Harmonizome 3.0

SKI proto-oncogene

This gene encodes the nuclear protooncogene protein homolog of avian sarcoma viral (v-ski) oncogene. It functions as a repressor of TGF-beta signaling, and may play a role in neural tube development and muscle differentiation. [provided by RefSeq, Oct 2009]

SKI-like proto-oncogene

The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

SKI family transcriptional corepressor 2

Enables SMAD binding activity and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transforming growth factor beta receptor signaling pathway. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Mar 2025]

SKI family transcriptional corepressor 1

Enables SMAD binding activity and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of BMP signaling pathway. Located in dendrite and neuronal cell body. [provided by Alliance of Genome Resources, Mar 2025]

SKI/DACH domain containing 1

Predicted to enable DNA-binding transcription factor activity. Predicted to be involved in regulation of transcription by RNA polymerase II. [provided by Alliance of Genome Resources, Mar 2025]

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Ski oncogene protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Ski-related oncogene Sno protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From NURSA Protein Complexes

proteins in the a-SKI (SKI) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term oncogene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GO Biological Process Annotations 2015

genes participating in the oncogene-induced cell senescence biological process from the curated GO Biological Process Annotations 2015 dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the FGFR1 oncogene partner (FOP), N-terminal dimerisation domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Proto-oncogene Mas protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From Phosphosite Textmining Biological Term Annotations

proteins co-occuring with the biological term proto-oncogene-proteins in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

From Phosphosite Textmining Biological Term Annotations

proteins co-occuring with the biological term proto-oncogene-proteins-c-abl in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

From Reactome Pathways 2014

proteins participating in the Oncogene Induced Senescence pathway from the Reactome Pathways dataset.

From GO Biological Process Annotations 2023

genes participating in the oncogene-induced cell senescence biological process from the curated GO Biological Process Annotations 2023 dataset.

From WikiPathways Pathways 2024

proteins participating in the NAD metabolism in oncogene induced senescence and mitochondrial dysfunction associated senescence pathway from the WikiPathways Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Evasion of Oncogene Induced Senescence Due to p14ARF Defects pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Evasion of Oncogene Induced Senescence Due to p16INK4A Defects pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Oncogene Induced Senescence pathway from the Reactome Pathways 2024 dataset.

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the ski complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the ski complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

From CORUM Protein Complexes

proteins in the SMAD4-SKI complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SKI-SMAD2-SMAD4 pentameric complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SKI-SMAD2 hexameric complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SKI-NCOR1-SIN3A-HDAC1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SMAD4-SNO-SKI complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SMAD3-SKI-NCOR complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SKI-SMAD3 hexameric complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SMAD3-SKI complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SKI-SMAD3-SMAD4 pentameric complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SMAD2-SKI complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SMAD2-SKI-NCOR complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SKI complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SMAD4-SKI-NCOR complex protein complex from the CORUM Protein Complexes dataset.

From COSMIC Cell Line Gene CNV Profiles

genes with high or low copy number in CA-SKI relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.

From COSMIC Cell Line Gene Mutation Profiles

genes mutated in the CA-SKI cell line from the COSMIC Cell Line Gene Mutation Profiles dataset.

From GDSC Cell Line Gene Expression Profiles

genes with high or low expression in Ca-Ski relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ski in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GO Cellular Component Annotations 2015

proteins localized to the ski complex cellular component from the curated GO Cellular Component Annotations 2015 dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the SKI-interacting protein SKIP, SNW domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Ski family transcriptional corepressor 1 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Transforming protein Ski protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the SKI family transcriptional corepressor 2 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the c-SKI SMAD4-binding domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Transcription regulator SKI/SnoN protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the SKI-interacting protein, SKIP protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles

genes with high or low copy number in CA SKI relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.

From Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles

genes with high or low expression in CA SKI relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset.

From Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles

genes mutated in the CA SKI cell line from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for SKI from the Pathway Commons Protein-Protein Interactions dataset.

From Sanger Dependency Map Cancer Cell Line Proteomics

proteins associated with the cell line Ca-Ski from the Sanger Dependency Map Cancer Cell Line Proteomics dataset.

From DeepCoverMOA Drug Mechanisms of Action

proteins with high or low expression in SKI II relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

From WikiPathways Pathways 2024

proteins participating in the Transcription co factors SKI and SKIL protein partners pathway from the WikiPathways Pathways 2024 dataset.

From COMPARTMENTS Curated Protein Localization Evidence Scores 2025

proteins localized to the Ski complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025

proteins co-occuring with the Ski complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the SKI II drug from theDGIdb Drug Targets 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC9811786-13148_2022_1394_MOESM17_ESM.xlsx-SKI-Stress_CpG_gene_SKI transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the SKI gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.