Harmonizome 3.0

breakpoint cluster region

A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The unregulated tyrosine kinase activity of BCR-ABL1 contributes to the immortality of leukaemic cells. The BCR protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac and other kinases. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2020]

oncoprotein induced transcript 3

This gene was identified due to its downregulation in hepatocarcinomas. The encoded protein may be involved in liver development and function. [provided by RefSeq, Sep 2016]

putative BCR-like protein 2

putative BCR-like protein 2

active BCR-related

This gene encodes a protein that is similar to the protein encoded by the breakpoint cluster region gene located on chromosome 22. The protein encoded by this gene contains a GTPase-activating protein domain, a domain found in members of the Rho family of GTP-binding proteins. Functional studies in mice determined that this protein plays a role in vestibular morphogenesis. Alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Feb 2012]

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Bcr-Abl oncoprotein oligomerisation protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term oncoprotein in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Phosphosite Textmining Biological Term Annotations

proteins co-occuring with the biological term oncoprotein in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term oligomerisation in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Co-chaperone HscB, C-terminal oligomerisation domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Oligomerisation domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Carbamoyl-phosphate synthetase, large subunit oligomerisation domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Vps4 oligomerisation, C-terminal protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Ribosomal protein L7/L12, oligomerisation protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From Biocarta Pathways

proteins participating in the bcr signaling pathway pathway from the Biocarta Pathways dataset.

From CORUM Protein Complexes

proteins in the PLC-gamma-1-Lab-Blnk complex, BCR stimulated protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the PLC-gamma-2-Lab-Blnk complex, BCR stimulated protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Lab-Grb2 complex, BCR stimulated protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Grb2-Lab-Blnk complex, BCR stimulated protein complex from the CORUM Protein Complexes dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term bcr in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From KEA Substrates of Kinases

substrates of the kinase BCR from the curated KEA Substrates of Kinases dataset.

From NURSA Protein Complexes

proteins in the BL6415 (BCR) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From NURSA Protein Complexes

proteins in the BL6417 (BCR) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for BCR from the Pathway Commons Protein-Protein Interactions dataset.

From Phosphosite Textmining Biological Term Annotations

proteins co-occuring with the biological term bcr in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase BCR from the curated PhosphoSitePlus Substrates of Kinases dataset.

From PID Pathways

proteins participating in the BCR signaling pathway pathway from the PID Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Signaling by the B Cell Receptor (BCR) pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Downstream signaling events of B Cell Receptor (BCR) pathway from the Reactome Pathways dataset.

From DisGeNET Gene-Disease Associations

genes associated with the disease Childhood B Acute Lymphoblastic Leukemia With T(9;22)(Q34.1;Q11.2); Bcr-Abl1 in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

From DisGeNET Gene-Disease Associations

genes associated with the disease Childhood Chronic Myelogenous Leukemia, Bcr-Abl1 Positive in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

From DisGeNET Gene-Disease Associations

genes associated with the disease Recurrent Chronic Myelogenous Leukemia, Bcr-Abl1 Positive in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

From DisGeNET Gene-Disease Associations

genes associated with the disease Refractory Chronic Myelogenous Leukemia, Bcr-Abl1 Positive in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

From Reactome Pathways 2024

proteins participating in the Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the CD22 mediated BCR regulation pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Downstream signaling events of B Cell Receptor (BCR) pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the RUNX1 regulates transcription of genes involved in BCR signaling pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Signaling by the B Cell Receptor (BCR) pathway from the Reactome Pathways 2024 dataset.

From DISEASES Text-mining Gene-Disease Association Evidence Scores 2025

genes co-occuring with the disease Atypical chronic myeloid leukemia, BCR-ABL1 negative in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

From DISEASES Text-mining Gene-Disease Association Evidence Scores 2025

genes co-occuring with the disease B-lymphoblastic leukemia/lymphoma with BCR-ABL1 in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

From DISEASES Text-mining Gene-Disease Association Evidence Scores 2025

genes co-occuring with the disease Chronic myelogenous leukemia, BCR-ABL1 positive in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

From DISEASES Text-mining Gene-Disease Association Evidence Scores 2025

genes co-occuring with the disease Acute myeloid leukemia with BCR-ABL1 in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

From DISEASES Text-mining Gene-Disease Association Evidence Scores 2025

genes co-occuring with the disease B-lymphoblastic leukemia/lymphoma, BCR-ABL1–like in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

From ClinVar Gene-Phenotype Associations 2025

genes associated with the BCR-A phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the BCR gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.