Name

ISG15 Gene

ISG15 ubiquitin-like modifier

The protein encoded by this gene is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted. [provided by RefSeq, Dec 2012]

isg15 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term isg15 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ISG15 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for ISG15 from the Pathway Commons Protein-Protein Interactions dataset.

ISG15 Gene Set

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the ISG15 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

ISG15 Gene Set

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the ISG15 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

isg15-protein conjugation Gene Set

From GO Biological Process Annotations 2015

genes participating in the isg15-protein conjugation biological process from the curated GO Biological Process Annotations 2015 dataset.

isg15 transferase activity Gene Set

From GO Molecular Function Annotations 2015

genes performing the isg15 transferase activity molecular function from the curated GO Molecular Function Annotations 2015 dataset.

isg15-specific protease activity Gene Set

From GO Molecular Function Annotations 2015

genes performing the isg15-specific protease activity molecular function from the curated GO Molecular Function Annotations 2015 dataset.

isg15 activating enzyme activity Gene Set

From GO Molecular Function Annotations 2015

genes performing the isg15 activating enzyme activity molecular function from the curated GO Molecular Function Annotations 2015 dataset.

ISG15 antiviral mechanism Gene Set

From Reactome Pathways 2014

proteins participating in the ISG15 antiviral mechanism pathway from the Reactome Pathways dataset.

ISG15-protein conjugation Gene Set

From GO Biological Process Annotations 2023

genes participating in the ISG15-protein conjugation biological process from the curated GO Biological Process Annotations 2023 dataset.

ISG15 transferase activity Gene Set

From GO Molecular Function Annotations 2023

genes performing the ISG15 transferase activity molecular function from the curated GO Molecular Function Annotations 2023 dataset.

ISG15-specific peptidase activity Gene Set

From GO Molecular Function Annotations 2023

genes performing the ISG15-specific peptidase activity molecular function from the curated GO Molecular Function Annotations 2023 dataset.

ISG15 antiviral mechanism Gene Set

From Reactome Pathways 2024

proteins participating in the ISG15 antiviral mechanism pathway from the Reactome Pathways 2024 dataset.

ISG15-protein conjugation Gene Set

From GO Biological Process Annotations 2025

genes participating in the ISG15-protein conjugation biological process from the curated GO Biological Process Annotations 2025 dataset.

ISG15 transferase activity Gene Set

From GO Molecular Function Annotations 2025

genes performing the ISG15 transferase activity molecular function from the curated GO Molecular Function Annotations 2025 dataset.

ISG15-specific peptidase activity Gene Set

From GO Molecular Function Annotations 2025

genes performing the ISG15-specific peptidase activity molecular function from the curated GO Molecular Function Annotations 2025 dataset.

Mendelian susceptibility to mycobacterial diseases due to complete ISG15 deficiency Gene Set

From ClinVar Gene-Phenotype Associations 2025

genes associated with the Mendelian susceptibility to mycobacterial diseases due to complete ISG15 deficiency phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset.