Harmonizome 3.0

coagulation factor XII (Hageman factor)

This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged. [provided by RefSeq, Jul 2008]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term f12 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for F12 from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the F12 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the F12 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From GAD Gene-Disease Associations

genes associated with the disease f12 plasma deficiency, moderate in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

From ClinVar Gene-Phenotype Associations 2025

genes associated with the F12 POLYMORPH phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset.

From Carcinogenome Chemical Perturbation Carcinogenicity Signatures

genes differentially expressed following the CRCGN008_HEPG2_24H:F12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

From Carcinogenome Chemical Perturbation Carcinogenicity Signatures

genes differentially expressed following the CRCGN010_HEPG2_24H:F12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

From Carcinogenome Chemical Perturbation Carcinogenicity Signatures

genes differentially expressed following the CRCGN011_HEPG2_24H:F12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

From Carcinogenome Chemical Perturbation Carcinogenicity Signatures

genes differentially expressed following the CRCGN013_HEPG2_24H:F12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

From Carcinogenome Chemical Perturbation Carcinogenicity Signatures

genes differentially expressed following the CRCGN014_HEPG2_24H:F12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

From Carcinogenome Chemical Perturbation Carcinogenicity Signatures

genes differentially expressed following the CRCGN014_HEPG2_3H:F12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

From Carcinogenome Chemical Perturbation Carcinogenicity Signatures

genes differentially expressed following the CRCGN012_HEPG2_24H:F12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

From Carcinogenome Chemical Perturbation Carcinogenicity Signatures

genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:F12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

From Carcinogenome Chemical Perturbation Carcinogenicity Signatures

genes differentially expressed following the CRCGN009_HEPG2_24H:F12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

From Carcinogenome Chemical Perturbation Carcinogenicity Signatures

genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:F12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

From Carcinogenome Chemical Perturbation Carcinogenicity Signatures

genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:F12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

From Carcinogenome Chemical Perturbation Carcinogenicity Signatures

genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:F12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

From Carcinogenome Chemical Perturbation Carcinogenicity Signatures

genes differentially expressed following the CRCGN015_MCF10A_48H:F12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

From Carcinogenome Chemical Perturbation Carcinogenicity Signatures

genes differentially expressed following the CRCGN015_HEPG2_48H:F12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

From Carcinogenome Chemical Perturbation Carcinogenicity Signatures

genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:F12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

From Carcinogenome Chemical Perturbation Carcinogenicity Signatures

genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:F12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.