Harmonizome 3.0

coagulation factor XI

This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq, Jul 2008]

F11 antisense RNA 1

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term f11 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for F11 from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the F11 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025

proteins co-occuring with the tissue f11 in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.

From Carcinogenome Chemical Perturbation Carcinogenicity Signatures

genes differentially expressed following the CRCGN015_HEPG2_48H:F11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

From Carcinogenome Chemical Perturbation Carcinogenicity Signatures

genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:F11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

From Carcinogenome Chemical Perturbation Carcinogenicity Signatures

genes differentially expressed following the CRCGN008_HEPG2_24H:F11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

From Carcinogenome Chemical Perturbation Carcinogenicity Signatures

genes differentially expressed following the CRCGN009_HEPG2_24H:F11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

From Carcinogenome Chemical Perturbation Carcinogenicity Signatures

genes differentially expressed following the CRCGN011_HEPG2_24H:F11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

From Carcinogenome Chemical Perturbation Carcinogenicity Signatures

genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:F11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

From Carcinogenome Chemical Perturbation Carcinogenicity Signatures

genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:F11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

From Carcinogenome Chemical Perturbation Carcinogenicity Signatures

genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:F11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

From Carcinogenome Chemical Perturbation Carcinogenicity Signatures

genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:F11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

From Carcinogenome Chemical Perturbation Carcinogenicity Signatures

genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:F11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

From Carcinogenome Chemical Perturbation Carcinogenicity Signatures

genes differentially expressed following the CRCGN013_HEPG2_24H:F11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

From Carcinogenome Chemical Perturbation Carcinogenicity Signatures

genes differentially expressed following the CRCGN014_HEPG2_3H:F11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

From Carcinogenome Chemical Perturbation Carcinogenicity Signatures

genes differentially expressed following the CRCGN010_HEPG2_24H:F11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

From Carcinogenome Chemical Perturbation Carcinogenicity Signatures

genes differentially expressed following the CRCGN015_MCF10A_48H:F11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

From Carcinogenome Chemical Perturbation Carcinogenicity Signatures

genes differentially expressed following the CRCGN014_HEPG2_24H:F11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

From Carcinogenome Chemical Perturbation Carcinogenicity Signatures

genes differentially expressed following the CRCGN012_HEPG2_24H:F11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.