Harmonizome 3.0

mechanistic target of rapamycin (serine/threonine kinase)

The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This kinase is a component of two distinct complexes, mTORC1, which controls protein synthesis, cell growth and proliferation, and mTORC2, which is a regulator of the actin cytoskeleton, and promotes cell survival and cell cycle progression. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. Inhibitors of mTOR are used in organ transplants as immunosuppressants, and are being evaluated for their therapeutic potential in SARS-CoV-2 infections. Mutations in this gene are associated with Smith-Kingsmore syndrome and somatic focal cortical dysplasia type II. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Aug 2020]

MTOR antisense RNA 1

RPTOR independent companion of MTOR, complex 2

RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008]

late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 pseudogene 1

MTOR associated protein, LST8 homolog (S. cerevisiae)

Enables protein serine/threonine kinase activator activity and protein-macromolecule adaptor activity. Involved in TOR signaling; positive regulation of TOR signaling; and regulation of actin cytoskeleton organization. Part of TORC1 complex and TORC2 complex. [provided by Alliance of Genome Resources, Mar 2025]

regulatory associated protein of MTOR, complex 1

This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 pseudogene 2

DEP domain containing MTOR-interacting protein

Enables phosphatidic acid binding activity and protein serine/threonine kinase inhibitor activity. Involved in several processes, including negative regulation of TOR signaling; negative regulation of cell size; and negative regulation of protein kinase activity. Is active in lysosomal membrane. [provided by Alliance of Genome Resources, Mar 2025]

late endosomal/lysosomal adaptor, MAPK and MTOR activator 4

Contributes to guanyl-nucleotide exchange factor activity and molecular adaptor activity. Involved in several processes, including cellular response to amino acid stimulus; positive regulation of TORC1 signaling; and protein localization to lysosome. Located in lysosome. Part of FNIP-folliculin RagC/D GAP and Ragulator complex. Is active in lysosomal membrane. [provided by Alliance of Genome Resources, Mar 2025]

late endosomal/lysosomal adaptor, MAPK and MTOR activator 5

This gene encodes a protein that specifically complexes with the C-terminus of hepatitis B virus X protein (HBx). The function of this protein is to negatively regulate HBx activity and thus to alter the replication life cycle of the virus. [provided by RefSeq, Jul 2008]

late endosomal/lysosomal adaptor, MAPK and MTOR activator 1

Enables GTPase binding activity and protein-membrane adaptor activity. Contributes to guanyl-nucleotide exchange factor activity and molecular adaptor activity. Involved in several processes, including cholesterol homeostasis; positive regulation of TORC1 signaling; and regulation of cholesterol transport. Located in lysosome. Part of FNIP-folliculin RagC/D GAP. Is active in Ragulator complex and lysosomal membrane. [provided by Alliance of Genome Resources, Mar 2025]

late endosomal/lysosomal adaptor, MAPK and MTOR activator 2

The product of this gene is highly conserved with a mouse protein associated with the cytoplasmic face of late endosomes and lysosomes. The mouse protein interacts with MAPK scaffold protein 1, a component of the mitogen-activated protein kinase pathway. In humans, a mutation in this gene has been associated with a primary immunodeficiency syndrome, and suggests a role for this protein in endosomal biogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

late endosomal/lysosomal adaptor, MAPK and MTOR activator 3

This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. Studies of the orthologous gene in mouse indicate that it regulates late endosomal traffic and cell proliferation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 13. [provided by RefSeq, Aug 2011]

MTOR associated protein, eak-7 homolog

Involved in several processes, including TOR signaling; positive regulation of protein localization to lysosome; and response to insulin. Located in cytosol; lysosomal membrane; and nuclear lumen. [provided by Alliance of Genome Resources, Mar 2025]

From NURSA Protein Complexes

proteins in the BL4774 (MTOR) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the mTOR-signaling complex (FRAP1/mTOR, GBL, RAPTOR) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the mTOR-signaling complex (mTOR/FRAP1, RAPTOR) protein complex from the CORUM Protein Complexes dataset.

From Biocarta Pathways

proteins participating in the mtor signaling pathway pathway from the Biocarta Pathways dataset.

From Biocarta Pathways

proteins participating in the skeletal muscle hypertrophy is regulated via akt-mtor pathway pathway from the Biocarta Pathways dataset.

From CORUM Protein Complexes

proteins in the RICTOR-mTOR complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the mTOR-RICTOR complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the RAPTOR-mTOR complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the mTOR-RAPTOR complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the mTORC2 complex (mTOR/FRAP1, LST8, mAVO3/RICTOR) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the mTOR-signaling complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the mTORC1 complex (mTOR/FRAP1, LST8, RAPTOR) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the mTORC2 complex (mTOR/FRAP1, LST8, mAVO3/RICTOR, SIN1) protein complex from the CORUM Protein Complexes dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term mtor in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GWAS Catalog SNP-Phenotype Associations

genes associated with the Response to mTOR inhibitor (rapamycin) phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations dataset.

From GWAS Catalog SNP-Phenotype Associations

genes associated with the Response to mTOR inhibitor (everolimus) phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations dataset.

From Hub Proteins Protein-Protein Interactions

interacting proteins for hub protein MTOR from the curated Hub Proteins Protein-Protein Interactions dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Rapamycin-insensitive companion of mTOR, N-terminal domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Rapamycin-insensitive companion of mTOR, phosphorylation-site protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Rapamycin-insensitive companion of mTOR, domain 4 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Rapamycin-insensitive companion of mTOR, domain 5 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Rapamycin-insensitive companion of mTOR, middle domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From KEA Substrates of Kinases

substrates of the kinase MTOR from the curated KEA Substrates of Kinases dataset.

From KEGG Pathways

proteins participating in the mtor signaling pathway pathway from the KEGG Pathways dataset.

From NURSA Protein Complexes

proteins in the BL897 (MTOR) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From NURSA Protein Complexes

proteins in the BL4773 (MTOR) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for MTOR from the Pathway Commons Protein-Protein Interactions dataset.

From Phosphosite Textmining Biological Term Annotations

proteins co-occuring with the biological term mtor in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase MTOR from the curated PhosphoSitePlus Substrates of Kinases dataset.

From PID Pathways

proteins participating in the mTOR signaling pathway pathway from the PID Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Energy dependent regulation of mTOR by LKB1-AMPK pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the mTOR signalling pathway from the Reactome Pathways dataset.

From Kinase Library Serine Threonine Kinome Atlas

substrates of the kinase MTOR from the Kinase Library Serine Threonine Kinome Atlas dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the MTOR gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From WikiPathways Pathways 2024

proteins participating in the PI3K AKT mTOR signaling and therapeutic opportunities in prostate cancer pathway from the WikiPathways Pathways 2024 dataset.

From WikiPathways Pathways 2024

proteins participating in the Focal adhesion PI3K Akt mTOR signaling pathway from the WikiPathways Pathways 2024 dataset.

From WikiPathways Pathways 2024

proteins participating in the PI3K AKT mTOR vitamin D3 signaling pathway from the WikiPathways Pathways 2024 dataset.

From WikiPathways Pathways 2024

proteins participating in the Modulation of PI3K Akt mTOR signaling by bioactive sphingolipids pathway from the WikiPathways Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Energy dependent regulation of mTOR by LKB1-AMPK pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the MTOR signalling pathway from the Reactome Pathways 2024 dataset.

From ClinVar Gene-Phenotype Associations 2025

genes associated with the Overgrowth syndrome and/or cerebral malformations due to abnormalities in MTOR pathway genes phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset.

From ClinVar Gene-Phenotype Associations 2025

genes associated with the MTOR-related megalencephaly and pigmentary mosaicism in skin phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset.

From GWAS Catalog SNP-Phenotype Associations 2025

genes associated with the Response to mTOR inhibitor (everolimus) phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.

From GWAS Catalog SNP-Phenotype Associations 2025

genes associated with the Response to mTOR inhibitor (rapamycin) phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.

From KEGG Pathways 2026

proteins participating in the mTOR signaling pathway pathway from the KEGG Pathways 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the MTOR INHIBITOR drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the MTOR KINASE INHIBITOR AZD8055 drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the MTOR KINASE INHIBITOR PP242 drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the PI3K/MTOR KINASE INHIBITOR WXFL10030390 drug from theDGIdb Drug Targets 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC5811220-NIHMS939330-supplement-Supplemental_Table_4.xlsx-mTOR_repressed_AA_mRNAs_txt-mTOR-repressed_mRNAs_with_functions_in_AA_metabolism_and_transport_MSIGDB_M11769_M19056_M456_TEAD1 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.