| Name |
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PTK6 Geneprotein tyrosine kinase 6 The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012] |
DCR GeneDown syndrome chromosome region Down syndrome, also known as trisomy 21, is the most frequent form of cognitive disability caused by a microscopically demonstrable chromosomal aberration. It is caused by a third copy (trisomy) of all or a critical portion of chromosome 21. Down syndrome is characterized by physical growth delays, dysmorphic facial features, heart and gastrointestinal disorders, and mild to moderate cognitive disability. [provided by RefSeq, Jul 2017] |
DSCR8 GeneDown syndrome critical region 8 |
DSCR3 GeneDown syndrome critical region 3 The region of chromosome 21 between genes CBR and ERG (CBR-ERG region), which spans 2.5 Mb on 21q22.2, has been defined by analysis of patients with partial trisomy 21. It contributes significantly to the pathogenesis of many characteristics of Down syndrome, including morphological features, hypotonia, and cognitive disability. The DSCR3 (Down syndrome critical region gene 3) gene is found in this region and is predictated to contain eight exons. DSCR3 is expressed in most tissues examined. [provided by RefSeq, Jul 2008] |
NEDD8 Geneneural precursor cell expressed, developmentally down-regulated 8 Enables ubiquitin protein ligase binding activity. Acts upstream of or within protein neddylation. Located in cytosol and nucleoplasm. Biomarker of Parkinson's disease and malignant astrocytoma. [provided by Alliance of Genome Resources, Mar 2025] |
NEDD9 Geneneural precursor cell expressed, developmentally down-regulated 9 The protein encoded by this gene is a member of the CRK-associated substrates family. Members of this family are adhesion docking molecules that mediate protein-protein interactions for signal transduction pathways. This protein is a focal adhesion protein that acts as a scaffold to regulate signaling complexes important in cell attachment, migration and invasion as well as apoptosis and the cell cycle. This protein has also been reported to have a role in cancer metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012] |
NEDD1 Geneneural precursor cell expressed, developmentally down-regulated 1 Predicted to enable gamma-tubulin binding activity. Predicted to be involved in microtubule nucleation and mitotic cell cycle. Located in centrosome; cytosol; and nuclear lumen. [provided by Alliance of Genome Resources, Mar 2025] |
NPCDR1 Genenasopharyngeal carcinoma, down-regulated 1 |
LOC100420893 GeneDown syndrome critical region 3 pseudogene |
LOC644456 GeneIK cytokine, down-regulator of HLA II pseudogene |
APCDD1L Geneadenomatosis polyposis coli down-regulated 1-like Predicted to enable Wnt-protein binding activity. Predicted to be involved in negative regulation of Wnt signaling pathway. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Mar 2025] |
HEPN1 Genehepatocellular carcinoma, down-regulated 1 This gene is expressed predominantly in the liver. Transient transfection studies show the expression of this gene significantly inhibits cell growth, suggesting a role for this gene in apoptosis. Expression of this gene is down-regulated or lost in hepatocellular carcinomas (HCC), suggesting that loss of this gene is involved in carcinogenesis of hepatocytes (PMID:12971969). This gene maps to the 3'-noncoding region of the HEPACAM gene (GeneID:220296) on the antisense strand. [provided by RefSeq, Aug 2020] |
NEDD4L Geneneural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012] |
LOC100128775 Geneneural precursor cell expressed, developmentally down-regulated 8 pseudogene |
APCDD1 Geneadenomatosis polyposis coli down-regulated 1 This locus encodes an inhibitor of the Wnt signaling pathway. Mutations at this locus have been associated with hereditary hypotrichosis simplex. Increased expression of this gene may also be associated with colorectal carcinogenesis.[provided by RefSeq, Sep 2010] |
DSCAM GeneDown syndrome cell adhesion molecule This gene is a member of the immunoglobulin superfamily of cell adhesion molecules (Ig-CAMs), and is involved in human central and peripheral nervous system development. This gene is a candidate for Down syndrome and congenital heart disease (DSCHD). A gene encoding a similar Ig-CAM protein is located on chromosome 11. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012] |
DR1 Genedown-regulator of transcription 1, TBP-binding (negative cofactor 2) This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription. [provided by RefSeq, Jul 2008] |
DSCR9 GeneDown syndrome critical region 9 (non-protein coding) |
DSCR4 GeneDown syndrome critical region 4 The gene is found in a region of chromosome 21 that has been linked to the pathogenesis of Down syndrome. This gene is transcribed from a bi-directional promoter located in an endogenous retrovirus. [provided by RefSeq, Jan 2015] |
GLIDR Geneglioblastoma down-regulated RNA |
LDOC1 Geneleucine zipper, down-regulated in cancer 1 The protein encoded by this gene contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. The protein localizes to the nucleus and is down-regulated in some cancer cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development and/or progression of some cancers. [provided by RefSeq, Jul 2008] |
DSCR10 GeneDown syndrome critical region 10 (non-protein coding) |
DSCAML1 GeneDown syndrome cell adhesion molecule like 1 The protein encoded by this gene is a member of the Ig superfamily of cell adhesion molecules and is involved in neuronal differentiation. The encoded membrane-bound protein localizes to the cell surface, where it forms aggregates that repel neuronal processes of the same cell type. [provided by RefSeq, Sep 2016] |
LDOC1L Geneleucine zipper, down-regulated in cancer 1-like |
NEDD4 Geneneural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase This gene is the founding member of the NEDD4 family of HECT ubiquitin ligases that function in the ubiquitin proteasome system of protein degradation. The encoded protein contains an N-terminal calcium and phospholipid binding C2 domain followed by multiple tryptophan-rich WW domains and, a C-terminal HECT ubiquitin ligase catalytic domain. It plays critical role in the regulation of a number of membrane receptors, endocytic machinery components and the tumor suppressor PTEN. [provided by RefSeq, Jul 2016] |
IK GeneIK cytokine, down-regulator of HLA II The protein encoded by this gene was identified by its RED repeat, a stretch of repeated arginine, glutamic acid and aspartic acid residues. The protein localizes to discrete dots within the nucleus, excluding the nucleolus. Its function is unknown. This gene maps to chromosome 5; however, a pseudogene may exist on chromosome 2. [provided by RefSeq, Jul 2008] |
PTK6 Down-Regulation Gene Setproteins participating in the PTK6 Down-Regulation pathway from the Reactome Pathways 2024 dataset. |
ptk6 Gene SetFrom GeneRIF Biological Term Annotations genes co-occuring with the biological term ptk6 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. |
PTK6 Gene SetFrom KEA Substrates of Kinases substrates of the kinase PTK6 from the curated KEA Substrates of Kinases dataset. |
PTK6 Gene SetFrom Pathway Commons Protein-Protein Interactions interacting proteins for PTK6 from the Pathway Commons Protein-Protein Interactions dataset. |
PTK6 Gene SetFrom PhosphoSitePlus Substrates of Kinases substrates of the kinase PTK6 from the curated PhosphoSitePlus Substrates of Kinases dataset. |
PTK6 Gene SetFrom LINCS L1000 CMAP CRISPR Knockout Consensus Signatures genes differentially expressed following the PTK6 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. |
ERBB2 Activates PTK6 Signaling Gene Setproteins participating in the ERBB2 Activates PTK6 Signaling pathway from the Reactome Pathways 2024 dataset. |
PTK6 Activates STAT3 Gene Setproteins participating in the PTK6 Activates STAT3 pathway from the Reactome Pathways 2024 dataset. |
PTK6 Expression Gene Setproteins participating in the PTK6 Expression pathway from the Reactome Pathways 2024 dataset. |
PTK6 Regulates Cell Cycle Gene Setproteins participating in the PTK6 Regulates Cell Cycle pathway from the Reactome Pathways 2024 dataset. |
PTK6 Regulates Proteins Involved in RNA Processing Gene Setproteins participating in the PTK6 Regulates Proteins Involved in RNA Processing pathway from the Reactome Pathways 2024 dataset. |
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases Gene Setproteins participating in the PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases pathway from the Reactome Pathways 2024 dataset. |
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 Gene Setproteins participating in the PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 pathway from the Reactome Pathways 2024 dataset. |
PTK6 promotes HIF1A stabilization Gene Setproteins participating in the PTK6 promotes HIF1A stabilization pathway from the Reactome Pathways 2024 dataset. |
Signaling by PTK6 Gene Setproteins participating in the Signaling by PTK6 pathway from the Reactome Pathways 2024 dataset. |
phosphorylation of mek1 by cdk5/p35 down regulates the map kinase pathway Gene SetFrom Biocarta Pathways proteins participating in the phosphorylation of mek1 by cdk5/p35 down regulates the map kinase pathway pathway from the Biocarta Pathways dataset. |
Transient Myeloproliferative Disorder of Down Syndrome Gene SetFrom CTD Gene-Disease Associations genes/proteins associated with the disease Transient Myeloproliferative Disorder of Down Syndrome from the curated CTD Gene-Disease Associations dataset. |
Leukemia, Megakaryoblastic, of Down Syndrome Gene SetFrom CTD Gene-Disease Associations genes/proteins associated with the disease Leukemia, Megakaryoblastic, of Down Syndrome from the curated CTD Gene-Disease Associations dataset. |
Down Syndrome Gene SetFrom CTD Gene-Disease Associations genes/proteins associated with the disease Down Syndrome from the curated CTD Gene-Disease Associations dataset. |
down syndrome Gene SetFrom DISEASES Text-mining Gene-Disease Association Evidence Scores genes co-occuring with the disease down syndrome in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. |
down syndrome; hirschsprung disease; nondisjunction, genetic Gene SetFrom GAD Gene-Disease Associations genes associated with the disease down syndrome; hirschsprung disease; nondisjunction, genetic in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. |
alzheimer disease; down syndrome Gene SetFrom GAD Gene-Disease Associations genes associated with the disease alzheimer disease; down syndrome in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. |
down syndrome; nondisjunction, genetic Gene SetFrom GAD Gene-Disease Associations genes associated with the disease down syndrome; nondisjunction, genetic in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. |
down syndrome; trisomy Gene SetFrom GAD Gene-Disease Associations genes associated with the disease down syndrome; trisomy in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. |
down syndrome; leukemia, myeloid; myeloid leukemia Gene SetFrom GAD Gene-Disease Associations genes associated with the disease down syndrome; leukemia, myeloid; myeloid leukemia in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. |
down syndrome; hepatitis b; hypothyroidism Gene SetFrom GAD Gene-Disease Associations genes associated with the disease down syndrome; hepatitis b; hypothyroidism in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. |
down syndrome; micronuclei, chromosome-defective Gene SetFrom GAD Gene-Disease Associations genes associated with the disease down syndrome; micronuclei, chromosome-defective in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. |
down syndrome; leukemia, myeloid, acute Gene SetFrom GAD Gene-Disease Associations genes associated with the disease down syndrome; leukemia, myeloid, acute in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. |
dementia; down syndrome Gene SetFrom GAD Gene-Disease Associations genes associated with the disease dementia; down syndrome in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. |
down syndrome; heart defects, congenital Gene SetFrom GAD Gene-Disease Associations genes associated with the disease down syndrome; heart defects, congenital in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. |
alzheimer disease; alzheimer's disease; down syndrome; olfaction disorders Gene SetFrom GAD Gene-Disease Associations genes associated with the disease alzheimer disease; alzheimer's disease; down syndrome; olfaction disorders in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. |
down syndrome Gene SetFrom GAD Gene-Disease Associations genes associated with the disease down syndrome in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. |
down syndrome; precursor cell lymphoblastic leukemia-lymphoma Gene SetFrom GAD Gene-Disease Associations genes associated with the disease down syndrome; precursor cell lymphoblastic leukemia-lymphoma in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. |
down syndrome; heart defects, congenital; hypertension, pulmonary Gene SetFrom GAD Gene-Disease Associations genes associated with the disease down syndrome; heart defects, congenital; hypertension, pulmonary in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. |
down syndrome; ehlers-danlos syndrome Gene SetFrom GAD Gene-Disease Associations genes associated with the disease down syndrome; ehlers-danlos syndrome in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. |
alzheimer's disease; down syndrome Gene SetFrom GAD Gene-Disease Associations genes associated with the disease alzheimer's disease; down syndrome in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. |
down's syndrome Gene SetFrom GAD Gene-Disease Associations genes associated with the disease down's syndrome in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. |
congenital heart defects; down syndrome; heart defects, congenital; heart septal defects Gene SetFrom GAD Gene-Disease Associations genes associated with the disease congenital heart defects; down syndrome; heart defects, congenital; heart septal defects in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. |
down syndrome; fetal diseases Gene SetFrom GAD Gene-Disease Associations genes associated with the disease down syndrome; fetal diseases in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. |
down syndrome; Gene SetFrom GAD Gene-Disease Associations genes associated with the disease down syndrome; in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. |
alzheimer disease; down syndrome; Gene SetFrom GAD Gene-Disease Associations genes associated with the disease alzheimer disease; down syndrome; in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. |
celiac disease; down syndrome Gene SetFrom GAD Gene-Disease Associations genes associated with the disease celiac disease; down syndrome in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. |
down Gene SetFrom GeneRIF Biological Term Annotations genes co-occuring with the biological term down in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. |
Down Syndrome_CNS - Brain - Cerebellum (MMHCC)_GSE1611 Gene SetFrom GEO Signatures of Differentially Expressed Genes for Diseases genes differentially expressed during Down Syndrome_CNS - Brain - Cerebellum (MMHCC)_GSE1611 disease perturbation from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. |
Down Syndrome_Brain_GSE5390 Gene SetFrom GEO Signatures of Differentially Expressed Genes for Diseases genes differentially expressed during Down Syndrome_Brain_GSE5390 disease perturbation from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. |
Down Syndrome_Fetus_GSE10758 Gene SetFrom GEO Signatures of Differentially Expressed Genes for Diseases genes differentially expressed during Down Syndrome_Fetus_GSE10758 disease perturbation from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. |
NET1_KD_GDS4196_436_human_AGS - gastric adenocarcinoma cells - (63 shRNA Knock-Down) Gene SetFrom GEO Signatures of Differentially Expressed Genes for Gene Perturbations genes differentially expressed following the NET1_KD_GDS4196_436_human_AGS - gastric adenocarcinoma cells - (63 shRNA Knock-Down) gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. |
NET1_KD_GDS4196_437_human_AGS - gastric adenocarcinoma cells - (65 shRNA Knock-Down) Gene SetFrom GEO Signatures of Differentially Expressed Genes for Gene Perturbations genes differentially expressed following the NET1_KD_GDS4196_437_human_AGS - gastric adenocarcinoma cells - (65 shRNA Knock-Down) gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. |
energy coupled proton transport, down electrochemical gradient Gene SetFrom GO Biological Process Annotations 2015 genes participating in the energy coupled proton transport, down electrochemical gradient biological process from the curated GO Biological Process Annotations 2015 dataset. |
down-sloping shoulders Gene SetFrom HPO Gene-Disease Associations genes associated with the down-sloping shoulders phenotype by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset. |
Down Syndrome Gene SetFrom HuGE Navigator Gene-Phenotype Associations genes associated with the Down Syndrome phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. |
Down-regulated-in-metastasis protein Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Down-regulated-in-metastasis protein protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
abnormal hair-down neuron morphology Gene SetFrom MPO Gene-Phenotype Associations gene mutations causing the abnormal hair-down neuron morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset. |
absent hair-down neurons Gene SetFrom MPO Gene-Phenotype Associations gene mutations causing the absent hair-down neurons phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset. |
leukemia, megakaryoblastic, with or without down syndrome, somatic Gene SetFrom OMIM Gene-Disease Associations genes associated with the leukemia, megakaryoblastic, with or without down syndrome, somatic phenotype from the curated OMIM Gene-Disease Associations dataset. |
down syndrome Gene SetFrom OMIM Gene-Disease Associations genes associated with the down syndrome phenotype from the curated OMIM Gene-Disease Associations dataset. |
leukemia, transient, of down syndrome Gene SetFrom OMIM Gene-Disease Associations genes associated with the leukemia, transient, of down syndrome phenotype from the curated OMIM Gene-Disease Associations dataset. |
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters Gene Setproteins participating in the Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters pathway from the Reactome Pathways dataset. |
Down syndrome Gene SetFrom PhosphoSitePlus Phosphosite-Disease Associations proteins associated with the disease Down syndrome from the curated PhosphoSitePlus Phosphosite-Disease Associations dataset. |
Down Syndrome Gene SetFrom DisGeNET Gene-Disease Associations genes associated with the disease Down Syndrome in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. |
Down Syndrome Critical Region Gene SetFrom DisGeNET Gene-Disease Associations genes associated with the disease Down Syndrome Critical Region in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. |
Myeloid Leukemia Associated With Down Syndrome Gene SetFrom DisGeNET Gene-Disease Associations genes associated with the disease Myeloid Leukemia Associated With Down Syndrome in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. |
Transient Myeloproliferative Disorder Of Down Syndrome Gene SetFrom DisGeNET Gene-Disease Associations genes associated with the disease Transient Myeloproliferative Disorder Of Down Syndrome in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. |
Myeloid Proliferations Associated With Down Syndrome Gene SetFrom DisGeNET Gene-Disease Associations genes associated with the disease Myeloid Proliferations Associated With Down Syndrome in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. |
Down-Sloping Shoulders Gene SetFrom DisGeNET Gene-Phenotype Associations genes associated with the phenotype Down-Sloping Shoulders in GWAS and other genetic association datasets from the DisGeNET Gene-Phenotype Associations dataset. |
absent hair-down neurons Gene SetFrom MGI Mouse Phenotype Associations 2023 gene mutations causing the absent hair-down neurons phenotype in transgenic mice from the MGI Mouse Phenotype Associations 2023 dataset. |
down-turned corners of mouth Gene SetFrom MGI Mouse Phenotype Associations 2023 gene mutations causing the down-turned corners of mouth phenotype in transgenic mice from the MGI Mouse Phenotype Associations 2023 dataset. |
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis Gene Setproteins participating in the FBXL7 down-regulates AURKA during mitotic entry and in early mitosis pathway from the Reactome Pathways 2024 dataset. |
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters Gene Setproteins participating in the Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters pathway from the Reactome Pathways 2024 dataset. |
Down syndrome Gene SetFrom DISEASES Curated Gene-Disease Association Evidence Scores 2025 genes involed in the disease Down syndrome from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset. |
Down syndrome Gene SetFrom DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 genes co-occuring with the disease Down syndrome in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. |
Myeloid leukemia associated with Down Syndrome Gene SetFrom DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 genes co-occuring with the disease Myeloid leukemia associated with Down Syndrome in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. |
Down syndrome Gene SetFrom ClinVar Gene-Phenotype Associations 2025 genes associated with the Down syndrome phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset. |
Acute megakaryoblastic leukemia in down syndrome Gene SetFrom ClinVar Gene-Phenotype Associations 2025 genes associated with the Acute megakaryoblastic leukemia in down syndrome phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset. |
TRANSIENT MYELOPROLIFERATIVE DISORDER OF DOWN SYNDR Gene SetFrom ClinVar Gene-Phenotype Associations 2025 genes associated with the TRANSIENT MYELOPROLIFERATIVE DISORDER OF DOWN SYNDR phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset. |
PMC9633745-mmc3.xlsx-Table_S2-Down-regulated_in_MSC-2_MSC Gene SetFrom Rummagene Transcription Factor Associations 2026 target genes of the PMC9633745-mmc3.xlsx-Table_S2-Down-regulated_in_MSC-2_MSC transcription factor from the Rummagene Transcription Factor Associations 2026 dataset. |
PMC9974104-jci-133-159940-s017.xlsx-GT3-INCP-GATA3_Co-down-Gene_ID_GATA3 Gene SetFrom Rummagene Transcription Factor Associations 2026 target genes of the PMC9974104-jci-133-159940-s017.xlsx-GT3-INCP-GATA3_Co-down-Gene_ID_GATA3 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset. |
PMC9974104-jci-133-159940-s017.xlsx-GT3-INCP-GATA3_Co-down-Symbol_GATA3 Gene SetFrom Rummagene Transcription Factor Associations 2026 target genes of the PMC9974104-jci-133-159940-s017.xlsx-GT3-INCP-GATA3_Co-down-Symbol_GATA3 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset. |
PMC9530161-41419_2022_5296_MOESM2_ESM.xlsx-Tab9_KDM5C-KD-down-DKD-rescued-Table_9_Down-regluted_genes_in_KDM5C-KD_and_rescued_genes_in_DKD_AR Gene SetFrom Rummagene Transcription Factor Associations 2026 target genes of the PMC9530161-41419_2022_5296_MOESM2_ESM.xlsx-Tab9_KDM5C-KD-down-DKD-rescued-Table_9_Down-regluted_genes_in_KDM5C-KD_and_rescued_genes_in_DKD_AR transcription factor from the Rummagene Transcription Factor Associations 2026 dataset. |
PMC8755441-mmc3.xlsx-IRF1-Down-Symbol_IRF1 Gene SetFrom Rummagene Transcription Factor Associations 2026 target genes of the PMC8755441-mmc3.xlsx-IRF1-Down-Symbol_IRF1 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset. |
PMC8755441-mmc3.xlsx-IRF7-down-Symbol_IRF7 Gene SetFrom Rummagene Transcription Factor Associations 2026 target genes of the PMC8755441-mmc3.xlsx-IRF7-down-Symbol_IRF7 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset. |
PMC8040704-jcav12p2673s2.xlsx-Down-regulated_genes_in_EBF1-Unnamed_0_EBF1 Gene SetFrom Rummagene Transcription Factor Associations 2026 target genes of the PMC8040704-jcav12p2673s2.xlsx-Down-regulated_genes_in_EBF1-Unnamed_0_EBF1 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset. |
PMC8040704-jcav12p2673s2.xlsx-Down-regulated_genes_in_EBF1-Unnamed_5_EBF1 Gene SetFrom Rummagene Transcription Factor Associations 2026 target genes of the PMC8040704-jcav12p2673s2.xlsx-Down-regulated_genes_in_EBF1-Unnamed_5_EBF1 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset. |
PMC6344081-elife-40364-supp8.xlsx-PLZF-Si-diff-expressed-gen-Down-Symbol_ZBTB16 Gene SetFrom Rummagene Transcription Factor Associations 2026 target genes of the PMC6344081-elife-40364-supp8.xlsx-PLZF-Si-diff-expressed-gen-Down-Symbol_ZBTB16 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset. |
PMC4653014-oncotarget-06-20404-s004.xls-Down-regulated_in_AFAP1-AS1_KD-Unnamed_1_AR Gene SetFrom Rummagene Transcription Factor Associations 2026 target genes of the PMC4653014-oncotarget-06-20404-s004.xls-Down-regulated_in_AFAP1-AS1_KD-Unnamed_1_AR transcription factor from the Rummagene Transcription Factor Associations 2026 dataset. |
PMC3029394-pone.0016617.s001.xls-Down-regulated-Table_S1_Genes_down-regulated_by_SOX2_over-expression_0_5-fold_SOX2 Gene SetFrom Rummagene Transcription Factor Associations 2026 target genes of the PMC3029394-pone.0016617.s001.xls-Down-regulated-Table_S1_Genes_down-regulated_by_SOX2_over-expression_0_5-fold_SOX2 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset. |
PMC5798892-41421_2017_3_MOESM8_ESM.xlsx-down-regulated-Supplementary_Table_S3_Up-_and_downregulated_genes_in_ATF6-_-_hMSCs_compared_to_ATF6_hMSCs_late_passage_ATF6 Gene SetFrom Rummagene Transcription Factor Associations 2026 target genes of the PMC5798892-41421_2017_3_MOESM8_ESM.xlsx-down-regulated-Supplementary_Table_S3_Up-_and_downregulated_genes_in_ATF6-_-_hMSCs_compared_to_ATF6_hMSCs_late_passage_ATF6 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset. |
PMC5259899-13287_2016_455_MOESM2_ESM.xlsx-Down-regulated-Supplementary_Table_S2_Down-reguated_genes_expression_in_MESP1_negative_cells_MESP1 Gene SetFrom Rummagene Transcription Factor Associations 2026 target genes of the PMC5259899-13287_2016_455_MOESM2_ESM.xlsx-Down-regulated-Supplementary_Table_S2_Down-reguated_genes_expression_in_MESP1_negative_cells_MESP1 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset. |
PMC4909989-ncomms11840-s2.xlsx-down-regulate-TEAD4-FL_YAP_TEAD4 Gene SetFrom Rummagene Transcription Factor Associations 2026 target genes of the PMC4909989-ncomms11840-s2.xlsx-down-regulate-TEAD4-FL_YAP_TEAD4 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset. |
PMC4909989-ncomms11840-s2.xlsx-down-regulate-TEAD4-S_YAP_TEAD4 Gene SetFrom Rummagene Transcription Factor Associations 2026 target genes of the PMC4909989-ncomms11840-s2.xlsx-down-regulate-TEAD4-S_YAP_TEAD4 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset. |
PMC11799530-12276_2024_1380_MOESM1_ESM.xlsx-COMMON_KD-UP_and_OE-DOWN-86_common_elements_in_kd-up_and_oe-down_AR Gene SetFrom Rummagene Transcription Factor Associations 2026 target genes of the PMC11799530-12276_2024_1380_MOESM1_ESM.xlsx-COMMON_KD-UP_and_OE-DOWN-86_common_elements_in_kd-up_and_oe-down_AR transcription factor from the Rummagene Transcription Factor Associations 2026 dataset. |
PMC12621392-12864_2025_12212_MOESM2_ESM.xlsx-GSF-F_48h_2-down-regulated_PDX1 Gene SetFrom Rummagene Transcription Factor Associations 2026 target genes of the PMC12621392-12864_2025_12212_MOESM2_ESM.xlsx-GSF-F_48h_2-down-regulated_PDX1 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset. |
PMC12621392-12864_2025_12212_MOESM2_ESM.xlsx-GSF-F_72h_2-down-regulated_PDX1 Gene SetFrom Rummagene Transcription Factor Associations 2026 target genes of the PMC12621392-12864_2025_12212_MOESM2_ESM.xlsx-GSF-F_72h_2-down-regulated_PDX1 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset. |
PMC12621392-12864_2025_12212_MOESM2_ESM.xlsx-GSF-S_48h_2-down-regulated_PDX1 Gene SetFrom Rummagene Transcription Factor Associations 2026 target genes of the PMC12621392-12864_2025_12212_MOESM2_ESM.xlsx-GSF-S_48h_2-down-regulated_PDX1 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset. |
PMC12621392-12864_2025_12212_MOESM2_ESM.xlsx-GSF-S_72h_2-down-regulated_PDX1 Gene SetFrom Rummagene Transcription Factor Associations 2026 target genes of the PMC12621392-12864_2025_12212_MOESM2_ESM.xlsx-GSF-S_72h_2-down-regulated_PDX1 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset. |