Harmonizome 3.0

adenomatous polyposis coli

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Mutations in the APC gene have been found to occur in most colorectal cancers, where disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jun 2022]

cadherin 1, type 1, E-cadherin (epithelial)

This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015]

APC membrane recruitment protein 1

The protein encoded by this gene upregulates trancriptional activation by the Wilms tumor protein and interacts with many other proteins, including CTNNB1, APC, AXIN1, and AXIN2. Defects in this gene are a cause of osteopathia striata with cranial sclerosis (OSCS). [provided by RefSeq, May 2010]

suppressor APC domain containing 2 pseudogene 4

suppressor APC domain containing 2 pseudogene 1

suppressor APC domain containing 2 pseudogene 3

suppressor APC domain containing 2 pseudogene 2

APC membrane recruitment protein 2

Enables phosphatidylinositol-4,5-bisphosphate binding activity. Involved in negative regulation of canonical Wnt signaling pathway. Located in plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

APC membrane recruitment protein 3

Predicted to enable beta-catenin binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in regulation of canonical Wnt signaling pathway. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

suppressor APC domain containing 1

suppressor APC domain containing 2

Involved in negative regulation of protein localization to cell cortex and positive regulation of cell population proliferation. Located in several cellular components, including apical cortex; apical junction complex; and nuclear lumen. [provided by Alliance of Genome Resources, Mar 2025]

From Reactome Pathways 2014

proteins participating in the Autodegradation of Cdh1 by Cdh1:APC/C pathway from the Reactome Pathways dataset.

From Reactome Pathways 2024

proteins participating in the Autodegradation of Cdh1 by Cdh1:APC/C pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2014

proteins participating in the APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway from the Reactome Pathways dataset.

From Reactome Pathways 2024

proteins participating in the APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2014

proteins participating in the Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase pathway from the Reactome Pathways dataset.

From Reactome Pathways 2024

proteins participating in the Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2014

proteins participating in the Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Inactivation of APC/C via direct inhibition of the APC/C complex pathway from the Reactome Pathways dataset.

From Reactome Pathways 2024

proteins participating in the Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Inactivation of APC/C via direct inhibition of the APC/C complex pathway from the Reactome Pathways 2024 dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term autodegradation in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Reactome Pathways 2014

proteins participating in the Autodegradation of the E3 ubiquitin ligase COP1 pathway from the Reactome Pathways dataset.

From Reactome Pathways 2024

proteins participating in the Autodegradation of the E3 ubiquitin ligase COP1 pathway from the Reactome Pathways 2024 dataset.

From CORUM Protein Complexes

proteins in the CDH1-CKS1B complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Polycystin-1 multiprotein complex (ACTN1, CDH1, SRC, JUP, VCL, CTNNB1, PXN, BCAR1, PKD1, PTK2, TLN1) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SMAD3-HEF1-APC10-CDH1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the ITGAE-ITGB7-CDH1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the CDH1-SKP2 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Cell-cell junction complex (CDH1-CTNNB1) protein complex from the CORUM Protein Complexes dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdh1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Hub Proteins Protein-Protein Interactions

interacting proteins for hub protein CDH1 from the curated Hub Proteins Protein-Protein Interactions dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for CDH1 from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the CDH1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From ClinVar Gene-Phenotype Associations 2025

genes associated with the CDH1-related diffuse gastric and lobular breast cancer syndrome phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the CDH1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the scrib-apc-beta-catenin complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the apc-tubulin-iqgap1 complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

From CORUM Protein Complexes

proteins in the Axin2-Ctnnb1-Apc complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the EB1-APC-mDia2 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the APC-DLG4 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the 60S APC containing complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Scrib-APC-beta-catenin complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the EB1-APC-mDia1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the AXIN-APC-betaCatenin-GSK3B complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SCRIB-APC complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the APC-Axin-1-beta-catenin complex protein complex from the CORUM Protein Complexes dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term apc in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GO Biological Process Annotations 2015

genes participating in the inhibition of apc-cdc20 complex activity biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Biological Process Annotations 2015

genes participating in the negative regulation of apc-cdc20 complex activity biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Biological Process Annotations 2015

genes participating in the activation of apc-cdc20 complex activity biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Cellular Component Annotations 2015

proteins localized to the scrib-apc-beta-catenin complex cellular component from the curated GO Cellular Component Annotations 2015 dataset.

From Hub Proteins Protein-Protein Interactions

interacting proteins for hub protein APC from the curated Hub Proteins Protein-Protein Interactions dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Adenomatous polyposis coli (APC) family protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Suppressor APC domain-containing protein 1/2 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From NURSA Protein Complexes

proteins in the BL3106 (APC) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From NURSA Protein-Protein Interactions

interacting proteins for APC from the NURSA Protein-Protein Interactions dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for APC from the Pathway Commons Protein-Protein Interactions dataset.

From Reactome Pathways 2014

proteins participating in the APC truncation mutants have impaired AXIN binding pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the APC truncation mutants are not K63 polyubiquitinated pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Phosphorylation of the APC/C pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the APC/C:Cdc20 mediated degradation of mitotic proteins pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the APC-Cdc20 mediated degradation of Nek2A pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Regulation of APC/C activators between G1/S and early anaphase pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the truncated APC mutants destabilize the destruction complex pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the APC/C:Cdc20 mediated degradation of Securin pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the APC/C:Cdc20 mediated degradation of Cyclin B pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the APC/C-mediated degradation of cell cycle proteins pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Cdc20:Phospho-APC/C mediated degradation of Cyclin A pathway from the Reactome Pathways dataset.

From Reactome Pathways 2024

proteins participating in the APC truncation mutants are not K63 polyubiquitinated pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the APC truncation mutants have impaired AXIN binding pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the APC-Cdc20 mediated degradation of Nek2A pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the APC/C-mediated degradation of cell cycle proteins pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the APC/C:Cdc20 mediated degradation of Cyclin B pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the APC/C:Cdc20 mediated degradation of Securin pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the APC/C:Cdc20 mediated degradation of mitotic proteins pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Cdc20:Phospho-APC/C mediated degradation of Cyclin A pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Phosphorylation of the APC/C pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Regulation of APC/C activators between G1/S and early anaphase pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Signaling by APC mutants pathway from the Reactome Pathways 2024 dataset.

From COMPARTMENTS Curated Protein Localization Evidence Scores 2025

proteins localized to the Scrib-APC-beta-catenin complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025

proteins co-occuring with the APC-tubulin-IQGAP1 complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025

proteins co-occuring with the Scrib-APC-beta-catenin complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.

From ClinVar Gene-Phenotype Associations 2025

genes associated with the APC-Associated Polyposis Disorders phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset.

From ClinVar Gene-Phenotype Associations 2025

genes associated with the APC-related attenuated familial adenomatous polyposis phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the APC-100 drug from theDGIdb Drug Targets 2026 dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the APC gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.