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APC Geneadenomatous polyposis coli This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Mutations in the APC gene have been found to occur in most colorectal cancers, where disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jun 2022] |
apc Gene SetFrom GeneRIF Biological Term Annotations genes co-occuring with the biological term apc in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. |
APC Gene SetFrom Hub Proteins Protein-Protein Interactions interacting proteins for hub protein APC from the curated Hub Proteins Protein-Protein Interactions dataset. |
APC Gene SetFrom NURSA Protein-Protein Interactions interacting proteins for APC from the NURSA Protein-Protein Interactions dataset. |
APC Gene SetFrom Pathway Commons Protein-Protein Interactions interacting proteins for APC from the Pathway Commons Protein-Protein Interactions dataset. |
APC Gene SetFrom CM4AI KOLF21J CRISPRi Gene Perturbation Atlas genes differentially expressed following the APC gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas. |
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Gene Setproteins participating in the Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase pathway from the Reactome Pathways dataset. |
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Gene Setproteins participating in the Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway from the Reactome Pathways dataset. |
Inactivation of APC/C via direct inhibition of the APC/C complex Gene Setproteins participating in the Inactivation of APC/C via direct inhibition of the APC/C complex pathway from the Reactome Pathways dataset. |
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Gene Setproteins participating in the APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway from the Reactome Pathways dataset. |
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Gene Setproteins participating in the APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway from the Reactome Pathways 2024 dataset. |
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Gene Setproteins participating in the Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway from the Reactome Pathways 2024 dataset. |
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Gene Setproteins participating in the Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase pathway from the Reactome Pathways 2024 dataset. |
Inactivation of APC/C via direct inhibition of the APC/C complex Gene Setproteins participating in the Inactivation of APC/C via direct inhibition of the APC/C complex pathway from the Reactome Pathways 2024 dataset. |
scrib-apc-beta-catenin complex Gene SetFrom COMPARTMENTS Curated Protein Localization Evidence Scores proteins localized to the scrib-apc-beta-catenin complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. |
apc-tubulin-iqgap1 complex Gene SetFrom COMPARTMENTS Text-mining Protein Localization Evidence Scores proteins co-occuring with the apc-tubulin-iqgap1 complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. |
Axin2-Ctnnb1-Apc complex Gene Setproteins in the Axin2-Ctnnb1-Apc complex protein complex from the CORUM Protein Complexes dataset. |
EB1-APC-mDia2 complex Gene Setproteins in the EB1-APC-mDia2 complex protein complex from the CORUM Protein Complexes dataset. |
APC-DLG4 complex Gene Setproteins in the APC-DLG4 complex protein complex from the CORUM Protein Complexes dataset. |
60S APC containing complex Gene Setproteins in the 60S APC containing complex protein complex from the CORUM Protein Complexes dataset. |
Scrib-APC-beta-catenin complex Gene Setproteins in the Scrib-APC-beta-catenin complex protein complex from the CORUM Protein Complexes dataset. |
EB1-APC-mDia1 complex Gene Setproteins in the EB1-APC-mDia1 complex protein complex from the CORUM Protein Complexes dataset. |
AXIN-APC-betaCatenin-GSK3B complex Gene Setproteins in the AXIN-APC-betaCatenin-GSK3B complex protein complex from the CORUM Protein Complexes dataset. |
SCRIB-APC complex Gene Setproteins in the SCRIB-APC complex protein complex from the CORUM Protein Complexes dataset. |
APC-Axin-1-beta-catenin complex Gene Setproteins in the APC-Axin-1-beta-catenin complex protein complex from the CORUM Protein Complexes dataset. |
inhibition of apc-cdc20 complex activity Gene SetFrom GO Biological Process Annotations 2015 genes participating in the inhibition of apc-cdc20 complex activity biological process from the curated GO Biological Process Annotations 2015 dataset. |
negative regulation of apc-cdc20 complex activity Gene SetFrom GO Biological Process Annotations 2015 genes participating in the negative regulation of apc-cdc20 complex activity biological process from the curated GO Biological Process Annotations 2015 dataset. |
activation of apc-cdc20 complex activity Gene SetFrom GO Biological Process Annotations 2015 genes participating in the activation of apc-cdc20 complex activity biological process from the curated GO Biological Process Annotations 2015 dataset. |
scrib-apc-beta-catenin complex Gene SetFrom GO Cellular Component Annotations 2015 proteins localized to the scrib-apc-beta-catenin complex cellular component from the curated GO Cellular Component Annotations 2015 dataset. |
Adenomatous polyposis coli (APC) family Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Adenomatous polyposis coli (APC) family protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
Suppressor APC domain-containing protein 1/2 Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Suppressor APC domain-containing protein 1/2 protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
BL3106 (APC) Gene Setproteins in the BL3106 (APC) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset. |
Autodegradation of Cdh1 by Cdh1:APC/C Gene Setproteins participating in the Autodegradation of Cdh1 by Cdh1:APC/C pathway from the Reactome Pathways dataset. |
APC truncation mutants have impaired AXIN binding Gene Setproteins participating in the APC truncation mutants have impaired AXIN binding pathway from the Reactome Pathways dataset. |
APC truncation mutants are not K63 polyubiquitinated Gene Setproteins participating in the APC truncation mutants are not K63 polyubiquitinated pathway from the Reactome Pathways dataset. |
Phosphorylation of the APC/C Gene Setproteins participating in the Phosphorylation of the APC/C pathway from the Reactome Pathways dataset. |
APC/C:Cdc20 mediated degradation of mitotic proteins Gene Setproteins participating in the APC/C:Cdc20 mediated degradation of mitotic proteins pathway from the Reactome Pathways dataset. |
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Gene Setproteins participating in the APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint pathway from the Reactome Pathways dataset. |
APC-Cdc20 mediated degradation of Nek2A Gene Setproteins participating in the APC-Cdc20 mediated degradation of Nek2A pathway from the Reactome Pathways dataset. |
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Gene Setproteins participating in the Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components pathway from the Reactome Pathways dataset. |
Regulation of APC/C activators between G1/S and early anaphase Gene Setproteins participating in the Regulation of APC/C activators between G1/S and early anaphase pathway from the Reactome Pathways dataset. |
truncated APC mutants destabilize the destruction complex Gene Setproteins participating in the truncated APC mutants destabilize the destruction complex pathway from the Reactome Pathways dataset. |
APC/C:Cdc20 mediated degradation of Securin Gene Setproteins participating in the APC/C:Cdc20 mediated degradation of Securin pathway from the Reactome Pathways dataset. |
APC/C:Cdc20 mediated degradation of Cyclin B Gene Setproteins participating in the APC/C:Cdc20 mediated degradation of Cyclin B pathway from the Reactome Pathways dataset. |
APC/C-mediated degradation of cell cycle proteins Gene Setproteins participating in the APC/C-mediated degradation of cell cycle proteins pathway from the Reactome Pathways dataset. |
Cdc20:Phospho-APC/C mediated degradation of Cyclin A Gene Setproteins participating in the Cdc20:Phospho-APC/C mediated degradation of Cyclin A pathway from the Reactome Pathways dataset. |
APC truncation mutants are not K63 polyubiquitinated Gene Setproteins participating in the APC truncation mutants are not K63 polyubiquitinated pathway from the Reactome Pathways 2024 dataset. |
APC truncation mutants have impaired AXIN binding Gene Setproteins participating in the APC truncation mutants have impaired AXIN binding pathway from the Reactome Pathways 2024 dataset. |
APC-Cdc20 mediated degradation of Nek2A Gene Setproteins participating in the APC-Cdc20 mediated degradation of Nek2A pathway from the Reactome Pathways 2024 dataset. |
APC/C-mediated degradation of cell cycle proteins Gene Setproteins participating in the APC/C-mediated degradation of cell cycle proteins pathway from the Reactome Pathways 2024 dataset. |
APC/C:Cdc20 mediated degradation of Cyclin B Gene Setproteins participating in the APC/C:Cdc20 mediated degradation of Cyclin B pathway from the Reactome Pathways 2024 dataset. |
APC/C:Cdc20 mediated degradation of Securin Gene Setproteins participating in the APC/C:Cdc20 mediated degradation of Securin pathway from the Reactome Pathways 2024 dataset. |
APC/C:Cdc20 mediated degradation of mitotic proteins Gene Setproteins participating in the APC/C:Cdc20 mediated degradation of mitotic proteins pathway from the Reactome Pathways 2024 dataset. |
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Gene Setproteins participating in the APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint pathway from the Reactome Pathways 2024 dataset. |
Autodegradation of Cdh1 by Cdh1:APC/C Gene Setproteins participating in the Autodegradation of Cdh1 by Cdh1:APC/C pathway from the Reactome Pathways 2024 dataset. |
Cdc20:Phospho-APC/C mediated degradation of Cyclin A Gene Setproteins participating in the Cdc20:Phospho-APC/C mediated degradation of Cyclin A pathway from the Reactome Pathways 2024 dataset. |
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Gene Setproteins participating in the Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components pathway from the Reactome Pathways 2024 dataset. |
Phosphorylation of the APC/C Gene Setproteins participating in the Phosphorylation of the APC/C pathway from the Reactome Pathways 2024 dataset. |
Regulation of APC/C activators between G1/S and early anaphase Gene Setproteins participating in the Regulation of APC/C activators between G1/S and early anaphase pathway from the Reactome Pathways 2024 dataset. |
Signaling by APC mutants Gene Setproteins participating in the Signaling by APC mutants pathway from the Reactome Pathways 2024 dataset. |
Scrib-APC-beta-catenin complex Gene SetFrom COMPARTMENTS Curated Protein Localization Evidence Scores 2025 proteins localized to the Scrib-APC-beta-catenin complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. |
APC-tubulin-IQGAP1 complex Gene SetFrom COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 proteins co-occuring with the APC-tubulin-IQGAP1 complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. |
Scrib-APC-beta-catenin complex Gene SetFrom COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 proteins co-occuring with the Scrib-APC-beta-catenin complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. |
APC-Associated Polyposis Disorders Gene SetFrom ClinVar Gene-Phenotype Associations 2025 genes associated with the APC-Associated Polyposis Disorders phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset. |
APC-related attenuated familial adenomatous polyposis Gene SetFrom ClinVar Gene-Phenotype Associations 2025 genes associated with the APC-related attenuated familial adenomatous polyposis phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset. |
APC-100 Gene Setinteracting proteins for the APC-100 drug from theDGIdb Drug Targets 2026 dataset. |
