Harmonizome 3.0

inactivation escape 2 (non-protein coding)

inactivation escape 1 (non-protein coding)

X chromosome inactivation provides dosage compensation for the expression level of X-linked genes from the single X in males and the two in females. This X chromosome gene is intronless and was identified because its transcription escapes X inactivation in females. This gene does not make a protein.[provided by RefSeq, May 2010]

X inactivation, familial skewed, 2

X chromosome inactivation center

AKT interacting protein pseudogene

AKT interacting protein pseudogene

AKT interacting protein

The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

AKT-interacting protein-like

AKT interacting protein pseudogene

v-akt murine thymoma viral oncogene homolog 1

This gene encodes one of the three members of the human AKT serine-threonine protein kinase family which are often referred to as protein kinase B alpha, beta, and gamma. These highly similar AKT proteins all have an N-terminal pleckstrin homology domain, a serine/threonine-specific kinase domain and a C-terminal regulatory domain. These proteins are phosphorylated by phosphoinositide 3-kinase (PI3K). AKT/PI3K forms a key component of many signalling pathways that involve the binding of membrane-bound ligands such as receptor tyrosine kinases, G-protein coupled receptors, and integrin-linked kinase. These AKT proteins therefore regulate a wide variety of cellular functions including cell proliferation, survival, metabolism, and angiogenesis in both normal and malignant cells. AKT proteins are recruited to the cell membrane by phosphatidylinositol 3,4,5-trisphosphate (PIP3) after phosphorylation of phosphatidylinositol 4,5-bisphosphate (PIP2) by PI3K. Subsequent phosphorylation of both threonine residue 308 and serine residue 473 is required for full activation of the AKT1 protein encoded by this gene. Phosphorylation of additional residues also occurs, for example, in response to insulin growth factor-1 and epidermal growth factor. Protein phosphatases act as negative regulators of AKT proteins by dephosphorylating AKT or PIP3. The PI3K/AKT signalling pathway is crucial for tumor cell survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating AKT1 which then phosphorylates and inactivates components of the apoptotic machinery. AKT proteins also participate in the mammalian target of rapamycin (mTOR) signalling pathway which controls the assembly of the eukaryotic translation initiation factor 4F (eIF4E) complex and this pathway, in addition to responding to extracellular signals from growth factors and cytokines, is disregulated in many cancers. Mutations in this gene are associated with multiple types of cancer and excessive tissue growth including Proteus syndrome and Cowden syndrome 6, and breast, colorectal, and ovarian cancers. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2020]

v-akt murine thymoma viral oncogene homolog 2

This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains, which is involved in signaling pathways. The gene serves as an oncogene in the tumorigenesis of cancer cells For example, its overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins, and has also been implicated in insulin signaling. [provided by RefSeq, Nov 2019]

v-akt murine thymoma viral oncogene homolog 3

The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

AKT interacting protein pseudogene

From Reactome Pathways 2014

proteins participating in the AKT-mediated inactivation of FOXO1A pathway from the Reactome Pathways dataset.

From Reactome Pathways 2024

proteins participating in the AKT-mediated inactivation of FOXO1A pathway from the Reactome Pathways 2024 dataset.

From Biocarta Pathways

proteins participating in the inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages pathway from the Biocarta Pathways dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term foxo1a in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Biocarta Pathways

proteins participating in the akt signaling pathway pathway from the Biocarta Pathways dataset.

From Biocarta Pathways

proteins participating in the skeletal muscle hypertrophy is regulated via akt-mtor pathway pathway from the Biocarta Pathways dataset.

From CORUM Protein Complexes

proteins in the eNOS-HSP90-AKT complex, VEGF induced protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the AR-AKT-APPL complex protein complex from the CORUM Protein Complexes dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Akt-I-1 compound from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Akt-I-1,2 compound from the curated CTD Gene-Chemical Interactions dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term akt in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From NURSA Protein Complexes

proteins in the a-AKT (BS) (AKT1) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From Phosphosite Textmining Biological Term Annotations

proteins co-occuring with the biological term akt in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

From Phosphosite Textmining Biological Term Annotations

proteins co-occuring with the biological term akt/pkb in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

From Reactome Pathways 2014

proteins participating in the PIP3 activates AKT signaling pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the PI3K/AKT Signaling in Cancer pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the AKT phosphorylates targets in the cytosol pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Constitutive PI3K/AKT Signaling in Cancer pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Negative regulation of the PI3K/AKT network pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the CD28 dependent PI3K/Akt signaling pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the AKT phosphorylates targets in the nucleus pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the PI3K/AKT activation pathway from the Reactome Pathways dataset.

From WikiPathways Pathways 2024

proteins participating in the PI3K AKT mTOR signaling and therapeutic opportunities in prostate cancer pathway from the WikiPathways Pathways 2024 dataset.

From WikiPathways Pathways 2024

proteins participating in the Factors and pathways affecting insulin like growth factor IGF1 Akt signaling pathway from the WikiPathways Pathways 2024 dataset.

From WikiPathways Pathways 2024

proteins participating in the Focal adhesion PI3K Akt mTOR signaling pathway from the WikiPathways Pathways 2024 dataset.

From WikiPathways Pathways 2024

proteins participating in the PI3K AKT mTOR vitamin D3 signaling pathway from the WikiPathways Pathways 2024 dataset.

From WikiPathways Pathways 2024

proteins participating in the PI3K Akt signaling pathway from the WikiPathways Pathways 2024 dataset.

From WikiPathways Pathways 2024

proteins participating in the Modulation of PI3K Akt mTOR signaling by bioactive sphingolipids pathway from the WikiPathways Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the AKT phosphorylates targets in the cytosol pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the AKT phosphorylates targets in the nucleus pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the CD28 dependent PI3K/Akt signaling pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the MET activates PI3K/AKT signaling pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Negative regulation of the PI3K/AKT network pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the PI3K/AKT Signaling in Cancer pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the PI3K/AKT activation pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the PIP3 activates AKT signaling pathway from the Reactome Pathways 2024 dataset.

From KEGG Pathways 2026

proteins participating in the PI3K-Akt signaling pathway pathway from the KEGG Pathways 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the AKT INHIBITOR VIII drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the AKT INHIBITOR MK2206 drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the AKT INHIBITOR LY2780301 drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the PAN-AKT KINASE INHIBITOR GSK690693 drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the AKT INHIBITOR X drug from theDGIdb Drug Targets 2026 dataset.

From Biocarta Pathways

proteins participating in the map kinase inactivation of smrt corepressor pathway from the Biocarta Pathways dataset.

From ClinVar Gene-Phenotype Associations

genes associated with the Immune dysfunction with T-cell inactivation due to calcium entry defect 1 phenotype from the curated ClinVar Gene-Phenotype Associations dataset.

From ClinVar Gene-Phenotype Associations

genes associated with the Immune dysfunction with T-cell inactivation due to calcium entry defect 2 phenotype from the curated ClinVar Gene-Phenotype Associations dataset.

From CTD Gene-Disease Associations

genes/proteins associated with the disease Immune dysfunction with T-cell inactivation due to calcium entry defect 1 from the curated CTD Gene-Disease Associations dataset.

From CTD Gene-Disease Associations

genes/proteins associated with the disease Immune dysfunction with T-cell inactivation due to calcium entry defect 2 from the curated CTD Gene-Disease Associations dataset.

From GAD Gene-Disease Associations

genes associated with the disease transcriptional inactivation of the fhit gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term inactivation in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GO Biological Process Annotations 2015

genes participating in the peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Biological Process Annotations 2015

genes participating in the random inactivation of x chromosome biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Biological Process Annotations 2015

genes participating in the inactivation of mapk activity involved in osmosensory signaling pathway biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Biological Process Annotations 2015

genes participating in the inactivation of x chromosome by dna methylation biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Biological Process Annotations 2015

genes participating in the dosage compensation by inactivation of x chromosome biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Biological Process Annotations 2015

genes participating in the inactivation of mapkk activity biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Biological Process Annotations 2015

genes participating in the inactivation of mapk activity biological process from the curated GO Biological Process Annotations 2015 dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Potassium channel, voltage dependent, Kv3, inactivation domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Potassium channel, voltage dependent, Kv1.4, tandem inactivation domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From MPO Gene-Phenotype Associations

gene mutations causing the abnormal dosage compensation, by inactivation of x chromosome phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

From OMIM Gene-Disease Associations

genes associated with the x inactivation, familial skewed, 2 phenotype from the curated OMIM Gene-Disease Associations dataset.

From OMIM Gene-Disease Associations

genes associated with the x-inactivation, familial skewed phenotype from the curated OMIM Gene-Disease Associations dataset.

From Phosphosite Textmining Biological Term Annotations

proteins co-occuring with the biological term inactivation in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

From Reactome Pathways 2014

proteins participating in the Inactivation, recovery and regulation of the phototransduction cascade pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Inactivation of APC/C via direct inhibition of the APC/C complex pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Incretin synthesis, secretion, and inactivation pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Inactivation of Cdc42 and Rac pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) pathway from the Reactome Pathways dataset.

From DisGeNET Gene-Disease Associations

genes associated with the disease Immune Dysfunction With T-Cell Inactivation in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

From DisGeNET Gene-Disease Associations

genes associated with the disease Factor Viii Inactivation in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

From DisGeNET Gene-Phenotype Associations

genes associated with the phenotype Skewed Maternal X Inactivation in GWAS and other genetic association datasets from the DisGeNET Gene-Phenotype Associations dataset.

From GO Biological Process Annotations 2023

genes participating in the dosage compensation by inactivation of X chromosome biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the inactivation of X chromosome by heterochromatin formation biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the regulation of dosage compensation by inactivation of X chromosome biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the inactivation of X chromosome by genomic imprinting biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the random inactivation of X chromosome biological process from the curated GO Biological Process Annotations 2023 dataset.

From MGI Mouse Phenotype Associations 2023

gene mutations causing the abnormal dosage compensation, by inactivation of X chromosome phenotype in transgenic mice from the MGI Mouse Phenotype Associations 2023 dataset.

From Reactome Pathways 2024

proteins participating in the Inactivation of APC/C via direct inhibition of the APC/C complex pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Inactivation of CDC42 and RAC1 pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Inactivation of CSF3 (G-CSF) signaling pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Inactivation, recovery and regulation of the phototransduction cascade pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Incretin synthesis, secretion, and inactivation pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Phase 1 - inactivation of fast Na+ channels pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) pathway from the Reactome Pathways 2024 dataset.

From GO Biological Process Annotations 2025

genes participating in the dosage compensation by inactivation of X chromosome biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Biological Process Annotations 2025

genes participating in the peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Biological Process Annotations 2025

genes participating in the random inactivation of X chromosome biological process from the curated GO Biological Process Annotations 2025 dataset.

From ClinVar Gene-Phenotype Associations 2025

genes associated with the Disorders of GNAS Inactivation phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset.