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ATF6 Geneactivating transcription factor 6 This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq, Aug 2011] |
ATF6 (ATF6-alpha) activates chaperones Gene Setproteins participating in the ATF6 (ATF6-alpha) activates chaperones pathway from the Reactome Pathways 2024 dataset. |
ATF6-alpha activates chaperones Gene Setproteins participating in the ATF6-alpha activates chaperones pathway from the Reactome Pathways dataset. |
ATF6B (ATF6-beta) activates chaperones Gene Setproteins participating in the ATF6B (ATF6-beta) activates chaperones pathway from the Reactome Pathways 2024 dataset. |
ATF6 (ATF6-alpha) activates chaperone genes Gene Setproteins participating in the ATF6 (ATF6-alpha) activates chaperone genes pathway from the Reactome Pathways 2024 dataset. |
IRE1alpha activates chaperones Gene Setproteins participating in the IRE1alpha activates chaperones pathway from the Reactome Pathways dataset. |
IRE1alpha activates chaperones Gene Setproteins participating in the IRE1alpha activates chaperones pathway from the Reactome Pathways 2024 dataset. |
ATF6-alpha activates chaperone genes Gene Setproteins participating in the ATF6-alpha activates chaperone genes pathway from the Reactome Pathways dataset. |
chaperones modulate interferon signaling pathway Gene SetFrom Biocarta Pathways proteins participating in the chaperones modulate interferon signaling pathway pathway from the Biocarta Pathways dataset. |
chaperones Gene SetFrom GeneRIF Biological Term Annotations genes co-occuring with the biological term chaperones in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. |
atf6 Gene SetFrom GeneRIF Biological Term Annotations genes co-occuring with the biological term atf6 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. |
ATF6 Gene SetFrom MotifMap Predicted Transcription Factor Targets target genes of the ATF6 transcription factor predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. |
ATF6 Gene SetFrom Pathway Commons Protein-Protein Interactions interacting proteins for ATF6 from the Pathway Commons Protein-Protein Interactions dataset. |
ATF6-mediated unfolded protein response Gene SetFrom GO Biological Process Annotations 2023 genes participating in the ATF6-mediated unfolded protein response biological process from the curated GO Biological Process Annotations 2023 dataset. |
negative regulation of ATF6-mediated unfolded protein response Gene SetFrom GO Biological Process Annotations 2023 genes participating in the negative regulation of ATF6-mediated unfolded protein response biological process from the curated GO Biological Process Annotations 2023 dataset. |
regulation of ATF6-mediated unfolded protein response Gene SetFrom GO Biological Process Annotations 2023 genes participating in the regulation of ATF6-mediated unfolded protein response biological process from the curated GO Biological Process Annotations 2023 dataset. |
positive regulation of ATF6-mediated unfolded protein response Gene SetFrom GO Biological Process Annotations 2023 genes participating in the positive regulation of ATF6-mediated unfolded protein response biological process from the curated GO Biological Process Annotations 2023 dataset. |
ATF6 Gene SetFrom LINCS L1000 CMAP CRISPR Knockout Consensus Signatures genes differentially expressed following the ATF6 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. |
ATF6-mediated unfolded protein response Gene SetFrom GO Biological Process Annotations 2025 genes participating in the ATF6-mediated unfolded protein response biological process from the curated GO Biological Process Annotations 2025 dataset. |
negative regulation of ATF6-mediated unfolded protein response Gene SetFrom GO Biological Process Annotations 2025 genes participating in the negative regulation of ATF6-mediated unfolded protein response biological process from the curated GO Biological Process Annotations 2025 dataset. |
regulation of ATF6-mediated unfolded protein response Gene SetFrom GO Biological Process Annotations 2025 genes participating in the regulation of ATF6-mediated unfolded protein response biological process from the curated GO Biological Process Annotations 2025 dataset. |
positive regulation of ATF6-mediated unfolded protein response Gene SetFrom GO Biological Process Annotations 2025 genes participating in the positive regulation of ATF6-mediated unfolded protein response biological process from the curated GO Biological Process Annotations 2025 dataset. |
ATF6 Gene SetFrom JASPAR Predicted Human Transcription Factor Targets 2025 target genes of the ATF6 transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. |
PMC9882204-media-5.xlsx-ATF6-ATF6_Target_geneset_ATF6 Gene SetFrom Rummagene Transcription Factor Associations 2026 target genes of the PMC9882204-media-5.xlsx-ATF6-ATF6_Target_geneset_ATF6 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset. |
PMC8567035-CTM2-11-e578-s001.xlsx-ATF6-SEC61A1_ATF6 Gene SetFrom Rummagene Transcription Factor Associations 2026 target genes of the PMC8567035-CTM2-11-e578-s001.xlsx-ATF6-SEC61A1_ATF6 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset. |
ATF6 Gene SetFrom CM4AI KOLF21J CRISPRi Gene Perturbation Atlas genes differentially expressed following the ATF6 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas. |
activates Gene SetFrom GeneRIF Biological Term Annotations genes co-occuring with the biological term activates in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. |
ATF4 activates genes Gene Setproteins participating in the ATF4 activates genes pathway from the Reactome Pathways dataset. |
ChREBP activates metabolic gene expression Gene Setproteins participating in the ChREBP activates metabolic gene expression pathway from the Reactome Pathways dataset. |
PIP3 activates AKT signaling Gene Setproteins participating in the PIP3 activates AKT signaling pathway from the Reactome Pathways dataset. |
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Gene Setproteins participating in the Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway from the Reactome Pathways dataset. |
TGF-beta receptor signaling activates SMADs Gene Setproteins participating in the TGF-beta receptor signaling activates SMADs pathway from the Reactome Pathways dataset. |
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Gene Setproteins participating in the LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production pathway from the Reactome Pathways dataset. |
XBP1(S) activates chaperone genes Gene Setproteins participating in the XBP1(S) activates chaperone genes pathway from the Reactome Pathways dataset. |
PPARA activates gene expression Gene Setproteins participating in the PPARA activates gene expression pathway from the Reactome Pathways dataset. |
RORA activates circadian gene expression Gene Setproteins participating in the RORA activates circadian gene expression pathway from the Reactome Pathways dataset. |
TAK1 activates NFkB by phosphorylation and activation of IKKs complex Gene Setproteins participating in the TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway from the Reactome Pathways dataset. |
BMAL1:CLOCK,NPAS2 activates circadian gene expression Gene Setproteins participating in the BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway from the Reactome Pathways dataset. |
ATF4 activates genes in response to endoplasmic reticulum stress Gene Setproteins participating in the ATF4 activates genes in response to endoplasmic reticulum stress pathway from the Reactome Pathways 2024 dataset. |
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Gene Setproteins participating in the Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway from the Reactome Pathways 2024 dataset. |
BDNF activates NTRK2 (TRKB) signaling Gene Setproteins participating in the BDNF activates NTRK2 (TRKB) signaling pathway from the Reactome Pathways 2024 dataset. |
BMAL1:CLOCK,NPAS2 activates circadian gene expression Gene Setproteins participating in the BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway from the Reactome Pathways 2024 dataset. |
Calcineurin activates NFAT Gene Setproteins participating in the Calcineurin activates NFAT pathway from the Reactome Pathways 2024 dataset. |
ChREBP activates metabolic gene expression Gene Setproteins participating in the ChREBP activates metabolic gene expression pathway from the Reactome Pathways 2024 dataset. |
ERBB2 Activates PTK6 Signaling Gene Setproteins participating in the ERBB2 Activates PTK6 Signaling pathway from the Reactome Pathways 2024 dataset. |
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Gene Setproteins participating in the Erythropoietin activates Phosphoinositide-3-kinase (PI3K) pathway from the Reactome Pathways 2024 dataset. |
Erythropoietin activates Phospholipase C gamma (PLCG) Gene Setproteins participating in the Erythropoietin activates Phospholipase C gamma (PLCG) pathway from the Reactome Pathways 2024 dataset. |
Erythropoietin activates RAS Gene Setproteins participating in the Erythropoietin activates RAS pathway from the Reactome Pathways 2024 dataset. |
Erythropoietin activates STAT5 Gene Setproteins participating in the Erythropoietin activates STAT5 pathway from the Reactome Pathways 2024 dataset. |
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Gene Setproteins participating in the High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells pathway from the Reactome Pathways 2024 dataset. |
IFNG signaling activates MAPKs Gene Setproteins participating in the IFNG signaling activates MAPKs pathway from the Reactome Pathways 2024 dataset. |
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Gene Setproteins participating in the LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production pathway from the Reactome Pathways 2024 dataset. |
MET activates PI3K/AKT signaling Gene Setproteins participating in the MET activates PI3K/AKT signaling pathway from the Reactome Pathways 2024 dataset. |
MET activates PTK2 signaling Gene Setproteins participating in the MET activates PTK2 signaling pathway from the Reactome Pathways 2024 dataset. |
MET activates PTPN11 Gene Setproteins participating in the MET activates PTPN11 pathway from the Reactome Pathways 2024 dataset. |
MET activates RAP1 and RAC1 Gene Setproteins participating in the MET activates RAP1 and RAC1 pathway from the Reactome Pathways 2024 dataset. |
MET activates RAS signaling Gene Setproteins participating in the MET activates RAS signaling pathway from the Reactome Pathways 2024 dataset. |
MET activates STAT3 Gene Setproteins participating in the MET activates STAT3 pathway from the Reactome Pathways 2024 dataset. |
MTF1 activates gene expression Gene Setproteins participating in the MTF1 activates gene expression pathway from the Reactome Pathways 2024 dataset. |
NTF3 activates NTRK2 (TRKB) signaling Gene Setproteins participating in the NTF3 activates NTRK2 (TRKB) signaling pathway from the Reactome Pathways 2024 dataset. |
NTF3 activates NTRK3 signaling Gene Setproteins participating in the NTF3 activates NTRK3 signaling pathway from the Reactome Pathways 2024 dataset. |
NTF4 activates NTRK2 (TRKB) signaling Gene Setproteins participating in the NTF4 activates NTRK2 (TRKB) signaling pathway from the Reactome Pathways 2024 dataset. |
NTRK2 activates RAC1 Gene Setproteins participating in the NTRK2 activates RAC1 pathway from the Reactome Pathways 2024 dataset. |
PIP3 activates AKT signaling Gene Setproteins participating in the PIP3 activates AKT signaling pathway from the Reactome Pathways 2024 dataset. |
PPARA activates gene expression Gene Setproteins participating in the PPARA activates gene expression pathway from the Reactome Pathways 2024 dataset. |
PTK6 Activates STAT3 Gene Setproteins participating in the PTK6 Activates STAT3 pathway from the Reactome Pathways 2024 dataset. |
RORA activates gene expression Gene Setproteins participating in the RORA activates gene expression pathway from the Reactome Pathways 2024 dataset. |
SARS-CoV-1 activates/modulates innate immune responses Gene Setproteins participating in the SARS-CoV-1 activates/modulates innate immune responses pathway from the Reactome Pathways 2024 dataset. |
SARS-CoV-2 activates/modulates innate and adaptive immune responses Gene Setproteins participating in the SARS-CoV-2 activates/modulates innate and adaptive immune responses pathway from the Reactome Pathways 2024 dataset. |
TGF-beta receptor signaling activates SMADs Gene Setproteins participating in the TGF-beta receptor signaling activates SMADs pathway from the Reactome Pathways 2024 dataset. |
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Gene Setproteins participating in the Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells pathway from the Reactome Pathways 2024 dataset. |
XBP1(S) activates chaperone genes Gene Setproteins participating in the XBP1(S) activates chaperone genes pathway from the Reactome Pathways 2024 dataset. |
