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CXCR4 Genechemokine (C-X-C motif) receptor 4 This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] |
cxcr4 Gene SetFrom GeneRIF Biological Term Annotations genes co-occuring with the biological term cxcr4 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. |
CXCR4 Gene SetFrom Pathway Commons Protein-Protein Interactions interacting proteins for CXCR4 from the Pathway Commons Protein-Protein Interactions dataset. |
CXCR4 Gene SetFrom LINCS L1000 CMAP CRISPR Knockout Consensus Signatures genes differentially expressed following the CXCR4 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. |
CXCR4 Gene SetFrom CM4AI KOLF21J CRISPRi Gene Perturbation Atlas genes differentially expressed following the CXCR4 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas. |
cxcr4 signaling pathway Gene SetFrom Biocarta Pathways proteins participating in the cxcr4 signaling pathway pathway from the Biocarta Pathways dataset. |
cxcr4 chemokine receptor binding Gene SetFrom GO Molecular Function Annotations 2015 genes performing the cxcr4 chemokine receptor binding molecular function from the curated GO Molecular Function Annotations 2015 dataset. |
CXCR4-mediated signaling events Gene SetFrom PID Pathways proteins participating in the CXCR4-mediated signaling events pathway from the PID Pathways dataset. |
C-X-C chemokine receptor CXCR4 signaling pathway Gene SetFrom GO Biological Process Annotations 2023 genes participating in the C-X-C chemokine receptor CXCR4 signaling pathway biological process from the curated GO Biological Process Annotations 2023 dataset. |
CXCL12-activated CXCR4 signaling pathway Gene SetFrom GO Biological Process Annotations 2023 genes participating in the CXCL12-activated CXCR4 signaling pathway biological process from the curated GO Biological Process Annotations 2023 dataset. |
CXCR4 chemokine receptor binding Gene SetFrom GO Molecular Function Annotations 2023 genes performing the CXCR4 chemokine receptor binding molecular function from the curated GO Molecular Function Annotations 2023 dataset. |
C-X-C chemokine receptor CXCR4 signaling pathway Gene SetFrom GO Biological Process Annotations 2025 genes participating in the C-X-C chemokine receptor CXCR4 signaling pathway biological process from the curated GO Biological Process Annotations 2025 dataset. |
CXCL12-activated CXCR4 signaling pathway Gene SetFrom GO Biological Process Annotations 2025 genes participating in the CXCL12-activated CXCR4 signaling pathway biological process from the curated GO Biological Process Annotations 2025 dataset. |
CXCR4 chemokine receptor binding Gene SetFrom GO Molecular Function Annotations 2025 genes performing the CXCR4 chemokine receptor binding molecular function from the curated GO Molecular Function Annotations 2025 dataset. |
AUTOLOGOUS BONE MARROW-DERIVED CD34/CXCR4-POSITIVE STEM CELLS AMR-001 Gene Setinteracting proteins for the AUTOLOGOUS BONE MARROW-DERIVED CD34/CXCR4-POSITIVE STEM CELLS AMR-001 drug from theDGIdb Drug Targets 2026 dataset. |
CXCR4 ANTAGONIST 22 Gene Setinteracting proteins for the CXCR4 ANTAGONIST 22 drug from theDGIdb Drug Targets 2026 dataset. |
CXCR4 ANTAGONIST USL311 Gene Setinteracting proteins for the CXCR4 ANTAGONIST USL311 drug from theDGIdb Drug Targets 2026 dataset. |