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EPOR Geneerythropoietin receptor This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010] |
EPO Geneerythropoietin This gene encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The encoded protein is mainly synthesized in the kidney, secreted into the blood plasma, and binds to the erythropoietin receptor to promote red blood cell production, or erythropoiesis, in the bone marrow. Expression of this gene is upregulated under hypoxic conditions, in turn leading to increased erythropoiesis and enhanced oxygen-carrying capacity of the blood. Expression of this gene has also been observed in brain and in the eye, and elevated expression levels have been observed in diabetic retinopathy and ocular hypertension. Recombinant forms of the encoded protein exhibit neuroprotective activity against a variety of potential brain injuries, as well as antiapoptotic functions in several tissue types, and have been used in the treatment of anemia and to enhance the efficacy of cancer therapies. [provided by RefSeq, Aug 2017] |
Erythropoietin activates STAT5 Gene Setproteins participating in the Erythropoietin activates STAT5 pathway from the Reactome Pathways 2024 dataset. |
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Gene Setproteins participating in the Erythropoietin activates Phosphoinositide-3-kinase (PI3K) pathway from the Reactome Pathways 2024 dataset. |
Erythropoietin activates Phospholipase C gamma (PLCG) Gene Setproteins participating in the Erythropoietin activates Phospholipase C gamma (PLCG) pathway from the Reactome Pathways 2024 dataset. |
Erythropoietin activates RAS Gene Setproteins participating in the Erythropoietin activates RAS pathway from the Reactome Pathways 2024 dataset. |
STAT5-23275557-MAMMARY-EPITHELIUM-MOUSE Gene SetFrom ChEA Transcription Factor Binding Site Profiles genes with transcription factor binding evidence in the STAT5-23275557-MAMMARY-EPITHELIUM-MOUSE transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset. |
stat5 Gene SetFrom GeneRIF Biological Term Annotations genes co-occuring with the biological term stat5 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. |
regulation of tyrosine phosphorylation of stat5 protein Gene SetFrom GO Biological Process Annotations 2015 genes participating in the regulation of tyrosine phosphorylation of stat5 protein biological process from the curated GO Biological Process Annotations 2015 dataset. |
tyrosine phosphorylation of stat5 protein Gene SetFrom GO Biological Process Annotations 2015 genes participating in the tyrosine phosphorylation of stat5 protein biological process from the curated GO Biological Process Annotations 2015 dataset. |
negative regulation of tyrosine phosphorylation of stat5 protein Gene SetFrom GO Biological Process Annotations 2015 genes participating in the negative regulation of tyrosine phosphorylation of stat5 protein biological process from the curated GO Biological Process Annotations 2015 dataset. |
positive regulation of tyrosine phosphorylation of stat5 protein Gene SetFrom GO Biological Process Annotations 2015 genes participating in the positive regulation of tyrosine phosphorylation of stat5 protein biological process from the curated GO Biological Process Annotations 2015 dataset. |
stat5-transcription-factor Gene SetFrom Phosphosite Textmining Biological Term Annotations proteins co-occuring with the biological term stat5-transcription-factor in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset. |
IL2 signaling events mediated by STAT5 Gene SetFrom PID Pathways proteins participating in the IL2 signaling events mediated by STAT5 pathway from the PID Pathways dataset. |
STAT5-23275557-MAMMARY-EPITHELIUM-MOUSE Gene SetFrom ChEA Transcription Factor Targets 2022 target genes of the STAT5-23275557-MAMMARY-EPITHELIUM-MOUSE transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. |
STAT5 Activation Gene Setproteins participating in the STAT5 Activation pathway from the Reactome Pathways 2024 dataset. |
STAT5 activation downstream of FLT3 ITD mutants Gene Setproteins participating in the STAT5 activation downstream of FLT3 ITD mutants pathway from the Reactome Pathways 2024 dataset. |
erythropoietin mediated neuroprotection through nf-kb Gene SetFrom Biocarta Pathways proteins participating in the erythropoietin mediated neuroprotection through nf-kb pathway from the Biocarta Pathways dataset. |
Erythropoietin Gene SetFrom CTD Gene-Chemical Interactions genes/proteins interacting with the chemical Erythropoietin from the curated CTD Gene-Chemical Interactions dataset. |
erythropoietin induced hypertension Gene SetFrom GAD Gene-Disease Associations genes associated with the disease erythropoietin induced hypertension in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. |
erythropoietin Gene SetFrom GAD Gene-Disease Associations genes associated with the disease erythropoietin in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. |
erythropoietin Gene SetFrom GeneRIF Biological Term Annotations genes co-occuring with the biological term erythropoietin in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. |
response to erythropoietin Gene SetFrom GO Biological Process Annotations 2015 genes participating in the response to erythropoietin biological process from the curated GO Biological Process Annotations 2015 dataset. |
erythropoietin-mediated signaling pathway Gene SetFrom GO Biological Process Annotations 2015 genes participating in the erythropoietin-mediated signaling pathway biological process from the curated GO Biological Process Annotations 2015 dataset. |
cellular response to erythropoietin Gene SetFrom GO Biological Process Annotations 2015 genes participating in the cellular response to erythropoietin biological process from the curated GO Biological Process Annotations 2015 dataset. |
erythropoietin receptor binding Gene SetFrom GO Molecular Function Annotations 2015 genes performing the erythropoietin receptor binding molecular function from the curated GO Molecular Function Annotations 2015 dataset. |
erythropoietin receptor activity Gene SetFrom GO Molecular Function Annotations 2015 genes performing the erythropoietin receptor activity molecular function from the curated GO Molecular Function Annotations 2015 dataset. |
Erythropoietin receptor Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Erythropoietin receptor protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
Erythropoietin/thrombopoeitin Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Erythropoietin/thrombopoeitin protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
Erythropoietin/thrombopoeitin, conserved site Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Erythropoietin/thrombopoeitin, conserved site protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
Growth hormone/erythropoietin receptor, ligand binding Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Growth hormone/erythropoietin receptor, ligand binding protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
Erythropoietin Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Erythropoietin protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
increased circulating erythropoietin level Gene SetFrom MPO Gene-Phenotype Associations gene mutations causing the increased circulating erythropoietin level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset. |
abnormal circulating erythropoietin level Gene SetFrom MPO Gene-Phenotype Associations gene mutations causing the abnormal circulating erythropoietin level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset. |
increased erythropoietin level Gene SetFrom MPO Gene-Phenotype Associations gene mutations causing the increased erythropoietin level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset. |
abnormal erythropoietin level Gene SetFrom MPO Gene-Phenotype Associations gene mutations causing the abnormal erythropoietin level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset. |
Erythropoietin-Resistant Anemia Gene SetFrom DisGeNET Gene-Disease Associations genes associated with the disease Erythropoietin-Resistant Anemia in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. |
Polycythemia Due To Erythropoietin Gene SetFrom DisGeNET Gene-Disease Associations genes associated with the disease Polycythemia Due To Erythropoietin in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. |
erythropoietin-mediated signaling pathway Gene SetFrom GO Biological Process Annotations 2023 genes participating in the erythropoietin-mediated signaling pathway biological process from the curated GO Biological Process Annotations 2023 dataset. |
cellular response to erythropoietin Gene SetFrom GO Biological Process Annotations 2023 genes participating in the cellular response to erythropoietin biological process from the curated GO Biological Process Annotations 2023 dataset. |
response to erythropoietin Gene SetFrom GO Biological Process Annotations 2023 genes participating in the response to erythropoietin biological process from the curated GO Biological Process Annotations 2023 dataset. |
erythropoietin receptor binding Gene SetFrom GO Molecular Function Annotations 2023 genes performing the erythropoietin receptor binding molecular function from the curated GO Molecular Function Annotations 2023 dataset. |
erythropoietin receptor activity Gene SetFrom GO Molecular Function Annotations 2023 genes performing the erythropoietin receptor activity molecular function from the curated GO Molecular Function Annotations 2023 dataset. |
increased circulating erythropoietin level Gene SetFrom MGI Mouse Phenotype Associations 2023 gene mutations causing the increased circulating erythropoietin level phenotype in transgenic mice from the MGI Mouse Phenotype Associations 2023 dataset. |
decreased circulating erythropoietin level Gene SetFrom MGI Mouse Phenotype Associations 2023 gene mutations causing the decreased circulating erythropoietin level phenotype in transgenic mice from the MGI Mouse Phenotype Associations 2023 dataset. |
Signaling by Erythropoietin Gene Setproteins participating in the Signaling by Erythropoietin pathway from the Reactome Pathways 2024 dataset. |
erythropoietin-mediated signaling pathway Gene SetFrom GO Biological Process Annotations 2025 genes participating in the erythropoietin-mediated signaling pathway biological process from the curated GO Biological Process Annotations 2025 dataset. |
cellular response to erythropoietin Gene SetFrom GO Biological Process Annotations 2025 genes participating in the cellular response to erythropoietin biological process from the curated GO Biological Process Annotations 2025 dataset. |
response to erythropoietin Gene SetFrom GO Biological Process Annotations 2025 genes participating in the response to erythropoietin biological process from the curated GO Biological Process Annotations 2025 dataset. |
erythropoietin receptor binding Gene SetFrom GO Molecular Function Annotations 2025 genes performing the erythropoietin receptor binding molecular function from the curated GO Molecular Function Annotations 2025 dataset. |
erythropoietin receptor activity Gene SetFrom GO Molecular Function Annotations 2025 genes performing the erythropoietin receptor activity molecular function from the curated GO Molecular Function Annotations 2025 dataset. |
Serum erythropoietin levels Gene SetFrom GWAS Catalog SNP-Phenotype Associations 2025 genes associated with the Serum erythropoietin levels phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset. |
Erythropoietin levels Gene SetFrom GWAS Catalog SNP-Phenotype Associations 2025 genes associated with the Erythropoietin levels phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset. |
activates Gene SetFrom GeneRIF Biological Term Annotations genes co-occuring with the biological term activates in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. |
ATF4 activates genes Gene Setproteins participating in the ATF4 activates genes pathway from the Reactome Pathways dataset. |
ChREBP activates metabolic gene expression Gene Setproteins participating in the ChREBP activates metabolic gene expression pathway from the Reactome Pathways dataset. |
PIP3 activates AKT signaling Gene Setproteins participating in the PIP3 activates AKT signaling pathway from the Reactome Pathways dataset. |
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Gene Setproteins participating in the Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway from the Reactome Pathways dataset. |
TGF-beta receptor signaling activates SMADs Gene Setproteins participating in the TGF-beta receptor signaling activates SMADs pathway from the Reactome Pathways dataset. |
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Gene Setproteins participating in the LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production pathway from the Reactome Pathways dataset. |
XBP1(S) activates chaperone genes Gene Setproteins participating in the XBP1(S) activates chaperone genes pathway from the Reactome Pathways dataset. |
PPARA activates gene expression Gene Setproteins participating in the PPARA activates gene expression pathway from the Reactome Pathways dataset. |
ATF6-alpha activates chaperone genes Gene Setproteins participating in the ATF6-alpha activates chaperone genes pathway from the Reactome Pathways dataset. |
RORA activates circadian gene expression Gene Setproteins participating in the RORA activates circadian gene expression pathway from the Reactome Pathways dataset. |
TAK1 activates NFkB by phosphorylation and activation of IKKs complex Gene Setproteins participating in the TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway from the Reactome Pathways dataset. |
BMAL1:CLOCK,NPAS2 activates circadian gene expression Gene Setproteins participating in the BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway from the Reactome Pathways dataset. |
ATF6-alpha activates chaperones Gene Setproteins participating in the ATF6-alpha activates chaperones pathway from the Reactome Pathways dataset. |
IRE1alpha activates chaperones Gene Setproteins participating in the IRE1alpha activates chaperones pathway from the Reactome Pathways dataset. |
ATF4 activates genes in response to endoplasmic reticulum stress Gene Setproteins participating in the ATF4 activates genes in response to endoplasmic reticulum stress pathway from the Reactome Pathways 2024 dataset. |
ATF6 (ATF6-alpha) activates chaperone genes Gene Setproteins participating in the ATF6 (ATF6-alpha) activates chaperone genes pathway from the Reactome Pathways 2024 dataset. |
ATF6 (ATF6-alpha) activates chaperones Gene Setproteins participating in the ATF6 (ATF6-alpha) activates chaperones pathway from the Reactome Pathways 2024 dataset. |
ATF6B (ATF6-beta) activates chaperones Gene Setproteins participating in the ATF6B (ATF6-beta) activates chaperones pathway from the Reactome Pathways 2024 dataset. |
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Gene Setproteins participating in the Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway from the Reactome Pathways 2024 dataset. |
BDNF activates NTRK2 (TRKB) signaling Gene Setproteins participating in the BDNF activates NTRK2 (TRKB) signaling pathway from the Reactome Pathways 2024 dataset. |
BMAL1:CLOCK,NPAS2 activates circadian gene expression Gene Setproteins participating in the BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway from the Reactome Pathways 2024 dataset. |
Calcineurin activates NFAT Gene Setproteins participating in the Calcineurin activates NFAT pathway from the Reactome Pathways 2024 dataset. |
ChREBP activates metabolic gene expression Gene Setproteins participating in the ChREBP activates metabolic gene expression pathway from the Reactome Pathways 2024 dataset. |
ERBB2 Activates PTK6 Signaling Gene Setproteins participating in the ERBB2 Activates PTK6 Signaling pathway from the Reactome Pathways 2024 dataset. |
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Gene Setproteins participating in the High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells pathway from the Reactome Pathways 2024 dataset. |
IFNG signaling activates MAPKs Gene Setproteins participating in the IFNG signaling activates MAPKs pathway from the Reactome Pathways 2024 dataset. |
IRE1alpha activates chaperones Gene Setproteins participating in the IRE1alpha activates chaperones pathway from the Reactome Pathways 2024 dataset. |
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Gene Setproteins participating in the LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production pathway from the Reactome Pathways 2024 dataset. |
MET activates PI3K/AKT signaling Gene Setproteins participating in the MET activates PI3K/AKT signaling pathway from the Reactome Pathways 2024 dataset. |
MET activates PTK2 signaling Gene Setproteins participating in the MET activates PTK2 signaling pathway from the Reactome Pathways 2024 dataset. |
MET activates PTPN11 Gene Setproteins participating in the MET activates PTPN11 pathway from the Reactome Pathways 2024 dataset. |
MET activates RAP1 and RAC1 Gene Setproteins participating in the MET activates RAP1 and RAC1 pathway from the Reactome Pathways 2024 dataset. |
MET activates RAS signaling Gene Setproteins participating in the MET activates RAS signaling pathway from the Reactome Pathways 2024 dataset. |
MET activates STAT3 Gene Setproteins participating in the MET activates STAT3 pathway from the Reactome Pathways 2024 dataset. |
MTF1 activates gene expression Gene Setproteins participating in the MTF1 activates gene expression pathway from the Reactome Pathways 2024 dataset. |
NTF3 activates NTRK2 (TRKB) signaling Gene Setproteins participating in the NTF3 activates NTRK2 (TRKB) signaling pathway from the Reactome Pathways 2024 dataset. |
NTF3 activates NTRK3 signaling Gene Setproteins participating in the NTF3 activates NTRK3 signaling pathway from the Reactome Pathways 2024 dataset. |
NTF4 activates NTRK2 (TRKB) signaling Gene Setproteins participating in the NTF4 activates NTRK2 (TRKB) signaling pathway from the Reactome Pathways 2024 dataset. |
NTRK2 activates RAC1 Gene Setproteins participating in the NTRK2 activates RAC1 pathway from the Reactome Pathways 2024 dataset. |
PIP3 activates AKT signaling Gene Setproteins participating in the PIP3 activates AKT signaling pathway from the Reactome Pathways 2024 dataset. |
PPARA activates gene expression Gene Setproteins participating in the PPARA activates gene expression pathway from the Reactome Pathways 2024 dataset. |
PTK6 Activates STAT3 Gene Setproteins participating in the PTK6 Activates STAT3 pathway from the Reactome Pathways 2024 dataset. |
RORA activates gene expression Gene Setproteins participating in the RORA activates gene expression pathway from the Reactome Pathways 2024 dataset. |
SARS-CoV-1 activates/modulates innate immune responses Gene Setproteins participating in the SARS-CoV-1 activates/modulates innate immune responses pathway from the Reactome Pathways 2024 dataset. |
SARS-CoV-2 activates/modulates innate and adaptive immune responses Gene Setproteins participating in the SARS-CoV-2 activates/modulates innate and adaptive immune responses pathway from the Reactome Pathways 2024 dataset. |
TGF-beta receptor signaling activates SMADs Gene Setproteins participating in the TGF-beta receptor signaling activates SMADs pathway from the Reactome Pathways 2024 dataset. |
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Gene Setproteins participating in the Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells pathway from the Reactome Pathways 2024 dataset. |
XBP1(S) activates chaperone genes Gene Setproteins participating in the XBP1(S) activates chaperone genes pathway from the Reactome Pathways 2024 dataset. |
