Harmonizome 3.0

cholinergic receptor, muscarinic 5

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, stimulation of this receptor is known to increase cyclic AMP levels. [provided by RefSeq, Jul 2008]

cholinergic receptor, muscarinic 4

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, mouse studies link its function to adenylyl cyclase inhibition. [provided by RefSeq, Jul 2008]

cholinergic receptor, muscarinic 3

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue. Alternative promoter use and alternative splicing results in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016]

cholinergic receptor, muscarinic 2

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]

cholinergic receptor, muscarinic 1

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13. [provided by RefSeq, Jul 2008]

ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) pseudogene

anthrax toxin receptor 1

This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. [provided by RefSeq, Oct 2008]

anthrax toxin receptor 2

This gene encodes a receptor for anthrax toxin. The protein binds to collagen IV and laminin, suggesting that it may be involved in extracellular matrix adhesion. Mutations in this gene cause juvenile hyaline fibromatosis and infantile systemic hyalinosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

anthrax toxin receptor-like

Predicted to enable transmembrane signaling receptor activity. Predicted to be located in membrane. Predicted to be active in cell surface and plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

ras-related C3 botulinum toxin substrate 1 pseudogene 5

This locus encodes one of the pseudogenes of the functional ras-related C3 botulinum toxin substrate 1 gene (RAC1, GeneID:5879) located on chr 7. It is intronless, shares overall 93% sequence identity with the RAC1 gene, and has enough differences in the coding region so as not to be able to code for a functional protein. There is no evidence of transcription at this pseudogene locus on chr 4. [provided by RefSeq, Jul 2008]

ras-related C3 botulinum toxin substrate 1 pseudogene 4

ras-related C3 botulinum toxin substrate 1 pseudogene 1

ras-related C3 botulinum toxin substrate 1 pseudogene 3

ras-related C3 botulinum toxin substrate 1 pseudogene 2

solute carrier family 47 (multidrug and toxin extrusion), member 2

This gene encodes a protein belonging to a family of transporters involved in excretion of toxic electrolytes, both endogenous and exogenous, through urine and bile. This transporter family shares homology with the bacterial MATE (multidrug and toxin extrusion) protein family responsible for drug resistance. This gene is one of two members of the MATE transporter family located near each other on chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

solute carrier family 47 (multidrug and toxin extrusion), member 1

This gene is located within the Smith-Magenis syndrome region on chromosome 17. It encodes a protein of unknown function. [provided by RefSeq, Jul 2008]

solute carrier family 47 (multidrug and toxin extrusion), member 2 pseudogene

anthrax toxin receptor-like pseudogene 1

ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)

This gene encodes a member of the Ras superfamily of small guanosine triphosphate (GTP)-metabolizing proteins. The encoded protein localizes to the plasma membrane, where it regulates diverse processes, such as secretion, phagocytosis, and cell polarization. Activity of this protein is also involved in the generation of reactive oxygen species. Mutations in this gene are associated with neutrophil immunodeficiency syndrome. There is a pseudogene for this gene on chromosome 6. [provided by RefSeq, Jul 2013]

ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)

The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)

The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

multidrug and toxin extrusion protein 2-like

ras-related C3 botulinum toxin substrate 1 pseudogene 9

ras-related C3 botulinum toxin substrate 1 pseudogene 8

ras-related C3 botulinum toxin substrate 1 pseudogene 6

ras-related C3 botulinum toxin substrate 1 pseudogene 7

From DGIdb Drug Targets 2026

interacting proteins for the MUSCARINIC TOXIN 2 drug from theDGIdb Drug Targets 2026 dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical muscarinic toxin 7 from the curated CTD Gene-Chemical Interactions dataset.

From DGIdb Drug Targets 2026

interacting proteins for the MUSCARINIC TOXIN Β drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the MUSCARINIC TOXIN 3 drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the MUSCARINIC TOXIN 1 drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the MUSCARINIC TOXIN 7 drug from theDGIdb Drug Targets 2026 dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Muscarinic Agonists from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Muscarinic Antagonists from the curated CTD Gene-Chemical Interactions dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term muscarinic in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Muscarinic acetylcholine receptor M3 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Muscarinic acetylcholine receptor M2 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Muscarinic acetylcholine receptor M5 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Muscarinic acetylcholine receptor M4 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Muscarinic acetylcholine receptor family protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Muscarinic acetylcholine receptor M1 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From PANTHER Pathways

proteins participating in the Muscarinic acetylcholine receptor 2 and 4 signaling pathway pathway from the PANTHER Pathways dataset.

From PANTHER Pathways

proteins participating in the Muscarinic acetylcholine receptor 1 and 3 signaling pathway pathway from the PANTHER Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Muscarinic acetylcholine receptors pathway from the Reactome Pathways dataset.

From Reactome Pathways 2024

proteins participating in the Muscarinic acetylcholine receptors pathway from the Reactome Pathways 2024 dataset.

From Biocarta Pathways

proteins participating in the anthrax toxin mechanism of action pathway from the Biocarta Pathways dataset.

From Biocarta Pathways

proteins participating in the pertussis toxin-insensitive ccr5 signaling in macrophage pathway from the Biocarta Pathways dataset.

From CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the HC toxin-909 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Cholera Toxin from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Pertussis Toxin from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical BeKm-1 toxin from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical botulinum toxin type E from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical toxin II (Anemonia sulcata) from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Shiga Toxin from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Clostridium difficile lethal toxin B from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Shiga Toxin 2 from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Shiga Toxin 1 from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical staphylococcal delta toxin from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical botulinum toxin type D from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical botulinum toxin type C from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical cyanobacterial toxin from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical HT-2 toxin from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical staphylococcal alpha-toxin from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Tetanus Toxin from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical T-2 Toxin from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical BmK IT2 scorpion toxin from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Adenylate Cyclase Toxin from the curated CTD Gene-Chemical Interactions dataset.

From DrugBank Drug Targets

interacting proteins for the Botulinum Toxin Type A drug from the curated DrugBank Drug Targets dataset.

From DrugBank Drug Targets

interacting proteins for the Botulinum Toxin Type B drug from the curated DrugBank Drug Targets dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term toxin in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GO Biological Process Annotations 2015

genes participating in the toxin biosynthetic process biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Biological Process Annotations 2015

genes participating in the toxin metabolic process biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Biological Process Annotations 2015

genes participating in the toxin transport biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Molecular Function Annotations 2015

genes performing the toxin transporter activity molecular function from the curated GO Molecular Function Annotations 2015 dataset.

From GO Molecular Function Annotations 2015

genes performing the toxin receptor binding molecular function from the curated GO Molecular Function Annotations 2015 dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the β-scorpion toxin Css IV ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the β-scorpion toxin Cn2 ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the α-scorpion toxin ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the joro toxin ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the ShK Toxin ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the sea anemone toxin BDS-I ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the β-scorpion toxin TiTXγ ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Type II toxin-antitoxin system, antitoxin Phd/YefM protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Endothelin-like toxin protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Anthrax toxin receptor protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Anthrax toxin receptor, C-terminal protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Anthrax toxin receptor, extracellular protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Endothelin-like toxin, conserved site protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From Phosphosite Textmining Biological Term Annotations

proteins co-occuring with the biological term toxin in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

From PID Pathways

proteins participating in the Cellular roles of Anthrax toxin pathway from the PID Pathways dataset.

From PID Pathways

proteins participating in the Effects of Botulinum toxin pathway from the PID Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Toxicity of botulinum toxin type G (BoNT/G) pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Uptake and function of diphtheria toxin pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Toxicity of botulinum toxin type F (BoNT/F) pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Toxicity of tetanus toxin (TeNT) pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Toxicity of botulinum toxin type E (BoNT/E) pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Toxicity of botulinum toxin type D (BoNT/D) pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Toxicity of botulinum toxin type B (BoNT/B) pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Toxicity of botulinum toxin type C (BoNT/C) pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Toxicity of botulinum toxin type A (BoNT/A) pathway from the Reactome Pathways dataset.

From GO Biological Process Annotations 2023

genes participating in the toxin transport biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the toxin biosynthetic process biological process from the curated GO Biological Process Annotations 2023 dataset.

From LINCS L1000 CMAP Chemical Perturbation Consensus Signatures

genes differentially expressed following the HC-toxin small molecule perturbation from the LINCS L1000 CMAP Chemical Perturbation Consensus Signatures dataset.

From Reactome Pathways 2024

proteins participating in the Toxicity of botulinum toxin type A (botA) pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Toxicity of botulinum toxin type B (botB) pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Toxicity of botulinum toxin type C (botC) pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Toxicity of botulinum toxin type D (botD) pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Toxicity of botulinum toxin type E (botE) pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Toxicity of botulinum toxin type F (botF) pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Toxicity of botulinum toxin type G (botG) pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Toxicity of tetanus toxin (tetX) pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Uptake and function of diphtheria toxin pathway from the Reactome Pathways 2024 dataset.

From GO Biological Process Annotations 2025

genes participating in the toxin biosynthetic process biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Biological Process Annotations 2025

genes participating in the toxin metabolic process biological process from the curated GO Biological Process Annotations 2025 dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025

proteins co-occuring with the toxin-antitoxin complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the MAMBA TOXIN CM-3 drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the JORO SPIDER TOXIN drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the HC-TOXIN drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the SHK TOXIN drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the DIPHTHERIA TOXIN drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the Β-SCORPION TOXIN CN2 drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the BOTULINUM TOXIN TYPE A drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the BOTULINUM TOXIN TYPE B drug from theDGIdb Drug Targets 2026 dataset.