Harmonizome 3.0

From Guide to Pharmacology

Chemical ligand-receptor interactions curated by experts

From Guide to Pharmacology

Protein ligand-receptor interactions curated by experts

leukotriene A4 hydrolase

The protein encoded by this gene is an enzyme that contains both hydrolase and aminopeptidase activities. The hydrolase activity is used in the final step of the biosynthesis of leukotriene B4, a proinflammatory mediator. The aminopeptidase activity has been shown to degrade proline-glycine-proline (PGP), a neutrophil chemoattractant and biomarker for chronic obstructive pulmonary disease (COPD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

cysteinyl leukotriene receptor 2

The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR1. This encoded receptor is a member of the superfamily of G protein-coupled receptors. It seems to play a major role in endocrine and cardiovascular systems. [provided by RefSeq, Jul 2008]

cysteinyl leukotriene receptor 1

This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for cysteinyl leukotrienes, and is involved in mediating bronchoconstriction via activation of a phosphatidylinositol-calcium second messenger system. Activation of the encoded receptor results in contraction and proliferation of bronchial smooth muscle cells, eosinophil migration, and damage to the mucus layer in the lung. Upregulation of this gene is associated with asthma and dysregulation may also be implicated in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

leukotriene B4 receptor

Predicted to enable G protein-coupled peptide receptor activity and leukotriene B4 receptor activity. Predicted to be involved in neuropeptide signaling pathway. Predicted to act upstream of or within signal transduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

leukotriene C4 synthase

The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family includes a number of human proteins, several of which are involved the production of leukotrienes. This gene encodes an enzyme that catalyzes the first step in the biosynthesis of cysteinyl leukotrienes, potent biological compounds derived from arachidonic acid. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as human bronchial asthma. This protein localizes to the nuclear envelope and adjacent endoplasmic reticulum. [provided by RefSeq, Jul 2008]

leukotriene B4 receptor 2

Predicted to enable G protein-coupled peptide receptor activity and leukotriene B4 receptor activity. Predicted to be involved in neuropeptide signaling pathway. Predicted to act upstream of or within keratinocyte migration and signal transduction. Located in nucleoplasm and plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

From Reactome Pathways 2014

proteins participating in the Leukotriene receptors pathway from the Reactome Pathways dataset.

From Reactome Pathways 2024

proteins participating in the Leukotriene receptors pathway from the Reactome Pathways 2024 dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical cysteinyl-leukotriene from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Leukotriene B4 from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical leukotriene A methyl ester from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Leukotriene D4 from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Leukotriene E4 from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Leukotriene C4 from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical leukotriene B5 from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Leukotriene A4 from the curated CTD Gene-Chemical Interactions dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term leukotriene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GO Biological Process Annotations 2015

genes participating in the leukotriene metabolic process biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Biological Process Annotations 2015

genes participating in the leukotriene b4 catabolic process biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Biological Process Annotations 2015

genes participating in the leukotriene a4 metabolic process biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Biological Process Annotations 2015

genes participating in the leukotriene biosynthetic process biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Biological Process Annotations 2015

genes participating in the positive regulation of leukotriene production involved in inflammatory response biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Biological Process Annotations 2015

genes participating in the leukotriene b4 metabolic process biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Biological Process Annotations 2015

genes participating in the leukotriene catabolic process biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Biological Process Annotations 2015

genes participating in the regulation of leukotriene production involved in inflammatory response biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Biological Process Annotations 2015

genes participating in the leukotriene production involved in inflammatory response biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Molecular Function Annotations 2015

genes performing the leukotriene-b4 20-monooxygenase activity molecular function from the curated GO Molecular Function Annotations 2015 dataset.

From GO Molecular Function Annotations 2015

genes performing the cysteinyl leukotriene receptor activity molecular function from the curated GO Molecular Function Annotations 2015 dataset.

From GO Molecular Function Annotations 2015

genes performing the leukotriene-c4 synthase activity molecular function from the curated GO Molecular Function Annotations 2015 dataset.

From GO Molecular Function Annotations 2015

genes performing the leukotriene receptor activity molecular function from the curated GO Molecular Function Annotations 2015 dataset.

From GO Molecular Function Annotations 2015

genes performing the leukotriene b4 receptor activity molecular function from the curated GO Molecular Function Annotations 2015 dataset.

From GO Molecular Function Annotations 2015

genes performing the leukotriene-a4 hydrolase activity molecular function from the curated GO Molecular Function Annotations 2015 dataset.

From HMDB Metabolites of Enzymes

interacting proteins for the Leukotriene B4 metabolite from the curated HMDB Metabolites of Enzymes dataset.

From HMDB Metabolites of Enzymes

interacting proteins for the Leukotriene E4 metabolite from the curated HMDB Metabolites of Enzymes dataset.

From HMDB Metabolites of Enzymes

interacting proteins for the 12-Keto-tetrahydro-leukotriene B4 metabolite from the curated HMDB Metabolites of Enzymes dataset.

From HMDB Metabolites of Enzymes

interacting proteins for the 20-Hydroxy-leukotriene B4 metabolite from the curated HMDB Metabolites of Enzymes dataset.

From HMDB Metabolites of Enzymes

interacting proteins for the Leukotriene C4 metabolite from the curated HMDB Metabolites of Enzymes dataset.

From HMDB Metabolites of Enzymes

interacting proteins for the Leukotriene F4 metabolite from the curated HMDB Metabolites of Enzymes dataset.

From HMDB Metabolites of Enzymes

interacting proteins for the Leukotriene A4 metabolite from the curated HMDB Metabolites of Enzymes dataset.

From HMDB Metabolites of Enzymes

interacting proteins for the 12(S)-Leukotriene B4 metabolite from the curated HMDB Metabolites of Enzymes dataset.

From HMDB Metabolites of Enzymes

interacting proteins for the Leukotriene D4 metabolite from the curated HMDB Metabolites of Enzymes dataset.

From HumanCyc Pathways

proteins participating in the leukotriene biosynthesis pathway from the HumanCyc Pathways dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Leukotriene B4 type 2 receptor protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Leukotriene B4 type 1 receptor protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Cysteinyl leukotriene receptor protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Leukotriene A4 hydrolase protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Peptidase M1, leukotriene A4 hydrolase, aminopeptidase C-terminal protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Cysteinyl leukotriene receptor 1 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Cysteinyl leukotriene receptor 2 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Leukotriene B4 receptor protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From MPO Gene-Phenotype Associations

gene mutations causing the abnormal leukotriene level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

From MPO Gene-Phenotype Associations

gene mutations causing the decreased leukotriene level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

From MPO Gene-Phenotype Associations

gene mutations causing the increased leukotriene level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

From OMIM Gene-Disease Associations

genes associated with the leukotriene c4 synthase deficiency phenotype from the curated OMIM Gene-Disease Associations dataset.

From DisGeNET Gene-Disease Associations

genes associated with the disease Leukotriene C4 Synthase Deficiency in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

From GO Biological Process Annotations 2023

genes participating in the leukotriene D4 biosynthetic process biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the leukotriene biosynthetic process biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the leukotriene transport biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the positive regulation of leukotriene production involved in inflammatory response biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the leukotriene metabolic process biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the leukotriene A4 biosynthetic process biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the leukotriene D4 catabolic process biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the leukotriene A4 metabolic process biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the leukotriene B4 catabolic process biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the leukotriene signaling pathway biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the leukotriene B4 metabolic process biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the leukotriene D4 metabolic process biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the regulation of leukotriene production involved in inflammatory response biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the leukotriene catabolic process biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Molecular Function Annotations 2023

genes performing the leukotriene-C4 synthase activity molecular function from the curated GO Molecular Function Annotations 2023 dataset.

From GO Molecular Function Annotations 2023

genes performing the leukotriene-A4 hydrolase activity molecular function from the curated GO Molecular Function Annotations 2023 dataset.

From GO Molecular Function Annotations 2023

genes performing the leukotriene-C(4) hydrolase molecular function from the curated GO Molecular Function Annotations 2023 dataset.

From GO Molecular Function Annotations 2023

genes performing the leukotriene-B4 20-monooxygenase activity molecular function from the curated GO Molecular Function Annotations 2023 dataset.

From GO Molecular Function Annotations 2023

genes performing the 20-hydroxy-leukotriene B4 omega oxidase activity molecular function from the curated GO Molecular Function Annotations 2023 dataset.

From GO Molecular Function Annotations 2023

genes performing the 20-aldehyde-leukotriene B4 20-monooxygenase activity molecular function from the curated GO Molecular Function Annotations 2023 dataset.

From GO Molecular Function Annotations 2023

genes performing the leukotriene B4 12-hydroxy dehydrogenase activity molecular function from the curated GO Molecular Function Annotations 2023 dataset.

From GO Molecular Function Annotations 2023

genes performing the leukotriene receptor activity molecular function from the curated GO Molecular Function Annotations 2023 dataset.

From GO Molecular Function Annotations 2023

genes performing the cysteinyl leukotriene receptor activity molecular function from the curated GO Molecular Function Annotations 2023 dataset.

From GO Molecular Function Annotations 2023

genes performing the leukotriene B4 receptor activity molecular function from the curated GO Molecular Function Annotations 2023 dataset.

From MGI Mouse Phenotype Associations 2023

gene mutations causing the increased leukotriene level phenotype in transgenic mice from the MGI Mouse Phenotype Associations 2023 dataset.

From MGI Mouse Phenotype Associations 2023

gene mutations causing the decreased leukotriene level phenotype in transgenic mice from the MGI Mouse Phenotype Associations 2023 dataset.

From MGI Mouse Phenotype Associations 2023

gene mutations causing the abnormal leukotriene level phenotype in transgenic mice from the MGI Mouse Phenotype Associations 2023 dataset.

From WikiPathways Pathways 2024

proteins participating in the Prostaglandin and leukotriene metabolism in senescence pathway from the WikiPathways Pathways 2024 dataset.

From WikiPathways Pathways 2024

proteins participating in the Leukotriene metabolic pathway pathway from the WikiPathways Pathways 2024 dataset.

From GO Biological Process Annotations 2025

genes participating in the leukotriene D4 biosynthetic process biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Biological Process Annotations 2025

genes participating in the leukotriene biosynthetic process biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Biological Process Annotations 2025

genes participating in the leukotriene transport biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Biological Process Annotations 2025

genes participating in the positive regulation of leukotriene production involved in inflammatory response biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Biological Process Annotations 2025

genes participating in the leukotriene metabolic process biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Biological Process Annotations 2025

genes participating in the leukotriene A4 biosynthetic process biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Biological Process Annotations 2025

genes participating in the leukotriene D4 catabolic process biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Biological Process Annotations 2025

genes participating in the leukotriene A4 metabolic process biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Biological Process Annotations 2025

genes participating in the leukotriene B4 catabolic process biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Biological Process Annotations 2025

genes participating in the leukotriene signaling pathway biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Biological Process Annotations 2025

genes participating in the leukotriene B4 metabolic process biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Biological Process Annotations 2025

genes participating in the leukotriene D4 metabolic process biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Biological Process Annotations 2025

genes participating in the regulation of leukotriene production involved in inflammatory response biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Biological Process Annotations 2025

genes participating in the leukotriene catabolic process biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Molecular Function Annotations 2025

genes performing the leukotriene-C4 synthase activity molecular function from the curated GO Molecular Function Annotations 2025 dataset.

From GO Molecular Function Annotations 2025

genes performing the leukotriene-A4 hydrolase activity molecular function from the curated GO Molecular Function Annotations 2025 dataset.

From GO Molecular Function Annotations 2025

genes performing the leukotriene-C(4) hydrolase molecular function from the curated GO Molecular Function Annotations 2025 dataset.

From GO Molecular Function Annotations 2025

genes performing the leukotriene-B4 20-monooxygenase activity molecular function from the curated GO Molecular Function Annotations 2025 dataset.

From GO Molecular Function Annotations 2025

genes performing the 20-hydroxy-leukotriene B4 omega oxidase activity molecular function from the curated GO Molecular Function Annotations 2025 dataset.

From GO Molecular Function Annotations 2025

genes performing the 20-aldehyde-leukotriene B4 20-monooxygenase activity molecular function from the curated GO Molecular Function Annotations 2025 dataset.

From GO Molecular Function Annotations 2025

genes performing the leukotriene B4 12-hydroxy dehydrogenase activity molecular function from the curated GO Molecular Function Annotations 2025 dataset.

From GO Molecular Function Annotations 2025

genes performing the leukotriene receptor activity molecular function from the curated GO Molecular Function Annotations 2025 dataset.

From GO Molecular Function Annotations 2025

genes performing the leukotriene B4 receptor activity molecular function from the curated GO Molecular Function Annotations 2025 dataset.

From GO Molecular Function Annotations 2025

genes performing the cysteinyl leukotriene receptor activity molecular function from the curated GO Molecular Function Annotations 2025 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the LEUKOTRIENE D4 drug from theDGIdb Drug Targets 2026 dataset.

From Biocarta Pathways

proteins participating in the thrombin signaling and protease-activated receptors pathway from the Biocarta Pathways dataset.

From Biocarta Pathways

proteins participating in the cbl mediated ligand-induced downregulation of egf receptors pathway pathway from the Biocarta Pathways dataset.

From Biocarta Pathways

proteins participating in the nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells pathway from the Biocarta Pathways dataset.

From Biocarta Pathways

proteins participating in the activation of pkc through g-protein coupled receptors pathway from the Biocarta Pathways dataset.

From Biocarta Pathways

proteins participating in the regulation of ck1/cdk5 by type 1 glutamate receptors pathway from the Biocarta Pathways dataset.

From Biocarta Pathways

proteins participating in the role of nicotinic acetylcholine receptors in the regulation of apoptosis pathway from the Biocarta Pathways dataset.

From Biocarta Pathways

proteins participating in the induction of apoptosis through dr3 and dr4/5 death receptors pathway from the Biocarta Pathways dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Receptors, IgG from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Receptors, IgE from the curated CTD Gene-Chemical Interactions dataset.

From dbGAP Gene-Trait Associations

genes associated with the trait Receptors, Tumor Necrosis Factor in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.

From dbGAP Gene-Trait Associations

genes associated with the trait Receptors, Interleukin-6 in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.

From dbGAP Gene-Trait Associations

genes associated with the trait Receptors, Leptin in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.

From dbGAP Gene-Trait Associations

genes associated with the trait Receptors, Transferrin in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.

From dbGAP Gene-Trait Associations

genes associated with the trait Receptors, Tumor Necrosis Factor, Type II in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.

From GAD Gene-Disease Associations

genes associated with the disease receptors, tumor necrosis factor, type ii in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

From GAD Gene-Disease Associations

genes associated with the disease receptors, leptin in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

From GAD Gene-Disease Associations

genes associated with the disease receptors, interleukin-6 in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

From GAD Gene-Disease Associations

genes associated with the disease receptors, transferrin in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

From GAD Gene-Disease Associations

genes associated with the disease receptors, tumor necrosis factor in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term receptors in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GO Biological Process Annotations 2015

genes participating in the negative regulation of extrinsic apoptotic signaling pathway via death domain receptors biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Biological Process Annotations 2015

genes participating in the somatic diversification of immune receptors via germline recombination within a single locus biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Biological Process Annotations 2015

genes participating in the adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Biological Process Annotations 2015

genes participating in the extrinsic apoptotic signaling pathway via death domain receptors biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Biological Process Annotations 2015

genes participating in the somatic diversification of immune receptors biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Biological Process Annotations 2015

genes participating in the regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Biological Process Annotations 2015

genes participating in the positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Biological Process Annotations 2015

genes participating in the positive regulation of extrinsic apoptotic signaling pathway via death domain receptors biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Biological Process Annotations 2015

genes participating in the somatic diversification of immune receptors via somatic mutation biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Biological Process Annotations 2015

genes participating in the negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Biological Process Annotations 2015

genes participating in the regulation of extrinsic apoptotic signaling pathway via death domain receptors biological process from the curated GO Biological Process Annotations 2015 dataset.

From HPO Gene-Disease Associations

genes associated with the increased number of cd4-/cd8- t cells expressing alpha/beta t-cell receptors phenotype by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the PDZ-associated domain of NMDA receptors protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Signalling lymphocyte activation molecule family receptors protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From Phosphosite Textmining Biological Term Annotations

proteins co-occuring with the biological term receptors in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

From Phosphosite Textmining Biological Term Annotations

proteins co-occuring with the biological term receptors-n-methyl-d-aspartate in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

From PID Pathways

proteins participating in the Retinoic acid receptors-mediated signaling pathway from the PID Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Class C/3 (Metabotropic glutamate/pheromone receptors) pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Hydroxycarboxylic acid-binding receptors pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Lysosphingolipid and LPA receptors pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Nucleotide-like (purinergic) receptors pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Eicosanoid ligand-binding receptors pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Activation of Na-permeable Kainate Receptors pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Highly sodium permeable acetylcholine nicotinic receptors pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Scavenging by Class A Receptors pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Highly calcium permeable nicotinic acetylcholine receptors pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Calcitonin-like ligand receptors pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Muscarinic acetylcholine receptors pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Formyl peptide receptors bind formyl peptides and many other ligands pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Histamine receptors pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Toll-Like Receptors Cascades pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Thrombin signalling through proteinase activated receptors (PARs) pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Amine ligand-binding receptors pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Peptide ligand-binding receptors pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Vasopressin-like receptors pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Trafficking of GluR2-containing AMPA receptors pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Activation of TRKA receptors pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Class A/1 (Rhodopsin-like receptors) pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Relaxin receptors pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Class B/2 (Secretin family receptors) pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Postsynaptic nicotinic acetylcholine receptors pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Serotonin receptors pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Trafficking of AMPA receptors pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Orexin and neuropeptides FF and QRFP bind to their respective receptors pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Activation of Kainate Receptors upon glutamate binding pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Highly calcium permeable postsynaptic nicotinic acetylcholine receptors pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Binding and Uptake of Ligands by Scavenger Receptors pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Scavenging by Class H Receptors pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Activation of AMPA receptors pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Prostanoid ligand receptors pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Presynaptic function of Kainate receptors pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Tachykinin receptors bind tachykinins pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Ionotropic activity of Kainate Receptors pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Scavenging by Class B Receptors pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Hormone ligand-binding receptors pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Activation of Nicotinic Acetylcholine Receptors pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Presynaptic nicotinic acetylcholine receptors pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Chemokine receptors bind chemokines pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Adenosine P1 receptors pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the P2Y receptors pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Dopamine receptors pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Free fatty acid receptors pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Activation of GABAB receptors pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Glucagon-type ligand receptors pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Scavenging by Class F Receptors pathway from the Reactome Pathways dataset.

From WikiPathways Pathways 2014

proteins participating in the Nuclear Receptors(Mus musculus) pathway from the WikiPathways Pathways 2014 dataset.

From WikiPathways Pathways 2014

proteins participating in the Nuclear Receptors(Homo sapiens) pathway from the WikiPathways Pathways 2014 dataset.

From WikiPathways Pathways 2014

proteins participating in the Nuclear receptors in lipid metabolism and toxicity(Mus musculus) pathway from the WikiPathways Pathways 2014 dataset.

From WikiPathways Pathways 2014

proteins participating in the Nuclear Receptors in Lipid Metabolism and Toxicity(Homo sapiens) pathway from the WikiPathways Pathways 2014 dataset.

From GO Biological Process Annotations 2023

genes participating in the extrinsic apoptotic signaling pathway via death domain receptors biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the negative regulation of extrinsic apoptotic signaling pathway via death domain receptors biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the positive regulation of extrinsic apoptotic signaling pathway via death domain receptors biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the regulation of extrinsic apoptotic signaling pathway via death domain receptors biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains biological process from the curated GO Biological Process Annotations 2023 dataset.

From WikiPathways Pathways 2024

proteins participating in the Nuclear receptors pathway from the WikiPathways Pathways 2024 dataset.

From WikiPathways Pathways 2024

proteins participating in the Nuclear receptors meta pathway pathway from the WikiPathways Pathways 2024 dataset.

From WikiPathways Pathways 2024

proteins participating in the miRNA targets in ECM and membrane receptors pathway from the WikiPathways Pathways 2024 dataset.

From WikiPathways Pathways 2024

proteins participating in the Nuclear receptors in lipid metabolism and toxicity pathway from the WikiPathways Pathways 2024 dataset.

From WikiPathways Pathways 2024

proteins participating in the Selective expression of chemokine receptors during T cell polarization pathway from the WikiPathways Pathways 2024 dataset.

From WikiPathways Pathways 2024

proteins participating in the Major receptors targeted by epinephrine and norepinephrine pathway from the WikiPathways Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Activation of AMPA receptors pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Activation of GABAB receptors pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Activation of NMDA receptors and postsynaptic events pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Activation of Na-permeable kainate receptors pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Activation of TRKA receptors pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Activation of kainate receptors upon glutamate binding pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Adenosine P1 receptors pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Amine ligand-binding receptors pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Assembly and cell surface presentation of NMDA receptors pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Binding and Uptake of Ligands by Scavenger Receptors pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the C-type lectin receptors (CLRs) pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Calcitonin-like ligand receptors pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Caspase activation via Death Receptors in the presence of ligand pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Caspase activation via Dependence Receptors in the absence of ligand pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Chemokine receptors bind chemokines pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Class A/1 (Rhodopsin-like receptors) pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Class B/2 (Secretin family receptors) pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Class C/3 (Metabotropic glutamate/pheromone receptors) pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Diseases of signal transduction by growth factor receptors and second messengers pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Dopamine receptors pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Eicosanoid ligand-binding receptors pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Expression and translocation of olfactory receptors pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Formyl peptide receptors bind formyl peptides and many other ligands pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Free fatty acid receptors pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Glucagon-type ligand receptors pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Glutamate binding, activation of AMPA receptors and synaptic plasticity pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Highly calcium permeable nicotinic acetylcholine receptors pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Highly calcium permeable postsynaptic nicotinic acetylcholine receptors pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Highly sodium permeable postsynaptic acetylcholine nicotinic receptors pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Histamine receptors pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Hormone ligand-binding receptors pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Hydroxycarboxylic acid-binding receptors pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Ionotropic activity of kainate receptors pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Lysosphingolipid and LPA receptors pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the MECP2 regulates neuronal receptors and channels pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Muscarinic acetylcholine receptors pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Neurotransmitter receptors and postsynaptic signal transmission pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Nucleotide-like (purinergic) receptors pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Orexin and neuropeptides FF and QRFP bind to their respective receptors pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the P2Y receptors pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Peptide ligand-binding receptors pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Postsynaptic nicotinic acetylcholine receptors pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Presynaptic function of Kainate receptors pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Presynaptic nicotinic acetylcholine receptors pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Prostanoid ligand receptors pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the ROBO receptors bind AKAP5 pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Relaxin receptors pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the SUMOylation of intracellular receptors pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Scavenging by Class A Receptors pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Scavenging by Class B Receptors pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Scavenging by Class F Receptors pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Scavenging by Class H Receptors pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Serotonin receptors pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Signaling by Nuclear Receptors pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Signaling by ROBO receptors pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the TFAP2 (AP-2) family regulates transcription of growth factors and their receptors pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the TNFs bind their physiological receptors pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the TP53 Regulates Transcription of Death Receptors and Ligands pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Tachykinin receptors bind tachykinins pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Thrombin signalling through proteinase activated receptors (PARs) pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Trafficking of AMPA receptors pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Trafficking of GluR2-containing AMPA receptors pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Unblocking of NMDA receptors, glutamate binding and activation pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Vasopressin-like receptors pathway from the Reactome Pathways 2024 dataset.

From GO Biological Process Annotations 2025

genes participating in the extrinsic apoptotic signaling pathway via death domain receptors biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Biological Process Annotations 2025

genes participating in the negative regulation of extrinsic apoptotic signaling pathway via death domain receptors biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Biological Process Annotations 2025

genes participating in the positive regulation of extrinsic apoptotic signaling pathway via death domain receptors biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Biological Process Annotations 2025

genes participating in the regulation of extrinsic apoptotic signaling pathway via death domain receptors biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Biological Process Annotations 2025

genes participating in the adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Biological Process Annotations 2025

genes participating in the negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Biological Process Annotations 2025

genes participating in the positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Biological Process Annotations 2025

genes participating in the regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains biological process from the curated GO Biological Process Annotations 2025 dataset.