Harmonizome 3.0

S-phase kinase-associated protein 2, E3 ubiquitin protein ligase

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2011]

WEE1 G2 checkpoint kinase

This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase. [provided by RefSeq, Jul 2008]

beta-transducin repeat containing E3 ubiquitin protein ligase

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6. [provided by RefSeq, Mar 2012]

WEE1 homolog (S. pombe) pseudogene

WEE1 homolog (S. pombe) pseudogene

WEE1 homolog (S. pombe) pseudogene

WEE1 homolog (S. pombe) pseudogene

WEE1 homolog 2 (S. pombe)

Predicted to enable protein tyrosine kinase activity. Predicted to be involved in several processes, including female pronucleus assembly; negative regulation of cyclin-dependent protein serine/threonine kinase activity; and regulation of meiotic cell cycle. Located in cytosol; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

WEE1 homolog 2 (S. pombe) pseudogene

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3 pseudogene 3

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, pseudogene 1

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3 pseudogene 1

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1 pseudogene 2

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa pseudogene 1

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12 pseudogene

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa pseudogene

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa pseudogene

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa

This gene encodes a subunit of the membrane-bound mitochondrial complex I. Complex I is composed of numerous subunits and functions as the NADH-ubiquinol reductase of the mitochondrial electron transport chain. Mutations in this gene are associated with severe mitochondrial complex I deficiency. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010]

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12

This gene encodes a protein which is part of mitochondrial complex 1, part of the oxidative phosphorylation system in mitochondria. Complex 1 transfers electrons to ubiquinone from NADH which establishes a proton gradient for the generation of ATP. Mutations in this gene are associated with Leigh syndrome due to mitochondrial complex 1 deficiency. Pseudogenes of this gene are located on chromosomes 5 and 13. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13

This gene encodes a subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain. The protein is required for complex I assembly and electron transfer activity. The protein binds the signal transducers and activators of transcription 3 (STAT3) transcription factor, and can function as a tumor suppressor. The human protein purified from mitochondria migrates at approximately 16 kDa. Transcripts originating from an upstream promoter and capable of expressing a protein with a longer N-terminus have been found, but their biological validity has not been determined. [provided by RefSeq, Oct 2009]

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa pseudogene

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, pseudogene 1

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, pseudogene 3

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa pseudogene

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 pseudogene

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa pseudogene 2

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa pseudogene 5

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa

The protein encoded by this gene is a subunit of the mitochondrial oxidative phosphorylation complex I (nicotinamide adenine dinucleotide: ubiquinone oxidoreductase). Complex I is localized to the inner mitochondrial membrane and functions to dehydrogenate nicotinamide adenine dinucleotide and to shuttle electrons to coenzyme Q. Complex I deficiency is the most common defect found in oxidative phosphorylation disorders and results in a range of conditions, including lethal neonatal disease, hypertrophic cardiomyopathy, liver disease, and adult-onset neurodegenerative disorders. Pseudogenes of this gene are found on chromosomes five, seven and eight. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa

Predicted to enable NADH dehydrogenase (ubiquinone) activity. Involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Part of mitochondrial inner membrane and respiratory chain complex I. Implicated in nuclear type mitochondrial complex I deficiency 32. Biomarker of Alzheimer's disease and Parkinson's disease. [provided by Alliance of Genome Resources, Mar 2025]

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa

The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. It is located at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. [provided by RefSeq, Jul 2008]

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa

The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Alternative splicing occurs at this locus and three transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jan 2011]

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa

The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa

This gene encodes a non-catalytic subunit of the multisubunit NADH:ubiquinone oxidoreductase, the first enzyme complex in the mitochondrial electron transport chain (complex I). Mammalian complex I is composed of 45 different subunits and transfers electrons from NADH to ubiquinone. [provided by RefSeq, Dec 2009]

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa

This gene encodes an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which is the first enzyme in the electron transport chain of mitochondria. This protein localizes to the inner membrane of the mitochondrion as a single-pass membrane protein. Mutations in this gene contribute to mitochondrial complex 1 deficiency. Alternative splicing results in multiple transcript variants encoding the same protein. Humans have multiple pseudogenes of this gene. [provided by RefSeq, Mar 2012]

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa

The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. This protein has NADH dehydrogenase activity and oxidoreductase activity. It plays a important role in transfering electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Hydropathy analysis revealed that this subunit and 4 other subunits have an overall hydrophilic pattern, even though they are found within the hydrophobic protein (HP) fraction of complex I. [provided by RefSeq, Jul 2008]

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa

Predicted to enable NADH dehydrogenase (ubiquinone) activity. Involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion and nuclear speck. Part of mitochondrial inner membrane and respiratory chain complex I. [provided by Alliance of Genome Resources, Mar 2025]

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa pseudogene 2

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa pseudogene 3

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa pseudogene 1

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa pseudogene 4

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa

This gene encodes a member of the LYR family of proteins that contain a highly conserved tripeptide (LYR) motif near the N-terminus. The encoded protein is an accessory subunit of NADH: ubiquinone oxidorerductase (Complex I), which is the largest enzyme of the mitochondrial membrane respiratory chain. Complex I functions in electron transfer from NADH to the respiratory chain. [provided by RefSeq, Oct 2016]

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa

This gene encodes a subunit of NADH:ubiquinone oxidoreductase (complex I), which is a multiprotein complex located in the inner mitochondrial membrane. Complex I functions in the transfer of electrons from NADH to the respiratory chain. [provided by RefSeq, Mar 2011]

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5

This nuclear gene encodes a conserved protein that comprises the B13 subunit of complex I of the mitochondrial respiratory chain. The encoded protein localizes to the inner mitochondrial membrane, where it is thought to aid in the transfer of electrons from NADH to ubiquinone. Alternative splicing results in multiple transcript variants. There are numerous pseudogenes of this gene on chromosomes 1, 3, 6, 8, 9, 11, 12, and 16. [provided by RefSeq, Apr 2014]

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa

The encoded protein is a subunit of the hydrophobic protein fraction of the NADH:ubiquinone oxidoreductase (complex 1), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane, and may be involved in regulating complex I activity or its assembly via assistance in redox processes. Mutations in this gene are associated with Leigh syndrome, an early-onset progressive neurodegenerative disorder. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa

Predicted to enable NADH dehydrogenase (ubiquinone) activity. Involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Part of mitochondrial inner membrane and respiratory chain complex I. [provided by Alliance of Genome Resources, Mar 2025]

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa

The human NDUFA1 gene codes for an essential component of complex I of the respiratory chain, which transfers electrons from NADH to ubiquinone. It has been noted that the N-terminal hydrophobic domain has the potential to be folded into an alpha-helix spanning the inner mitochondrial membrane with a C-terminal hydrophilic domain interacting with globular subunits of complex I. The highly conserved two-domain structure suggests that this feature is critical for the protein function and might act as an anchor for the NADH:ubiquinone oxidoreductase complex at the inner mitochondrial membrane. However, the NDUFA1 peptide is one of about 31 components of the `hydrophobic protein` (HP) fraction of complex I which is involved in proton translocation. Thus the NDUFA1 peptide may also participate in that function. [provided by RefSeq, Jul 2008]

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa

The protein encoded by this gene belongs to the complex I 19 kDa subunit family. Mammalian complex I is composed of 45 different subunits. This protein has NADH dehydrogenase activity and oxidoreductase activity. It plays an important role in transfering electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa

The encoded protein is a subunit of the hydrophobic protein fraction of the NADH:ubiquinone oxidoreductase (complex I), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane. A pseudogene has been identified on chromosome 12. [provided by RefSeq, May 2010]

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 pseudogene

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa pseudogene

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 pseudogene 5

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 pseudogene 4

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 pseudogene 6

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 pseudogene 1

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 pseudogene 3

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, pseudogene 1

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 pseudogene 12

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 pseudogene

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 pseudogene 9

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa, pseudogene 1

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa, pseudogene 2

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2

Located in mitochondrion. [provided by Alliance of Genome Resources, Mar 2025]

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa pseudogene

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa

The protein encoded by this gene is a component of 42 kDa complex I, the first enzyme complex in the electron transport chain of mitochondria. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. A mutation in this gene was found in an individual with Leigh syndrome. [provided by RefSeq, Apr 2016]

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa pseudogene

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 pseudogene

NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa

The encoded protein is a subunit of the NADH:ubiquinone oxidoreductase (complex I), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa

Predicted to enable NADH dehydrogenase (ubiquinone) activity. Involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Part of mitochondrial inner membrane and respiratory chain complex I. Implicated in nuclear type mitochondrial complex I deficiency. [provided by Alliance of Genome Resources, Mar 2025]

NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa

Enables mitochondrial large ribosomal subunit binding activity. Involved in [2Fe-2S] cluster assembly; mitochondrial respiratory chain complex I assembly; and protein lipoylation. Located in mitochondrion and nucleoplasm. Part of mitochondrial [2Fe-2S] assembly complex; mitochondrial inner membrane; and respiratory chain complex I. [provided by Alliance of Genome Resources, Mar 2025]

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12 pseudogene 1

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, pseudogene 2

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1 pseudogene 1

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa

The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is located at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to ubiquinone. Mutations in the human gene are associated with linear skin defects with multiple congenital anomalies 3 and mitochondrial complex I deficiency. [provided by RefSeq, Dec 2016]

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa

Predicted to enable NADH dehydrogenase (ubiquinone) activity. Involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Part of mitochondrial inner membrane and respiratory chain complex I. Implicated in nuclear type mitochondrial complex I deficiency 35. [provided by Alliance of Genome Resources, Mar 2025]

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 pseudogene

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa pseudogene

From CORUM Protein Complexes

proteins in the SCF subcomplex (WEE1, SKP2, BTRC) protein complex from the CORUM Protein Complexes dataset.

From Reactome Pathways 2014

proteins participating in the SCF(Skp2)-mediated degradation of p27/p21 pathway from the Reactome Pathways dataset.

From Reactome Pathways 2024

proteins participating in the SCF(Skp2)-mediated degradation of p27/p21 pathway from the Reactome Pathways 2024 dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025

proteins co-occuring with the SCF-Skp2 ubiquitin ligase complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term wee1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Wee1-like protein kinase protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From KEA Substrates of Kinases

substrates of the kinase WEE1 from the curated KEA Substrates of Kinases dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for WEE1 from the Pathway Commons Protein-Protein Interactions dataset.

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase WEE1 from the curated PhosphoSitePlus Substrates of Kinases dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the WEE1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From Kinase Library Tyrosine Kinome Atlas

substrates of the kinase WEE1 from the Kinase Library Tyrosine Kinome Atlas dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the WEE1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (NFKBIA, FBXW11, BTRC, CUL1, SKP1A) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (SMAD3, BTRC, CUL1, SKP1A, RBX1) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the TNF-alpha/NF-kappa B signaling complex (CHUK, BTRC, NFKB2, PPP6C, REL, CUL1, IKBKE, SAPS2, SAPS1, ANKRD28, RELA, SKP1) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (NFKBIA, BTRC, CUL1, SKP1A) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (CDC34, NEDD8, BTRC, CUL1, SKP1A, RBX1) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (SKP1A, BTRC, CUL1) protein complex from the CORUM Protein Complexes dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term btrc in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for BTRC from the Pathway Commons Protein-Protein Interactions dataset.

From Reactome Pathways 2024

proteins participating in the GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 pathway from the Reactome Pathways 2024 dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the BTRC gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From CORUM Protein Complexes

proteins in the p27-cyclinE-Cdk2 - Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1) complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (SKP1A, SKP2, CUL1) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the CDH1-SKP2 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the P-TEFb-SKP2 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (Skp1A, Skp2, Cul1, Rbx1) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (CSN1, CSN8, HRT1, SKP1, SKP2, CUL1, CUL2, CUL3) protein complex from the CORUM Protein Complexes dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term skp2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From NURSA Protein Complexes

proteins in the BL8037 (SKP2) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From NURSA Protein-Protein Interactions

interacting proteins for SKP2 from the NURSA Protein-Protein Interactions dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for SKP2 from the Pathway Commons Protein-Protein Interactions dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the SKP2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the scf ubiquitin ligase complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the scf ubiquitin ligase complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the cytoplasmic scf ubiquitin ligase complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the nuclear scf ubiquitin ligase complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term scf in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GO Biological Process Annotations 2015

genes participating in the scf-dependent proteasomal ubiquitin-dependent protein catabolic process biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Biological Process Annotations 2015

genes participating in the scf complex assembly biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Cellular Component Annotations 2015

proteins localized to the scf ubiquitin ligase complex cellular component from the curated GO Cellular Component Annotations 2015 dataset.

From Reactome Pathways 2014

proteins participating in the SCF-beta-TrCP mediated degradation of Emi1 pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Signaling by SCF-KIT pathway from the Reactome Pathways dataset.

From GO Biological Process Annotations 2023

genes participating in the SCF-dependent proteasomal ubiquitin-dependent protein catabolic process biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the SCF complex assembly biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the regulation of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Cellular Component Annotations 2023

proteins localized to the SCF ubiquitin ligase complex cellular component from the curated GO Cellular Component Annotations 2023 dataset.

From Reactome Pathways 2024

proteins participating in the SCF-beta-TrCP mediated degradation of Emi1 pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Signaling by SCF-KIT pathway from the Reactome Pathways 2024 dataset.

From GO Biological Process Annotations 2025

genes participating in the SCF-dependent proteasomal ubiquitin-dependent protein catabolic process biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Biological Process Annotations 2025

genes participating in the SCF complex assembly biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Biological Process Annotations 2025

genes participating in the negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Biological Process Annotations 2025

genes participating in the regulation of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Cellular Component Annotations 2025

proteins localized to the SCF ubiquitin ligase complex cellular component from the curated GO Cellular Component Annotations 2025 dataset.

From COMPARTMENTS Curated Protein Localization Evidence Scores 2025

proteins localized to the SCF ubiquitin ligase complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025

proteins co-occuring with the SCF ubiquitin ligase complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025

proteins co-occuring with the SCF-Cdc4 ubiquitin ligase complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025

proteins co-occuring with the Nuclear SCF ubiquitin ligase complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025

proteins co-occuring with the Cytoplasmic SCF ubiquitin ligase complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025

proteins co-occuring with the SCF-Das1 ubiquitin ligase complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025

proteins co-occuring with the SCF-Ucc1 ubiquitin ligase complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025

proteins co-occuring with the SCF-Mdm30 ubiquitin ligase complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.

From CM4AI U2OS Cell Map Protein Localization Assemblies

proteins comprising SCF ubiquitin ligase complex assembly using integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the proteasome regulatory particle, base subcomplex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the proteasome regulatory particle, lid subcomplex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the pwp2p-containing subcomplex of 90s preribosome cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

From CORUM Protein Complexes

proteins in the COG2-COG3-COG4 subcomplex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Binary COG subcomplex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the COG1-COG8-COG5-COG6-COG7 subcomplex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the NPC subcomplex (NUP98, NUP107, NUP133, NUP160) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the TAF4-TAF12 subcomplex of TFIID complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the 5S-DNA-TFIIIA-TFIIIC2-TFIIIB subcomplex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the MED18-MED20-MED29 mediator subcomplex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the 5S-DNA-TFIIIA-TFIIIC2 subcomplex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the TFIID subcomplex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the CTF18-RFC subcomplex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the COG5-COG6-COG7 subcomplex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the CTF8-DCC1 subcomplex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Tetrameric COG subcomplex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Nup 107-160 subcomplex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the RFC2-5 subcomplex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the COG1-COG8-COG2-COG3-COG4 subcomplex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the COG1-COG8 subcomplex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Ternary COG subcomplex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the TFIID subcomplex, testis-specific protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the CTF8-CTF18-DCC1 subcomplex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Sur2 subcomplex of mediator protein complex from the CORUM Protein Complexes dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term subcomplex in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GO Cellular Component Annotations 2015

proteins localized to the proteasome regulatory particle, base subcomplex cellular component from the curated GO Cellular Component Annotations 2015 dataset.

From GO Cellular Component Annotations 2015

proteins localized to the pwp2p-containing subcomplex of 90s preribosome cellular component from the curated GO Cellular Component Annotations 2015 dataset.

From GO Cellular Component Annotations 2015

proteins localized to the proteasome regulatory particle, lid subcomplex cellular component from the curated GO Cellular Component Annotations 2015 dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the 26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex subunit 1 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 6 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 8 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, metazoa protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the NADH dehydrogenase 1, beta subcomplex, subunit 6 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the 26S proteasome regulatory complex, non-ATPase subcomplex, Rpn2/Psmd1 subunit protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From COMPARTMENTS Curated Protein Localization Evidence Scores 2025

proteins localized to the Proteasome regulatory particle, lid subcomplex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.

From COMPARTMENTS Curated Protein Localization Evidence Scores 2025

proteins localized to the Pwp2p-containing subcomplex of 90S preribosome cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.

From COMPARTMENTS Curated Protein Localization Evidence Scores 2025

proteins localized to the exon-exon junction subcomplex mago-y14 cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.

From COMPARTMENTS Curated Protein Localization Evidence Scores 2025

proteins localized to the Proteasome regulatory particle, base subcomplex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025

proteins co-occuring with the Pwp2p-containing subcomplex of 90S preribosome cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025

proteins co-occuring with the exon-exon junction subcomplex mago-y14 cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025

proteins co-occuring with the Mitotic checkpoint complex, CDC20-MAD2 subcomplex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025

proteins co-occuring with the Proteasome regulatory particle, lid subcomplex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025

proteins co-occuring with the Proteasome regulatory particle, base subcomplex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.

From CM4AI U2OS Cell Map Protein Localization Assemblies

proteins comprising Nuclear speckle spliceosome subcomplex assembly using integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.

From CM4AI U2OS Cell Map Protein Localization Assemblies

proteins comprising Extracellular matrix organization subcomplex assembly using integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.