoskeletal rearrangement involved in phagocytosis, engulfment biological process from the curated GO Biological Process Annotations 2023 dataset. |
regulation of phagocytosis, engulfment Gene SetFrom GO Biological Process Annotations 2023 genes participating in the regulation of phagocytosis, engulfment biological process from the curated GO Biological Process Annotations 2023 dataset. |
regulation of Fc-gamma receptor signaling pathway involved in phagocytosis Gene SetFrom GO Biological Process Annotations 2023 genes participating in the regulation of Fc-gamma receptor signaling pathway involved in phagocytosis biological process from the curated GO Biological Process Annotations 2023 dataset. |
impaired neutrophil phagocytosis Gene SetFrom MGI Mouse Phenotype Associations 2023 gene mutations causing the impaired neutrophil phagocytosis phenotype in transgenic mice from the MGI Mouse Phenotype Associations 2023 dataset. |
impaired macrophage phagocytosis Gene SetFrom MGI Mouse Phenotype Associations 2023 gene mutations causing the impaired macrophage phagocytosis phenotype in transgenic mice from the MGI Mouse Phenotype Associations 2023 dataset. |
decreased Sertoli cell phagocytosis Gene SetFrom MGI Mouse Phenotype Associations 2023 gene mutations causing the decreased Sertoli cell phagocytosis phenotype in transgenic mice from the MGI Mouse Phenotype Associations 2023 dataset. |
increased Sertoli cell phagocytosis Gene SetFrom MGI Mouse Phenotype Associations 2023 gene mutations causing the increased Sertoli cell phagocytosis phenotype in transgenic mice from the MGI Mouse Phenotype Associations 2023 dataset. |
abnormal Sertoli cell phagocytosis Gene SetFrom MGI Mouse Phenotype Associations 2023 gene mutations causing the abnormal Sertoli cell phagocytosis phenotype in transgenic mice from the MGI Mouse Phenotype Associations 2023 dataset. |
Microglia pathogen phagocytosis pathway Gene SetFrom WikiPathways Pathways 2024 proteins participating in the Microglia pathogen phagocytosis pathway pathway from the WikiPathways Pathways 2024 dataset. |
Fcgamma receptor (FCGR) dependent phagocytosis Gene Setproteins participating in the Fcgamma receptor (FCGR) dependent phagocytosis pathway from the Reactome Pathways 2024 dataset. |
Latent infection - Other responses of Mtb to phagocytosis Gene Setproteins participating in the Latent infection - Other responses of Mtb to phagocytosis pathway from the Reactome Pathways 2024 dataset. |
Leishmania phagocytosis Gene Setproteins participating in the Leishmania phagocytosis pathway from the Reactome Pathways 2024 dataset. |
Response of Mtb to phagocytosis Gene Setproteins participating in the Response of Mtb to phagocytosis pathway from the Reactome Pathways 2024 dataset. |
Role of phospholipids in phagocytosis Gene Setproteins participating in the Role of phospholipids in phagocytosis pathway from the Reactome Pathways 2024 dataset. |
Fc-gamma receptor signaling pathway involved in phagocytosis Gene SetFrom GO Biological Process Annotations 2025 genes participating in the Fc-gamma receptor signaling pathway involved in phagocytosis biological process from the curated GO Biological Process Annotations 2025 dataset. |
phagocytosis Gene SetFrom GO Biological Process Annotations 2025 genes participating in the phagocytosis biological process from the curated GO Biological Process Annotations 2025 dataset. |
positive regulation of phagocytosis Gene SetFrom GO Biological Process Annotations 2025 genes participating in the positive regulation of phagocytosis biological process from the curated GO Biological Process Annotations 2025 dataset. |
negative regulation of phagocytosis Gene SetFrom GO Biological Process Annotations 2025 genes participating in the negative regulation of phagocytosis biological process from the curated GO Biological Process Annotations 2025 dataset. |
regulation of phagocytosis Gene SetFrom GO Biological Process Annotations 2025 genes participating in the regulation of phagocytosis biological process from the curated GO Biological Process Annotations 2025 dataset. |
positive regulation of phagocytosis, engulfment Gene SetFrom GO Biological Process Annotations 2025 genes participating in the positive regulation of phagocytosis, engulfment biological process from the curated GO Biological Process Annotations 2025 dataset. |
phagocytosis, engulfment Gene SetFrom GO Biological Process Annotations 2025 genes participating in the phagocytosis, engulfment biological process from the curated GO Biological Process Annotations 2025 dataset. |
respiratory burst after phagocytosis Gene SetFrom GO Biological Process Annotations 2025 genes participating in the respiratory burst after phagocytosis biological process from the curated GO Biological Process Annotations 2025 dataset. |
positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis Gene SetFrom GO Biological Process Annotations 2025 genes participating in the positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis biological process from the curated GO Biological Process Annotations 2025 dataset. |
negative regulation of phagocytosis, engulfment Gene SetFrom GO Biological Process Annotations 2025 genes participating in the negative regulation of phagocytosis, engulfment biological process from the curated GO Biological Process Annotations 2025 dataset. |
negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis Gene SetFrom GO Biological Process Annotations 2025 genes participating in the negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis biological process from the curated GO Biological Process Annotations 2025 dataset. |
cytoskeletal rearrangement involved in phagocytosis, engulfment Gene SetFrom GO Biological Process Annotations 2025 genes participating in the cytoskeletal rearrangement involved in phagocytosis, engulfment biological process from the curated GO Biological Process Annotations 2025 dataset. |
regulation of phagocytosis, engulfment Gene SetFrom GO Biological Process Annotations 2025 genes participating in the regulation of phagocytosis, engulfment biological process from the curated GO Biological Process Annotations 2025 dataset. |
regulation of Fc-gamma receptor signaling pathway involved in phagocytosis Gene SetFrom GO Biological Process Annotations 2025 genes participating in the regulation of Fc-gamma receptor signaling pathway involved in phagocytosis biological process from the curated GO Biological Process Annotations 2025 dataset. |