Harmonizome 3.0

cholinergic receptor, nicotinic, alpha 4 (neuronal)

This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]

cholinergic receptor, nicotinic, alpha 5 (neuronal)

The protein encoded by this gene is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. These receptors are thought to be heteropentamers composed of separate but similar subunits. Defects in this gene have been linked to susceptibility to lung cancer type 2 (LNCR2).[provided by RefSeq, Jun 2010]

cholinergic receptor, nicotinic, alpha 6 (neuronal)

This gene encodes an alpha subunit of neuronal nicotinic acetylcholine receptors. These receptors consist of five subunits and function as ion channels involved in neurotransmission. The encoded protein is a subunit of neuronal nicotinic acetylcholine receptors that mediate dopaminergic neurotransmission and are activated by acetylcholine and exogenous nicotine. Alternatively spliced transcript variants have been observed for this gene. Single nucleotide polymorphisms in this gene have been associated with both nicotine and alcohol dependence. [provided by RefSeq, Dec 2010]

cholinergic receptor, nicotinic, alpha 7 (neuronal)

The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]

cholinergic receptor, nicotinic, alpha 1 (muscle)

The muscle acetylcholine receptor consiststs of 5 subunits of 4 different types: 2 alpha subunits and 1 each of the beta, gamma, and delta subunits. This gene encodes an alpha subunit that plays a role in acetlycholine binding/channel gating. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Nov 2012]

cholinergic receptor, nicotinic, alpha 2 (neuronal)

Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels formed by a pentameric arrangement of alpha and beta subunits to create distinct muscle and neuronal receptors. Neuronal receptors are found throughout the peripheral and central nervous system where they are involved in fast synaptic transmission. This gene encodes an alpha subunit that is widely expressed in the brain. The proposed structure for nAChR subunits is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. Mutations in this gene cause autosomal dominant nocturnal frontal lobe epilepsy type 4. Single nucleotide polymorphisms (SNPs) in this gene have been associated with nicotine dependence. [provided by RefSeq, Nov 2009]

cholinergic receptor, nicotinic, alpha 3 (neuronal)

This locus encodes a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. This locus encodes an alpha-type subunit, as it contains characteristic adjacent cysteine residues. The encoded protein is a ligand-gated ion channel that likely plays a role in neurotransmission. Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2009]

cholinergic receptor, nicotinic, alpha 9 (neuronal)

This gene is a member of the ligand-gated ionic channel family and nicotinic acetylcholine receptor gene superfamily. It encodes a plasma membrane protein that forms homo- or hetero-oligomeric divalent cation channels. This protein is involved in cochlea hair cell development and is also expressed in the outer hair cells (OHCs) of the adult cochlea. [provided by RefSeq, Feb 2012]

CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion

The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 (FAM7A). Alternative splicing has been observed, and two variants exist, for this hybrid gene. The N-terminally truncated products predicted by the largest open reading frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription of this hybrid gene, translation of the nicotinic acetylcholine receptor-like protein-encoding open reading frames has not been confirmed. [provided by RefSeq, Jul 2008]

cholinergic receptor, nicotinic, alpha 10 (neuronal)

Predicted to enable acetylcholine-gated monoatomic cation-selective channel activity. Acts upstream of or within positive regulation of cytosolic calcium ion concentration. Predicted to be located in membrane. Predicted to be part of transmembrane transporter complex. Predicted to be active in cholinergic synapse; neuron projection; and postsynaptic specialization membrane. [provided by Alliance of Genome Resources, Mar 2025]

cholinergic receptor, nicotinic, beta 1 (muscle)

The muscle acetylcholine receptor is composed of five subunits: two alpha subunits and one beta, one gamma, and one delta subunit. This gene encodes the beta subunit of the acetylcholine receptor. The acetylcholine receptor changes conformation upon acetylcholine binding leading to the opening of an ion-conducting channel across the plasma membrane. Mutations in this gene are associated with slow-channel congenital myasthenic syndrome. [provided by RefSeq, Jul 2008]

cholinergic receptor, nicotinic, beta 3 (neuronal)

The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are (hetero)pentamers composed of homologous subunits. The subunits that make up the muscle and neuronal forms of nAChRs are encoded by separate genes and have different primary structure. There are several subtypes of neuronal nAChRs that vary based on which homologous subunits are arranged around the central channel. They are classified as alpha-subunits if, like muscle alpha-1 (MIM 100690), they have a pair of adjacent cysteines as part of the presumed acetylcholine binding site. Subunits lacking these cysteine residues are classified as beta-subunits (Groot Kormelink and Luyten, 1997 [PubMed 9009220]). Elliott et al. (1996) [PubMed 8906617] stated that the proposed structure for each subunit is a conserved N-terminal extracellular domain followed by 3 conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region.[supplied by OMIM, Apr 2010]

cholinergic receptor, nicotinic, beta 2 (neuronal)

Neuronal acetylcholine receptors are homo- or heteropentameric complexes composed of homologous alpha and beta subunits. They belong to a superfamily of ligand-gated ion channels which allow the flow of sodium and potassium across the plasma membrane in response to ligands such as acetylcholine and nicotine. This gene encodes one of several beta subunits. Mutations in this gene are associated with autosomal dominant nocturnal frontal lobe epilepsy. [provided by RefSeq, Jul 2008]

cholinergic receptor, nicotinic, beta 4 (neuronal)

This gene is found within a conserved gene cluster and encodes one of the beta subunits of the nicotinic acetylcholine receptor (nAChRs) superfamily which form ligand-gated ion channels with a central pore that forms a cation channel. Neuronal nAChRs are pentameric structures that can be either homomeric or heteromeric, with heteromeric structures containing both alpha and beta subunits. Each subunit contains an extracellular amino terminus and four transmembrane domains. Nicotine is one of the agonists that binds to the receptor. Variants in this gene have been associated with nicotine dependence and lung cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2017]

cholinergic receptor, nicotinic, gamma (muscle)

The mammalian muscle-type acetylcholine receptor is a transmembrane pentameric glycoprotein with two alpha subunits, one beta, one delta, and one epsilon (in adult skeletal muscle) or gamma (in fetal and denervated muscle) subunit. This gene, which encodes the gamma subunit, is expressed prior to the thirty-third week of gestation in humans. The gamma subunit of the acetylcholine receptor plays a role in neuromuscular organogenesis and ligand binding and disruption of gamma subunit expression prevents the correct localization of the receptor in cell membranes. Mutations in this gene cause Escobar syndrome and a lethal form of multiple pterygium syndrome. Muscle-type acetylcholine receptor is the major antigen in the autoimmune disease myasthenia gravis.[provided by RefSeq, Sep 2009]

cholinergic receptor, nicotinic, delta (muscle)

The acetylcholine receptor of muscle has 5 subunits of 4 different types: 2 alpha and 1 each of beta, gamma and delta subunits. After acetylcholine binding, the receptor undergoes an extensive conformation change that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Defects in this gene are a cause of multiple pterygium syndrome lethal type (MUPSL), congenital myasthenic syndrome slow-channel type (SCCMS), and congenital myasthenic syndrome fast-channel type (FCCMS). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2015]

cholinergic receptor, nicotinic, epsilon (muscle)

Acetylcholine receptors at mature mammalian neuromuscular junctions are pentameric protein complexes composed of four subunits in the ratio of two alpha subunits to one beta, one epsilon, and one delta subunit. The acetylcholine receptor changes subunit composition shortly after birth when the epsilon subunit replaces the gamma subunit seen in embryonic receptors. Mutations in the epsilon subunit are associated with congenital myasthenic syndrome. [provided by RefSeq, Sep 2009]

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Nicotinic Acids from the curated CTD Gene-Chemical Interactions dataset.

From Biocarta Pathways

proteins participating in the role of nicotinic acetylcholine receptors in the regulation of apoptosis pathway from the Biocarta Pathways dataset.

From CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the nicotinic acid-5301 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

From CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the nicotinic acid-6702 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

From CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the nicotinic acid-3381 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

From CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the nicotinic acid-3043 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical chromium nicotinic acid complex from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical nicotinic acid adenine dinucleotide from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical 2-(2-(3,4-dichlorophenyl)-2,3-dihydro-1H-isoindol-5-ylamino)nicotinic acid from the curated CTD Gene-Chemical Interactions dataset.

From DrugBank Drug Targets

interacting proteins for the 2-(4-CHLORO-PHENYLAMINO)-NICOTINIC ACID drug from the curated DrugBank Drug Targets dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nicotinic in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GO Molecular Function Annotations 2015

genes performing the nicotinic acid receptor activity molecular function from the curated GO Molecular Function Annotations 2015 dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the 5-methyl nicotinic acid ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the [³H]nicotinic acid ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the nicotinic acid ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From HMDB Metabolites of Enzymes

interacting proteins for the Nicotinic acid mononucleotide metabolite from the curated HMDB Metabolites of Enzymes dataset.

From HMDB Metabolites of Enzymes

interacting proteins for the Nicotinic acid metabolite from the curated HMDB Metabolites of Enzymes dataset.

From HMDB Metabolites of Enzymes

interacting proteins for the Nicotinic acid adenine dinucleotide metabolite from the curated HMDB Metabolites of Enzymes dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Nicotinic acetylcholine receptor protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Nicotinic acetylcholine-gated receptor, transmembrane domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From PANTHER Pathways

proteins participating in the Nicotinic acetylcholine receptor signaling pathway pathway from the PANTHER Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Highly sodium permeable acetylcholine nicotinic receptors pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Highly calcium permeable nicotinic acetylcholine receptors pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Postsynaptic nicotinic acetylcholine receptors pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Highly calcium permeable postsynaptic nicotinic acetylcholine receptors pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Activation of Nicotinic Acetylcholine Receptors pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Presynaptic nicotinic acetylcholine receptors pathway from the Reactome Pathways dataset.

From GO Molecular Function Annotations 2023

genes performing the nicotinic acid receptor activity molecular function from the curated GO Molecular Function Annotations 2023 dataset.

From MW Enzyme Metabolite Associations

interacting proteins for Nicotinic acid metabolite from the MW Gene Metabolite Associations dataset.

From MW Enzyme Metabolite Associations

interacting proteins for Nicotinic acid mononucleotide metabolite from the MW Gene Metabolite Associations dataset.

From Reactome Pathways 2024

proteins participating in the Highly calcium permeable nicotinic acetylcholine receptors pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Highly calcium permeable postsynaptic nicotinic acetylcholine receptors pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Highly sodium permeable postsynaptic acetylcholine nicotinic receptors pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Postsynaptic nicotinic acetylcholine receptors pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Presynaptic nicotinic acetylcholine receptors pathway from the Reactome Pathways 2024 dataset.

From GO Molecular Function Annotations 2025

genes performing the nicotinic acid receptor activity molecular function from the curated GO Molecular Function Annotations 2025 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the 5-METHYL NICOTINIC ACID drug from theDGIdb Drug Targets 2026 dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Hydroxyeicosatetraenoic Acids from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Hydroxy Acids from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Fibric Acids from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Aminosalicylic Acids from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Amino Acids, Peptides, and Proteins from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Fatty Acids, Omega-6 from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Fatty Acids, Volatile from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Phosphorous Acids from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical thiosulfinic acids from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Sulfenic Acids from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Hydroxamic Acids from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Bile Acids and Salts from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Linoleic Acids, Conjugated from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Carboxylic Acids from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Dicarboxylic Acids from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Coumaric Acids from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Fatty Acids, Nonesterified from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Anacardic Acids from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Pentanoic Acids from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Arachidonic Acids from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Fatty Acids, Monounsaturated from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Fatty Acids from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Phthalic Acids from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Heptanoic Acids from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Boric Acids from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Acids from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Linolenic Acids from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Pteroylpolyglutamic Acids from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Phosphatidic Acids from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Sialic Acids from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Docosahexaenoic Acids from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Fatty Acids, Unsaturated from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Isonicotinic Acids from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Aristolochic Acids from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Fatty Acids, Essential from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Fatty Acids, Omega-3 from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Sulfinic Acids from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Disease Associations

genes/proteins associated with the disease BETA-AMINO ACIDS, RENAL TRANSPORT OF from the curated CTD Gene-Disease Associations dataset.

From dbGAP Gene-Trait Associations

genes associated with the trait Docosahexaenoic Acids in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.

From GAD Gene-Disease Associations

genes associated with the disease docosahexaenoic acids in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

From GAD Gene-Disease Associations

genes associated with the disease polyunsaturated fatty acids in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term acids in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GO Molecular Function Annotations 2015

genes performing the racemase and epimerase activity, acting on amino acids and derivatives molecular function from the curated GO Molecular Function Annotations 2015 dataset.

From GO Molecular Function Annotations 2015

genes performing the endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters molecular function from the curated GO Molecular Function Annotations 2015 dataset.

From GO Molecular Function Annotations 2015

genes performing the endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters molecular function from the curated GO Molecular Function Annotations 2015 dataset.

From GO Molecular Function Annotations 2015

genes performing the exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters molecular function from the curated GO Molecular Function Annotations 2015 dataset.

From GO Molecular Function Annotations 2015

genes performing the racemase activity, acting on amino acids and derivatives molecular function from the curated GO Molecular Function Annotations 2015 dataset.

From HPO Gene-Disease Associations

genes associated with the elevated long chain fatty acids phenotype by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset.

From HPO Gene-Disease Associations

genes associated with the elevated plasma branched chain amino acids phenotype by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Large neutral amino acids transporter small subunit 4 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From MPO Gene-Phenotype Associations

gene mutations causing the decreased liver free fatty acids level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

From MPO Gene-Phenotype Associations

gene mutations causing the abnormal free fatty acids level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

From MPO Gene-Phenotype Associations

gene mutations causing the abnormal circulating free fatty acids level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

From MPO Gene-Phenotype Associations

gene mutations causing the increased liver free fatty acids level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

From OMIM Gene-Disease Associations

genes associated with the [polyunsaturated fatty acids plasma level qtl1] phenotype from the curated OMIM Gene-Disease Associations dataset.

From Reactome Pathways 2014

proteins participating in the Fatty acids pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the mitochondrial fatty acid beta-oxidation of unsaturated fatty acids pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Synthesis of 5-eicosatetraenoic acids pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Transport of fatty acids pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Beta-oxidation of very long chain fatty acids pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Recycling of bile acids and salts pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Conjugation of carboxylic acids pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Synthesis of bile acids and bile salts pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the mitochondrial fatty acid beta-oxidation of saturated fatty acids pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Synthesis of bile acids and bile salts via 24-hydroxycholesterol pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Free fatty acids regulate insulin secretion pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Synthesis of bile acids and bile salts via 27-hydroxycholesterol pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Transport of inorganic cations/anions and amino acids/oligopeptides pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Metabolism of amino acids and derivatives pathway from the Reactome Pathways dataset.

From DisGeNET Gene-Disease Associations

genes associated with the disease Synthetic Defect Of Bile Acids in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

From DisGeNET Gene-Phenotype Associations

genes associated with the phenotype Elevated Plasma Branched Chain Amino Acids in GWAS and other genetic association datasets from the DisGeNET Gene-Phenotype Associations dataset.

From GO Biological Process Annotations 2023

genes participating in the clearance of foreign intracellular nucleic acids biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Molecular Function Annotations 2023

genes performing the endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters molecular function from the curated GO Molecular Function Annotations 2023 dataset.

From GO Molecular Function Annotations 2023

genes performing the exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters molecular function from the curated GO Molecular Function Annotations 2023 dataset.

From GO Molecular Function Annotations 2023

genes performing the endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters molecular function from the curated GO Molecular Function Annotations 2023 dataset.

From MGI Mouse Phenotype Associations 2023

gene mutations causing the abnormal circulating free fatty acids level phenotype in transgenic mice from the MGI Mouse Phenotype Associations 2023 dataset.

From MGI Mouse Phenotype Associations 2023

gene mutations causing the decreased circulating free fatty acids level phenotype in transgenic mice from the MGI Mouse Phenotype Associations 2023 dataset.

From MGI Mouse Phenotype Associations 2023

gene mutations causing the increased fatty acids level phenotype in transgenic mice from the MGI Mouse Phenotype Associations 2023 dataset.

From MGI Mouse Phenotype Associations 2023

gene mutations causing the increased circulating free fatty acids level phenotype in transgenic mice from the MGI Mouse Phenotype Associations 2023 dataset.

From MGI Mouse Phenotype Associations 2023

gene mutations causing the increased saturated fatty acids level phenotype in transgenic mice from the MGI Mouse Phenotype Associations 2023 dataset.

From MGI Mouse Phenotype Associations 2023

gene mutations causing the increased unsaturated fatty acids level phenotype in transgenic mice from the MGI Mouse Phenotype Associations 2023 dataset.

From MGI Mouse Phenotype Associations 2023

gene mutations causing the decreased unsaturated fatty acids level phenotype in transgenic mice from the MGI Mouse Phenotype Associations 2023 dataset.

From MGI Mouse Phenotype Associations 2023

gene mutations causing the abnormal fatty acids level phenotype in transgenic mice from the MGI Mouse Phenotype Associations 2023 dataset.

From MGI Mouse Phenotype Associations 2023

gene mutations causing the decreased fatty acids level phenotype in transgenic mice from the MGI Mouse Phenotype Associations 2023 dataset.

From MGI Mouse Phenotype Associations 2023

gene mutations causing the decreased saturated fatty acids level phenotype in transgenic mice from the MGI Mouse Phenotype Associations 2023 dataset.

From MGI Mouse Phenotype Associations 2023

gene mutations causing the decreased liver free fatty acids level phenotype in transgenic mice from the MGI Mouse Phenotype Associations 2023 dataset.

From MGI Mouse Phenotype Associations 2023

gene mutations causing the abnormal free fatty acids level phenotype in transgenic mice from the MGI Mouse Phenotype Associations 2023 dataset.

From MGI Mouse Phenotype Associations 2023

gene mutations causing the increased liver free fatty acids level phenotype in transgenic mice from the MGI Mouse Phenotype Associations 2023 dataset.

From MGI Mouse Phenotype Associations 2023

gene mutations causing the increased muscle free fatty acids level phenotype in transgenic mice from the MGI Mouse Phenotype Associations 2023 dataset.

From IMPC Knockout Mouse Phenotypes

gene knockouts causing the decreased circulating free fatty acids level phenotype in mic from the IMPC Knockout Mouse Phenotypes dataset.

From IMPC Knockout Mouse Phenotypes

gene knockouts causing the increased circulating free fatty acids level phenotype in mic from the IMPC Knockout Mouse Phenotypes dataset.

From WikiPathways Pathways 2024

proteins participating in the 4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression pathway from the WikiPathways Pathways 2024 dataset.

From WikiPathways Pathways 2024

proteins participating in the Methionine metabolism leading to sulfur amino acids and related disorders pathway from the WikiPathways Pathways 2024 dataset.

From WikiPathways Pathways 2024

proteins participating in the Fatty acids and lipoproteins transport in hepatocytes pathway from the WikiPathways Pathways 2024 dataset.

From WikiPathways Pathways 2024

proteins participating in the Enterohepatic circulation of bile acids pathway from the WikiPathways Pathways 2024 dataset.

From WikiPathways Pathways 2024

proteins participating in the Omega 6 fatty acids in senescence pathway from the WikiPathways Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Amino acids regulate mTORC1 pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Beta-oxidation of very long chain fatty acids pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Conjugation of carboxylic acids pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Fatty acids pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Free fatty acids regulate insulin secretion pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Intracellular metabolism of fatty acids regulates insulin secretion pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Metabolism of amino acids and derivatives pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Recycling of bile acids and salts pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Synthesis of 5-eicosatetraenoic acids pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Synthesis of bile acids and bile salts pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Synthesis of bile acids and bile salts via 24-hydroxycholesterol pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Synthesis of bile acids and bile salts via 27-hydroxycholesterol pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Transport of bile salts and organic acids, metal ions and amine compounds pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Transport of fatty acids pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Transport of inorganic cations/anions and amino acids/oligopeptides pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the mitochondrial fatty acid beta-oxidation of saturated fatty acids pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the mitochondrial fatty acid beta-oxidation of unsaturated fatty acids pathway from the Reactome Pathways 2024 dataset.

From GO Biological Process Annotations 2025

genes participating in the clearance of foreign intracellular nucleic acids biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Molecular Function Annotations 2025

genes performing the endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters molecular function from the curated GO Molecular Function Annotations 2025 dataset.

From GO Molecular Function Annotations 2025

genes performing the exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters molecular function from the curated GO Molecular Function Annotations 2025 dataset.

From GO Molecular Function Annotations 2025

genes performing the endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters molecular function from the curated GO Molecular Function Annotations 2025 dataset.

From GWAS Catalog SNP-Phenotype Associations 2025

genes associated with the Hyperinsulinemia x saturated fatty acids interaction phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.

From GWAS Catalog SNP-Phenotype Associations 2025

genes associated with the Homeostasis model assessment of insulin resistance x saturated fatty acids interaction phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.

From KEGG Pathways 2026

proteins participating in the Biosynthesis of unsaturated fatty acids pathway from the KEGG Pathways 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the OMEGA-3 FATTY ACIDS drug from theDGIdb Drug Targets 2026 dataset.