Erythropoietin activates Phosphoinositide-3-kinase (PI3K)

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Results for "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)": 20 genes, 149 gene sets

Name
EPOR Gene erythropoietin receptor This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
EPO Gene erythropoietin This gene encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The encoded protein is mainly synthesized in the kidney, secreted into the blood plasma, and binds to the erythropoietin receptor to promote red blood cell production, or erythropoiesis, in the bone marrow. Expression of this gene is upregulated under hypoxic conditions, in turn leading to increased erythropoiesis and enhanced oxygen-carrying capacity of the blood. Expression of this gene has also been observed in brain and in the eye, and elevated expression levels have been observed in diabetic retinopathy and ocular hypertension. Recombinant forms of the encoded protein exhibit neuroprotective activity against a variety of potential brain injuries, as well as antiapoptotic functions in several tissue types, and have been used in the treatment of anemia and to enhance the efficacy of cancer therapies. [provided by RefSeq, Aug 2017]
TPTE2 Gene transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 TPIP is a member of a large class of membrane-associated phosphatases with substrate specificity for the 3-position phosphate of inositol phospholipids.[supplied by OMIM, Jul 2002]
LOC100422687 Gene pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 pseudogene
WIPI2 Gene WD repeat domain, phosphoinositide interacting 2 WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI2, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids (Proikas-Cezanne et al., 2004 [PubMed 15602573]).[supplied by OMIM, Mar 2008]
WIPI1 Gene WD repeat domain, phosphoinositide interacting 1 This gene encodes a WD40 repeat protein. Members of the WD40 repeat family are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
FIG4 Gene FIG4 phosphoinositide 5-phosphatase The protein encoded by this gene belongs to the SAC domain-containing protein gene family. The SAC domain, approximately 400 amino acids in length and consisting of seven conserved motifs, has been shown to possess phosphoinositide phosphatase activity. The yeast homolog, Sac1p, is involved in the regulation of various phosphoinositides, and affects diverse cellular functions such as actin cytoskeleton organization, Golgi function, and maintenance of vacuole morphology. Membrane-bound phosphoinositides function as signaling molecules and play a key role in vesicle trafficking in eukaryotic cells. Mutations in this gene have been associated with Charcot-Marie-Tooth disease, type 4J. [provided by RefSeq, Jul 2008]
TPTE2P5 Gene transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene 5
PLEKHA4 Gene pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 This gene encodes a pleckstrin homology (PH) domain-containing protein. The PH domain is found near the N-terminus and contains a putative phosphatidylinositol 3, 4, 5-triphosphate-binding motif (PPBM). Elevated expression of this gene has been observed in some melanomas. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2017]
PLEKHA1 Gene pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 This gene encodes a pleckstrin homology domain-containing adapter protein. The encoded protein is localized to the plasma membrane where it specifically binds phosphatidylinositol 3,4-bisphosphate. This protein may be involved in the formation of signaling complexes in the plasma membrane. Polymorphisms in this gene are associated with age-related macular degeneration. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 5.[provided by RefSeq, Sep 2010]
PLCB1 Gene phospholipase C, beta 1 (phosphoinositide-specific) The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
PIRT Gene phosphoinositide-interacting regulator of transient receptor potential channels Predicted to enable phosphatidylinositol bisphosphate binding activity and transmembrane transporter binding activity. Predicted to be involved in regulation of sensory perception of pain. Predicted to act upstream of or within behavioral response to pain; positive regulation of cation channel activity; and response to heat. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]
TPTE2P2 Gene transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene 2
TPTE2P3 Gene transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene 3
TPTE2P1 Gene transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene 1
TPTE2P6 Gene transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene 6
TPTE2P4 Gene transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene 4
PLEKHA2 Gene pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 Enables fibronectin binding activity; laminin binding activity; and phosphatidylinositol-3,4-bisphosphate binding activity. Involved in positive regulation of cell-matrix adhesion. Located in cytoplasm and membrane. Part of protein-containing complex. [provided by Alliance of Genome Resources, Mar 2025]
PLEKHA3 Gene pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3 Enables identical protein binding activity and phosphatidylinositol-4-phosphate binding activity. Predicted to be involved in endosome organization; receptor recycling; and retrograde transport, endosome to Golgi. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Mar 2025]
PLEKHA8 Gene pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8 Enables several functions, including ceramide binding activity; glycolipid transfer activity; and phosphatidylinositol-4-phosphate binding activity. Involved in ER to Golgi ceramide transport. Located in nucleoplasm and trans-Golgi network. [provided by Alliance of Genome Resources, Mar 2025]
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Gene Set From Reactome Pathways 2024 proteins participating in the Erythropoietin activates Phosphoinositide-3-kinase (PI3K) pathway from the Reactome Pathways 2024 dataset.
Erythropoietin activates Phospholipase C gamma (PLCG) Gene Set From Reactome Pathways 2024 proteins participating in the Erythropoietin activates Phospholipase C gamma (PLCG) pathway from the Reactome Pathways 2024 dataset.
Erythropoietin activates RAS Gene Set From Reactome Pathways 2024 proteins participating in the Erythropoietin activates RAS pathway from the Reactome Pathways 2024 dataset.
Erythropoietin activates STAT5 Gene Set From Reactome Pathways 2024 proteins participating in the Erythropoietin activates STAT5 pathway from the Reactome Pathways 2024 dataset.
MET activates PI3K/AKT signaling Gene Set From Reactome Pathways 2024 proteins participating in the MET activates PI3K/AKT signaling pathway from the Reactome Pathways 2024 dataset.
phosphoinositide Gene Set From GeneRIF Biological Term Annotations genes co-occuring with the biological term phosphoinositide in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
3-phosphoinositide degradation Gene Set From HumanCyc Pathways proteins participating in the 3-phosphoinositide degradation pathway from the HumanCyc Pathways dataset.
3-phosphoinositide biosynthesis Gene Set From HumanCyc Pathways proteins participating in the 3-phosphoinositide biosynthesis pathway from the HumanCyc Pathways dataset.
Phosphoinositide phospholipase C family Gene Set From InterPro Predicted Protein Domain Annotations proteins predicted to have the Phosphoinositide phospholipase C family protein domain from the InterPro Predicted Protein Domain Annotations dataset.
Phosphoinositide-interacting protein Gene Set From InterPro Predicted Protein Domain Annotations proteins predicted to have the Phosphoinositide-interacting protein protein domain from the InterPro Predicted Protein Domain Annotations dataset.
Phosphoinositide-binding clathrin adaptor, domain 2 Gene Set From InterPro Predicted Protein Domain Annotations proteins predicted to have the Phosphoinositide-binding clathrin adaptor, domain 2 protein domain from the InterPro Predicted Protein Domain Annotations dataset.
phosphoinositide Gene Set From Phosphosite Textmining Biological Term Annotations proteins co-occuring with the biological term phosphoinositide in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.
erythropoietin mediated neuroprotection through nf-kb Gene Set From Biocarta Pathways proteins participating in the erythropoietin mediated neuroprotection through nf-kb pathway from the Biocarta Pathways dataset.
Erythropoietin Gene Set From CTD Gene-Chemical Interactions genes/proteins interacting with the chemical Erythropoietin from the curated CTD Gene-Chemical Interactions dataset.
erythropoietin induced hypertension Gene Set From GAD Gene-Disease Associations genes associated with the disease erythropoietin induced hypertension in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
erythropoietin Gene Set From GAD Gene-Disease Associations genes associated with the disease erythropoietin in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
erythropoietin Gene Set From GeneRIF Biological Term Annotations genes co-occuring with the biological term erythropoietin in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
response to erythropoietin Gene Set From GO Biological Process Annotations 2015 genes participating in the response to erythropoietin biological process from the curated GO Biological Process Annotations 2015 dataset.
erythropoietin-mediated signaling pathway Gene Set From GO Biological Process Annotations 2015 genes participating in the erythropoietin-mediated signaling pathway biological process from the curated GO Biological Process Annotations 2015 dataset.
cellular response to erythropoietin Gene Set From GO Biological Process Annotations 2015 genes participating in the cellular response to erythropoietin biological process from the curated GO Biological Process Annotations 2015 dataset.
erythropoietin receptor binding Gene Set From GO Molecular Function Annotations 2015 genes performing the erythropoietin receptor binding molecular function from the curated GO Molecular Function Annotations 2015 dataset.
erythropoietin receptor activity Gene Set From GO Molecular Function Annotations 2015 genes performing the erythropoietin receptor activity molecular function from the curated GO Molecular Function Annotations 2015 dataset.
Erythropoietin receptor Gene Set From InterPro Predicted Protein Domain Annotations proteins predicted to have the Erythropoietin receptor protein domain from the InterPro Predicted Protein Domain Annotations dataset.
Erythropoietin/thrombopoeitin Gene Set From InterPro Predicted Protein Domain Annotations proteins predicted to have the Erythropoietin/thrombopoeitin protein domain from the InterPro Predicted Protein Domain Annotations dataset.
Erythropoietin/thrombopoeitin, conserved site Gene Set From InterPro Predicted Protein Domain Annotations proteins predicted to have the Erythropoietin/thrombopoeitin, conserved site protein domain from the InterPro Predicted Protein Domain Annotations dataset.
Growth hormone/erythropoietin receptor, ligand binding Gene Set From InterPro Predicted Protein Domain Annotations proteins predicted to have the Growth hormone/erythropoietin receptor, ligand binding protein domain from the InterPro Predicted Protein Domain Annotations dataset.
Erythropoietin Gene Set From InterPro Predicted Protein Domain Annotations proteins predicted to have the Erythropoietin protein domain from the InterPro Predicted Protein Domain Annotations dataset.
increased circulating erythropoietin level Gene Set From MPO Gene-Phenotype Associations gene mutations causing the increased circulating erythropoietin level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.
abnormal circulating erythropoietin level Gene Set From MPO Gene-Phenotype Associations gene mutations causing the abnormal circulating erythropoietin level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.
increased erythropoietin level Gene Set From MPO Gene-Phenotype Associations gene mutations causing the increased erythropoietin level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.
abnormal erythropoietin level Gene Set From MPO Gene-Phenotype Associations gene mutations causing the abnormal erythropoietin level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.
Erythropoietin-Resistant Anemia Gene Set From DisGeNET Gene-Disease Associations genes associated with the disease Erythropoietin-Resistant Anemia in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
Polycythemia Due To Erythropoietin Gene Set From DisGeNET Gene-Disease Associations genes associated with the disease Polycythemia Due To Erythropoietin in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
erythropoietin-mediated signaling pathway Gene Set From GO Biological Process Annotations 2023 genes participating in the erythropoietin-mediated signaling pathway biological process from the curated GO Biological Process Annotations 2023 dataset.
cellular response to erythropoietin Gene Set From GO Biological Process Annotations 2023 genes participating in the cellular response to erythropoietin biological process from the curated GO Biological Process Annotations 2023 dataset.
response to erythropoietin Gene Set From GO Biological Process Annotations 2023 genes participating in the response to erythropoietin biological process from the curated GO Biological Process Annotations 2023 dataset.
erythropoietin receptor binding Gene Set From GO Molecular Function Annotations 2023 genes performing the erythropoietin receptor binding molecular function from the curated GO Molecular Function Annotations 2023 dataset.
erythropoietin receptor activity Gene Set From GO Molecular Function Annotations 2023 genes performing the erythropoietin receptor activity molecular function from the curated GO Molecular Function Annotations 2023 dataset.
increased circulating erythropoietin level Gene Set From MGI Mouse Phenotype Associations 2023 gene mutations causing the increased circulating erythropoietin level phenotype in transgenic mice from the MGI Mouse Phenotype Associations 2023 dataset.
decreased circulating erythropoietin level Gene Set From MGI Mouse Phenotype Associations 2023 gene mutations causing the decreased circulating erythropoietin level phenotype in transgenic mice from the MGI Mouse Phenotype Associations 2023 dataset.
Signaling by Erythropoietin Gene Set From Reactome Pathways 2024 proteins participating in the Signaling by Erythropoietin pathway from the Reactome Pathways 2024 dataset.
erythropoietin-mediated signaling pathway Gene Set From GO Biological Process Annotations 2025 genes participating in the erythropoietin-mediated signaling pathway biological process from the curated GO Biological Process Annotations 2025 dataset.
cellular response to erythropoietin Gene Set From GO Biological Process Annotations 2025 genes participating in the cellular response to erythropoietin biological process from the curated GO Biological Process Annotations 2025 dataset.
response to erythropoietin Gene Set From GO Biological Process Annotations 2025 genes participating in the response to erythropoietin biological process from the curated GO Biological Process Annotations 2025 dataset.
erythropoietin receptor binding Gene Set From GO Molecular Function Annotations 2025 genes performing the erythropoietin receptor binding molecular function from the curated GO Molecular Function Annotations 2025 dataset.
erythropoietin receptor activity Gene Set From GO Molecular Function Annotations 2025 genes performing the erythropoietin receptor activity molecular function from the curated GO Molecular Function Annotations 2025 dataset.
Serum erythropoietin levels Gene Set From GWAS Catalog SNP-Phenotype Associations 2025 genes associated with the Serum erythropoietin levels phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.
Erythropoietin levels Gene Set From GWAS Catalog SNP-Phenotype Associations 2025 genes associated with the Erythropoietin levels phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.
activates Gene Set From GeneRIF Biological Term Annotations genes co-occuring with the biological term activates in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
ATF4 activates genes Gene Set From Reactome Pathways 2014 proteins participating in the ATF4 activates genes pathway from the Reactome Pathways dataset.
ChREBP activates metabolic gene expression Gene Set From Reactome Pathways 2014 proteins participating in the ChREBP activates metabolic gene expression pathway from the Reactome Pathways dataset.
PIP3 activates AKT signaling Gene Set From Reactome Pathways 2014 proteins participating in the PIP3 activates AKT signaling pathway from the Reactome Pathways dataset.
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Gene Set From Reactome Pathways 2014 proteins participating in the Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway from the Reactome Pathways dataset.
TGF-beta receptor signaling activates SMADs Gene Set From Reactome Pathways 2014 proteins participating in the TGF-beta receptor signaling activates SMADs pathway from the Reactome Pathways dataset.
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Gene Set From Reactome Pathways 2014 proteins participating in the LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production pathway from the Reactome Pathways dataset.
XBP1(S) activates chaperone genes Gene Set From Reactome Pathways 2014 proteins participating in the XBP1(S) activates chaperone genes pathway from the Reactome Pathways dataset.
PPARA activates gene expression Gene Set From Reactome Pathways 2014 proteins participating in the PPARA activates gene expression pathway from the Reactome Pathways dataset.
ATF6-alpha activates chaperone genes Gene Set From Reactome Pathways 2014 proteins participating in the ATF6-alpha activates chaperone genes pathway from the Reactome Pathways dataset.
RORA activates circadian gene expression Gene Set From Reactome Pathways 2014 proteins participating in the RORA activates circadian gene expression pathway from the Reactome Pathways dataset.
TAK1 activates NFkB by phosphorylation and activation of IKKs complex Gene Set From Reactome Pathways 2014 proteins participating in the TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway from the Reactome Pathways dataset.
BMAL1:CLOCK,NPAS2 activates circadian gene expression Gene Set From Reactome Pathways 2014 proteins participating in the BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway from the Reactome Pathways dataset.
ATF6-alpha activates chaperones Gene Set From Reactome Pathways 2014 proteins participating in the ATF6-alpha activates chaperones pathway from the Reactome Pathways dataset.
IRE1alpha activates chaperones Gene Set From Reactome Pathways 2014 proteins participating in the IRE1alpha activates chaperones pathway from the Reactome Pathways dataset.
ATF4 activates genes in response to endoplasmic reticulum stress Gene Set From Reactome Pathways 2024 proteins participating in the ATF4 activates genes in response to endoplasmic reticulum stress pathway from the Reactome Pathways 2024 dataset.
ATF6 (ATF6-alpha) activates chaperone genes Gene Set From Reactome Pathways 2024 proteins participating in the ATF6 (ATF6-alpha) activates chaperone genes pathway from the Reactome Pathways 2024 dataset.
ATF6 (ATF6-alpha) activates chaperones Gene Set From Reactome Pathways 2024 proteins participating in the ATF6 (ATF6-alpha) activates chaperones pathway from the Reactome Pathways 2024 dataset.
ATF6B (ATF6-beta) activates chaperones Gene Set From Reactome Pathways 2024 proteins participating in the ATF6B (ATF6-beta) activates chaperones pathway from the Reactome Pathways 2024 dataset.
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Gene Set From Reactome Pathways 2024 proteins participating in the Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway from the Reactome Pathways 2024 dataset.
BDNF activates NTRK2 (TRKB) signaling Gene Set From Reactome Pathways 2024 proteins participating in the BDNF activates NTRK2 (TRKB) signaling pathway from the Reactome Pathways 2024 dataset.
BMAL1:CLOCK,NPAS2 activates circadian gene expression Gene Set From Reactome Pathways 2024 proteins participating in the BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway from the Reactome Pathways 2024 dataset.
Calcineurin activates NFAT Gene Set From Reactome Pathways 2024 proteins participating in the Calcineurin activates NFAT pathway from the Reactome Pathways 2024 dataset.
ChREBP activates metabolic gene expression Gene Set From Reactome Pathways 2024 proteins participating in the ChREBP activates metabolic gene expression pathway from the Reactome Pathways 2024 dataset.
ERBB2 Activates PTK6 Signaling Gene Set From Reactome Pathways 2024 proteins participating in the ERBB2 Activates PTK6 Signaling pathway from the Reactome Pathways 2024 dataset.
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Gene Set From Reactome Pathways 2024 proteins participating in the High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells pathway from the Reactome Pathways 2024 dataset.
IFNG signaling activates MAPKs Gene Set From Reactome Pathways 2024 proteins participating in the IFNG signaling activates MAPKs pathway from the Reactome Pathways 2024 dataset.
IRE1alpha activates chaperones Gene Set From Reactome Pathways 2024 proteins participating in the IRE1alpha activates chaperones pathway from the Reactome Pathways 2024 dataset.
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Gene Set From Reactome Pathways 2024 proteins participating in the LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production pathway from the Reactome Pathways 2024 dataset.
MET activates PTK2 signaling Gene Set From Reactome Pathways 2024 proteins participating in the MET activates PTK2 signaling pathway from the Reactome Pathways 2024 dataset.
MET activates PTPN11 Gene Set From Reactome Pathways 2024 proteins participating in the MET activates PTPN11 pathway from the Reactome Pathways 2024 dataset.
MET activates RAP1 and RAC1 Gene Set From Reactome Pathways 2024 proteins participating in the MET activates RAP1 and RAC1 pathway from the Reactome Pathways 2024 dataset.
MET activates RAS signaling Gene Set From Reactome Pathways 2024 proteins participating in the MET activates RAS signaling pathway from the Reactome Pathways 2024 dataset.
MET activates STAT3 Gene Set From Reactome Pathways 2024 proteins participating in the MET activates STAT3 pathway from the Reactome Pathways 2024 dataset.
MTF1 activates gene expression Gene Set From Reactome Pathways 2024 proteins participating in the MTF1 activates gene expression pathway from the Reactome Pathways 2024 dataset.
NTF3 activates NTRK2 (TRKB) signaling Gene Set From Reactome Pathways 2024 proteins participating in the NTF3 activates NTRK2 (TRKB) signaling pathway from the Reactome Pathways 2024 dataset.
NTF3 activates NTRK3 signaling Gene Set From Reactome Pathways 2024 proteins participating in the NTF3 activates NTRK3 signaling pathway from the Reactome Pathways 2024 dataset.
NTF4 activates NTRK2 (TRKB) signaling Gene Set From Reactome Pathways 2024 proteins participating in the NTF4 activates NTRK2 (TRKB) signaling pathway from the Reactome Pathways 2024 dataset.
NTRK2 activates RAC1 Gene Set From Reactome Pathways 2024 proteins participating in the NTRK2 activates RAC1 pathway from the Reactome Pathways 2024 dataset.
PIP3 activates AKT signaling Gene Set From Reactome Pathways 2024 proteins participating in the PIP3 activates AKT signaling pathway from the Reactome Pathways 2024 dataset.
PPARA activates gene expression Gene Set From Reactome Pathways 2024 proteins participating in the PPARA activates gene expression pathway from the Reactome Pathways 2024 dataset.
PTK6 Activates STAT3 Gene Set From Reactome Pathways 2024 proteins participating in the PTK6 Activates STAT3 pathway from the Reactome Pathways 2024 dataset.
RORA activates gene expression Gene Set From Reactome Pathways 2024 proteins participating in the RORA activates gene expression pathway from the Reactome Pathways 2024 dataset.
SARS-CoV-1 activates/modulates innate immune responses Gene Set From Reactome Pathways 2024 proteins participating in the SARS-CoV-1 activates/modulates innate immune responses pathway from the Reactome Pathways 2024 dataset.
SARS-CoV-2 activates/modulates innate and adaptive immune responses Gene Set From Reactome Pathways 2024 proteins participating in the SARS-CoV-2 activates/modulates innate and adaptive immune responses pathway from the Reactome Pathways 2024 dataset.
TGF-beta receptor signaling activates SMADs Gene Set From Reactome Pathways 2024 proteins participating in the TGF-beta receptor signaling activates SMADs pathway from the Reactome Pathways 2024 dataset.
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Gene Set From Reactome Pathways 2024 proteins participating in the Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells pathway from the Reactome Pathways 2024 dataset.
XBP1(S) activates chaperone genes Gene Set From Reactome Pathways 2024 proteins participating in the XBP1(S) activates chaperone genes pathway from the Reactome Pathways 2024 dataset.
role of pi3k subunit p85 in regulation of actin organization and cell migration Gene Set From Biocarta Pathways proteins participating in the role of pi3k subunit p85 in regulation of actin organization and cell migration pathway from the Biocarta Pathways dataset.
Activated PI3K-delta syndrome Gene Set From ClinVar Gene-Phenotype Associations genes associated with the Activated PI3K-delta syndrome phenotype from the curated ClinVar Gene-Phenotype Associations dataset.
Notch1-p56lck-PI3K complex Gene Set From CORUM Protein Complexes proteins in the Notch1-p56lck-PI3K complex protein complex from the CORUM Protein Complexes dataset.
PDGFRA-PLC-gamma-1-PI3K-SHP-2 complex, PDGF stimulated Gene Set From CORUM Protein Complexes proteins in the PDGFRA-PLC-gamma-1-PI3K-SHP-2 complex, PDGF stimulated protein complex from the CORUM Protein Complexes dataset.
pi3k Gene Set From GeneRIF Biological Term Annotations genes co-occuring with the biological term pi3k in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain Gene Set From InterPro Predicted Protein Domain Annotations proteins predicted to have the Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.
Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain Gene Set From InterPro Predicted Protein Domain Annotations proteins predicted to have the Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.
pi3k Gene Set From Phosphosite Textmining Biological Term Annotations proteins co-occuring with the biological term pi3k in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.
Class I PI3K signaling events mediated by Akt Gene Set From PID Pathways proteins participating in the Class I PI3K signaling events mediated by Akt pathway from the PID Pathways dataset.
Class I PI3K signaling events Gene Set From PID Pathways proteins participating in the Class I PI3K signaling events pathway from the PID Pathways dataset.
Trk receptor signaling mediated by PI3K and PLC-gamma Gene Set From PID Pathways proteins participating in the Trk receptor signaling mediated by PI3K and PLC-gamma pathway from the PID Pathways dataset.
Class IB PI3K non-lipid kinase events Gene Set From PID Pathways proteins participating in the Class IB PI3K non-lipid kinase events pathway from the PID Pathways dataset.
IL2 signaling events mediated by PI3K Gene Set From PID Pathways proteins participating in the IL2 signaling events mediated by PI3K pathway from the PID Pathways dataset.
PI3K/AKT Signaling in Cancer Gene Set From Reactome Pathways 2014 proteins participating in the PI3K/AKT Signaling in Cancer pathway from the Reactome Pathways dataset.
Constitutive PI3K/AKT Signaling in Cancer Gene Set From Reactome Pathways 2014 proteins participating in the Constitutive PI3K/AKT Signaling in Cancer pathway from the Reactome Pathways dataset.
Negative regulation of the PI3K/AKT network Gene Set From Reactome Pathways 2014 proteins participating in the Negative regulation of the PI3K/AKT network pathway from the Reactome Pathways dataset.
CD28 dependent PI3K/Akt signaling Gene Set From Reactome Pathways 2014 proteins participating in the CD28 dependent PI3K/Akt signaling pathway from the Reactome Pathways dataset.
PI3K events in ERBB4 signaling Gene Set From Reactome Pathways 2014 proteins participating in the PI3K events in ERBB4 signaling pathway from the Reactome Pathways dataset.
PI3K Cascade Gene Set From Reactome Pathways 2014 proteins participating in the PI3K Cascade pathway from the Reactome Pathways dataset.
PI3K/AKT activation Gene Set From Reactome Pathways 2014 proteins participating in the PI3K/AKT activation pathway from the Reactome Pathways dataset.
PI3K events in ERBB2 signaling Gene Set From Reactome Pathways 2014 proteins participating in the PI3K events in ERBB2 signaling pathway from the Reactome Pathways dataset.
Activated Pi3K-Delta Syndrome Gene Set From DisGeNET Gene-Disease Associations genes associated with the disease Activated Pi3K-Delta Syndrome in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
PI3K AKT mTOR signaling and therapeutic opportunities in prostate cancer Gene Set From WikiPathways Pathways 2024 proteins participating in the PI3K AKT mTOR signaling and therapeutic opportunities in prostate cancer pathway from the WikiPathways Pathways 2024 dataset.
RIOK1 and RIOK2 in EGFR and PI3K mediated tumorigenesis Gene Set From WikiPathways Pathways 2024 proteins participating in the RIOK1 and RIOK2 in EGFR and PI3K mediated tumorigenesis pathway from the WikiPathways Pathways 2024 dataset.
Focal adhesion PI3K Akt mTOR signaling Gene Set From WikiPathways Pathways 2024 proteins participating in the Focal adhesion PI3K Akt mTOR signaling pathway from the WikiPathways Pathways 2024 dataset.
PI3K AKT mTOR vitamin D3 signaling Gene Set From WikiPathways Pathways 2024 proteins participating in the PI3K AKT mTOR vitamin D3 signaling pathway from the WikiPathways Pathways 2024 dataset.
PI3K Akt signaling Gene Set From WikiPathways Pathways 2024 proteins participating in the PI3K Akt signaling pathway from the WikiPathways Pathways 2024 dataset.
Modulation of PI3K Akt mTOR signaling by bioactive sphingolipids Gene Set From WikiPathways Pathways 2024 proteins participating in the Modulation of PI3K Akt mTOR signaling by bioactive sphingolipids pathway from the WikiPathways Pathways 2024 dataset.
Activated NTRK2 signals through PI3K Gene Set From Reactome Pathways 2024 proteins participating in the Activated NTRK2 signals through PI3K pathway from the Reactome Pathways 2024 dataset.
Activated NTRK3 signals through PI3K Gene Set From Reactome Pathways 2024 proteins participating in the Activated NTRK3 signals through PI3K pathway from the Reactome Pathways 2024 dataset.
CD28 dependent PI3K/Akt signaling Gene Set From Reactome Pathways 2024 proteins participating in the CD28 dependent PI3K/Akt signaling pathway from the Reactome Pathways 2024 dataset.
Constitutive Signaling by Aberrant PI3K in Cancer Gene Set From Reactome Pathways 2024 proteins participating in the Constitutive Signaling by Aberrant PI3K in Cancer pathway from the Reactome Pathways 2024 dataset.
Negative regulation of the PI3K/AKT network Gene Set From Reactome Pathways 2024 proteins participating in the Negative regulation of the PI3K/AKT network pathway from the Reactome Pathways 2024 dataset.
PI3K Cascade Gene Set From Reactome Pathways 2024 proteins participating in the PI3K Cascade pathway from the Reactome Pathways 2024 dataset.
PI3K events in ERBB2 signaling Gene Set From Reactome Pathways 2024 proteins participating in the PI3K events in ERBB2 signaling pathway from the Reactome Pathways 2024 dataset.
PI3K events in ERBB4 signaling Gene Set From Reactome Pathways 2024 proteins participating in the PI3K events in ERBB4 signaling pathway from the Reactome Pathways 2024 dataset.
PI3K/AKT Signaling in Cancer Gene Set From Reactome Pathways 2024 proteins participating in the PI3K/AKT Signaling in Cancer pathway from the Reactome Pathways 2024 dataset.
PI3K/AKT activation Gene Set From Reactome Pathways 2024 proteins participating in the PI3K/AKT activation pathway from the Reactome Pathways 2024 dataset.
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Gene Set From Reactome Pathways 2024 proteins participating in the PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling pathway from the Reactome Pathways 2024 dataset.
Activated PI3K-delta syndrome Gene Set From ClinVar Gene-Phenotype Associations 2025 genes associated with the Activated PI3K-delta syndrome phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
PI3K-Akt signaling pathway Gene Set From KEGG Pathways 2026 proteins participating in the PI3K-Akt signaling pathway pathway from the KEGG Pathways 2026 dataset.
BRAFV600/PI3K INHIBITOR ASN003 Gene Set From DGIdb Drug Targets 2026 interacting proteins for the BRAFV600/PI3K INHIBITOR ASN003 drug from theDGIdb Drug Targets 2026 dataset.
PI3K/BET INHIBITOR LY294002 Gene Set From DGIdb Drug Targets 2026 interacting proteins for the PI3K/BET INHIBITOR LY294002 drug from theDGIdb Drug Targets 2026 dataset.
PI3K-DELTA INHIBITOR AMG 319 Gene Set From DGIdb Drug Targets 2026 interacting proteins for the PI3K-DELTA INHIBITOR AMG 319 drug from theDGIdb Drug Targets 2026 dataset.
PI3K INHIBITOR BGT226 Gene Set From DGIdb Drug Targets 2026 interacting proteins for the PI3K INHIBITOR BGT226 drug from theDGIdb Drug Targets 2026 dataset.
MUTANT-SELECTIVE PI3K-ALPHA H1047R INHIBITOR LOXO-783 Gene Set From DGIdb Drug Targets 2026 interacting proteins for the MUTANT-SELECTIVE PI3K-ALPHA H1047R INHIBITOR LOXO-783 drug from theDGIdb Drug Targets 2026 dataset.
MUTANT-SELECTIVE PI3K-ALPHA H1047R INHIBITOR OKI-219 Gene Set From DGIdb Drug Targets 2026 interacting proteins for the MUTANT-SELECTIVE PI3K-ALPHA H1047R INHIBITOR OKI-219 drug from theDGIdb Drug Targets 2026 dataset.
PI3K ALPHA/BETA INHIBITOR BAY1082439 Gene Set From DGIdb Drug Targets 2026 interacting proteins for the PI3K ALPHA/BETA INHIBITOR BAY1082439 drug from theDGIdb Drug Targets 2026 dataset.
PI3K-ALPHA INHIBITOR HS-10352 Gene Set From DGIdb Drug Targets 2026 interacting proteins for the PI3K-ALPHA INHIBITOR HS-10352 drug from theDGIdb Drug Targets 2026 dataset.
PI3K-ALPHA INHIBITOR TOS-358 Gene Set From DGIdb Drug Targets 2026 interacting proteins for the PI3K-ALPHA INHIBITOR TOS-358 drug from theDGIdb Drug Targets 2026 dataset.
PI3K/MTOR KINASE INHIBITOR WXFL10030390 Gene Set From DGIdb Drug Targets 2026 interacting proteins for the PI3K/MTOR KINASE INHIBITOR WXFL10030390 drug from theDGIdb Drug Targets 2026 dataset.
PAN-PI3K INHIBITOR CLR457 Gene Set From DGIdb Drug Targets 2026 interacting proteins for the PAN-PI3K INHIBITOR CLR457 drug from theDGIdb Drug Targets 2026 dataset.
PI3K P110BETA/DELTA INHIBITOR CVL237 Gene Set From DGIdb Drug Targets 2026 interacting proteins for the PI3K P110BETA/DELTA INHIBITOR CVL237 drug from theDGIdb Drug Targets 2026 dataset.

Harmonizome 3.0

EPOR Gene

EPO Gene

TPTE2 Gene

LOC100422687 Gene

WIPI2 Gene

WIPI1 Gene

FIG4 Gene

TPTE2P5 Gene

PLEKHA4 Gene

PLEKHA1 Gene

PLCB1 Gene

PIRT Gene

TPTE2P2 Gene

TPTE2P3 Gene

TPTE2P1 Gene

TPTE2P6 Gene

TPTE2P4 Gene

PLEKHA2 Gene

PLEKHA3 Gene

PLEKHA8 Gene

Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Gene Set

Erythropoietin activates Phospholipase C gamma (PLCG) Gene Set

Erythropoietin activates RAS Gene Set

Erythropoietin activates STAT5 Gene Set

MET activates PI3K/AKT signaling Gene Set

phosphoinositide Gene Set

3-phosphoinositide degradation Gene Set

3-phosphoinositide biosynthesis Gene Set

Phosphoinositide phospholipase C family Gene Set

Phosphoinositide-interacting protein Gene Set

Phosphoinositide-binding clathrin adaptor, domain 2 Gene Set

phosphoinositide Gene Set

erythropoietin mediated neuroprotection through nf-kb Gene Set

Erythropoietin Gene Set

erythropoietin induced hypertension Gene Set

erythropoietin Gene Set

erythropoietin Gene Set

response to erythropoietin Gene Set

erythropoietin-mediated signaling pathway Gene Set

cellular response to erythropoietin Gene Set

erythropoietin receptor binding Gene Set

erythropoietin receptor activity Gene Set

Erythropoietin receptor Gene Set

Erythropoietin/thrombopoeitin Gene Set

Erythropoietin/thrombopoeitin, conserved site Gene Set

Growth hormone/erythropoietin receptor, ligand binding Gene Set

Erythropoietin Gene Set

increased circulating erythropoietin level Gene Set

abnormal circulating erythropoietin level Gene Set

increased erythropoietin level Gene Set

abnormal erythropoietin level Gene Set

Erythropoietin-Resistant Anemia Gene Set

Polycythemia Due To Erythropoietin Gene Set

erythropoietin-mediated signaling pathway Gene Set

cellular response to erythropoietin Gene Set

response to erythropoietin Gene Set

erythropoietin receptor binding Gene Set

erythropoietin receptor activity Gene Set

increased circulating erythropoietin level Gene Set

decreased circulating erythropoietin level Gene Set

Signaling by Erythropoietin Gene Set

erythropoietin-mediated signaling pathway Gene Set

cellular response to erythropoietin Gene Set

response to erythropoietin Gene Set

erythropoietin receptor binding Gene Set

erythropoietin receptor activity Gene Set

Serum erythropoietin levels Gene Set

Erythropoietin levels Gene Set

activates Gene Set

ATF4 activates genes Gene Set

ChREBP activates metabolic gene expression Gene Set

PIP3 activates AKT signaling Gene Set

Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Gene Set

TGF-beta receptor signaling activates SMADs Gene Set

LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Gene Set

XBP1(S) activates chaperone genes Gene Set

PPARA activates gene expression Gene Set

ATF6-alpha activates chaperone genes Gene Set

RORA activates circadian gene expression Gene Set