Name

CXCR4 Gene

chemokine (C-X-C motif) receptor 4

This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

cxcr4 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cxcr4 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

CXCR4 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CXCR4 from the Pathway Commons Protein-Protein Interactions dataset.

CXCR4 Gene Set

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the CXCR4 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

CXCR4 Gene Set

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the CXCR4 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

cxcr4 signaling pathway Gene Set

From Biocarta Pathways

proteins participating in the cxcr4 signaling pathway pathway from the Biocarta Pathways dataset.

cxcr4 chemokine receptor binding Gene Set

From GO Molecular Function Annotations 2015

genes performing the cxcr4 chemokine receptor binding molecular function from the curated GO Molecular Function Annotations 2015 dataset.

CXCR4-mediated signaling events Gene Set

From PID Pathways

proteins participating in the CXCR4-mediated signaling events pathway from the PID Pathways dataset.

C-X-C chemokine receptor CXCR4 signaling pathway Gene Set

From GO Biological Process Annotations 2023

genes participating in the C-X-C chemokine receptor CXCR4 signaling pathway biological process from the curated GO Biological Process Annotations 2023 dataset.

CXCL12-activated CXCR4 signaling pathway Gene Set

From GO Biological Process Annotations 2023

genes participating in the CXCL12-activated CXCR4 signaling pathway biological process from the curated GO Biological Process Annotations 2023 dataset.

CXCR4 chemokine receptor binding Gene Set

From GO Molecular Function Annotations 2023

genes performing the CXCR4 chemokine receptor binding molecular function from the curated GO Molecular Function Annotations 2023 dataset.

C-X-C chemokine receptor CXCR4 signaling pathway Gene Set

From GO Biological Process Annotations 2025

genes participating in the C-X-C chemokine receptor CXCR4 signaling pathway biological process from the curated GO Biological Process Annotations 2025 dataset.

CXCL12-activated CXCR4 signaling pathway Gene Set

From GO Biological Process Annotations 2025

genes participating in the CXCL12-activated CXCR4 signaling pathway biological process from the curated GO Biological Process Annotations 2025 dataset.

CXCR4 chemokine receptor binding Gene Set

From GO Molecular Function Annotations 2025

genes performing the CXCR4 chemokine receptor binding molecular function from the curated GO Molecular Function Annotations 2025 dataset.

AUTOLOGOUS BONE MARROW-DERIVED CD34/CXCR4-POSITIVE STEM CELLS AMR-001 Gene Set

From DGIdb Drug Targets 2026

interacting proteins for the AUTOLOGOUS BONE MARROW-DERIVED CD34/CXCR4-POSITIVE STEM CELLS AMR-001 drug from theDGIdb Drug Targets 2026 dataset.

CXCR4 ANTAGONIST 22 Gene Set

From DGIdb Drug Targets 2026

interacting proteins for the CXCR4 ANTAGONIST 22 drug from theDGIdb Drug Targets 2026 dataset.

CXCR4 ANTAGONIST USL311 Gene Set

From DGIdb Drug Targets 2026

interacting proteins for the CXCR4 ANTAGONIST USL311 drug from theDGIdb Drug Targets 2026 dataset.