Harmonizome 3.0

growth factor receptor-bound protein 2

The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term grb2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Hub Proteins Protein-Protein Interactions

interacting proteins for hub protein GRB2 from the curated Hub Proteins Protein-Protein Interactions dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for GRB2 from the Pathway Commons Protein-Protein Interactions dataset.

From Phosphosite Textmining Biological Term Annotations

proteins co-occuring with the biological term grb2 in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the GRB2 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the GRB2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the grb2-egfr complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the grb2-sos complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the grb2-shp-2 complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the grb2-sos complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the grb2-egfr complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the grb2-shc complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the egfr-shc-grb2-sos complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the shc-grb2-sos complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the egfr-grb2-sos complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

From CORUM Protein Complexes

proteins in the BCR-ABL (p185 fusion protein)-GRB2 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the ITGA6-ITGB4-SHC1-GRB2 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the LAT-PLC-gamma-1-p85-GRB2-SOS signaling complex, C305 activated protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the LAT-PLC-gamma-1-p85-GRB2-CBL-VAV-SLP-76 signaling complex, C305 activated protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Cbl-SLP-76-Grb2 complex, Fc receptor gamma-R1 stimulated protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Frs2-Grb2-Shp2 complex, FGF stimulated protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Shc-Grb2-mSos1 complex, EGF stimulated protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the CIN85 complex (CIN85, CRK, BCAR1, CBL, PIK3R1, GRB2, SOS1) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the GRB2-SHP-2 complex, PDGF stimulated protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the BCR-ABL (p210 fusion protein)-GRB2 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the LAT-GRB2 complex, Fyn-mLck(KA) or Syk kinase activated protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Egfr-Grb2-mSos1 complex, EGF stimulated protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Lab-Grb2 complex, BCR stimulated protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the EGFR-CBL-GRB2 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Grb2-Lab-Blnk complex, BCR stimulated protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SLP-76-Cbl-Grb2-Shc complex, Fc receptor gamma-R1 stimulated protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SHC-GRB2 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Shc-Ship-Grb2 complex, IL-3 stimulated protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Grb2-mSos1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the BCR-ABL (p210 fusion protein)-GRB2-SOS1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Grb2-Shp2 complex, FGF stimulated protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Grb2-Sos complex, Fc receptor gamma-R1 stimulated protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the PLC-gamma-2-SLP-76-Lyn-Grb2 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the cRET-Shc-Grb2-Gab2-P85PI3K-Shp2 complex protein complex from the CORUM Protein Complexes dataset.

From GO Cellular Component Annotations 2015

proteins localized to the grb2-egfr complex cellular component from the curated GO Cellular Component Annotations 2015 dataset.

From GO Cellular Component Annotations 2015

proteins localized to the grb2-sos complex cellular component from the curated GO Cellular Component Annotations 2015 dataset.

From Reactome Pathways 2014

proteins participating in the GRB2 events in EGFR signaling pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the GRB2 events in ERBB2 signaling pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the GRB2:SOS provides linkage to MAPK signaling for Integrins pathway from the Reactome Pathways dataset.

From GO Cellular Component Annotations 2023

proteins localized to the Grb2-EGFR complex cellular component from the curated GO Cellular Component Annotations 2023 dataset.

From Reactome Pathways 2024

proteins participating in the GRB2 events in EGFR signaling pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the GRB2 events in ERBB2 signaling pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the GRB2:SOS provides linkage to MAPK signaling for Integrins pathway from the Reactome Pathways 2024 dataset.

From GO Cellular Component Annotations 2025

proteins localized to the Grb2-EGFR complex cellular component from the curated GO Cellular Component Annotations 2025 dataset.

From COMPARTMENTS Curated Protein Localization Evidence Scores 2025

proteins localized to the Grb2-EGFR complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025

proteins co-occuring with the Grb2-Sos complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025

proteins co-occuring with the Shc-Grb2-Sos complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025

proteins co-occuring with the Grb2-EGFR complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025

proteins co-occuring with the Grb2-Shc complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025

proteins co-occuring with the EGFR-Shc-Grb2-Sos complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025

proteins co-occuring with the Grb2-SHP-2 complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025

proteins co-occuring with the EGFR-Grb2-Sos complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.