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ISG15 GeneISG15 ubiquitin-like modifier The protein encoded by this gene is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted. [provided by RefSeq, Dec 2012] |
isg15 Gene SetFrom GeneRIF Biological Term Annotations genes co-occuring with the biological term isg15 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. |
ISG15 Gene SetFrom Pathway Commons Protein-Protein Interactions interacting proteins for ISG15 from the Pathway Commons Protein-Protein Interactions dataset. |
ISG15 Gene SetFrom LINCS L1000 CMAP CRISPR Knockout Consensus Signatures genes differentially expressed following the ISG15 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. |
ISG15 Gene SetFrom CM4AI KOLF21J CRISPRi Gene Perturbation Atlas genes differentially expressed following the ISG15 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas. |
isg15-protein conjugation Gene SetFrom GO Biological Process Annotations 2015 genes participating in the isg15-protein conjugation biological process from the curated GO Biological Process Annotations 2015 dataset. |
isg15 transferase activity Gene SetFrom GO Molecular Function Annotations 2015 genes performing the isg15 transferase activity molecular function from the curated GO Molecular Function Annotations 2015 dataset. |
isg15-specific protease activity Gene SetFrom GO Molecular Function Annotations 2015 genes performing the isg15-specific protease activity molecular function from the curated GO Molecular Function Annotations 2015 dataset. |
isg15 activating enzyme activity Gene SetFrom GO Molecular Function Annotations 2015 genes performing the isg15 activating enzyme activity molecular function from the curated GO Molecular Function Annotations 2015 dataset. |
ISG15 antiviral mechanism Gene Setproteins participating in the ISG15 antiviral mechanism pathway from the Reactome Pathways dataset. |
ISG15-protein conjugation Gene SetFrom GO Biological Process Annotations 2023 genes participating in the ISG15-protein conjugation biological process from the curated GO Biological Process Annotations 2023 dataset. |
ISG15 transferase activity Gene SetFrom GO Molecular Function Annotations 2023 genes performing the ISG15 transferase activity molecular function from the curated GO Molecular Function Annotations 2023 dataset. |
ISG15-specific peptidase activity Gene SetFrom GO Molecular Function Annotations 2023 genes performing the ISG15-specific peptidase activity molecular function from the curated GO Molecular Function Annotations 2023 dataset. |
ISG15 antiviral mechanism Gene Setproteins participating in the ISG15 antiviral mechanism pathway from the Reactome Pathways 2024 dataset. |
ISG15-protein conjugation Gene SetFrom GO Biological Process Annotations 2025 genes participating in the ISG15-protein conjugation biological process from the curated GO Biological Process Annotations 2025 dataset. |
ISG15 transferase activity Gene SetFrom GO Molecular Function Annotations 2025 genes performing the ISG15 transferase activity molecular function from the curated GO Molecular Function Annotations 2025 dataset. |
ISG15-specific peptidase activity Gene SetFrom GO Molecular Function Annotations 2025 genes performing the ISG15-specific peptidase activity molecular function from the curated GO Molecular Function Annotations 2025 dataset. |
Mendelian susceptibility to mycobacterial diseases due to complete ISG15 deficiency Gene SetFrom ClinVar Gene-Phenotype Associations 2025 genes associated with the Mendelian susceptibility to mycobacterial diseases due to complete ISG15 deficiency phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset. |