Harmonizome 3.0

NKX2-2 antisense RNA 1

NKX2-1 antisense RNA 1

NK2 homeobox 8

The protein encoded by this gene is a homeobox-containing developmental regulator associated with liver development. The encoded protein binds to the alpha-fetoprotein (AFP) gene promoter and increases the expression of AFP. This gene is overexpressed in some lung cancers and is linked to poor patient survival, possibly due to its resistance to cisplatin. This gene is aberrantly methylated in pancreatic cancer, deleted in squamous cell lung carcinomas, and acts as a tumor suppressor in esophageal cancer. Mutations in this gene may also be a cause of neural tube defects. [provided by RefSeq, Dec 2015]

NK2 homeobox 2

The protein encoded by this gene contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor. [provided by RefSeq, Jul 2008]

NK2 homeobox 3

This gene encodes a homeodomain-containing transcription factor. The encoded protein is a member of the NKX family of homeodomain transcription factors. Studies of similar proteins in mouse and rat have indicated a potential role in cellular differentiation.[provided by RefSeq, Mar 2010]

NK2 homeobox 1

This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TTF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription. [provided by RefSeq, Feb 2014]

NK2 homeobox 6

This gene encodes a homeobox-containing protein that belongs to the NK-2 homeobox family. This protein is a vertebrate homolog of Drosophila homeobox-containing protein called 'tinman', which has been shown to be essential for development of the heart-like dorsal vessel. In conjunction with related gene, NKX2-5, this gene may play a role in both pharyngeal and cardiac embryonic development. Mutations in this gene are associated with persistent truncus arteriosus.[provided by RefSeq, Aug 2011]

NK2 homeobox 4

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Mar 2025]

NK2 homeobox 5

This gene encodes a homeobox-containing transcription factor. This transcription factor functions in heart formation and development. Mutations in this gene cause atrial septal defect with atrioventricular conduction defect, and also tetralogy of Fallot, which are both heart malformation diseases. Mutations in this gene can also cause congenital hypothyroidism non-goitrous type 5, a non-autoimmune condition. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

From MotifMap Predicted Transcription Factor Targets

target genes of the TTF-1 (Nkx2-1) transcription factor predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ttf in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Zinc finger, TTF-type protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From OMIM Gene-Disease Associations

genes associated with the goiter, familial, due to ttf-1 defect phenotype from the curated OMIM Gene-Disease Associations dataset.

From ChEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the NKX2-5-21415370-HL-1-MOUSE transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

From CORUM Protein Complexes

proteins in the Foxh1-Nkx2-5 complex protein complex from the CORUM Protein Complexes dataset.

From JASPAR Predicted Transcription Factor Targets

target genes of the NKX2-5 transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.

From MotifMap Predicted Transcription Factor Targets

target genes of the TTF1 (Nkx2-1) transcription factor predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.

From MotifMap Predicted Transcription Factor Targets

target genes of the Nkx2-5 transcription factor predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.

From MotifMap Predicted Transcription Factor Targets

target genes of the Nkx2-1 transcription factor predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for NKX2-5 from the Pathway Commons Protein-Protein Interactions dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for NKX2-2 from the Pathway Commons Protein-Protein Interactions dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for NKX2-1 from the Pathway Commons Protein-Protein Interactions dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for NKX2-3 from the Pathway Commons Protein-Protein Interactions dataset.

From KnockTF Gene Expression Profiles with Transcription Factor Perturbations

genesdifferentially expressed following the NKX2-1_01_66 trascription factor perturbation from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.

From KnockTF Gene Expression Profiles with Transcription Factor Perturbations

genesdifferentially expressed following the NKX2-1_01_67 trascription factor perturbation from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.

From ChEA Transcription Factor Targets 2022

target genes of the NKX2-5-21415370-HL-1-MOUSE transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the NKX2-3 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the NKX2-5 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the NKX2-6 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From ClinVar Gene-Phenotype Associations 2025

genes associated with the NKX2-5-related disorder phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset.

From ClinVar Gene-Phenotype Associations 2025

genes associated with the NKX2-1-related disorder phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset.

From ClinVar Gene-Phenotype Associations 2025

genes associated with the NKX2-6-related disorder phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset.

From JASPAR Predicted Human Transcription Factor Targets 2025

target genes of the NKX2-2 transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.

From JASPAR Predicted Human Transcription Factor Targets 2025

target genes of the NKX2-3 transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.

From JASPAR Predicted Human Transcription Factor Targets 2025

target genes of the NKX2-4 transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.

From JASPAR Predicted Human Transcription Factor Targets 2025

target genes of the NKX2-5 transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.

From JASPAR Predicted Human Transcription Factor Targets 2025

target genes of the NKX2-8 transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.

From JASPAR Predicted Mouse Transcription Factor Targets 2025

target genes of the Nkx2-1 transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2925 dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the NKX2-8 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the NKX2-1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the NKX2-2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the NKX2-4 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the NKX2-5 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the NKX2-3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the NKX2-6 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.