Harmonizome 3.0

hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)

This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011]

HIF1A antisense RNA 1

HIF1A antisense RNA 2

Enables miRNA inhibitor activity via base-pairing. Involved in lncRNA-mediated post-transcriptional gene silencing and positive regulation of miRNA catabolic process. [provided by Alliance of Genome Resources, Mar 2025]

HIF1A antisense RNA 3

From ChEA Transcription Factor Targets

target genes of the HIF1A transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term hif1a in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for HIF1A from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the HIF1A gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From JASPAR Predicted Human Transcription Factor Targets 2025

target genes of the HIF1A transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the HIF1A gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From ChEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the HIF1A-21447827-MCF7-HUMAN transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

From CORUM Protein Complexes

proteins in the VHL-TBP1-HIF1A complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the HIF1A-OS9-EGLN1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the HIF1A-OS9-EGLN3 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the ARNT-HIF1A complex protein complex from the CORUM Protein Complexes dataset.

From ChEA Transcription Factor Targets 2022

target genes of the HIF1A-21447827-MCF-7-HUMAN transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.

From WikiPathways Pathways 2024

proteins participating in the HIF1A and PPARG in cardiac hypertropthy pathway from the WikiPathways Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the PTK6 promotes HIF1A stabilization pathway from the Reactome Pathways 2024 dataset.

From JASPAR Predicted Human Transcription Factor Targets 2025

target genes of the ARNT::HIF1A transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.

From JASPAR Predicted Mouse Transcription Factor Targets 2025

target genes of the Arnt::Hif1a transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2925 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC4677459-NIHMS65392-supplement-Dataset3.xlsx-HIF1A-Unnamed_1_HIF1A transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC4677459-NIHMS65392-supplement-Dataset3.xlsx-HIF1A-Unnamed_2_HIF1A transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC12220722-NRR-21-677_Suppl1.pdf-37-HIF1A-AS3_HIF1A transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.