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SPART Genespartin This gene encodes a protein containing a MIT (Microtubule Interacting and Trafficking molecule) domain, and is implicated in regulating endosomal trafficking and mitochondria function. The protein localizes to mitochondria and partially co-localizes with microtubules. Stimulation with epidermal growth factor (EGF) results in protein translocation to the plasma membrane, and the protein functions in the degradation and intracellular trafficking of EGF receptor. Multiple alternatively spliced variants, encoding the same protein, have been identified. Mutations associated with this gene cause autosomal recessive spastic paraplegia 20 (Troyer syndrome). [provided by RefSeq, Nov 2008] |
SEN2 Genesenescence (cellular)-related 2 |
SEN3 Genesenescence (cellular)-related 3 |
SEN6 Genesenescence (cellular)-related 6 |
SEN6A Genesenescence (cellular)-related 6A |
SEN6B Genesenescence (cellular)-related 6B |
SALRNA3 Genesenescence associated long non-coding RNA 3 |
SALRNA1 Genesenescence associated long non-coding RNA 1 |
SALRNA2 Genesenescence associated long non-coding RNA 2 |
Senescence/spartin-associated Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Senescence/spartin-associated protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
spartin Gene SetFrom GeneRIF Biological Term Annotations genes co-occuring with the biological term spartin in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. |
senescence Gene SetFrom GeneRIF Biological Term Annotations genes co-occuring with the biological term senescence in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. |
regulation of cellular senescence Gene SetFrom GO Biological Process Annotations 2015 genes participating in the regulation of cellular senescence biological process from the curated GO Biological Process Annotations 2015 dataset. |
replicative senescence Gene SetFrom GO Biological Process Annotations 2015 genes participating in the replicative senescence biological process from the curated GO Biological Process Annotations 2015 dataset. |
oncogene-induced cell senescence Gene SetFrom GO Biological Process Annotations 2015 genes participating in the oncogene-induced cell senescence biological process from the curated GO Biological Process Annotations 2015 dataset. |
cellular senescence Gene SetFrom GO Biological Process Annotations 2015 genes participating in the cellular senescence biological process from the curated GO Biological Process Annotations 2015 dataset. |
stress-induced premature senescence Gene SetFrom GO Biological Process Annotations 2015 genes participating in the stress-induced premature senescence biological process from the curated GO Biological Process Annotations 2015 dataset. |
negative regulation of cellular senescence Gene SetFrom GO Biological Process Annotations 2015 genes participating in the negative regulation of cellular senescence biological process from the curated GO Biological Process Annotations 2015 dataset. |
oxidative stress-induced premature senescence Gene SetFrom GO Biological Process Annotations 2015 genes participating in the oxidative stress-induced premature senescence biological process from the curated GO Biological Process Annotations 2015 dataset. |
organ senescence Gene SetFrom GO Biological Process Annotations 2015 genes participating in the organ senescence biological process from the curated GO Biological Process Annotations 2015 dataset. |
positive regulation of cellular senescence Gene SetFrom GO Biological Process Annotations 2015 genes participating in the positive regulation of cellular senescence biological process from the curated GO Biological Process Annotations 2015 dataset. |
Senescence marker protein-30 (SMP-30) Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Senescence marker protein-30 (SMP-30) protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
abnormal cellular replicative senescence Gene SetFrom MPO Gene-Phenotype Associations gene mutations causing the abnormal cellular replicative senescence phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset. |
early reproductive senescence Gene SetFrom MPO Gene-Phenotype Associations gene mutations causing the early reproductive senescence phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset. |
early cellular replicative senescence Gene SetFrom MPO Gene-Phenotype Associations gene mutations causing the early cellular replicative senescence phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset. |
delayed cellular replicative senescence Gene SetFrom MPO Gene-Phenotype Associations gene mutations causing the delayed cellular replicative senescence phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset. |
senescence Gene SetFrom Phosphosite Textmining Biological Term Annotations proteins co-occuring with the biological term senescence in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset. |
DNA Damage/Telomere Stress Induced Senescence Gene Setproteins participating in the DNA Damage/Telomere Stress Induced Senescence pathway from the Reactome Pathways dataset. |
Oncogene Induced Senescence Gene Setproteins participating in the Oncogene Induced Senescence pathway from the Reactome Pathways dataset. |
Cellular Senescence Gene Setproteins participating in the Cellular Senescence pathway from the Reactome Pathways dataset. |
Oxidative Stress Induced Senescence Gene Setproteins participating in the Oxidative Stress Induced Senescence pathway from the Reactome Pathways dataset. |
Senescence and Autophagy(Homo sapiens) Gene SetFrom WikiPathways Pathways 2014 proteins participating in the Senescence and Autophagy(Homo sapiens) pathway from the WikiPathways Pathways 2014 dataset. |
oxidative stress-induced premature senescence Gene SetFrom GO Biological Process Annotations 2023 genes participating in the oxidative stress-induced premature senescence biological process from the curated GO Biological Process Annotations 2023 dataset. |
regulation of cellular senescence Gene SetFrom GO Biological Process Annotations 2023 genes participating in the regulation of cellular senescence biological process from the curated GO Biological Process Annotations 2023 dataset. |
negative regulation of cellular senescence Gene SetFrom GO Biological Process Annotations 2023 genes participating in the negative regulation of cellular senescence biological process from the curated GO Biological Process Annotations 2023 dataset. |
positive regulation of cellular senescence Gene SetFrom GO Biological Process Annotations 2023 genes participating in the positive regulation of cellular senescence biological process from the curated GO Biological Process Annotations 2023 dataset. |
oncogene-induced cell senescence Gene SetFrom GO Biological Process Annotations 2023 genes participating in the oncogene-induced cell senescence biological process from the curated GO Biological Process Annotations 2023 dataset. |
stress-induced premature senescence Gene SetFrom GO Biological Process Annotations 2023 genes participating in the stress-induced premature senescence biological process from the curated GO Biological Process Annotations 2023 dataset. |
delayed cellular replicative senescence Gene SetFrom MGI Mouse Phenotype Associations 2023 gene mutations causing the delayed cellular replicative senescence phenotype in transgenic mice from the MGI Mouse Phenotype Associations 2023 dataset. |
early reproductive senescence Gene SetFrom MGI Mouse Phenotype Associations 2023 gene mutations causing the early reproductive senescence phenotype in transgenic mice from the MGI Mouse Phenotype Associations 2023 dataset. |
early cellular replicative senescence Gene SetFrom MGI Mouse Phenotype Associations 2023 gene mutations causing the early cellular replicative senescence phenotype in transgenic mice from the MGI Mouse Phenotype Associations 2023 dataset. |
abnormal cellular replicative senescence Gene SetFrom MGI Mouse Phenotype Associations 2023 gene mutations causing the abnormal cellular replicative senescence phenotype in transgenic mice from the MGI Mouse Phenotype Associations 2023 dataset. |
delayed reproductive senescence Gene SetFrom MGI Mouse Phenotype Associations 2023 gene mutations causing the delayed reproductive senescence phenotype in transgenic mice from the MGI Mouse Phenotype Associations 2023 dataset. |
Kynurenine pathway and links to cell senescence Gene SetFrom WikiPathways Pathways 2024 proteins participating in the Kynurenine pathway and links to cell senescence pathway from the WikiPathways Pathways 2024 dataset. |
Glycolysis in senescence Gene SetFrom WikiPathways Pathways 2024 proteins participating in the Glycolysis in senescence pathway from the WikiPathways Pathways 2024 dataset. |
TCA cycle in senescence Gene SetFrom WikiPathways Pathways 2024 proteins participating in the TCA cycle in senescence pathway from the WikiPathways Pathways 2024 dataset. |
Sphingolipid metabolism in senescence Gene SetFrom WikiPathways Pathways 2024 proteins participating in the Sphingolipid metabolism in senescence pathway from the WikiPathways Pathways 2024 dataset. |
Prostaglandin and leukotriene metabolism in senescence Gene SetFrom WikiPathways Pathways 2024 proteins participating in the Prostaglandin and leukotriene metabolism in senescence pathway from the WikiPathways Pathways 2024 dataset. |
COVID 19 and endothelial cell senescence Gene SetFrom WikiPathways Pathways 2024 proteins participating in the COVID 19 and endothelial cell senescence pathway from the WikiPathways Pathways 2024 dataset. |
Omega 6 fatty acids in senescence Gene SetFrom WikiPathways Pathways 2024 proteins participating in the Omega 6 fatty acids in senescence pathway from the WikiPathways Pathways 2024 dataset. |
Cellular Senescence Gene Setproteins participating in the Cellular Senescence pathway from the Reactome Pathways 2024 dataset. |
DNA Damage/Telomere Stress Induced Senescence Gene Setproteins participating in the DNA Damage/Telomere Stress Induced Senescence pathway from the Reactome Pathways 2024 dataset. |
Diseases of Cellular Senescence Gene Setproteins participating in the Diseases of Cellular Senescence pathway from the Reactome Pathways 2024 dataset. |
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 Gene Setproteins participating in the Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 pathway from the Reactome Pathways 2024 dataset. |
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Gene Setproteins participating in the Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 pathway from the Reactome Pathways 2024 dataset. |
Evasion of Oncogene Induced Senescence Due to p14ARF Defects Gene Setproteins participating in the Evasion of Oncogene Induced Senescence Due to p14ARF Defects pathway from the Reactome Pathways 2024 dataset. |
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects Gene Setproteins participating in the Evasion of Oncogene Induced Senescence Due to p16INK4A Defects pathway from the Reactome Pathways 2024 dataset. |
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 Gene Setproteins participating in the Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 pathway from the Reactome Pathways 2024 dataset. |
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Gene Setproteins participating in the Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 pathway from the Reactome Pathways 2024 dataset. |
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects Gene Setproteins participating in the Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects pathway from the Reactome Pathways 2024 dataset. |
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects Gene Setproteins participating in the Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects pathway from the Reactome Pathways 2024 dataset. |
Oncogene Induced Senescence Gene Setproteins participating in the Oncogene Induced Senescence pathway from the Reactome Pathways 2024 dataset. |
Oxidative Stress Induced Senescence Gene Setproteins participating in the Oxidative Stress Induced Senescence pathway from the Reactome Pathways 2024 dataset. |
Regulation of MITF-M-dependent genes involved in DNA damage repair and senescence Gene Setproteins participating in the Regulation of MITF-M-dependent genes involved in DNA damage repair and senescence pathway from the Reactome Pathways 2024 dataset. |
oxidative stress-induced premature senescence Gene SetFrom GO Biological Process Annotations 2025 genes participating in the oxidative stress-induced premature senescence biological process from the curated GO Biological Process Annotations 2025 dataset. |
regulation of cellular senescence Gene SetFrom GO Biological Process Annotations 2025 genes participating in the regulation of cellular senescence biological process from the curated GO Biological Process Annotations 2025 dataset. |
negative regulation of cellular senescence Gene SetFrom GO Biological Process Annotations 2025 genes participating in the negative regulation of cellular senescence biological process from the curated GO Biological Process Annotations 2025 dataset. |
positive regulation of cellular senescence Gene SetFrom GO Biological Process Annotations 2025 genes participating in the positive regulation of cellular senescence biological process from the curated GO Biological Process Annotations 2025 dataset. |
Cellular senescence Gene SetFrom KEGG Pathways 2026 proteins participating in the Cellular senescence pathway from the KEGG Pathways 2026 dataset. |