Harmonizome 3.0

<strong>neuropeptidestrong> Y receptor Y2

Predicted to enable calcium channel regulator activity and <strong>neuropeptidestrong> Y receptor activity. Involved in cardiac left ventricle morphogenesis and outflow tract morphogenesis. Located in cilium. Implicated in Huntington's disease; morbid obesity; and obesity. Biomarker of peripheral artery disease and temporal lobe epilepsy. [provided by Alliance of Genome Resources, Mar 2025]

<strong>neuropeptidestrong> Y receptor Y1

This gene belongs to the G-protein-coupled receptor superfamily. The encoded transmembrane protein mediates the function of <strong>neuropeptidestrong> Y (NPY), a neurotransmitter, and peptide YY (PYY), a gastrointestinal hormone. The encoded receptor undergoes fast agonist-induced internalization through clathrin-coated pits and is subsequently recycled back to the cell membrane. Activation of Y1 receptors may result in mobilization of intracellular calcium and inhibition of adenylate cyclase activity. [provided by RefSeq, Aug 2013]

<strong>neuropeptidestrong> FF receptor 2

This gene encodes a member of a subfamily of G-protein-coupled <strong>neuropeptidestrong> receptors. This protein is activated by the <strong>neuropeptidestrong>s A-18-amide (NPAF) and F-8-amide (NPFF) and may function in pain modulation and regulation of the opioid system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]

<strong>neuropeptidestrong> FF receptor 1

Enables <strong>neuropeptidestrong> receptor activity. Involved in <strong>neuropeptidestrong> signaling pathway. Located in cilium. Is active in plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

hypocretin (orexin) <strong>neuropeptidestrong> precursor

This gene encodes a hypothalamic <strong>neuropeptidestrong> precursor protein that gives rise to two mature <strong>neuropeptidestrong>s, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This <strong>neuropeptidestrong> arrangement may also play a role in feeding behavior, metabolism, and homeostasis. [provided by RefSeq, Jan 2010]

<strong>neuropeptidestrong> Y receptor Y4

Enables pancreatic polypeptide receptor activity and peptide hormone binding activity. Involved in G protein-coupled receptor signaling pathway. Located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

agouti related <strong>neuropeptidestrong>

This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity. [provided by RefSeq, Dec 2009]

<strong>neuropeptidestrong> Y receptor type 4

<strong>neuropeptidestrong> B

This gene encodes a member of the <strong>neuropeptidestrong> B/W family of proteins and preproprotein that is proteolytically processed to generate multiple protein products. The encoded products include <strong>neuropeptidestrong> B-23 and a C-terminally extended form, <strong>neuropeptidestrong> B-29, which are characterized by an N-terminal brominated tryptophan amino acid. Both of the encoded peptides bind with higher affinity to <strong>neuropeptidestrong> B/W (NPB/W) receptor 1 compared to the related NPB/W receptor 2. These peptides may regulate feeding, pain perception, and stress in rodents. [provided by RefSeq, Jul 2015]

<strong>neuropeptidestrong> Y

This gene encodes a <strong>neuropeptidestrong> that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The <strong>neuropeptidestrong> functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014]

<strong>neuropeptidestrong> W

The product of this gene is processed into 23- and 30-amino acid <strong>neuropeptidestrong>s that bind and activate two G-protein coupled receptors in the central nervous system. The <strong>neuropeptidestrong>s have been shown to enhance cortisol secretion from adrenal cells through the adenylate cyclase/protein kinase A signaling cascade. The preproprotein is translated using a non-AUG initiation codon that is inferred from analyses of the mouse ortholog. [provided by RefSeq, Jul 2008]

<strong>neuropeptidestrong> S

Predicted to be involved in positive regulation of GABAergic synaptic transmission; positive regulation of action potential; and positive regulation of glutamatergic synaptic transmission. Predicted to act upstream of or within visual learning. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Mar 2025]

<strong>neuropeptidestrong> Y receptor Y6 (pseudogene)

Predicted to enable <strong>neuropeptidestrong> binding activity and peptide YY receptor activity. Predicted to be involved in <strong>neuropeptidestrong> signaling pathway. Predicted to be located in membrane. Predicted to be active in neuron projection and plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

<strong>neuropeptidestrong> Y receptor Y5

The protein encoded by this gene is a receptor for <strong>neuropeptidestrong> Y and peptide YY. The encoded protein appears to be involved in regulating food intake, with defects in this gene being associated with eating disorders. Also, the encoded protein is involved in a pathway that protects neuroblastoma cells from chemotherapy-induced cell death, providing a possible therapeutic target against neuroblastoma. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2015]

<strong>neuropeptidestrong> S receptor 1

This gene encodes a member of the vasopressin/oxytocin subfamily of G protein-coupled receptors. The encoded membrane protein acts as a receptor for <strong>neuropeptidestrong> S and affects a variety of cellular processes through its signaling. Increased expression of this gene in ciliated cells of the respiratory epithelium and in bronchial smooth muscle cells is associated with asthma. Polymorphisms in this gene have also been associated with asthma susceptibility, panic disorders, inflammatory bowel disease, and rheumatoid arthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

<strong>neuropeptidestrong> Y receptor type 4-like

Enables pancreatic polypeptide receptor activity and peptide hormone binding activity. Involved in G protein-coupled receptor signaling pathway. Located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

<strong>neuropeptidestrong> FF-amide peptide precursor

This gene encodes a member of the FMRFamide related peptide (FARP) family of <strong>neuropeptidestrong>s. The encoded preproprotein is proteolytically processed to generate multiple amidated peptides. These peptides may play a role in the regulation of heart rate and blood pressure and the modulation of morphine-induced antinociception. Patients with hypertension exhibit decreased expression of the encoded protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

<strong>neuropeptidestrong> VF precursor

Enables <strong>neuropeptidestrong> activity. Involved in negative regulation of gonadotropin secretion and <strong>neuropeptidestrong> signaling pathway. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Mar 2025]

<strong>neuropeptidestrong> Y receptor Y4-2

Enables pancreatic polypeptide receptor activity and peptide hormone binding activity. Involved in G protein-coupled receptor signaling pathway. Located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the <strong>Neuropeptidestrong> S protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From DGIdb Drug Targets 2026

interacting proteins for the NEUROPEPTIDE S drug from theDGIdb Drug Targets 2026 dataset.

From Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles

genes with high or low expression in <strong>neuropeptidestrong>-S nucleus relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical <strong>neuropeptidestrong> Y, Leu(31)-Pro(34)- from the curated CTD Gene-Chemical Interactions dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term <strong>neuropeptidestrong> in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GO Biological Process Annotations 2015

genes participating in the <strong>neuropeptidestrong> signaling pathway biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Biological Process Annotations 2015

genes participating in the <strong>neuropeptidestrong> catabolic process biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Molecular Function Annotations 2015

genes performing the <strong>neuropeptidestrong> receptor activity molecular function from the curated GO Molecular Function Annotations 2015 dataset.

From GO Molecular Function Annotations 2015

genes performing the <strong>neuropeptidestrong> binding molecular function from the curated GO Molecular Function Annotations 2015 dataset.

From GO Molecular Function Annotations 2015

genes performing the <strong>neuropeptidestrong> hormone activity molecular function from the curated GO Molecular Function Annotations 2015 dataset.

From GO Molecular Function Annotations 2015

genes performing the <strong>neuropeptidestrong> y receptor binding molecular function from the curated GO Molecular Function Annotations 2015 dataset.

From GO Molecular Function Annotations 2015

genes performing the <strong>neuropeptidestrong> receptor binding molecular function from the curated GO Molecular Function Annotations 2015 dataset.

From GO Molecular Function Annotations 2015

genes performing the orexigenic <strong>neuropeptidestrong> qrfp receptor binding molecular function from the curated GO Molecular Function Annotations 2015 dataset.

From GO Molecular Function Annotations 2015

genes performing the <strong>neuropeptidestrong> y receptor activity molecular function from the curated GO Molecular Function Annotations 2015 dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the <strong>neuropeptidestrong>-α ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the <strong>neuropeptidestrong> head activator ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the <strong>Neuropeptidestrong> Y2 receptor protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Pro-FMRFamide-related <strong>neuropeptidestrong> FF protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the <strong>Neuropeptidestrong> FF receptor, type 1 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the <strong>Neuropeptidestrong> FF receptor, type 2 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the <strong>Neuropeptidestrong> W precursor protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the <strong>Neuropeptidestrong> B/W receptor family protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Opioid <strong>neuropeptidestrong> precursor protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the <strong>Neuropeptidestrong> B/W precursor family protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the <strong>Neuropeptidestrong> Y5 receptor protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the <strong>Neuropeptidestrong> Y4 receptor protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Orexigenic <strong>neuropeptidestrong> QRFP/P518 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Opiodes <strong>neuropeptidestrong> protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the <strong>Neuropeptidestrong> B/W receptor 2 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the <strong>Neuropeptidestrong> B/W receptor 1 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the <strong>Neuropeptidestrong> Y1 receptor protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the <strong>Neuropeptidestrong> FF receptor family protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the <strong>Neuropeptidestrong> Y receptor family protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the <strong>Neuropeptidestrong> B precursor protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the <strong>Neuropeptidestrong> S receptor protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From GO Biological Process Annotations 2023

genes participating in the <strong>neuropeptidestrong> signaling pathway biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the <strong>neuropeptidestrong> processing biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the <strong>neuropeptidestrong> catabolic process biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the trans-synaptic signaling by <strong>neuropeptidestrong>, modulating synaptic transmission biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the trans-synaptic signaling by <strong>neuropeptidestrong> biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Molecular Function Annotations 2023

genes performing the <strong>neuropeptidestrong> hormone activity molecular function from the curated GO Molecular Function Annotations 2023 dataset.

From GO Molecular Function Annotations 2023

genes performing the <strong>neuropeptidestrong> receptor activity molecular function from the curated GO Molecular Function Annotations 2023 dataset.

From GO Molecular Function Annotations 2023

genes performing the <strong>neuropeptidestrong> binding molecular function from the curated GO Molecular Function Annotations 2023 dataset.

From GO Molecular Function Annotations 2023

genes performing the <strong>neuropeptidestrong> receptor binding molecular function from the curated GO Molecular Function Annotations 2023 dataset.

From GO Molecular Function Annotations 2023

genes performing the <strong>neuropeptidestrong> Y receptor activity molecular function from the curated GO Molecular Function Annotations 2023 dataset.

From GO Molecular Function Annotations 2023

genes performing the orexigenic <strong>neuropeptidestrong> QRFP receptor binding molecular function from the curated GO Molecular Function Annotations 2023 dataset.

From GO Molecular Function Annotations 2023

genes performing the <strong>neuropeptidestrong> Y receptor binding molecular function from the curated GO Molecular Function Annotations 2023 dataset.

From GO Molecular Function Annotations 2023

genes performing the <strong>neuropeptidestrong> activity molecular function from the curated GO Molecular Function Annotations 2023 dataset.

From SynGO Synaptic Gene Annotations

genes associated with the synaptic term trans-synaptic signaling by <strong>neuropeptidestrong> from the SynGO Synaptic Gene Annotations dataset.

From SynGO Synaptic Gene Annotations

genes associated with the synaptic term synaptic signaling via <strong>neuropeptidestrong> from the SynGO Synaptic Gene Annotations dataset.

From GO Biological Process Annotations 2025

genes participating in the <strong>neuropeptidestrong> signaling pathway biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Biological Process Annotations 2025

genes participating in the synaptic signaling via <strong>neuropeptidestrong> biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Biological Process Annotations 2025

genes participating in the <strong>neuropeptidestrong> processing biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Biological Process Annotations 2025

genes participating in the <strong>neuropeptidestrong> catabolic process biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Molecular Function Annotations 2025

genes performing the <strong>neuropeptidestrong> hormone activity molecular function from the curated GO Molecular Function Annotations 2025 dataset.

From GO Molecular Function Annotations 2025

genes performing the <strong>neuropeptidestrong> receptor activity molecular function from the curated GO Molecular Function Annotations 2025 dataset.

From GO Molecular Function Annotations 2025

genes performing the <strong>neuropeptidestrong> activity molecular function from the curated GO Molecular Function Annotations 2025 dataset.

From GO Molecular Function Annotations 2025

genes performing the <strong>neuropeptidestrong> receptor binding molecular function from the curated GO Molecular Function Annotations 2025 dataset.

From GO Molecular Function Annotations 2025

genes performing the <strong>neuropeptidestrong> Y receptor activity molecular function from the curated GO Molecular Function Annotations 2025 dataset.

From GO Molecular Function Annotations 2025

genes performing the orexigenic <strong>neuropeptidestrong> QRFP receptor binding molecular function from the curated GO Molecular Function Annotations 2025 dataset.

From GO Molecular Function Annotations 2025

genes performing the <strong>neuropeptidestrong> Y receptor binding molecular function from the curated GO Molecular Function Annotations 2025 dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025

proteins co-occuring with the Bursicon <strong>neuropeptidestrong> hormone complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the NEUROPEPTIDE HEAD ACTIVATOR drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the DES-BR-NEUROPEPTIDE B-23 drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the DES-BR-NEUROPEPTIDE B-29 drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the NEUROPEPTIDE B-29 drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the NEUROPEPTIDE W-23 drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the NEUROPEPTIDE W-30 drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the NEUROPEPTIDE B-23 drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the NEUROPEPTIDE FF drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the NEUROPEPTIDE Y drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the NEUROPEPTIDE-Y drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the NEUROPEPTIDE Y-(3-36) drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the NEUROPEPTIDE &GAMMA; drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the NEUROPEPTIDE K drug from theDGIdb Drug Targets 2026 dataset.