Harmonizome 3.0

insulin-like 3 (Leydig cell)

This gene encodes a member of the insulin-like hormone superfamily. The encoded protein is mainly produced in gonadal tissues. Studies of the mouse counterpart suggest that this gene may be involved in the development of urogenital tract and female fertility. This protein may also act as a hormone to regulate growth and differentiation of gubernaculum, and thus mediating intra-abdominal testicular descent. Mutations in this gene may lead to cryptorchidism. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2012]

homeobox C10

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The protein level is controlled during cell differentiation and proliferation, which may indicate this protein has a role in origin activation. [provided by RefSeq, Jul 2008]

From DGIdb Drug Targets 2026

interacting proteins for the A(C10/15S)INSL3 drug from theDGIdb Drug Targets 2026 dataset.

From DrugBank Drug Targets

interacting proteins for the (2S,5R,8S,11R,12S,15S,18S,19S,E)-8-ISOBUTYL-18-((5S,6S)-6-METHOXY-3,5-DIMETHYL-7-PHENYLHEPTYL)-1,2,5,12,15,19-HEXAMETHYL-3,6,9,13,16,20,25-HEPTAOXO-1,4,7,10,14,17,21-HEPTAAZACYCLOPENTACOS-21-ENE-11,22-DICARBOXYLIC ACID drug from the curated DrugBank Drug Targets dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the 15S-HPETE ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the 15S-HETE ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From MW Enzyme Metabolite Associations

interacting proteins for 15S-HpETE metabolite from the MW Gene Metabolite Associations dataset.

From MW Enzyme Metabolite Associations

interacting proteins for 15S-HETE metabolite from the MW Gene Metabolite Associations dataset.

From DGIdb Drug Targets 2026

interacting proteins for the 15S-HETE drug from theDGIdb Drug Targets 2026 dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term insl3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the [¹²⁵I]INSL3 (human) ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the (des 1-8) A-chain INSL3 analogue ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the europium-labelled INSL3 ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the INSL3 B-chain analogue ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Protein Ligands of Receptors

receptors of the INSL3 ligand (protein) from the curated Guide to Pharmacology Protein Ligands of Receptors dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for INSL3 from the Pathway Commons Protein-Protein Interactions dataset.

From DGIdb Drug Targets 2026

interacting proteins for the INSL3 drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the (DES 1-8) A-CHAIN INSL3 ANALOGUE drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the A(Δ10/15C)INSL3 drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the A(10-24)INSL3 drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the A(9-26)INSL3 drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the CYCLIC INSL3 B-CHAIN ANALOGUE 6 drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the EUROPIUM-LABELLED INSL3 drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the INSL3 B CHAIN DIMER ANALOGUE 8 drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the INSL3 B-CHAIN ANALOGUE drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the INSL3 [A(5-26):B(7-27)] drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the NANOLUC-INSL3 drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the [125I]INSL3 (HUMAN) drug from theDGIdb Drug Targets 2026 dataset.

From GAD Gene-Disease Associations

genes associated with the disease parkinson disease(c10.228.140.079.862.500)/genetics in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

From GAD Gene-Disease Associations

genes associated with the disease migraine disorders(c10.228.140.546.399.750)/genetics in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term c10 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From HMDB Metabolites of Enzymes

interacting proteins for the Decanoyl-CoA (n-C10:0CoA) metabolite from the curated HMDB Metabolites of Enzymes dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein C10 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From DepMap CRISPR Gene Dependency

gene knockdowns changing fitness of C10 relative to other cell lines from the DepMap CRISPR Gene Dependency Dataset.

From TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025

proteins co-occuring with the tissue l6.c10 in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.

From Carcinogenome Chemical Perturbation Carcinogenicity Signatures

genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:C10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

From Carcinogenome Chemical Perturbation Carcinogenicity Signatures

genes differentially expressed following the CRCGN014_HEPG2_3H:C10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

From Carcinogenome Chemical Perturbation Carcinogenicity Signatures

genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:C10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

From Carcinogenome Chemical Perturbation Carcinogenicity Signatures

genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:C10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

From Carcinogenome Chemical Perturbation Carcinogenicity Signatures

genes differentially expressed following the CRCGN011_HEPG2_24H:C10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

From Carcinogenome Chemical Perturbation Carcinogenicity Signatures

genes differentially expressed following the CRCGN014_HEPG2_24H:C10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

From Carcinogenome Chemical Perturbation Carcinogenicity Signatures

genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:C10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

From Carcinogenome Chemical Perturbation Carcinogenicity Signatures

genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:C10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

From Carcinogenome Chemical Perturbation Carcinogenicity Signatures

genes differentially expressed following the CRCGN008_HEPG2_24H:C10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

From Carcinogenome Chemical Perturbation Carcinogenicity Signatures

genes differentially expressed following the CRCGN015_MCF10A_48H:C10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

From Carcinogenome Chemical Perturbation Carcinogenicity Signatures

genes differentially expressed following the CRCGN012_HEPG2_24H:C10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

From Carcinogenome Chemical Perturbation Carcinogenicity Signatures

genes differentially expressed following the CRCGN009_HEPG2_24H:C10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

From Carcinogenome Chemical Perturbation Carcinogenicity Signatures

genes differentially expressed following the CRCGN010_HEPG2_24H:C10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

From Carcinogenome Chemical Perturbation Carcinogenicity Signatures

genes differentially expressed following the CRCGN013_HEPG2_24H:C10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

From Carcinogenome Chemical Perturbation Carcinogenicity Signatures

genes differentially expressed following the CRCGN015_HEPG2_48H:C10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

From Carcinogenome Chemical Perturbation Carcinogenicity Signatures

genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:C10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

From DGIdb Drug Targets 2026

interacting proteins for the C10 (HOMOBIVALENT 4-AMINOQUINOLINE) drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the GAL-B2-C10 drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the COMPOUND C10 [PMID: 24297249] drug from theDGIdb Drug Targets 2026 dataset.