Harmonizome 3.0

endogenous retrovirus group K member 8 Gag polyprotein-like

endogenous retrovirus group W, member 28

endogenous retrovirus group V, member 1

Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on human chromosome 19 that has inactivating mutations in the gag and pol genes. The gene's envelope protein is expressed in the human placenta but is truncated at its C-terminus. [provided by RefSeq, Oct 2015]

endogenous retrovirus group V, member 2

Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on human chromosome 19 that has inactivating mutations in the gag and pol genes. This envelope glycoprotein gene appears to have been selectively preserved. The gene's protein product is expressed in the placenta and acts as a syncytin in Old World monkeys, but has lost the fusogenic activity in humans and other primate lineages. [provided by RefSeq, Jun 2015]

endogenous retrovirus group H, member 2

endogenous retrovirus group H, member 3

endogenous retrovirus group H, member 1

endogenous retrovirus group H, member 6

endogenous retrovirus group H, member 4

endogenous retrovirus group H, member 5

endogenous retrovirus group E, member 3

endogenous retrovirus group E, member 1

endogenous retrovirus group E, member 4

endogenous retrovirus group S71 member 1 Env polyprotein

endogenous retrovirus group K, member 19

endogenous retrovirus group K, member 18

endogenous retrovirus group K, member 14

endogenous retrovirus group K, member 17

endogenous retrovirus group K, member 11

endogenous retrovirus group K, member 13

endogenous retrovirus group K, member 12

endogenous retrovirus group MER61, member 1

apelin receptor early endogenous ligand

This gene encodes a peptide hormone that binds to the Apelin receptor. The encoded protein is required for heart development in zebrafish and has been shown to maintain self-renewal of human embryonic stem cells through activation of the PI3K/AKT pathway. Experiments in human and mouse cell lines point to additional roles for the encoded protein in angiogenesis and regulation of vascular tone. [provided by RefSeq, Jul 2016]

endogenous retrovirus group I, member 1

endogenous retrovirus group K member 19 Pol protein

endogenous Bornavirus-like nucleoprotein 1

endogenous Bornavirus-like nucleoprotein 2

endogenous retrovirus group 18, member 1

endogenous retrovirus group K member 11 Pol protein

endogenous retrovirus group K member 25 Pol protein-like

endogenous retrovirus group PABLB, member 1

endogenous retrovirus group 9, member 1

endogenous Bornavirus-like nucleoprotein 3

endogenous retrovirus group 3, member 1 pseudogene

endogenous retrovirus group 3, member 1 pseudogene

simian sarcoma-associated virus 1/gibbon ape leukemia virus-related endogenous retroviral element 1

endogenous retrovirus group S71, member 1

endogenous retrovirus group H, member 7

endogenous retrovirus group K, member 20

endogenous retrovirus group K, member 21

endogenous retrovirus group K, member 22

endogenous retrovirus group K, member 23

endogenous retrovirus group K, member 24

endogenous retrovirus group K, member 26

endogenous retrovirus group E, member 2

endogenous retrovirus group V member 2 Env polyprotein-like

endogenous retrovirus group K member 5 Gag polyprotein

endogenous retrovirus group FC1, member 1

endogenous retrovirus group K, member 9

endogenous retrovirus group K, member 8

endogenous retrovirus group K, member 1

endogenous retrovirus group K, member 3

endogenous retrovirus group K, member 5

Predicted to enable nucleic acid binding activity; structural molecule activity; and zinc ion binding activity. Predicted to be involved in viral translational frameshifting. Predicted to be located in nucleus and plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

endogenous retrovirus group K, member 4

endogenous retrovirus group K, member 7

Predicted to enable RNA stem-loop binding activity. Predicted to be involved in DNA metabolic process; proteolysis; and viral translational frameshifting. Predicted to be located in nucleus and plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

endogenous retrovirus group K, member 6

Enables RNA stem-loop binding activity and protein homodimerization activity. Involved in mRNA export from nucleus; positive regulation of gene expression; and protein homooligomerization. Located in cytoplasm and nucleolus. Part of protein-containing complex. [provided by Alliance of Genome Resources, Mar 2025]

endogenous retrovirus group FH21, member 1

endogenous retrovirus group K3, member 3

endogenous retrovirus group K3, member 2

endogenous retrovirus group K3, member 1

endogenous retrovirus group K3, member 6

endogenous retrovirus group K3, member 8

endogenous retrovirus group K, member 15

endogenous retrovirus group K, member 16

endogenous retrovirus group K13, member 1

Predicted to enable structural molecule activity. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

endogenous retrovirus group K11, member 1

endogenous retrovirus group 3, member 1

This gene contains sequence derived from endogenous retrovirus, and is therefore similar to multiple other loci in the genome. Transcripts at this locus encode a conserved protein with a predicted signal peptide and similarity to the Env polyprotein. This protein is overexpressed in colorectal and other cancers. [provided by RefSeq, Jan 2017]

endogenous retrovirus group 3, member 2

endogenous retrovirus group S71, member 2

endogenous retrovirus group K member 7 Env polyprotein-like

endogenous retrovirus group K, member 2

endogenous retrovirus group K member 25 Env polyprotein-like

endogenous retrovirus group K3, member 4

endogenous retrovirus group MER34, member 1

Predicted to be located in extracellular region and plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

endogenous retrovirus group FRD, member 1

Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of a human endogenous retrovirus provirus on chromosome 6 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product plays a major role in placental development and trophoblast fusion. The protein has the characteristics of a typical retroviral envelope protein, including a cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. [provided by RefSeq, Jun 2012]

endogenous retrovirus group FRD, member 2

endogenous retrovirus group FRD, member 3

endogenous retrovirus group 48, member 1

Many different endogenous retrovirus families are expressed in normal placental tissue at high levels, suggesting that endogenous retroviruses are functionally important in reproduction. This gene is part of an endogenous retrovirus provirus that has placenta specific expression. The protein encoded has the characteristics of a retroviral envelope protein but is truncated and lacks the transmembrane domain. The protein inhibits cell fusion by competing with syncytin-1 for binding to a cell receptor. [provided by RefSeq, May 2015]

endogenous retrovirus group FC1 Env polyprotein

endogenous retrovirus group K, member 10

HTLV-1 related endogenous sequence 2

HTLV-1 related endogenous sequence

endogenous retrovirus group K, member 25

endogenous retrovirus group K3, member 7

endogenous retrovirus group K3, member 5

endogenous retrovirus group K member 8 Pol protein-like

endogenous retrovirus group W, member 4

endogenous retrovirus group W, member 5

endogenous retrovirus group W, member 6

endogenous retrovirus group W, member 1

Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on chromosome 7 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product is expressed in the placental syncytiotrophoblast and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the placenta. The protein has the characteristics of a typical retroviral envelope protein, including a furin cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010]

endogenous retrovirus group W, member 3

endogenous retrovirus group W, member 2

endogenous retrovirus group FC1 Env polyprotein

cytoplasmic endogenous regulator of oxidative phosphorylation 1

competing endogenous lncRNA 1 for miR-4707-5p and miR-4767

endogenous Bornavirus like nucleoprotein 3, pseudogene

endogenous retrovirus group K member 18 Env polyprotein

melanoma highly expressed competing endogenous lncRNA for miR-425 and miR-489

endogenous retrovirus group K member 7 Env polyprotein-like

From Reactome Pathways 2014

proteins participating in the Endogenous sterols pathway from the Reactome Pathways dataset.

From Reactome Pathways 2024

proteins participating in the Endogenous sterols pathway from the Reactome Pathways 2024 dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Sterols from the curated CTD Gene-Chemical Interactions dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term sterols in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Reactome Pathways 2014

proteins participating in the Trafficking of dietary sterols pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Sterols are 12-hydroxylated by CYP8B1 pathway from the Reactome Pathways dataset.

From Reactome Pathways 2024

proteins participating in the Sterols are 12-hydroxylated by CYP8B1 pathway from the Reactome Pathways 2024 dataset.

From Biocarta Pathways

proteins participating in the metabolism of anandamide an endogenous cannabinoid pathway from the Biocarta Pathways dataset.

From DISEASES Text-mining Gene-Disease Association Evidence Scores

genes co-occuring with the disease endogenous depression in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

From GAD Gene-Disease Associations

genes associated with the disease endogenous hypertriglyceridemia and familial hypercholesterolemia in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

From GAD Gene-Disease Associations

genes associated with the disease endogenous psychoses in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

From GAD Gene-Disease Associations

genes associated with the disease juvenile endogenous attack-like psychoses in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term endogenous in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GO Biological Process Annotations 2015

genes participating in the antigen processing and presentation, endogenous lipid antigen via mhc class ib biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Biological Process Annotations 2015

genes participating in the antigen processing and presentation of endogenous peptide antigen biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Biological Process Annotations 2015

genes participating in the antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Biological Process Annotations 2015

genes participating in the response to endogenous stimulus biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Biological Process Annotations 2015

genes participating in the antigen processing and presentation of endogenous peptide antigen via mhc class ib biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Biological Process Annotations 2015

genes participating in the detection of endogenous stimulus biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Biological Process Annotations 2015

genes participating in the antigen processing and presentation of endogenous antigen biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Biological Process Annotations 2015

genes participating in the antigen processing and presentation of endogenous peptide antigen via mhc class ib via er pathway, tap-dependent biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Biological Process Annotations 2015

genes participating in the antigen processing and presentation of endogenous peptide antigen via mhc class ib via er pathway biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Biological Process Annotations 2015

genes participating in the antigen processing and presentation of endogenous peptide antigen via mhc class i biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Biological Process Annotations 2015

genes participating in the antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway, tap-dependent biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Biological Process Annotations 2015

genes participating in the cellular response to endogenous stimulus biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Molecular Function Annotations 2015

genes performing the endogenous lipid antigen binding molecular function from the curated GO Molecular Function Annotations 2015 dataset.

From GWASdb SNP-Disease Associations

genes associated with the disease endogenous depression in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Endogenous retrovirus receptor protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From MPO Gene-Phenotype Associations

gene mutations causing the abnormal response/metabolism to endogenous compounds phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

From PID Pathways

proteins participating in the Endogenous TLR signaling pathway from the PID Pathways dataset.

From TISSUES Text-mining Tissue Protein Expression Evidence Scores

proteins co-occuring with the tissue endogenous progenitor cell in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.

From DisGeNET Gene-Disease Associations

genes associated with the disease Endogenous Depression in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

From DisGeNET Gene-Disease Associations

genes associated with the disease Endogenous Hyperinsulinism in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

From DisGeNET Gene-Disease Associations

genes associated with the disease Endogenous Endophthalmitis in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

From GO Biological Process Annotations 2023

genes participating in the antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the antigen processing and presentation of endogenous peptide antigen via MHC class II biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the antigen processing and presentation of endogenous peptide antigen via MHC class I biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the antigen processing and presentation of endogenous peptide antigen via MHC class Ib biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the antigen processing and presentation, endogenous lipid antigen via MHC class Ib biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the antigen processing and presentation of endogenous peptide antigen biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Molecular Function Annotations 2023

genes performing the endogenous lipid antigen binding molecular function from the curated GO Molecular Function Annotations 2023 dataset.

From MGI Mouse Phenotype Associations 2023

gene mutations causing the abnormal response/metabolism to endogenous compounds phenotype in transgenic mice from the MGI Mouse Phenotype Associations 2023 dataset.

From Reactome Pathways 2024

proteins participating in the Competing endogenous RNAs (ceRNAs) regulate PTEN translation pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Defective regulation of TLR7 by endogenous ligand pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Regulation of TLR by endogenous ligand pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Regulation of endogenous retroelements pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Regulation of endogenous retroelements by KRAB-ZFP proteins pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex pathway from the Reactome Pathways 2024 dataset.

From GO Biological Process Annotations 2025

genes participating in the antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Biological Process Annotations 2025

genes participating in the antigen processing and presentation of endogenous peptide antigen via MHC class II biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Biological Process Annotations 2025

genes participating in the antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Biological Process Annotations 2025

genes participating in the antigen processing and presentation of endogenous peptide antigen via MHC class I biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Biological Process Annotations 2025

genes participating in the antigen processing and presentation of endogenous peptide antigen via MHC class Ib biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Biological Process Annotations 2025

genes participating in the antigen processing and presentation, endogenous lipid antigen via MHC class Ib biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Biological Process Annotations 2025

genes participating in the antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Biological Process Annotations 2025

genes participating in the negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Biological Process Annotations 2025

genes participating in the antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Biological Process Annotations 2025

genes participating in the antigen processing and presentation of endogenous peptide antigen biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Biological Process Annotations 2025

genes participating in the antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Biological Process Annotations 2025

genes participating in the regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Molecular Function Annotations 2025

genes performing the endogenous lipid antigen binding molecular function from the curated GO Molecular Function Annotations 2025 dataset.

From TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025

proteins co-occuring with the tissue Endogenous progenitor cell in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the APELIN RECEPTOR EARLY ENDOGENOUS LIGAND drug from theDGIdb Drug Targets 2026 dataset.