Harmonizome 3.0

SMAD family member 2

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]

From ChEA Transcription Factor Targets

target genes of the SMAD2 transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term smad2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Hub Proteins Protein-Protein Interactions

interacting proteins for hub protein SMAD2 from the curated Hub Proteins Protein-Protein Interactions dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for SMAD2 from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the SMAD2 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From JASPAR Predicted Human Transcription Factor Targets 2025

target genes of the SMAD2 transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the SMAD2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From ChEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the SMAD2-18955504-HaCaT-human transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the smad2-smad3 protein complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the smad2-smad4 protein complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the smad2-smad3 protein complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

From CORUM Protein Complexes

proteins in the SKI-SMAD2-SMAD4 pentameric complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SKI-SMAD2 hexameric complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the TIF1gamma-SMAD2-SMAD3 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SMAD2-FAST1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SMAD2-SMAD4-FAST1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the PML-SMAD2/3-SARA complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Smad2-Smad4 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the CREBBP-SMAD2 hexameric complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SMAD2-SKI complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the CREBBP-SMAD2-SMAD4 pentameric complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SMAD2-SKI-NCOR complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SMAD4-SMAD2-SMAD3 complex protein complex from the CORUM Protein Complexes dataset.

From GO Cellular Component Annotations 2015

proteins localized to the smad2-smad3 protein complex cellular component from the curated GO Cellular Component Annotations 2015 dataset.

From PID Pathways

proteins participating in the Regulation of cytoplasmic and nuclear SMAD2/3 signaling pathway from the PID Pathways dataset.

From PID Pathways

proteins participating in the Regulation of nuclear SMAD2/3 signaling pathway from the PID Pathways dataset.

From Reactome Pathways 2014

proteins participating in the SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the SMAD2/3 MH2 Domain Mutants in Cancer pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Loss of Function of SMAD2/3 in Cancer pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Downregulation of SMAD2/3:SMAD4 transcriptional activity pathway from the Reactome Pathways dataset.

From ChEA Transcription Factor Targets 2022

target genes of the SMAD2/3-21741376-ESCS-HUMAN transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.

From ChEA Transcription Factor Targets 2022

target genes of the SMAD2-18955504-HACAT-HUMAN transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.

From ChEA Transcription Factor Targets 2022

target genes of the SMAD2/3-21741376-EPCS-HUMAN transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.

From Reactome Pathways 2024

proteins participating in the Downregulation of SMAD2/3:SMAD4 transcriptional activity pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Loss of Function of SMAD2/3 in Cancer pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the SMAD2/3 MH2 Domain Mutants in Cancer pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway from the Reactome Pathways 2024 dataset.