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MET GeneMET proto-oncogene, receptor tyrosine kinase This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016] |
TRM-CAT2-1 Genetransfer RNA-Met (CAT) 2-1 |
TRM-CAT3-2 Genetransfer RNA-Met (CAT) 3-2 |
TRM-CAT3-1 Genetransfer RNA-Met (CAT) 3-1 |
TRM-CAT6-1 Genetransfer RNA-Met (CAT) 6-1 |
TRM-CAT4-1 Genetransfer RNA-Met (CAT) 4-1 |
TRM-CAT4-3 Genetransfer RNA-Met (CAT) 4-3 |
TRM-CAT4-2 Genetransfer RNA-Met (CAT) 4-2 |
TRM-CAT1-1 Genetransfer RNA-Met (CAT) 1-1 |
TRM-CAT5-1 Genetransfer RNA-Met (CAT) 5-1 |
GZMM Genegranzyme M (lymphocyte met-ase 1) Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and the protein encoded by this gene, granzyme M. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012] |
TRM-CAT7-1 Genetransfer RNA-Met (CAT) 7-1 |
Met-Met-Trp-Leu-Leu Gene SetFrom Guide to Pharmacology Chemical Ligands of Receptors receptors of the Met-Met-Trp-Leu-Leu ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset. |
MET-MET-TRP-LEU-LEU Gene Setinteracting proteins for the MET-MET-TRP-LEU-LEU drug from theDGIdb Drug Targets 2026 dataset. |
HGF-Met complex Gene Setproteins in the HGF-Met complex protein complex from the CORUM Protein Complexes dataset. |
MET-CIN85-SH3GL3-CBL complex, HGF stimulated Gene Setproteins in the MET-CIN85-SH3GL3-CBL complex, HGF stimulated protein complex from the CORUM Protein Complexes dataset. |
cyclo(Gln-Trp-Phe-Gly-Leu-Met) Gene SetFrom CTD Gene-Chemical Interactions genes/proteins interacting with the chemical cyclo(Gln-Trp-Phe-Gly-Leu-Met) from the curated CTD Gene-Chemical Interactions dataset. |
met Gene SetFrom GeneRIF Biological Term Annotations genes co-occuring with the biological term met in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. |
[3H](Pyr1)[Met(0)11]-apelin-13 Gene SetFrom Guide to Pharmacology Chemical Ligands of Receptors receptors of the [3H](Pyr1)[Met(0)11]-apelin-13 ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset. |
fMet-Met-Tyr-Ala-Leu-Phe Gene SetFrom Guide to Pharmacology Chemical Ligands of Receptors receptors of the fMet-Met-Tyr-Ala-Leu-Phe ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset. |
i-Boc-Met-Leu-Phe Gene SetFrom Guide to Pharmacology Chemical Ligands of Receptors receptors of the i-Boc-Met-Leu-Phe ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset. |
t-Boc-Met-Leu-Phe Gene SetFrom Guide to Pharmacology Chemical Ligands of Receptors receptors of the t-Boc-Met-Leu-Phe ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset. |
[Met5]dynorphin-(1-17) Gene SetFrom Guide to Pharmacology Chemical Ligands of Receptors receptors of the [Met5]dynorphin-(1-17) ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset. |
fMet-Met-Trp-Leu-Leu Gene SetFrom Guide to Pharmacology Chemical Ligands of Receptors receptors of the fMet-Met-Trp-Leu-Leu ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset. |
Met-Ckβ7 Gene SetFrom Guide to Pharmacology Chemical Ligands of Receptors receptors of the Met-Ckβ7 ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset. |
Met-Lys-bradykinin Gene SetFrom Guide to Pharmacology Chemical Ligands of Receptors receptors of the Met-Lys-bradykinin ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset. |
[125I]BH-[Sar9 Met(O2)11]SP Gene SetFrom Guide to Pharmacology Chemical Ligands of Receptors receptors of the [125I]BH-[Sar9 Met(O2)11]SP ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset. |
[3H]BH-[Sar9 Met(O2)11]SP Gene SetFrom Guide to Pharmacology Chemical Ligands of Receptors receptors of the [3H]BH-[Sar9 Met(O2)11]SP ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset. |
[Sar9 Met(O2)11]SP Gene SetFrom Guide to Pharmacology Chemical Ligands of Receptors receptors of the [Sar9 Met(O2)11]SP ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset. |
Cys/Met metabolism, pyridoxal phosphate-dependent enzyme Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Cys/Met metabolism, pyridoxal phosphate-dependent enzyme protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
MET Gene SetFrom KEA Substrates of Kinases substrates of the kinase MET from the curated KEA Substrates of Kinases dataset. |
MET Gene SetFrom Pathway Commons Protein-Protein Interactions interacting proteins for MET from the Pathway Commons Protein-Protein Interactions dataset. |
MET Gene SetFrom PhosphoSitePlus Substrates of Kinases substrates of the kinase MET from the curated PhosphoSitePlus Substrates of Kinases dataset. |
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) Gene SetFrom PID Pathways proteins participating in the Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) pathway from the PID Pathways dataset. |
met-enkephalinrgl Gene SetFrom LINCS L1000 CMAP Chemical Perturbation Consensus Signatures genes differentially expressed following the met-enkephalinrgl small molecule perturbation from the LINCS L1000 CMAP Chemical Perturbation Consensus Signatures dataset. |
MET Gene SetFrom Kinase Library Tyrosine Kinome Atlas substrates of the kinase MET from the Kinase Library Tyrosine Kinome Atlas dataset. |
MET in type 1 papillary renal cell carcinoma Gene SetFrom WikiPathways Pathways 2024 proteins participating in the MET in type 1 papillary renal cell carcinoma pathway from the WikiPathways Pathways 2024 dataset. |
Drug-mediated inhibition of MET activation Gene Setproteins participating in the Drug-mediated inhibition of MET activation pathway from the Reactome Pathways 2024 dataset. |
MET Receptor Activation Gene Setproteins participating in the MET Receptor Activation pathway from the Reactome Pathways 2024 dataset. |
MET activates PI3K/AKT signaling Gene Setproteins participating in the MET activates PI3K/AKT signaling pathway from the Reactome Pathways 2024 dataset. |
MET activates PTK2 signaling Gene Setproteins participating in the MET activates PTK2 signaling pathway from the Reactome Pathways 2024 dataset. |
MET activates PTPN11 Gene Setproteins participating in the MET activates PTPN11 pathway from the Reactome Pathways 2024 dataset. |
MET activates RAP1 and RAC1 Gene Setproteins participating in the MET activates RAP1 and RAC1 pathway from the Reactome Pathways 2024 dataset. |
MET activates RAS signaling Gene Setproteins participating in the MET activates RAS signaling pathway from the Reactome Pathways 2024 dataset. |
MET activates STAT3 Gene Setproteins participating in the MET activates STAT3 pathway from the Reactome Pathways 2024 dataset. |
MET interacts with TNS proteins Gene Setproteins participating in the MET interacts with TNS proteins pathway from the Reactome Pathways 2024 dataset. |
MET promotes cell motility Gene Setproteins participating in the MET promotes cell motility pathway from the Reactome Pathways 2024 dataset. |
MET receptor recycling Gene Setproteins participating in the MET receptor recycling pathway from the Reactome Pathways 2024 dataset. |
Negative regulation of MET activity Gene Setproteins participating in the Negative regulation of MET activity pathway from the Reactome Pathways 2024 dataset. |
Signaling by MET Gene Setproteins participating in the Signaling by MET pathway from the Reactome Pathways 2024 dataset. |
ALK/C-MET INHIBITOR TQ-B3139 Gene Setinteracting proteins for the ALK/C-MET INHIBITOR TQ-B3139 drug from theDGIdb Drug Targets 2026 dataset. |
[3H](PYR1)[MET(0)11]-APELIN-13 Gene Setinteracting proteins for the [3H](PYR1)[MET(0)11]-APELIN-13 drug from theDGIdb Drug Targets 2026 dataset. |
MET-LYS-BRADYKININ Gene Setinteracting proteins for the MET-LYS-BRADYKININ drug from theDGIdb Drug Targets 2026 dataset. |
MET-CKΒ7 Gene Setinteracting proteins for the MET-CKΒ7 drug from theDGIdb Drug Targets 2026 dataset. |
ANTI-MET MONOCLONAL ANTIBODY MIXTURE SYM015 Gene Setinteracting proteins for the ANTI-MET MONOCLONAL ANTIBODY MIXTURE SYM015 drug from theDGIdb Drug Targets 2026 dataset. |
ANTI-MET/EGFR MONOCLONAL ANTIBODY LY3164530 Gene Setinteracting proteins for the ANTI-MET/EGFR MONOCLONAL ANTIBODY LY3164530 drug from theDGIdb Drug Targets 2026 dataset. |
FMET-MET-TRP-LEU-LEU Gene Setinteracting proteins for the FMET-MET-TRP-LEU-LEU drug from theDGIdb Drug Targets 2026 dataset. |
FMET-MET-TYR-ALA-LEU-PHE Gene Setinteracting proteins for the FMET-MET-TYR-ALA-LEU-PHE drug from theDGIdb Drug Targets 2026 dataset. |
I-BOC-MET-LEU-PHE Gene Setinteracting proteins for the I-BOC-MET-LEU-PHE drug from theDGIdb Drug Targets 2026 dataset. |
T-BOC-MET-LEU-PHE Gene Setinteracting proteins for the T-BOC-MET-LEU-PHE drug from theDGIdb Drug Targets 2026 dataset. |
ANTI-C-MET MONOCLONAL ANTIBODY SAIT301 Gene Setinteracting proteins for the ANTI-C-MET MONOCLONAL ANTIBODY SAIT301 drug from theDGIdb Drug Targets 2026 dataset. |
C-MET INHIBITOR Gene Setinteracting proteins for the C-MET INHIBITOR drug from theDGIdb Drug Targets 2026 dataset. |
C-MET INHIBITOR AMG 208 Gene Setinteracting proteins for the C-MET INHIBITOR AMG 208 drug from theDGIdb Drug Targets 2026 dataset. |
C-MET INHIBITOR AMG 337 Gene Setinteracting proteins for the C-MET INHIBITOR AMG 337 drug from theDGIdb Drug Targets 2026 dataset. |
C-MET INHIBITOR MK2461 Gene Setinteracting proteins for the C-MET INHIBITOR MK2461 drug from theDGIdb Drug Targets 2026 dataset. |
MET TYROSINE KINASE INHIBITOR SGX523 Gene Setinteracting proteins for the MET TYROSINE KINASE INHIBITOR SGX523 drug from theDGIdb Drug Targets 2026 dataset. |
[SAR9,MET(O2)11]SP Gene Setinteracting proteins for the [SAR9,MET(O2)11]SP drug from theDGIdb Drug Targets 2026 dataset. |
CYCLOLINOPEPTIDE 1-MSO,3-MET-CL6 Gene Setinteracting proteins for the CYCLOLINOPEPTIDE 1-MSO,3-MET-CL6 drug from theDGIdb Drug Targets 2026 dataset. |
PMC4176154-supp_gku626_nar-01170-met-g-2014-File003.pdf-6-CREB3L4_CREB3L4 Gene SetFrom Rummagene Transcription Factor Associations 2026 target genes of the PMC4176154-supp_gku626_nar-01170-met-g-2014-File003.pdf-6-CREB3L4_CREB3L4 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset. |
PMC4176154-supp_gku626_nar-01170-met-g-2014-File003.pdf-7-FOXD2_FOXD2 Gene SetFrom Rummagene Transcription Factor Associations 2026 target genes of the PMC4176154-supp_gku626_nar-01170-met-g-2014-File003.pdf-7-FOXD2_FOXD2 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset. |
PMC2800233-gkp882_nar-01053-met-g-2009-File009.xls-Sheet1-The_basic_statistic_of_63_novel_promoter_CGIs_identified_only_by_CpG_MI_MITF Gene SetFrom Rummagene Transcription Factor Associations 2026 target genes of the PMC2800233-gkp882_nar-01053-met-g-2009-File009.xls-Sheet1-The_basic_statistic_of_63_novel_promoter_CGIs_identified_only_by_CpG_MI_MITF transcription factor from the Rummagene Transcription Factor Associations 2026 dataset. |
PMC5159535-supp_gkw757_nar-00810-met-z-2016-File016.xlsx-S9_SOM-Unnamed_3_GRHL3 Gene SetFrom Rummagene Transcription Factor Associations 2026 target genes of the PMC5159535-supp_gkw757_nar-00810-met-z-2016-File016.xlsx-S9_SOM-Unnamed_3_GRHL3 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset. |
PMC4994863-supp_gkw430_nar-02567-met-g-2015-File013.xlsx-LPS-Gene_Name_IRF6 Gene SetFrom Rummagene Transcription Factor Associations 2026 target genes of the PMC4994863-supp_gkw430_nar-02567-met-g-2015-File013.xlsx-LPS-Gene_Name_IRF6 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset. |
PMC4083110-supp_M113.034876_mcp.M113.034876-9.xlsx-AR-KIT-MET-GAB1_HPRD-SH2_domain_AR Gene SetFrom Rummagene Transcription Factor Associations 2026 target genes of the PMC4083110-supp_M113.034876_mcp.M113.034876-9.xlsx-AR-KIT-MET-GAB1_HPRD-SH2_domain_AR transcription factor from the Rummagene Transcription Factor Associations 2026 dataset. |
PMC4083110-supp_M113.034876_mcp.M113.034876-9.xlsx-AR-KIT-MET-GAB1_BioGRID-SH2_domain_AR Gene SetFrom Rummagene Transcription Factor Associations 2026 target genes of the PMC4083110-supp_M113.034876_mcp.M113.034876-9.xlsx-AR-KIT-MET-GAB1_BioGRID-SH2_domain_AR transcription factor from the Rummagene Transcription Factor Associations 2026 dataset. |
PMC4083110-supp_M113.034876_mcp.M113.034876-9.xlsx-AR-KIT-MET-GAB1_IntACT-SH2_domain_AR Gene SetFrom Rummagene Transcription Factor Associations 2026 target genes of the PMC4083110-supp_M113.034876_mcp.M113.034876-9.xlsx-AR-KIT-MET-GAB1_IntACT-SH2_domain_AR transcription factor from the Rummagene Transcription Factor Associations 2026 dataset. |
PMC4838354-supp_gkv1491_nar-01150-met-k-2015-File011.xlsx-Differentially_expressed_genes-Differntially_expressed_PBX1_and_NOTCH3_common_genes_under_siPBX1_Fold_Change_FC_1_3_PBX1 Gene SetFrom Rummagene Transcription Factor Associations 2026 target genes of the PMC4838354-supp_gkv1491_nar-01150-met-k-2015-File011.xlsx-Differentially_expressed_genes-Differntially_expressed_PBX1_and_NOTCH3_common_genes_under_siPBX1_Fold_Change_FC_1_3_PBX1 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset. |
PMC4838354-supp_gkv1491_nar-01150-met-k-2015-File011.xlsx-Differentially_expressed_genes-Differntially_expressed_PBX1_and_NOTCH3_common_genes_under_siNOTCH3_FC_1_3_PBX1 Gene SetFrom Rummagene Transcription Factor Associations 2026 target genes of the PMC4838354-supp_gkv1491_nar-01150-met-k-2015-File011.xlsx-Differentially_expressed_genes-Differntially_expressed_PBX1_and_NOTCH3_common_genes_under_siNOTCH3_FC_1_3_PBX1 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset. |
PMC4838354-supp_gkv1491_nar-01150-met-k-2015-File011.xlsx-Differentially_expressed_genes-Differntially_expressed_PBX1_and_NOTCH3_common_genes_under_GSI_FC_1_3_PBX1 Gene SetFrom Rummagene Transcription Factor Associations 2026 target genes of the PMC4838354-supp_gkv1491_nar-01150-met-k-2015-File011.xlsx-Differentially_expressed_genes-Differntially_expressed_PBX1_and_NOTCH3_common_genes_under_GSI_FC_1_3_PBX1 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset. |
PMC4838354-supp_gkv1491_nar-01150-met-k-2015-File010.xlsx-ChIP-seq_defined_target_genes-PBX1_and_Notch3_common_target_gene_list_621_PBX1 Gene SetFrom Rummagene Transcription Factor Associations 2026 target genes of the PMC4838354-supp_gkv1491_nar-01150-met-k-2015-File010.xlsx-ChIP-seq_defined_target_genes-PBX1_and_Notch3_common_target_gene_list_621_PBX1 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset. |
PMC4797273-supp_gkv1281_nar-02445-met-n-2015-File009.xlsx-Supp_Tab_S3A_A549-Table_S3_Prediction_accuracies_of_CTCF-TF_co-occupancy_in_the_A_A549_B_GM12878_C_H1-hESC_D_HepG-2_and_E_K562_cell_lines_CTCF Gene SetFrom Rummagene Transcription Factor Associations 2026 target genes of the PMC4797273-supp_gkv1281_nar-02445-met-n-2015-File009.xlsx-Supp_Tab_S3A_A549-Table_S3_Prediction_accuracies_of_CTCF-TF_co-occupancy_in_the_A_A549_B_GM12878_C_H1-hESC_D_HepG-2_and_E_K562_cell_lines_CTCF transcription factor from the Rummagene Transcription Factor Associations 2026 dataset. |
PMC4797273-supp_gkv1281_nar-02445-met-n-2015-File009.xlsx-Supp_Tab_S5_SP1-TF-Unnamed_19_SP1 Gene SetFrom Rummagene Transcription Factor Associations 2026 target genes of the PMC4797273-supp_gkv1281_nar-02445-met-n-2015-File009.xlsx-Supp_Tab_S5_SP1-TF-Unnamed_19_SP1 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset. |
MET Gene SetFrom CM4AI KOLF21J CRISPRi Gene Perturbation Atlas genes differentially expressed following the MET gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas. |