Harmonizome 3.0

ret proto-oncogene

This gene encodes a transmembrane receptor and member of the tyrosine protein kinase family of proteins. Binding of ligands such as GDNF (glial cell-line derived neurotrophic factor) and other related proteins to the encoded receptor stimulates receptor dimerization and activation of downstream signaling pathways that play a role in cell differentiation, growth, migration and survival. The encoded receptor is important in development of the nervous system, and the development of organs and tissues derived from the neural crest. This proto-oncogene can undergo oncogenic activation through both cytogenetic rearrangement and activating point mutations. Mutations in this gene are associated with Hirschsprung disease and central hypoventilation syndrome and have been identified in patients with renal agenesis. [provided by RefSeq, Sep 2017]

ret finger protein-like 4A-like 1

Predicted to enable protein homodimerization activity; protein kinase binding activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including positive regulation of autophagy; positive regulation of canonical NF-kappaB signal transduction; and regulation of viral entry into host cell. Predicted to be active in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Mar 2025]

ret finger protein-like 4B

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including defense response to symbiont; negative regulation of viral entry into host cell; and negative regulation of viral transcription. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Mar 2025]

ret finger protein-like 4A

Predicted to enable protein homodimerization activity; protein kinase binding activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including positive regulation of autophagy; positive regulation of canonical NF-kappaB signal transduction; and regulation of viral entry into host cell. Predicted to be located in female germ cell nucleus. Predicted to be active in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Mar 2025]

ret finger protein-like 4A

ret finger protein-like 2 pseudogene

ret finger protein-like 1

Predicted to enable protein homodimerization activity; protein kinase binding activity; and ubiquitin protein ligase activity. Involved in several processes, including negative regulation of G2/M transition of mitotic cell cycle; negative regulation of cell division; and positive regulation of proteolysis. Located in cytoplasm. [provided by Alliance of Genome Resources, Mar 2025]

ret finger protein-like 4A pseudogene 1

ret finger protein-like 4A pseudogene 5

ret finger protein-like 4A pseudogene 4

ret finger protein-like 4A pseudogene 6

ret finger protein-like 3

Predicted to enable protein homodimerization activity; protein kinase binding activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including positive regulation of autophagy; positive regulation of canonical NF-kappaB signal transduction; and regulation of viral entry into host cell. Predicted to be located in nucleus. Predicted to be active in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Mar 2025]

ret finger protein-like 2

Predicted to enable protein homodimerization activity; protein kinase binding activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including positive regulation of autophagy; positive regulation of canonical NF-kappaB signal transduction; and regulation of viral entry into host cell. Predicted to be active in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Mar 2025]

ret finger protein-like 3 pseudogene

ret finger protein-like 4A pseudogene 2

ret finger protein-like 4A pseudogene 7

From NURSA Protein Complexes

proteins in the RET (RET) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the RET-Rai complex protein complex from the CORUM Protein Complexes dataset.

From GAD Gene-Disease Associations

genes associated with the disease familial non-ret c cell hyperplasia in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ret in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tyrosine-protein kinase, Ret receptor protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the RDM domain, Ret finger protein-like protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From KEA Substrates of Kinases

substrates of the kinase RET from the curated KEA Substrates of Kinases dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for RET from the Pathway Commons Protein-Protein Interactions dataset.

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase RET from the curated PhosphoSitePlus Substrates of Kinases dataset.

From PID Pathways

proteins participating in the Signaling events regulated by Ret tyrosine kinase pathway from the PID Pathways dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the RET gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From Kinase Library Tyrosine Kinome Atlas

substrates of the kinase RET from the Kinase Library Tyrosine Kinome Atlas dataset.

From WikiPathways Pathways 2024

proteins participating in the GDNF RET signaling axis pathway from the WikiPathways Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the RET signaling pathway from the Reactome Pathways 2024 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the RET INHIBITOR FHND5071 drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the RET INHIBITOR HS-10365 drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the RET INHIBITOR SY-5007 drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the RET INHIBITOR TY-1091 drug from theDGIdb Drug Targets 2026 dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the RET gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.