| Name |
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RAP1GAP GeneRAP1 GTPase activating protein This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Aug 2011] |
RAP1GAP2 GeneRAP1 GTPase activating protein 2 This gene encodes a GTPase-activating protein that activates the small guanine-nucleotide-binding protein Rap1 in platelets. The protein interacts with synaptotagmin-like protein 1 and Rab27 and regulates secretion of dense granules from platelets at sites of endothelial damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] |
RAP1GDS1 GeneRAP1, GTP-GDP dissociation stimulator 1 The smg GDP dissociation stimulator (smgGDS) protein is a stimulatory GDP/GTP exchange protein with GTPase activity (Riess et al., 1993 [PubMed 8262526]).[supplied by OMIM, Feb 2010] |
Rap1 signalling Gene Setproteins participating in the Rap1 signalling pathway from the Reactome Pathways dataset. |
Rap1 signalling Gene Setproteins participating in the Rap1 signalling pathway from the Reactome Pathways 2024 dataset. |
TRF2-Rap1 complex III Gene Setproteins in the TRF2-Rap1 complex III protein complex from the CORUM Protein Complexes dataset. |
RIAM-Rap1-GTP complex Gene Setproteins in the RIAM-Rap1-GTP complex protein complex from the CORUM Protein Complexes dataset. |
TRF-Rap1 complex I, 2MD Gene Setproteins in the TRF-Rap1 complex I, 2MD protein complex from the CORUM Protein Complexes dataset. |
Rap1 complex Gene Setproteins in the Rap1 complex protein complex from the CORUM Protein Complexes dataset. |
TRF2-Rap1 complex II Gene Setproteins in the TRF2-Rap1 complex II protein complex from the CORUM Protein Complexes dataset. |
TERF2-RAP1 complex Gene Setproteins in the TERF2-RAP1 complex protein complex from the CORUM Protein Complexes dataset. |
rap1 Gene SetFrom GeneRIF Biological Term Annotations genes co-occuring with the biological term rap1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. |
Rap1 Myb domain Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Rap1 Myb domain protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
TRF2-interacting telomeric protein/Rap1, C-terminal Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the TRF2-interacting telomeric protein/Rap1, C-terminal protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
MET activates RAP1 and RAC1 Gene Setproteins participating in the MET activates RAP1 and RAC1 pathway from the Reactome Pathways 2024 dataset. |
Rap1 signaling pathway Gene SetFrom KEGG Pathways 2026 proteins participating in the Rap1 signaling pathway pathway from the KEGG Pathways 2026 dataset. |
phospholipids as signalling intermediaries Gene SetFrom Biocarta Pathways proteins participating in the phospholipids as signalling intermediaries pathway from the Biocarta Pathways dataset. |
wnt lrp6 signalling Gene SetFrom Biocarta Pathways proteins participating in the wnt lrp6 signalling pathway from the Biocarta Pathways dataset. |
P2X7 receptor signalling complex Gene Setproteins in the P2X7 receptor signalling complex protein complex from the CORUM Protein Complexes dataset. |
signalling Gene SetFrom GeneRIF Biological Term Annotations genes co-occuring with the biological term signalling in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. |
BMP Signalling Pathway Gene SetFrom HumanCyc Pathways proteins participating in the BMP Signalling Pathway pathway from the HumanCyc Pathways dataset. |
Suppressor of cytokine signalling Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Suppressor of cytokine signalling protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
NO signalling/Golgi transport ligand-binding domain Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the NO signalling/Golgi transport ligand-binding domain protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
Suppressor of cytokine signalling 6 Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Suppressor of cytokine signalling 6 protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
Suppressor of cytokine signalling 7 Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Suppressor of cytokine signalling 7 protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
Suppressor of cytokine signalling 4 Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Suppressor of cytokine signalling 4 protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
Suppressor of cytokine signalling 5 Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Suppressor of cytokine signalling 5 protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
Suppressor of cytokine signalling 2 Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Suppressor of cytokine signalling 2 protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
Suppressor of cytokine signalling 3 Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Suppressor of cytokine signalling 3 protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
Suppressor of cytokine signalling 1 Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Suppressor of cytokine signalling 1 protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
G-protein-signalling modulator 1 Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the G-protein-signalling modulator 1 protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
G-protein-signalling modulator 3 Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the G-protein-signalling modulator 3 protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
Regulator of G-protein signalling 1 Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Regulator of G-protein signalling 1 protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
CD3 signalling complex delta subunit Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the CD3 signalling complex delta subunit protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
Hedgehog, N-terminal signalling domain Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Hedgehog, N-terminal signalling domain protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
Regulator of G protein signalling-like domain Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Regulator of G protein signalling-like domain protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
SRC kinase signalling inhibitor 1 Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the SRC kinase signalling inhibitor 1 protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
Signalling lymphocyte activation molecule family receptors Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Signalling lymphocyte activation molecule family receptors protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
Phosphorylated immunoreceptor signalling ITAM Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Phosphorylated immunoreceptor signalling ITAM protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
Hedgehog signalling/DD-peptidase zinc-binding domain Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Hedgehog signalling/DD-peptidase zinc-binding domain protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
Mitochondrial antiviral-signalling protein Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Mitochondrial antiviral-signalling protein protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
Regulator of G-protein signalling 9-binding protein Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Regulator of G-protein signalling 9-binding protein protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
Integrin signalling pathway Gene SetFrom PANTHER Pathways proteins participating in the Integrin signalling pathway pathway from the PANTHER Pathways dataset. |
Cell death signalling via NRAGE, NRIF and NADE Gene Setproteins participating in the Cell death signalling via NRAGE, NRIF and NADE pathway from the Reactome Pathways dataset. |
G beta:gamma signalling through PLC beta Gene Setproteins participating in the G beta:gamma signalling through PLC beta pathway from the Reactome Pathways dataset. |
Retrograde neurotrophin signalling Gene Setproteins participating in the Retrograde neurotrophin signalling pathway from the Reactome Pathways dataset. |
Thromboxane signalling through TP receptor Gene Setproteins participating in the Thromboxane signalling through TP receptor pathway from the Reactome Pathways dataset. |
PLC-gamma1 signalling Gene Setproteins participating in the PLC-gamma1 signalling pathway from the Reactome Pathways dataset. |
Ceramide signalling Gene Setproteins participating in the Ceramide signalling pathway from the Reactome Pathways dataset. |
Activated TLR4 signalling Gene Setproteins participating in the Activated TLR4 signalling pathway from the Reactome Pathways dataset. |
IRS-mediated signalling Gene Setproteins participating in the IRS-mediated signalling pathway from the Reactome Pathways dataset. |
Death Receptor Signalling Gene Setproteins participating in the Death Receptor Signalling pathway from the Reactome Pathways dataset. |
Signalling to RAS Gene Setproteins participating in the Signalling to RAS pathway from the Reactome Pathways dataset. |
G beta:gamma signalling through PI3Kgamma Gene Setproteins participating in the G beta:gamma signalling through PI3Kgamma pathway from the Reactome Pathways dataset. |
Prostacyclin signalling through prostacyclin receptor Gene Setproteins participating in the Prostacyclin signalling through prostacyclin receptor pathway from the Reactome Pathways dataset. |
mTOR signalling Gene Setproteins participating in the mTOR signalling pathway from the Reactome Pathways dataset. |
SOS-mediated signalling Gene Setproteins participating in the SOS-mediated signalling pathway from the Reactome Pathways dataset. |
Opioid Signalling Gene Setproteins participating in the Opioid Signalling pathway from the Reactome Pathways dataset. |
G alpha (12/13) signalling events Gene Setproteins participating in the G alpha (12/13) signalling events pathway from the Reactome Pathways dataset. |
Thrombin signalling through proteinase activated receptors (PARs) Gene Setproteins participating in the Thrombin signalling through proteinase activated receptors (PARs) pathway from the Reactome Pathways dataset. |
Signalling by NGF Gene Setproteins participating in the Signalling by NGF pathway from the Reactome Pathways dataset. |
p75 NTR receptor-mediated signalling Gene Setproteins participating in the p75 NTR receptor-mediated signalling pathway from the Reactome Pathways dataset. |
PDE3B signalling Gene Setproteins participating in the PDE3B signalling pathway from the Reactome Pathways dataset. |
GP1b-IX-V activation signalling Gene Setproteins participating in the GP1b-IX-V activation signalling pathway from the Reactome Pathways dataset. |
Signalling to ERKs Gene Setproteins participating in the Signalling to ERKs pathway from the Reactome Pathways dataset. |
p75NTR recruits signalling complexes Gene Setproteins participating in the p75NTR recruits signalling complexes pathway from the Reactome Pathways dataset. |
Signalling to ERK5 Gene Setproteins participating in the Signalling to ERK5 pathway from the Reactome Pathways dataset. |
S6K1 signalling Gene Setproteins participating in the S6K1 signalling pathway from the Reactome Pathways dataset. |
G alpha (z) signalling events Gene Setproteins participating in the G alpha (z) signalling events pathway from the Reactome Pathways dataset. |
ADP signalling through P2Y purinoceptor 12 Gene Setproteins participating in the ADP signalling through P2Y purinoceptor 12 pathway from the Reactome Pathways dataset. |
Signalling to STAT3 Gene Setproteins participating in the Signalling to STAT3 pathway from the Reactome Pathways dataset. |
NGF signalling via TRKA from the plasma membrane Gene Setproteins participating in the NGF signalling via TRKA from the plasma membrane pathway from the Reactome Pathways dataset. |
G alpha (s) signalling events Gene Setproteins participating in the G alpha (s) signalling events pathway from the Reactome Pathways dataset. |
PKA activation in glucagon signalling Gene Setproteins participating in the PKA activation in glucagon signalling pathway from the Reactome Pathways dataset. |
ADP signalling through P2Y purinoceptor 1 Gene Setproteins participating in the ADP signalling through P2Y purinoceptor 1 pathway from the Reactome Pathways dataset. |
Gastrin-CREB signalling pathway via PKC and MAPK Gene Setproteins participating in the Gastrin-CREB signalling pathway via PKC and MAPK pathway from the Reactome Pathways dataset. |
Insulin receptor signalling cascade Gene Setproteins participating in the Insulin receptor signalling cascade pathway from the Reactome Pathways dataset. |
G alpha (i) signalling events Gene Setproteins participating in the G alpha (i) signalling events pathway from the Reactome Pathways dataset. |
NADE modulates death signalling Gene Setproteins participating in the NADE modulates death signalling pathway from the Reactome Pathways dataset. |
SHC-mediated signalling Gene Setproteins participating in the SHC-mediated signalling pathway from the Reactome Pathways dataset. |
S6K1-mediated signalling Gene Setproteins participating in the S6K1-mediated signalling pathway from the Reactome Pathways dataset. |
Signalling to p38 via RIT and RIN Gene Setproteins participating in the Signalling to p38 via RIT and RIN pathway from the Reactome Pathways dataset. |
G-protein beta:gamma signalling Gene Setproteins participating in the G-protein beta:gamma signalling pathway from the Reactome Pathways dataset. |
Adrenaline signalling through Alpha-2 adrenergic receptor Gene Setproteins participating in the Adrenaline signalling through Alpha-2 adrenergic receptor pathway from the Reactome Pathways dataset. |
mTORC1-mediated signalling Gene Setproteins participating in the mTORC1-mediated signalling pathway from the Reactome Pathways dataset. |
G alpha (q) signalling events Gene Setproteins participating in the G alpha (q) signalling events pathway from the Reactome Pathways dataset. |
SREBP signalling(Homo sapiens) Gene SetFrom WikiPathways Pathways 2014 proteins participating in the SREBP signalling(Homo sapiens) pathway from the WikiPathways Pathways 2014 dataset. |
Estrogen signalling(Mus musculus) Gene SetFrom WikiPathways Pathways 2014 proteins participating in the Estrogen signalling(Mus musculus) pathway from the WikiPathways Pathways 2014 dataset. |
BMP Signalling and Regulation(Homo sapiens) Gene SetFrom WikiPathways Pathways 2014 proteins participating in the BMP Signalling and Regulation(Homo sapiens) pathway from the WikiPathways Pathways 2014 dataset. |
trans-synaptic signalling via exosome Gene SetFrom SynGO Synaptic Gene Annotations genes associated with the synaptic term trans-synaptic signalling via exosome from the SynGO Synaptic Gene Annotations dataset. |
ADP signalling through P2Y purinoceptor 1 Gene Setproteins participating in the ADP signalling through P2Y purinoceptor 1 pathway from the Reactome Pathways 2024 dataset. |
ADP signalling through P2Y purinoceptor 12 Gene Setproteins participating in the ADP signalling through P2Y purinoceptor 12 pathway from the Reactome Pathways 2024 dataset. |
Adrenaline signalling through Alpha-2 adrenergic receptor Gene Setproteins participating in the Adrenaline signalling through Alpha-2 adrenergic receptor pathway from the Reactome Pathways 2024 dataset. |
Aryl hydrocarbon receptor signalling Gene Setproteins participating in the Aryl hydrocarbon receptor signalling pathway from the Reactome Pathways 2024 dataset. |
Caspase activation via extrinsic apoptotic signalling pathway Gene Setproteins participating in the Caspase activation via extrinsic apoptotic signalling pathway pathway from the Reactome Pathways 2024 dataset. |
Cell death signalling via NRAGE, NRIF and NADE Gene Setproteins participating in the Cell death signalling via NRAGE, NRIF and NADE pathway from the Reactome Pathways 2024 dataset. |
Ceramide signalling Gene Setproteins participating in the Ceramide signalling pathway from the Reactome Pathways 2024 dataset. |
G alpha (12/13) signalling events Gene Setproteins participating in the G alpha (12/13) signalling events pathway from the Reactome Pathways 2024 dataset. |
G alpha (i) signalling events Gene Setproteins participating in the G alpha (i) signalling events pathway from the Reactome Pathways 2024 dataset. |
G alpha (q) signalling events Gene Setproteins participating in the G alpha (q) signalling events pathway from the Reactome Pathways 2024 dataset. |
G alpha (s) signalling events Gene Setproteins participating in the G alpha (s) signalling events pathway from the Reactome Pathways 2024 dataset. |
G alpha (z) signalling events Gene Setproteins participating in the G alpha (z) signalling events pathway from the Reactome Pathways 2024 dataset. |
G beta:gamma signalling through BTK Gene Setproteins participating in the G beta:gamma signalling through BTK pathway from the Reactome Pathways 2024 dataset. |
G beta:gamma signalling through CDC42 Gene Setproteins participating in the G beta:gamma signalling through CDC42 pathway from the Reactome Pathways 2024 dataset. |
G beta:gamma signalling through PI3Kgamma Gene Setproteins participating in the G beta:gamma signalling through PI3Kgamma pathway from the Reactome Pathways 2024 dataset. |
G beta:gamma signalling through PLC beta Gene Setproteins participating in the G beta:gamma signalling through PLC beta pathway from the Reactome Pathways 2024 dataset. |
G-protein beta:gamma signalling Gene Setproteins participating in the G-protein beta:gamma signalling pathway from the Reactome Pathways 2024 dataset. |
GP1b-IX-V activation signalling Gene Setproteins participating in the GP1b-IX-V activation signalling pathway from the Reactome Pathways 2024 dataset. |
GPCR downstream signalling Gene Setproteins participating in the GPCR downstream signalling pathway from the Reactome Pathways 2024 dataset. |
Gastrin-CREB signalling pathway via PKC and MAPK Gene Setproteins participating in the Gastrin-CREB signalling pathway via PKC and MAPK pathway from the Reactome Pathways 2024 dataset. |
IRS-mediated signalling Gene Setproteins participating in the IRS-mediated signalling pathway from the Reactome Pathways 2024 dataset. |
Insulin receptor signalling cascade Gene Setproteins participating in the Insulin receptor signalling cascade pathway from the Reactome Pathways 2024 dataset. |
Interleukin-35 Signalling Gene Setproteins participating in the Interleukin-35 Signalling pathway from the Reactome Pathways 2024 dataset. |
MTOR signalling Gene Setproteins participating in the MTOR signalling pathway from the Reactome Pathways 2024 dataset. |
NADE modulates death signalling Gene Setproteins participating in the NADE modulates death signalling pathway from the Reactome Pathways 2024 dataset. |
Opioid Signalling Gene Setproteins participating in the Opioid Signalling pathway from the Reactome Pathways 2024 dataset. |
PDE3B signalling Gene Setproteins participating in the PDE3B signalling pathway from the Reactome Pathways 2024 dataset. |
PKA activation in glucagon signalling Gene Setproteins participating in the PKA activation in glucagon signalling pathway from the Reactome Pathways 2024 dataset. |
PLC-gamma1 signalling Gene Setproteins participating in the PLC-gamma1 signalling pathway from the Reactome Pathways 2024 dataset. |
Prostacyclin signalling through prostacyclin receptor Gene Setproteins participating in the Prostacyclin signalling through prostacyclin receptor pathway from the Reactome Pathways 2024 dataset. |
Reelin signalling pathway Gene Setproteins participating in the Reelin signalling pathway pathway from the Reactome Pathways 2024 dataset. |
Retrograde neurotrophin signalling Gene Setproteins participating in the Retrograde neurotrophin signalling pathway from the Reactome Pathways 2024 dataset. |
SARS-CoV-1 targets host intracellular signalling and regulatory pathways Gene Setproteins participating in the SARS-CoV-1 targets host intracellular signalling and regulatory pathways pathway from the Reactome Pathways 2024 dataset. |
SARS-CoV-2 targets host intracellular signalling and regulatory pathways Gene Setproteins participating in the SARS-CoV-2 targets host intracellular signalling and regulatory pathways pathway from the Reactome Pathways 2024 dataset. |
SOS-mediated signalling Gene Setproteins participating in the SOS-mediated signalling pathway from the Reactome Pathways 2024 dataset. |
Signalling to ERK5 Gene Setproteins participating in the Signalling to ERK5 pathway from the Reactome Pathways 2024 dataset. |
Signalling to ERKs Gene Setproteins participating in the Signalling to ERKs pathway from the Reactome Pathways 2024 dataset. |
Signalling to RAS Gene Setproteins participating in the Signalling to RAS pathway from the Reactome Pathways 2024 dataset. |
Signalling to STAT3 Gene Setproteins participating in the Signalling to STAT3 pathway from the Reactome Pathways 2024 dataset. |
Signalling to p38 via RIT and RIN Gene Setproteins participating in the Signalling to p38 via RIT and RIN pathway from the Reactome Pathways 2024 dataset. |
Thrombin signalling through proteinase activated receptors (PARs) Gene Setproteins participating in the Thrombin signalling through proteinase activated receptors (PARs) pathway from the Reactome Pathways 2024 dataset. |
Thromboxane signalling through TP receptor Gene Setproteins participating in the Thromboxane signalling through TP receptor pathway from the Reactome Pathways 2024 dataset. |
mTORC1-mediated signalling Gene Setproteins participating in the mTORC1-mediated signalling pathway from the Reactome Pathways 2024 dataset. |
p75 NTR receptor-mediated signalling Gene Setproteins participating in the p75 NTR receptor-mediated signalling pathway from the Reactome Pathways 2024 dataset. |
p75NTR recruits signalling complexes Gene Setproteins participating in the p75NTR recruits signalling complexes pathway from the Reactome Pathways 2024 dataset. |