Harmonizome 3.0

myeloid differentiation primary response 88

This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term myd88 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From MSigDB Cancer Gene Co-expression Modules

co-expressed genes for MYD88 from the MSigDB Cancer Gene Co-expression Modules dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for MYD88 from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the MYD88 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the MYD88 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From ClinVar Gene-Phenotype Associations

genes associated with the Myd88 deficiency phenotype from the curated ClinVar Gene-Phenotype Associations dataset.

From CTD Gene-Disease Associations

genes/proteins associated with the disease MYD88 Deficiency from the curated CTD Gene-Disease Associations dataset.

From GO Biological Process Annotations 2015

genes participating in the positive regulation of myd88-dependent toll-like receptor signaling pathway biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Biological Process Annotations 2015

genes participating in the regulation of myd88-independent toll-like receptor signaling pathway biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Biological Process Annotations 2015

genes participating in the myd88-independent toll-like receptor signaling pathway biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Biological Process Annotations 2015

genes participating in the myd88-dependent toll-like receptor signaling pathway biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Biological Process Annotations 2015

genes participating in the regulation of myd88-dependent toll-like receptor signaling pathway biological process from the curated GO Biological Process Annotations 2015 dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Myeloid differentiation primary response protein MyD88 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From OMIM Gene-Disease Associations

genes associated with the pyogenic bacterial infections, recurrent, due to myd88 deficiency phenotype from the curated OMIM Gene-Disease Associations dataset.

From Reactome Pathways 2014

proteins participating in the MyD88 dependent cascade initiated on endosome pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the MyD88-independent cascade pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the MyD88 cascade initiated on plasma membrane pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the MyD88:Mal cascade initiated on plasma membrane pathway from the Reactome Pathways dataset.

From DisGeNET Gene-Disease Associations

genes associated with the disease Myd88 Deficiency in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

From GO Biological Process Annotations 2023

genes participating in the MyD88-dependent toll-like receptor signaling pathway biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the regulation of MyD88-dependent toll-like receptor signaling pathway biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the negative regulation of MyD88-dependent toll-like receptor signaling pathway biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the regulation of MyD88-independent toll-like receptor signaling pathway biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the MyD88-independent toll-like receptor signaling pathway biological process from the curated GO Biological Process Annotations 2023 dataset.

From WikiPathways Pathways 2024

proteins participating in the Toll like receptor signaling related to MyD88 pathway from the WikiPathways Pathways 2024 dataset.

From WikiPathways Pathways 2024

proteins participating in the MYD88 distinct input output pathway pathway from the WikiPathways Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the MyD88 cascade initiated on plasma membrane pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the MyD88 deficiency (TLR2/4) pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the MyD88 deficiency (TLR5) pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the MyD88 dependent cascade initiated on endosome pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the MyD88-independent TLR4 cascade pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the MyD88:MAL(TIRAP) cascade initiated on plasma membrane pathway from the Reactome Pathways 2024 dataset.

From GO Biological Process Annotations 2025

genes participating in the MyD88-dependent toll-like receptor signaling pathway biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Biological Process Annotations 2025

genes participating in the regulation of MyD88-dependent toll-like receptor signaling pathway biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Biological Process Annotations 2025

genes participating in the negative regulation of MyD88-dependent toll-like receptor signaling pathway biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Biological Process Annotations 2025

genes participating in the regulation of MyD88-independent toll-like receptor signaling pathway biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Biological Process Annotations 2025

genes participating in the MyD88-independent toll-like receptor signaling pathway biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Biological Process Annotations 2025

genes participating in the positive regulation of MyD88-dependent toll-like receptor signaling pathway biological process from the curated GO Biological Process Annotations 2025 dataset.

From ClinVar Gene-Phenotype Associations 2025

genes associated with the Pyogenic bacterial infections due to MyD88 deficiency phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset.