Harmonizome 3.0

ATM serine/threonine kinase

The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]

ATM interactor pseudogene

ATM interactor

Enables dynein complex binding activity. Involved in positive regulation of DNA-templated transcription. Located in nuclear body. [provided by Alliance of Genome Resources, Mar 2025]

ATM interactor pseudogene

BRCA1-associated ATM activator 1

The protein encoded by this ubiquitously expressed gene interacts with the tumor suppressing BRCA1 (breast cancer 1) protein and and the ATM (ataxia telangiectasia mutated) protein. ATM is thought to be a master controller of cell cycle checkpoint signalling pathways that are required for cellular responses to DNA damage such as double-strand breaks that are induced by ionizing radiation and complexes with BRCA1 in the multi-protein complex BASC (BRAC1-associated genome surveillance complex). The protein encoded by this gene is thought to play a role in the DNA damage pathway regulated by BRCA1 and ATM. [provided by RefSeq, Mar 2012]

From NURSA Protein Complexes

proteins in the SC-7230 (ATM) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From NURSA Protein Complexes

proteins in the BL-ATM (ATM) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From NURSA Protein Complexes

proteins in the a-ATM (Ab-3) (ATM) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From Biocarta Pathways

proteins participating in the atm signaling pathway pathway from the Biocarta Pathways dataset.

From CORUM Protein Complexes

proteins in the ATM homodimer complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the ATM-NBS1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the MDC1-MRN-ATM-FANCD2 complex protein complex from the CORUM Protein Complexes dataset.

From GAD Gene-Disease Associations

genes associated with the disease mutations in the atm gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term atm in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Hub Proteins Protein-Protein Interactions

interacting proteins for hub protein ATM from the curated Hub Proteins Protein-Protein Interactions dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the ATM protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From KEA Substrates of Kinases

substrates of the kinase ATM from the curated KEA Substrates of Kinases dataset.

From MSigDB Cancer Gene Co-expression Modules

co-expressed genes for ATM from the MSigDB Cancer Gene Co-expression Modules dataset.

From NURSA Protein-Protein Interactions

interacting proteins for ATM from the NURSA Protein-Protein Interactions dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for ATM from the Pathway Commons Protein-Protein Interactions dataset.

From Phosphosite Textmining Biological Term Annotations

proteins co-occuring with the biological term atm in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

From Phosphosite Textmining Biological Term Annotations

proteins co-occuring with the biological term atm-dependent in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase ATM from the curated PhosphoSitePlus Substrates of Kinases dataset.

From PID Pathways

proteins participating in the ATM pathway pathway from the PID Pathways dataset.

From Reactome Pathways 2014

proteins participating in the ATM mediated phosphorylation of repair proteins pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the ATM mediated response to DNA double-strand break pathway from the Reactome Pathways dataset.

From WikiPathways Pathways 2014

proteins participating in the ATM Signaling Pathway(Homo sapiens) pathway from the WikiPathways Pathways 2014 dataset.

From WikiPathways Pathways 2014

proteins participating in the DNA Damage Response (only ATM dependent)(Homo sapiens) pathway from the WikiPathways Pathways 2014 dataset.

From Kinase Library Serine Threonine Kinome Atlas

substrates of the kinase ATM from the Kinase Library Serine Threonine Kinome Atlas dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the ATM gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From WikiPathways Pathways 2024

proteins participating in the ATM signaling pathway from the WikiPathways Pathways 2024 dataset.

From WikiPathways Pathways 2024

proteins participating in the ATM signaling in development and disease pathway from the WikiPathways Pathways 2024 dataset.

From WikiPathways Pathways 2024

proteins participating in the DNA IR double strand breaks and cellular response via ATM pathway from the WikiPathways Pathways 2024 dataset.

From WikiPathways Pathways 2024

proteins participating in the DNA damage response only ATM dependent pathway from the WikiPathways Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks pathway from the Reactome Pathways 2024 dataset.

From ClinVar Gene-Phenotype Associations 2025

genes associated with the ATM-related cancer predisposition phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset.

From ClinVar Gene-Phenotype Associations 2025

genes associated with the ATM-related cancer predisposition syndrome phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the ATM INHIBITOR M 3541 drug from theDGIdb Drug Targets 2026 dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the ATM gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.