Harmonizome 3.0

From DGIdb Drug Targets 2026

interacting proteins for the ACETAMINOPHEN /</strong></</strong>strong></</strong></</strong>strong>strong> CAFFEINE /</strong></</strong>strong></</strong></</strong>strong>strong> DIHYDROCODEINE drug from theDGIdb Drug Targets 2026 dataset.

From GWAS Catalog SNP-Phenotype Associations 2025

genes associated with the Caffeine</</strong>strong> metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine</</strong>strong>) ratio) phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.

From GWAS Catalog SNP-Phenotype Associations 2025

genes associated with the Caffeine</</strong>strong> metabolism (plasma 1,3,7-trimethylxanthine (caffeine</</strong>strong>) level) phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.

From Biocarta Pathways

proteins participating in the mechanism of acetaminophen</</strong></</strong>strong></</strong></</strong>strong>strong>strong> activity and toxicity pathway from the Biocarta Pathways dataset.

From CTD Gene-Chemical Interactions

genes/</strong></</strong>strong></</strong></</strong>strong>strong>proteins interacting with the chemical acetaminophen</</strong></</strong>strong></</strong></</strong>strong>strong>strong> cysteine from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/</strong></</strong>strong></</strong></</strong>strong>strong>proteins interacting with the chemical acetaminophen</</strong></</strong>strong></</strong></</strong>strong>strong>strong> glucuronide from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/</strong></</strong>strong></</strong></</strong>strong>strong>proteins interacting with the chemical Acetaminophen</</strong></</strong>strong></</strong></</strong>strong>strong>strong> from the curated CTD Gene-Chemical Interactions dataset.

From dbGAP Gene-Trait Associations

genes associated with the trait Acetaminophen</</strong></</strong>strong></</strong></</strong>strong>strong>strong> in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.

From DrugBank Drug Targets

interacting proteins for the Acetaminophen</</strong></</strong>strong></</strong></</strong>strong>strong>strong> drug from the curated DrugBank Drug Targets dataset.

From GAD Gene-Disease Associations

genes associated with the disease acetaminophen</</strong></</strong>strong></</strong></</strong>strong>strong>strong> in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term acetaminophen</</strong></</strong>strong></</strong></</strong>strong>strong>strong> in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GWAS Catalog SNP-Phenotype Associations

genes associated with the Response to acetaminophen</</strong></</strong>strong></</strong></</strong>strong>strong>strong> (hepatotoxicity) phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations dataset.

From HMDB Metabolites of Enzymes

interacting proteins for the Acetaminophen</</strong></</strong>strong></</strong></</strong>strong>strong>strong> glucuronide metabolite from the curated HMDB Metabolites of Enzymes dataset.

From HMDB Metabolites of Enzymes

interacting proteins for the Acetaminophen</</strong></</strong>strong></</strong></</strong>strong>strong>strong> metabolite from the curated HMDB Metabolites of Enzymes dataset.

From WikiPathways Pathways 2024

proteins participating in the Acetaminophen</</strong></</strong>strong></</strong></</strong>strong>strong>strong> in analgesia and antipyresis pathway from the WikiPathways Pathways 2024 dataset.

From GWAS Catalog SNP-Phenotype Associations 2025

genes associated with the Response to acetaminophen</</strong></</strong>strong></</strong></</strong>strong>strong>strong> (hepatotoxicity) phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the ACETAMINOPHEN /</strong></</strong>strong></</strong></</strong>strong>strong> CODEINE drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the ACETAMINOPHEN/</strong></</strong>strong></</strong></</strong>strong>strong>TRAMADOL drug from theDGIdb Drug Targets 2026 dataset.

From CTD Gene-Chemical Interactions

genes/</strong></</strong>strong></</strong></</strong>strong>strong>proteins interacting with the chemical 8-(3-chlorostyryl)caffeine</</strong>strong> from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/</strong></</strong>strong></</strong></</strong>strong>strong>proteins interacting with the chemical Caffeine</</strong>strong> from the curated CTD Gene-Chemical Interactions dataset.

From dbGAP Gene-Trait Associations

genes associated with the trait Caffeine</</strong>strong> in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.

From DrugBank Drug Targets

interacting proteins for the Caffeine</</strong>strong> drug from the curated DrugBank Drug Targets dataset.

From GAD Gene-Disease Associations

genes associated with the disease plasma caffeine</</strong>strong> metabolite ratio in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

From GAD Gene-Disease Associations

genes associated with the disease caffeine</</strong>strong> metabolic ratio; smoking mutagenicity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

From GAD Gene-Disease Associations

genes associated with the disease caffeine</</strong>strong>-induced anxiety. in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

From GAD Gene-Disease Associations

genes associated with the disease caffeine</</strong>strong> in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

From GAD Gene-Disease Associations

genes associated with the disease caffeine</</strong>strong> metabolic ratio in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

From GAD Gene-Disease Associations

genes associated with the disease caffeine</</strong>strong> metabolite ratio in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term caffeine</</strong>strong> in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GO Biological Process Annotations 2015

genes participating in the cellular response to caffeine</</strong>strong> biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Biological Process Annotations 2015

genes participating in the response to caffeine</</strong>strong> biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Molecular Function Annotations 2015

genes performing the caffeine</</strong>strong> oxidase activity molecular function from the curated GO Molecular Function Annotations 2015 dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the caffeine</</strong>strong> ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From GWAS Catalog SNP-Phenotype Associations

genes associated with the Caffeine</</strong>strong> consumption phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations dataset.

From GWAS Catalog SNP-Phenotype Associations

genes associated with the Insomnia (caffeine</</strong>strong>-induced) phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations dataset.

From HMDB Metabolites of Enzymes

interacting proteins for the Caffeine</</strong>strong> metabolite from the curated HMDB Metabolites of Enzymes dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Caffeine</</strong>strong>-induced death protein 2 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From KEGG Pathways

proteins participating in the caffeine</</strong>strong> metabolism pathway from the KEGG Pathways dataset.

From DisGeNET Gene-Disease Associations

genes associated with the disease Caffeine</</strong>strong> Withdrawal in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

From DisGeNET Gene-Phenotype Associations

genes associated with the phenotype Caffeine</</strong>strong> Dependence in GWAS and other genetic association datasets from the DisGeNET Gene-Phenotype Associations dataset.

From GO Biological Process Annotations 2023

genes participating in the cellular response to caffeine</</strong>strong> biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the response to caffeine</</strong>strong> biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Molecular Function Annotations 2023

genes performing the caffeine</</strong>strong> oxidase activity molecular function from the curated GO Molecular Function Annotations 2023 dataset.

From MW Enzyme Metabolite Associations

interacting proteins for Caffeine</</strong>strong> metabolite from the MW Gene Metabolite Associations dataset.

From WikiPathways Pathways 2024

proteins participating in the Caffeine</</strong>strong> and theobromine metabolism pathway from the WikiPathways Pathways 2024 dataset.

From GO Biological Process Annotations 2025

genes participating in the cellular response to caffeine</</strong>strong> biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Biological Process Annotations 2025

genes participating in the response to caffeine</</strong>strong> biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Molecular Function Annotations 2025

genes performing the caffeine</</strong>strong> oxidase activity molecular function from the curated GO Molecular Function Annotations 2025 dataset.

From GWAS Catalog SNP-Phenotype Associations 2025

genes associated with the Caffeine</</strong>strong> consumption from coffee or tea phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.

From GWAS Catalog SNP-Phenotype Associations 2025

genes associated with the Caffeine</</strong>strong> consumption from coffee phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.

From GWAS Catalog SNP-Phenotype Associations 2025

genes associated with the Caffeine</</strong>strong> consumption from tea phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.

From GWAS Catalog SNP-Phenotype Associations 2025

genes associated with the Caffeine</</strong>strong> metabolism (plasma 1,7-dimethylxanthine (paraxanthine) level) phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.

From GWAS Catalog SNP-Phenotype Associations 2025

genes associated with the Caffeine</</strong>strong> metabolism (plasma 3,7-dimethylxanthine (theobromine) level) phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.

From GWAS Catalog SNP-Phenotype Associations 2025

genes associated with the Caffeine</</strong>strong> metabolism (plasma 1,3-dimethylxanthine (theophylline) level) phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.

From GWAS Catalog SNP-Phenotype Associations 2025

genes associated with the Insomnia (caffeine</</strong>strong>-induced) phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.

From GWAS Catalog SNP-Phenotype Associations 2025

genes associated with the Caffeine</</strong>strong> consumption phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.

From KEGG Pathways 2026

proteins participating in the Caffeine</</strong>strong> metabolism pathway from the KEGG Pathways 2026 dataset.