Harmonizome 3.0

v-crk avian sarcoma virus CT10 oncogene homolog

This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]

inhibitor of CDK, cyclin A1 interacting protein 1

Enables cyclin binding activity; cyclin-dependent protein serine/threonine kinase inhibitor activity; and identical protein binding activity. Acts upstream of or within negative regulation of cyclin-dependent protein serine/threonine kinase activity. Located in cytoplasm and nuclear body. [provided by Alliance of Genome Resources, Mar 2025]

v-crk avian sarcoma virus CT10 oncogene homolog-like

This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009]

MNAT CDK-activating kinase assembly factor 1

The protein encoded by this gene, along with cyclin H and CDK7, forms the CDK-activating kinase (CAK) enzymatic complex. This complex activates several cyclin-associated kinases and can also associate with TFIIH to activate transcription by RNA polymerase II. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

From LINCS L1000 CMAP Chemical Perturbation Consensus Signatures

genes differentially expressed following the cdk/crk-inhibitor small molecule perturbation from the LINCS L1000 CMAP Chemical Perturbation Consensus Signatures dataset.

From CORUM Protein Complexes

proteins in the CIN85 complex (CIN85, CRK, BCAR1, CBL, PIK3R1, GRB2, SOS1) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the CRKL-PDGFRA-CRK-RAPGEF1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the CRK-BCAR1-DOCK1 complex protein complex from the CORUM Protein Complexes dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term crk in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Hub Proteins Protein-Protein Interactions

interacting proteins for hub protein CRK from the curated Hub Proteins Protein-Protein Interactions dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for CRK from the Pathway Commons Protein-Protein Interactions dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the CRK gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From Biocarta Pathways

proteins participating in the cdk regulation of dna replication pathway from the Biocarta Pathways dataset.

From CORUM Protein Complexes

proteins in the CAK complex (Cdk-activating kinase complex) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the CAK core complex (Cdk-activating kinase core complex) protein complex from the CORUM Protein Complexes dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdk in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Cdk-activating kinase assembly factor MAT1, centre protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Cdk-activating kinase assembly factor MAT1/Tfb3 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From Phosphosite Textmining Biological Term Annotations

proteins co-occuring with the biological term cdk in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

From Reactome Pathways 2014

proteins participating in the CDK-mediated phosphorylation and removal of Cdc6 pathway from the Reactome Pathways dataset.

From GO Cellular Component Annotations 2023

proteins localized to the cyclin/CDK positive transcription elongation factor complex cellular component from the curated GO Cellular Component Annotations 2023 dataset.

From WikiPathways Pathways 2024

proteins participating in the H19 Rb E2F1 and CDK beta catenin in colorectal cancer pathway from the WikiPathways Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the CDK-mediated phosphorylation and removal of Cdc6 pathway from the Reactome Pathways 2024 dataset.

From GO Cellular Component Annotations 2025

proteins localized to the cyclin/CDK positive transcription elongation factor complex cellular component from the curated GO Cellular Component Annotations 2025 dataset.

From COMPARTMENTS Curated Protein Localization Evidence Scores 2025

proteins localized to the cyclin/CDK positive transcription elongation factor complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025

proteins co-occuring with the cyclin/CDK positive transcription elongation factor complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025

proteins co-occuring with the Pho85-Pho80 CDK-cyclin complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.