Harmonizome 3.0

CREB regulated transcription coactivator 2 pseudogene

CREB regulated transcription coactivator 1 pseudogene

CREB regulated transcription coactivator 1

Enables cAMP response element binding protein binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in cytosol; nuclear body; and plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

CREB regulated transcription coactivator 3

This gene is a member of the CREB regulated transcription coactivator gene family. This family regulates CREB-dependent gene transcription in a phosphorylation-independent manner and may be selective for cAMP-responsive genes. The protein encoded by this gene may induce mitochondrial biogenesis and attenuate catecholamine signaling in adipose tissue. A translocation event between this gene and Notch coactivator mastermind-like gene 2, which results in a fusion protein, has been reported in mucoepidermoid carcinomas. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

CREB regulated transcription coactivator 2

This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2010]

CREB/ATF bZIP transcription factor

Enables identical protein binding activity. Involved in negative regulation of gene expression, epigenetic; regulation of DNA-templated transcription; and response to virus. Located in mitochondrion and nucleoplasm. Part of RNA polymerase II transcription regulator complex. [provided by Alliance of Genome Resources, Mar 2025]

CREB binding protein

This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009]

From MotifMap Predicted Transcription Factor Targets

target genes of the CREB, ATF transcription factor predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term atf in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the cAMP-dependent transcription factor ATF-3 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the cAMP-dependent transcription factor ATF-2 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Basic leucine zipper transcriptional factor ATF-like 2 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Basic leucine zipper transcriptional factor ATF-like 3 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Basic leucine zipper transcriptional factor ATF-like protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the cAMP-dependent transcription factor ATF-6 alpha protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the cAMP-dependent transcription factor ATF-6 beta protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the cAMP-dependent transcription factor ATF-5 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the cAMP-dependent transcription factor ATF-4 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From MotifMap Predicted Transcription Factor Targets

target genes of the ATF transcription factor predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.

From PID Pathways

proteins participating in the ATF-2 transcription factor network pathway from the PID Pathways dataset.

From DGIdb Drug Targets 2026

interacting proteins for the ATF-936 drug from theDGIdb Drug Targets 2026 dataset.

From Biocarta Pathways

proteins participating in the transcription factor creb and its extracellular signals pathway from the Biocarta Pathways dataset.

From CORUM Protein Complexes

proteins in the FHL2-CREB complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the ACT-CREB complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the FHL3-CREB complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the LMO4-CREB complex protein complex from the CORUM Protein Complexes dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term creb in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GO Biological Process Annotations 2015

genes participating in the negative regulation of creb transcription factor activity biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Biological Process Annotations 2015

genes participating in the positive regulation of creb transcription factor activity biological process from the curated GO Biological Process Annotations 2015 dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Transducer of regulated CREB activity, middle domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Transducer of regulated CREB activity, C-terminal protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the cAMP response element binding (CREB) protein protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Transducer of regulated CREB activity, N-terminal protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Transducer of regulated CREB activity protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Nuclear receptor coactivator, CREB-bp-like, interlocking protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From MotifMap Predicted Transcription Factor Targets

target genes of the Tax/CREB transcription factor predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.

From MotifMap Predicted Transcription Factor Targets

target genes of the CREB transcription factor predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.

From Phosphosite Textmining Biological Term Annotations

proteins co-occuring with the biological term creb in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

From Reactome Pathways 2014

proteins participating in the PKA-mediated phosphorylation of CREB pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the CREB phosphorylation through the activation of CaMKII pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the CREB phosphorylation pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the CaMK IV-mediated phosphorylation of CREB pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the CREB phosphorylation through the activation of Adenylate Cyclase pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Gastrin-CREB signalling pathway via PKC and MAPK pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the CREB phosphorylation through the activation of CaMKK pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the CREB phosphorylation through the activation of Ras pathway from the Reactome Pathways dataset.

From GO Biological Process Annotations 2023

genes participating in the positive regulation of CREB transcription factor activity biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the negative regulation of CREB transcription factor activity biological process from the curated GO Biological Process Annotations 2023 dataset.

From Reactome Pathways 2024

proteins participating in the CREB phosphorylation pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the CaMK IV-mediated phosphorylation of CREB pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Gastrin-CREB signalling pathway via PKC and MAPK pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the PKA-mediated phosphorylation of CREB pathway from the Reactome Pathways 2024 dataset.

From GO Biological Process Annotations 2025

genes participating in the positive regulation of CREB transcription factor activity biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Biological Process Annotations 2025

genes participating in the negative regulation of CREB transcription factor activity biological process from the curated GO Biological Process Annotations 2025 dataset.