Harmonizome 3.0

ATR serine/threonine kinase

The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1. [provided by RefSeq, Aug 2017]

ATR interacting protein

This gene encodes an essential component of the DNA damage checkpoint. The encoded protein binds to single-stranded DNA coated with replication protein A. The protein also interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2012]

From NURSA Protein Complexes

proteins in the a-ATR (YW) (ATR) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From Biocarta Pathways

proteins participating in the role of brca1 brca2 and atr in cancer susceptibility pathway from the Biocarta Pathways dataset.

From ClinVar Gene-Phenotype Associations

genes associated with the ATR-X syndrome phenotype from the curated ClinVar Gene-Phenotype Associations dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the atr-atrip complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

From CORUM Protein Complexes

proteins in the ATR-ATRIP complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the ATR-HDAC2-CHD4 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the ATR-HDAC2 complex protein complex from the CORUM Protein Complexes dataset.

From CTD Gene-Disease Associations

genes/proteins associated with the disease ATR-X syndrome from the curated CTD Gene-Disease Associations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term atr in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From KEA Substrates of Kinases

substrates of the kinase ATR from the curated KEA Substrates of Kinases dataset.

From NURSA Protein Complexes

proteins in the BL117 (ATR) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From NURSA Protein Complexes

proteins in the BL119 (ATR) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From NURSA Protein-Protein Interactions

interacting proteins for ATR from the NURSA Protein-Protein Interactions dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for ATR from the Pathway Commons Protein-Protein Interactions dataset.

From Phosphosite Textmining Biological Term Annotations

proteins co-occuring with the biological term atr in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase ATR from the curated PhosphoSitePlus Substrates of Kinases dataset.

From PID Pathways

proteins participating in the ATR signaling pathway pathway from the PID Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Activation of ATR in response to replication stress pathway from the Reactome Pathways dataset.

From Kinase Library Serine Threonine Kinome Atlas

substrates of the kinase ATR from the Kinase Library Serine Threonine Kinome Atlas dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the ATR gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From WikiPathways Pathways 2024

proteins participating in the ATR signaling pathway from the WikiPathways Pathways 2024 dataset.

From WikiPathways Pathways 2024

proteins participating in the DNA IR damage and cellular response via ATR pathway from the WikiPathways Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Activation of ATR in response to replication stress pathway from the Reactome Pathways 2024 dataset.

From COMPARTMENTS Curated Protein Localization Evidence Scores 2025

proteins localized to the ATR-ATRIP complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025

proteins co-occuring with the ATR-ATRIP complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.

From ClinVar Gene-Phenotype Associations 2025

genes associated with the ATR-X-related syndrome phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the ATR gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.