Harmonizome 3.0

cyclin-dependent kinase 2

This gene encodes a member of a family of serine/threonine protein kinases that participate in cell cycle regulation. The encoded protein is the catalytic subunit of the cyclin-dependent protein kinase complex, which regulates progression through the cell cycle. Activity of this protein is especially critical during the G1 to S phase transition. This protein associates with and regulated by other subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A), and p27Kip1 (CDKN1B). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

CDK2-associated, cullin domain 1

Enables protein kinase binding activity. Involved in G1/S transition of mitotic cell cycle; positive regulation of cell population proliferation; and positive regulation of protein kinase activity. [provided by Alliance of Genome Resources, Mar 2025]

From NURSA Protein Complexes

proteins in the SC-163 (CDK2) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the cyclin e1-cdk2 complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the cyclin a1-cdk2 complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the cyclin a2-cdk2 complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the cyclin e2-cdk2 complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

From CORUM Protein Complexes

proteins in the ADAR1-CDK2 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the CDK2-CCNE1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the CDC2-CCNA2-CDK2 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the CyclinA2-Cdk2 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the p27-cyclinE-Cdk2 - Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1) complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Ccna2-Cdk2 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Cell cycle kinase complex CDK2 protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the CDK2-CCNA2 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the p27-cyclinE-CDK2 complex protein complex from the CORUM Protein Complexes dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdk2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Hub Proteins Protein-Protein Interactions

interacting proteins for hub protein CDK2 from the curated Hub Proteins Protein-Protein Interactions dataset.

From KEA Substrates of Kinases

substrates of the kinase CDK2 from the curated KEA Substrates of Kinases dataset.

From MSigDB Cancer Gene Co-expression Modules

co-expressed genes for CDK2 from the MSigDB Cancer Gene Co-expression Modules dataset.

From NURSA Protein Complexes

proteins in the BL7394 (CDK2) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for CDK2 from the Pathway Commons Protein-Protein Interactions dataset.

From Phosphosite Textmining Biological Term Annotations

proteins co-occuring with the biological term cdk2 in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase CDK2 from the curated PhosphoSitePlus Substrates of Kinases dataset.

From Reactome Pathways 2014

proteins participating in the Cyclin A:Cdk2-associated events at S phase entry pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes pathway from the Reactome Pathways dataset.

From Kinase Library Serine Threonine Kinome Atlas

substrates of the kinase CDK2 from the Kinase Library Serine Threonine Kinome Atlas dataset.

From GO Cellular Component Annotations 2023

proteins localized to the cyclin A2-CDK2 complex cellular component from the curated GO Cellular Component Annotations 2023 dataset.

From GO Cellular Component Annotations 2023

proteins localized to the cyclin E1-CDK2 complex cellular component from the curated GO Cellular Component Annotations 2023 dataset.

From GO Cellular Component Annotations 2023

proteins localized to the cyclin E2-CDK2 complex cellular component from the curated GO Cellular Component Annotations 2023 dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the CDK2 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From Reactome Pathways 2024

proteins participating in the Cyclin A:Cdk2-associated events at S phase entry pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes pathway from the Reactome Pathways 2024 dataset.

From GO Cellular Component Annotations 2025

proteins localized to the cyclin E2-CDK2 complex cellular component from the curated GO Cellular Component Annotations 2025 dataset.

From GO Cellular Component Annotations 2025

proteins localized to the cyclin A2-CDK2 complex cellular component from the curated GO Cellular Component Annotations 2025 dataset.

From GO Cellular Component Annotations 2025

proteins localized to the cyclin E1-CDK2 complex cellular component from the curated GO Cellular Component Annotations 2025 dataset.

From GO Cellular Component Annotations 2025

proteins localized to the cyclin A1-CDK2 complex cellular component from the curated GO Cellular Component Annotations 2025 dataset.

From COMPARTMENTS Curated Protein Localization Evidence Scores 2025

proteins localized to the Cyclin A2-CDK2 complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.

From COMPARTMENTS Curated Protein Localization Evidence Scores 2025

proteins localized to the Cyclin A1-CDK2 complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.

From COMPARTMENTS Curated Protein Localization Evidence Scores 2025

proteins localized to the Cyclin E2-CDK2 complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.

From COMPARTMENTS Curated Protein Localization Evidence Scores 2025

proteins localized to the Cyclin E1-CDK2 complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025

proteins co-occuring with the Cyclin E2-CDK2 complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025

proteins co-occuring with the Cyclin E1-CDK2 complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025

proteins co-occuring with the Cyclin A1-CDK2 complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025

proteins co-occuring with the Cyclin A2-CDK2 complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the CDK2 INHIBITOR IV drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the CDK2 INHIBITOR III drug from theDGIdb Drug Targets 2026 dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the CDK2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.