Harmonizome 3.0

Raf-1 proto-oncogene, serine/threonine kinase

This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term raf1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Hub Proteins Protein-Protein Interactions

interacting proteins for hub protein RAF1 from the curated Hub Proteins Protein-Protein Interactions dataset.

From KEA Substrates of Kinases

substrates of the kinase RAF1 from the curated KEA Substrates of Kinases dataset.

From MSigDB Cancer Gene Co-expression Modules

co-expressed genes for RAF1 from the MSigDB Cancer Gene Co-expression Modules dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for RAF1 from the Pathway Commons Protein-Protein Interactions dataset.

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase RAF1 from the curated PhosphoSitePlus Substrates of Kinases dataset.

From Kinase Library Serine Threonine Kinome Atlas

substrates of the kinase RAF1 from the Kinase Library Serine Threonine Kinome Atlas dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the RAF1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the RAF1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From CORUM Protein Complexes

proteins in the Raf1-PP2A core enzyme complex (Ppp2r1a, Ppp2ca), untreated protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the BRAF-RAF1-14-3-3 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Raf1-PP2A holoenzyme complex (Ppp2r1a, Ppp2r2b, Ppp2ca), PDGF stimulated protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the RAF1-PPP2-PIN1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the RAF1-RAS complex, EGF induced protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the RAF1-MAP2K1-YWHAE complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the KSR1-RAF1-MEK complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the G protein complex (GNG2, GNB2L1, RAF1) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the CNK1-SRC-RAF1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the MAP2K1-BRAF-RAF1-YWHAE-KSR1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the RAF1-BRAF complex, RAS stimulated protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the RAF1-CNK1 complex, RAS stimulated protein complex from the CORUM Protein Complexes dataset.

From NURSA Protein Complexes

proteins in the BL5963 (RAF1) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From Reactome Pathways 2024

proteins participating in the Signaling by BRAF and RAF1 fusions pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Signaling by RAF1 mutants pathway from the Reactome Pathways 2024 dataset.