Harmonizome 3.0

SID1 transmembrane family, member 1

The protein encoded by this gene belongs to SID1 family of transmembrane dsRNA-gated channels. Family members transport dsRNA into cells and are required for systemic RNA interference. [provided by RefSeq, May 2017]

SID1 transmembrane family, member 2

Predicted to enable several functions, including AP-1 adaptor complex binding activity; AP-2 adaptor complex binding activity; and RNA transmembrane transporter activity. Involved in RNA transport. Located in lysosomal membrane and plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane epididymal protein 1 pseudogene

transmembrane protein 200B

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 160

Located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 163

Predicted to enable zinc ion binding activity. Involved in myelination and zinc export across plasma membrane. Predicted to be located in early endosome membrane. Predicted to be active in plasma membrane and synaptic vesicle membrane. Implicated in hypomyelinating leukodystrophy 25. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 165

This gene encodes a predicted transmembrane protein with a perinuclear Golgi-like distribution in fibroblasts. Mutations in this gene are associated with the autosomal recessive disorder congenital disorder of glycosylation, type IIk. Knockdown of this gene's expression causes decreased sialylation in HEK cells and suggests this gene plays a role in terminal Golgi glycosylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

transmembrane protein 164

Involved in positive regulation of ferroptosis. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 168

Enables sodium channel regulator activity. Predicted to act upstream of or within regulation of ubiquitin-dependent protein catabolic process and regulation of voltage-gated sodium channel activity. Located in nuclear membrane and transport vesicle. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 255B

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 255A

Predicted to act upstream of or within response to bacterium. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 167A pseudogene 1

transmembrane protein 92 pseudogene

transmembrane protein 98 pseudogene

growth hormone inducible transmembrane protein

Enables calcium:proton antiporter activity. Involved in calcium export from the mitochondrion; inner mitochondrial membrane organization; and negative regulation of release of cytochrome c from mitochondria. Located in endoplasmic reticulum membrane and mitochondrial inner membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane channel-like 5

Predicted to enable mechanosensitive monoatomic ion channel activity. Predicted to be involved in monoatomic ion transmembrane transport. Located in extracellular exosome. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane 4 L six family member 18

Predicted to be active in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane 4 L six family member 19

The protein encoded by this gene is a member of the four-transmembrane L6 superfamily. Members of this family function in various cellular processes including cell proliferation, motility, and adhesion via their interactions with integrins. In human brain tissue, this gene is expressed at high levels in the parietal lobe, occipital lobe, hippocampus, pons, white matter, corpus callosum, and cerebellum. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2017]

interferon induced transmembrane protein 3 pseudogene

calmin (calponin-like, transmembrane)

Predicted to enable actin filament binding activity. Predicted to be involved in negative regulation of cell population proliferation and nuclear migration. Predicted to act upstream of or within neuron projection development. Predicted to be located in membrane. Predicted to be part of meiotic nuclear membrane microtubule tethering complex. Predicted to be active in cytoplasm and nuclear outer membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 98 pseudogene

transmembrane protein C9orf144B pseudogene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 258

Predicted to enable oligosaccharyltransferase complex binding activity. Involved in protein N-linked glycosylation. Located in endoplasmic reticulum and membrane. Part of oligosaccharyltransferase complex. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 257

This intronless gene is expressed in the hippocampus and maps close to a candidate region for several X-linked mental retardation (XLMR) syndromes. It is conserved in primates, cow, and horse, but not found in mouse and rat. The exact function of this gene is not known, but on the basis of its physical location and expression pattern, it is proposed to have an important function in the brain. [provided by RefSeq, Jan 2010]

transmembrane protein 256

Located in extracellular exosome and mitochondrion. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 254

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 253

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 252

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 251

Involved in lysosomal transport; lysosome organization; and regulation of vesicle-mediated transport. Located in Golgi cisterna. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane and ubiquitin-like domain containing 1

Involved in ERAD pathway. Predicted to be located in several cellular components, including centrosome; postsynaptic membrane; and recycling endosome. Predicted to be active in postsynaptic recycling endosome membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane and ubiquitin-like domain containing 2

Predicted to be involved in ERAD pathway. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

fibronectin leucine rich transmembrane protein 1

This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. The family members may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. The encoded protein shares sequence similarity with two other family members, FLRT2 and FLRT3. This gene is expressed in kidney and brain. [provided by RefSeq, Jul 2008]

fibronectin leucine rich transmembrane protein 3

This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. FLRTs may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. This gene is expressed in many tissues. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2010]

fibronectin leucine rich transmembrane protein 2

This gene encodes a member of the fibronectin leucine rich transmembrane (FLRT) family of cell adhesion molecules, which regulate early embryonic vascular and neural development. The encoded type I transmembrane protein has an extracellular region consisting of an N-terminal leucine-rich repeat domain and a type 3 fibronectin domain, followed by a transmembrane domain and a short C-terminal cytoplasmic tail domain. It functions as both a homophilic cell adhesion molecule and a heterophilic chemorepellent through its interaction with members of the uncoordinated-5 receptor family. Proteolytic removal of the extracellular region controls the migration of neurons in the developing cortex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

interferon induced transmembrane protein 8 pseudogene

transmembrane protein with metallophosphoesterase domain

Predicted to enable hydrolase activity and metal ion binding activity. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 192 pseudogene

transmembrane protein 247

Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 241

Enables UDP-N-acetylglucosamine transmembrane transporter activity. Involved in UDP-N-acetylglucosamine transmembrane transport. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 242

Involved in mitochondrial proton-transporting ATP synthase complex assembly. Located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Mar 2025]

POM121 transmembrane nucleoporin-like 4 pseudogene

transmembrane protein 185B

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 185A

The protein encoded by this gene is predicted to be a transmembrane protein. This gene is best known for localizing to the CpG island of the fragile site FRAXF. The 5' untranslated region of this gene contains a CGG trinucleotide repeat sequence that normally consists of 7-40 tandem CGG repeats but which can expand to greater than 300 repeats. Methylation of the CpG island leads to transcriptional silencing of this gene, but neither the silencing nor an expanded repeat region appear to manifest itself in a clear phenotypic manner. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome. [provided by RefSeq, Aug 2013]

osteopetrosis associated transmembrane protein 1

This gene encodes a protein that may be involved in the degradation of G proteins via the ubiquitin-dependent proteasome pathway. The encoded protein binds to members of subfamily A of the regulator of the G-protein signaling (RGS) family through an N-terminal leucine-rich region. This protein also has a central RING finger-like domain and E3 ubiquitin ligase activity. This protein is highly conserved from flies to humans. Defects in this gene may cause the autosomal recessive, infantile malignant form of osteopetrosis. [provided by RefSeq, Jul 2008]

transmembrane protein 37

Predicted to enable calcium channel activity and voltage-gated monoatomic ion channel activity. Predicted to be involved in calcium ion transmembrane transport. Predicted to be located in membrane. Predicted to be part of monoatomic ion channel complex. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 31

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 33

Involved in positive regulation of endoplasmic reticulum unfolded protein response; regulation of endoplasmic reticulum tubular network organization; and response to endoplasmic reticulum stress. Located in endoplasmic reticulum membrane; melanosome; and nuclear envelope. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 169

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane phosphoinositide 3-phosphatase and tensin homolog 2

TPIP is a member of a large class of membrane-associated phosphatases with substrate specificity for the 3-position phosphate of inositol phospholipids.[supplied by OMIM, Jul 2002]

transmembrane and coiled-coil domain family 1 pseudogene 1

transmembrane and tetratricopeptide repeat containing 2

The protein encoded by this gene is an integral membrane protein localized to the endoplasmic reticulum (ER). The encoded protein contains many tetratricopeptide repeats, sequences known for being involved in protein-protein interactions. This protein binds both the calcium uptake pump SERCA2B and the carbohydrate-binding chaperone calnexin, and it appears to play a role in calcium homeostasis in the ER. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

transmembrane anterior posterior transformation 1

This gene encodes a highly conserved protein that localizes to the centrosome and/or ciliary basal body. Mutations in this gene disrupt Golgi morphology and trafficking and normal primary cilium formation and these mutations are congenitally manifested by severe undermineralization of the intra-uterine skeleton. A mutation in the mouse ortholog of this gene results in homeotic, posterior-to-anterior transformations of the axial skeleton which are similar to the phenotype of mouse homeobox C8 gene mutants. In mouse, this gene is thought to function downstream of homeobox C8 to transduce extracellular patterning information during axial skeleton development. [provided by RefSeq, Jan 2017]

transmembrane protein 225-like

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

amnion associated transmembrane protein

The protein encoded by this gene is a type I transmembrane protein. It is thought to modulate bone morphogenetic protein (BMP) receptor function by serving as an accessory or coreceptor, and thus facilitates or hinders BMP binding. It is known that the mouse AMN gene is expressed in the extraembryonic visceral endoderm layer during gastrulation, but it is found to be mutated in amnionless mouse. The encoded protein has sequence similarity to short gastrulation (Sog) and procollagen IIA proteins in Drosophila. [provided by RefSeq, Jul 2008]

transmembrane channel-like 6 pseudogene

transmembrane protein 178B

Predicted to be active in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 38B pseudogene

V-set and transmembrane domain containing 5

Predicted to be involved in several processes, including filopodium assembly; positive regulation of excitatory synapse assembly; and protein homooligomerization. Predicted to be located in membrane. Predicted to be active in axon; dendrite; and plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

V-set and transmembrane domain containing 4

Predicted to act upstream of or within several processes, including endothelial cell proliferation; retina blood vessel maintenance; and vasculature development. Predicted to be located in extracellular region and plasma membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Mar 2025]

V-set and transmembrane domain containing 1

Predicted to enable cytokine activity. Predicted to be involved in immune response-regulating signaling pathway. Predicted to be located in extracellular space and membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

proline-rich transmembrane protein 1-like

Predicted to be active in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane and tetratricopeptide repeat containing 1 pseudogene

Lck interacting transmembrane adaptor 1

This gene encodes a transmembrane adaptor protein that links the T and B-cell receptor stimulation to downstream signaling pathways via its association with the Src family kinases Lck and Lyn, respectively. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Mar 2015]

interferon induced transmembrane protein 3 pseudogene

interferon induced transmembrane protein 5

This gene encodes a membrane protein thought to play a role in bone mineralization. This gene is located on chromosome 11 in a cluster of related genes which are induced by interferon, however, this gene has not been shown to be interferon inducible. A similar gene, located in a gene cluster on mouse chromosome 7, is a member of the interferon-inducible fragilis gene family. The mouse gene encodes a transmembrane protein described as participating in germ cell competence. A mutation in the 5' UTR of this gene has been associated with osteogenesis imperfecta type V (PMID: 22863190, 22863195). [provided by RefSeq, Aug 2012]

transmembrane protein 133

There is evidence that this intronless gene is transcribed but the protein is predicted. The gene function is unknown. [provided by RefSeq, Jul 2008]

transmembrane protein 130

Located in Golgi apparatus. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 131

Enables collagen binding activity. Involved in collagen biosynthetic process. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 136

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 134

Located in cytosol and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 135

Predicted to be involved in peroxisome organization. Predicted to act upstream of or within several processes, including regulation of oxidative phosphorylation; response to food; and retinal pigment epithelium development. Predicted to be located in peroxisome. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 138

This gene encodes a multi-pass transmembrane protein. Reduced expression of this gene in mouse fibroblasts causes short cilia and failure of ciliogenesis. Expression of this gene is tightly coordinated with expression of the neighboring gene TMEM216. Mutations in this gene are associated with the autosomal recessive neurodevelopmental disorder Joubert Syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]

transmembrane protein 139

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 183A pseudogene

transmembrane BAX inhibitor motif containing 6

Enables endoribonuclease inhibitor activity and ubiquitin protein ligase binding activity. Involved in several processes, including negative regulation of intrinsic apoptotic signaling pathway; negative regulation of macromolecule metabolic process; and response to L-glutamate. Acts upstream of or within negative regulation of calcium ion transport into cytosol. Located in endoplasmic reticulum membrane. Biomarker of cervical squamous cell carcinoma and prostate carcinoma. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane BAX inhibitor motif containing 4

Predicted to enable calcium channel activity. Involved in negative regulation of apoptotic process and regulation of calcium-mediated signaling. Located in Golgi stack and endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane BAX inhibitor motif containing 1

Enables death receptor binding activity. Involved in negative regulation of Fas signaling pathway; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; and negative regulation of protein localization to plasma membrane. Located in Golgi membrane; endosome membrane; and lysosomal membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein with EGF-like and two follistatin-like domains 1

Enables receptor ligand inhibitor activity. Involved in negative regulation of viral entry into host cell. Is active in plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein with EGF-like and two follistatin-like domains 2

This gene encodes a member of the tomoregulin family of transmembrane proteins. This protein has been shown to function as both an oncogene and a tumor suppressor depending on the cellular context and may regulate prostate cancer cell invasion. Multiple soluble forms of this protein have been identified that arise from both an alternative splice variant and ectodomain shedding. Additionally, this gene has been found to be hypermethylated in multiple cancer types. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

transmembrane protein 69 pseudogene

transmembrane protein 50B

Predicted to be involved in late endosome to vacuole transport via multivesicular body sorting pathway. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 50A

This gene is located in the RH gene locus, between the RHD and RHCE genes. The function of its protein product is unknown; however, its sequence has potential transmembrane domains suggesting that it may be an integral membrane protein. Its position between the RH genes suggests that polymorphisms in this gene may be tightly linked to RH haplotypes and may contribute to selective pressure for or against certain RH haplotypes. [provided by RefSeq, Jul 2008]

transmembrane emp24 protein transport domain containing 7

Predicted to be involved in Golgi organization; endoplasmic reticulum to Golgi vesicle-mediated transport; and intracellular protein transport. Located in Golgi apparatus; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane emp24 protein transport domain containing 6

Predicted to be involved in Golgi organization; endoplasmic reticulum to Golgi vesicle-mediated transport; and intracellular protein transport. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in several cellular components, including COPII-coated ER to Golgi transport vesicle; Golgi apparatus; and endoplasmic reticulum-Golgi intermediate compartment. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane emp24 protein transport domain containing 5

Involved in Golgi ribbon formation. Located in cis-Golgi network; endoplasmic reticulum exit site; and endoplasmic reticulum-Golgi intermediate compartment. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane emp24 protein transport domain containing 4

Involved in positive regulation of canonical NF-kappaB signal transduction. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in several cellular components, including COPII-coated ER to Golgi transport vesicle; Golgi apparatus; and endoplasmic reticulum-Golgi intermediate compartment. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane emp24 protein transport domain containing 3

Predicted to be involved in Golgi organization; endoplasmic reticulum to Golgi vesicle-mediated transport; and intracellular protein transport. Located in Golgi apparatus; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane emp24 domain trafficking protein 2

Predicted to enable frizzled binding activity and smoothened binding activity. Involved in several processes, including Golgi organization; negative regulation of GTPase activity; and protein localization to plasma membrane. Located in Golgi apparatus; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane emp24 protein transport domain containing 1

This gene belongs to the TMED (transmembrane emp24 domain-containing) protein family, which is involved in the vesicular trafficking of proteins. The protein encoded by this gene was identified by its interaction with interleukin 1 receptor-like 1 (IL1RL1) and may play a role in innate immunity. This protein lacks any similarity to other interleukin 1 ligands. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

transmembrane emp24 protein transport domain containing 9

This gene is a member of a family of genes encoding transport proteins located in the endoplasmic reticulum and the Golgi. A similar gene in mouse is the target of microRNA miR-296, which is part of an imprinted cluster. [provided by RefSeq, Jul 2016]

transmembrane emp24 protein transport domain containing 8

plasminogen receptor, C-terminal lysine transmembrane protein

Predicted to be involved in positive regulation of plasminogen activation. Located in mitochondrion. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 160 pseudogene

POM121 transmembrane nucleoporin-like 9, pseudogene

This locus is inferred to be a transcribed pseudogene based on the observation that protein homology is limited to the first of seven exons (indicated by alignment of AL117401.1 to the assembled human genome). This pattern suggests rapid turnover by the nonsense-mediated decay pathway. [provided by RefSeq, Jul 2008]

transmembrane emp24-like trafficking protein 10 (yeast) pseudogene 1

transmembrane emp24-like trafficking protein 10 (yeast) pseudogene 2

transmembrane protein 201

Predicted to enable actin filament binding activity and lamin binding activity. Involved in centrosome localization; nuclear envelope organization; and protein localization to nuclear envelope. Located in cortical endoplasmic reticulum; nuclear inner membrane; and spindle pole centrosome. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 202

Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 203

Involved in intracellular calcium ion homeostasis. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 204

C16ORF30 plays a role in cell adhesion and cellular permeability at adherens junctions (Kearsey et al., 2004 [PubMed 15206924]).[supplied by OMIM, Mar 2008]

transmembrane protein 205

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 206

Enables pH-gated chloride channel activity. Involved in chloride transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 207

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 208

This gene encodes a highly conserved protein which is localized in the endoplasmic reticulum (ER). The protein is linked to autophagy and ER stress. Knockdown of this gene increased autophagy and triggered ER stress. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

transmembrane protein 209

Predicted to be located in Golgi apparatus and nuclear envelope. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 65

Predicted to be involved in cardiac conduction; cardiac ventricle development; and regulation of cardiac conduction. Located in intercalated disc; mitochondrial inner membrane; and plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 64

Predicted to be involved in several processes, including negative regulation of canonical Wnt signaling pathway; negative regulation of osteoblast differentiation; and positive regulation of cell differentiation. Predicted to act upstream of or within regulation of ATP-dependent activity. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 62

Predicted to enable hydrolase activity. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 61

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 60

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 69

Located in mitochondrion. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 68

Enables phospholipid:diacylglycerol acyltransferase activity. Involved in triglyceride biosynthetic process. Is active in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 258 pseudogene

transmembrane protein 67

The protein encoded by this gene localizes to the primary cilium and to the plasma membrane. The gene functions in centriole migration to the apical membrane and formation of the primary cilium. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Meckel syndrome type 3 (MKS3) and Joubert syndrome type 6 (JBTS6). [provided by RefSeq, Nov 2008]

transmembrane protein 161B pseudogene 1

ring finger protein, transmembrane 1

Enables ubiquitin binding activity and ubiquitin protein ligase activity. Involved in positive regulation of ERAD pathway and protein autoubiquitination. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 183A pseudogene 1

lysosomal protein transmembrane 4 alpha

This gene encodes a protein that has four predicted transmembrane domains. The function of this gene has not yet been determined; however, studies in the mouse homolog suggest a role in the transport of small molecules across endosomal and lysosomal membranes. [provided by RefSeq, Jul 2008]

lysosomal protein transmembrane 4 beta

Enables ceramide binding activity; enzyme binding activity; and phosphatidylinositol bisphosphate binding activity. Involved in several processes, including endosome transport via multivesicular body sorting pathway; negative regulation of macromolecule metabolic process; and regulation of lysosomal membrane permeability. Located in several cellular components, including endosome; lysosomal membrane; and plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

POM121 transmembrane nucleoporin-like 1, pseudogene

This locus appears to be a pseudogene related to DKFZp434K191, which is of unknown function. This pseudogene lies in the immunoglobulin lambda gene cluster on chromosome 22q11.21. [provided by RefSeq, Jul 2008]

POM121 transmembrane nucleoporin-like 11, pseudogene

POM121 transmembrane nucleoporin-like 12

transmembrane protease, serine 11G, pseudogene

POM121 transmembrane nucleoporin

This gene encodes a transmembrane protein that localizes to the inner nuclear membrane and forms a core component of the nuclear pore complex, which mediates transport to and from the nucleus. The encoded protein may anchor this complex to the nuclear envelope. There are multiple related genes and pseudogenes for this gene on chromosomes 5, 7, 15, and 22. Alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2013]

transmembrane domain-containing protein ENSP00000320207-like

transmembrane protein 183A pseudogene

leucine zipper-EF-hand containing transmembrane protein 2

Predicted to enable transmembrane transporter activity. Predicted to be involved in mitochondrial calcium ion transmembrane transport and mitochondrion organization. Located in mitochondrion. [provided by Alliance of Genome Resources, Mar 2025]

signaling threshold regulating transmembrane adaptor 1

Enables kinase binding activity. Involved in regulation of T cell activation. Located in plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 161A

Involved in several processes, including cellular response to UV; regulation of cellular response to stress; and response to retinoic acid. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 161B

Predicted to enable nucleic acid binding activity. Predicted to be involved in regulation of cardiac muscle cell action potential and regulation of heart rate. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane 7 superfamily member 3

Involved in cellular response to unfolded protein; negative regulation of programmed cell death; and positive regulation of insulin secretion. Located in plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane 7 superfamily member 2

Enables delta14-sterol reductase activity. Involved in cholesterol biosynthetic process. Located in endoplasmic reticulum. Part of receptor complex. [provided by Alliance of Genome Resources, Mar 2025]

leucine-rich repeats and transmembrane domains 2

Predicted to enable Roundabout binding activity and heparin binding activity. Predicted to be involved in axon guidance and negative chemotaxis. Predicted to act upstream of or within positive regulation of synapse assembly. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane emp24 domain trafficking protein 2 pseudogene

transmembrane protein 179B

Located in nuclear speck and nucleolus. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 132E

Involved in posterior lateral line neuromast hair cell development. Predicted to be located in cell body. Implicated in autosomal recessive nonsyndromic deafness 99. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 132D

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 132A

This gene encodes a protein that is highly similar to the rat Grp78-binding protein (GBP). Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

transmembrane protein 132B

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

lysosomal protein transmembrane 4 beta pseudogene

transmembrane protein 126A pseudogene

transmembrane protein 109

Predicted to enable voltage-gated monoatomic cation channel activity. Acts upstream of or within cellular response to gamma radiation and negative regulation of programmed cell death. Located in extracellular exosome. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 108

Predicted to be involved in several processes, including cellular response to brain-derived neurotrophic factor stimulus; nervous system development; and regulation of signal transduction. Predicted to be located in somatodendritic compartment. Predicted to be active in several cellular components, including endosome; glutamatergic synapse; and postsynaptic density membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 102

Involved in regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; response to cytokine; and signal transduction. Acts upstream of or within positive regulation of T cell migration and positive regulation of cell adhesion. Located in cell surface. Part of protein-containing complex. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 101

Involved in positive regulation of canonical NF-kappaB signal transduction. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 107

This gene encodes a transmembrane protein and component of the primary cilia transition zone. The encoded protein regulates ciliogenesis and ciliary protein composition. Human fibroblasts expressing a mutant allele of this gene exhibit reduced numbers of cilia, altered cilia length, and impaired sonic hedgehog signaling. In human patients, different mutations in this gene cause different ciliopathies, including Meckel-Gruber syndrome and orofaciodigital syndrome. [provided by RefSeq, May 2017]

transmembrane protein 105

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 104

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

seven transmembrane helix receptor

transmembrane and coiled-coil domain family 1

Enables identical protein binding activity. Involved in several processes, including endosome fission; endosome membrane tubulation; and membrane fission. Located in cytosol; endoplasmic reticulum-endosome membrane contact site; and rough endoplasmic reticulum. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane and coiled-coil domain family 2

Involved in amyloid precursor protein metabolic process. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane and coiled-coil domain family 3

Enables 14-3-3 protein binding activity and identical protein binding activity. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Mar 2025]

vezatin, adherens junctions transmembrane protein pseudogene

transmembrane protein 74B

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

POM121 transmembrane nucleoporin B (pseudogene)

Predicted to enable nuclear localization sequence binding activity. Predicted to be a structural constituent of nuclear pore. Predicted to be involved in RNA export from nucleus and protein import into nucleus. Predicted to be located in nucleus. Predicted to be part of nuclear pore. [provided by Alliance of Genome Resources, Mar 2025]

ring finger protein, transmembrane 2

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in positive regulation of ERAD pathway. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

leucine zipper-EF-hand containing transmembrane protein 1, pseudogene 2

leucine zipper-EF-hand containing transmembrane protein 1, pseudogene 3

transmembrane protein 259

Predicted to be involved in positive regulation of ERAD pathway and response to endoplasmic reticulum stress. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane 9 superfamily protein member 4

Involved in several processes, including positive regulation of protein localization; regulation of intracellular pH; and vacuolar proton-transporting V-type ATPase complex assembly. Located in Golgi apparatus and early endosome. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane 9 superfamily member 1

Predicted to be involved in protein localization to membrane. Predicted to be located in autophagosome membrane; cytoplasmic vesicle; and lysosomal membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane 9 superfamily member 3

Predicted to be involved in protein localization to membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane 9 superfamily member 2

This gene encodes a member of the transmembrane 9 superfamily. The encoded 76 kDa protein localizes to early endosomes in human cells. The encoded protein possesses a conserved and highly hydrophobic C-terminal domain which contains nine transmembrane domains. The protein may play a role in small molecule transport or act as an ion channel. A pseudogene associated with this gene is located on the X chromosome. [provided by RefSeq, Oct 2012]

CKLF-like MARVEL transmembrane domain containing 8

This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene acts as a tumor suppressor, and plays a role in regulating the migration of tumor cells. The encoded protein is thought to function as a a negative regulator of epidermal growth factor-induced signaling. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]

CKLF-like MARVEL transmembrane domain containing 2

This gene belongs to the chemokine-like factor gene superfamily, a novel family that links the chemokine and the transmembrane 4 superfamilies of signaling molecules. The protein encoded by this gene may play an important role in testicular development. [provided by RefSeq, Jul 2008]

CKLF-like MARVEL transmembrane domain containing 3

This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies of signaling molecules. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. Alternatively spliced transcript variants containing different 5' UTRs, but encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

CKLF-like MARVEL transmembrane domain containing 1

This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies of signaling molecules. The protein encoded by this gene may play an important role in testicular development. Alternatively spliced transcript variants encoding different isoforms have been identified. Naturally occurring read-through transcription occurs between this locus and the neighboring locus CKLF (chemokine-like factor).[provided by RefSeq, Feb 2011]

CKLF-like MARVEL transmembrane domain containing 6

This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene is widely expressed in many tissues, but the exact function of the encoded protein is unknown. [provided by RefSeq, Jul 2008]

CKLF-like MARVEL transmembrane domain containing 4

This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies of signaling molecules. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

CKLF-like MARVEL transmembrane domain containing 5

This gene encodes a member of the chemokine-like factor superfamily. This family of genes encodes multi-pass membrane proteins that are similar to both the chemokine and the transmembrane 4 superfamilies of signaling molecules. The encoded protein may exhibit tumor suppressor activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

transmembrane protein 150A

Involved in phosphatidylinositol phosphate biosynthetic process and protein localization to plasma membrane. Located in plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 150C

This gene encodes a transmembrane protein component of a mechanosensitve ion channel that is activated by mechanical stimuli in various cell types and confers slowly adapting, mechanically activated currents in dorsal root ganglion neurons. Mechanically activated ion channels are sensors that are critical for hearing, touch, pain, and blood pressure regulation. [provided by RefSeq, Jul 2017]

transmembrane protein 150B

This gene encodes a protein that belongs to the DRAM (damage-regulated autophagy modulator) family of membrane-spanning proteins. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

transmembrane protein C9orf144B pseudogene

transmembrane protein 191B-like

transmembrane protein 182

Predicted to be involved in myotube cell development involved in skeletal muscle regeneration; negative regulation of myoblast differentiation; and negative regulation of myoblast fusion. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 181

The TMEM181 gene encodes a putative G protein-coupled receptor expressed on the cell surface (Carette et al., 2009 [PubMed 19965467]; Wollscheid et al., 2009 [PubMed 19349973]).[supplied by OMIM, Jan 2010]

transmembrane protein 180

Located in plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 187

This gene consists of two exons and encodes a multi-pass membrane protein. An alternatively spliced transcript variant encoding the same protein has been found, but its biological validity is not determined. [provided by RefSeq, May 2010]

transmembrane protein 186

This gene encodes a potential transmembrane protein. [provided by RefSeq, Dec 2012]

transmembrane protein 189

Co-transcription of this gene and the neighboring downstream gene (ubiquitin-conjugating enzyme E2 variant 1) generates a rare read-through transcript, which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. The protein encoded by this individual gene lacks a UEV1 domain but includes three transmembrane regions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]

transmembrane protein 59

This gene encodes a protein shown to regulate autophagy in response to bacterial infection. This protein may also regulate the retention of amyloid precursor protein (APP) in the Golgi apparatus through its control of APP glycosylation. Overexpression of this protein has been found to promote apoptosis in a glioma cell line. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

transmembrane protein 57

Predicted to enable microtubule binding activity. Involved in neuronal signal transduction. Located in rough endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 54

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 52

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 53

Involved in negative regulation of BMP signaling pathway; negative regulation of ossification; and regulation of nucleocytoplasmic transport. Located in nuclear membrane. Implicated in craniotubular dysplasia Ikegawa type. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 51

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 198B, pseudogene

transmembrane protein 154

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

prostate transmembrane protein, androgen induced 1

This gene encodes a transmembrane protein that contains a Smad interacting motif (SIM). Expression of this gene is induced by androgens and transforming growth factor beta, and the encoded protein suppresses the androgen receptor and transforming growth factor beta signaling pathways though interactions with Smad proteins. Overexpression of this gene may play a role in multiple types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

multiple C2 domains, transmembrane 1

Enables calcium ion binding activity. Predicted to be involved in several processes, including modulation of chemical synaptic transmission; negative regulation of endocytosis; and negative regulation of response to oxidative stress. Located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

multiple C2 domains, transmembrane 2

Enables calcium ion binding activity. Predicted to be involved in regulation of neurotransmitter secretion. Located in cytosol; membrane; and nucleoplasm. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 183A pseudogene

NDC1 transmembrane nucleoporin

A structural constituent of nuclear pore. Involved in nuclear pore complex assembly and nuclear pore localization. Located in actin cytoskeleton; nuclear membrane; and plasma membrane. Part of nuclear pore. [provided by Alliance of Genome Resources, Mar 2025]

ring finger protein, transmembrane 1 pseudogene 1

ring finger protein, transmembrane 1 pseudogene 2

transmembrane and immunoglobulin domain containing 3

This gene encodes a transmembrane and immunoglobulin domain-containing protein. Alternative splicing results in multiple transcript variants, one of which shares its 5' terminal exon with that of the overlapping adenosine A3 receptor gene (GeneID:140), thus resulting in a fusion product. [provided by RefSeq, Nov 2014]

transmembrane and immunoglobulin domain containing 2

Enables coreceptor activity. Involved in positive regulation of T cell activation; positive regulation of angiogenesis; and positive regulation of cytokine production. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 55A

TMEM55A catalyzes the degradation of phosphatidylinositol 4,5-bisphosphate (PtdIns-4,5-P2) by removing the 4-phosphate (Ungewickell et al., 2005 [PubMed 16365287]).[supplied by OMIM, Mar 2008]

transmembrane protein 55B

TMEM55B catalyzes the degradation of phosphatidylinositol 4,5-bisphosphate (PtdIns-4,5-P2) by removing the 4-phosphate (Ungewickell et al., 2005 [PubMed 16365287]).[supplied by OMIM, Mar 2008]

seven transmembrane helix receptor

fat storage-inducing transmembrane protein 2

Enables coenzyme A diphosphatase activity. Involved in several processes, including fatty-acyl-CoA catabolic process; lipid droplet formation; and lipid homeostasis. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane. Implicated in Siddiqi syndrome. [provided by Alliance of Genome Resources, Mar 2025]

fat storage-inducing transmembrane protein 1

Predicted to enable diacylglycerol binding activity and triglyceride binding activity. Predicted to be involved in lipid droplet formation; phospholipid biosynthetic process; and positive regulation of sequestering of triglyceride. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 55B pseudogene

dendrocyte expressed seven transmembrane protein

This gene encodes a seven-pass transmembrane protein that is primarily expressed in dendritic cells. The encoded protein is involved in a range of immunological functions carried out by dendritic cells. This protein plays a role in osteoclastogenesis and myeloid differentiation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]

RING finger and transmembrane domain-containing protein 1-like

thioredoxin-related transmembrane protein 4

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, one transmembrane domain and C-terminal ASP/GLU-rich calcium binding domain. Unlike most members of this gene family, it lacks a C-terminal ER-retention sequence. The encoded protein has been shown to have reductase activity in vitro. [provided by RefSeq, Jan 2017]

thioredoxin-related transmembrane protein 1

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and one transmembrane domain. Unlike most members of this gene family, it lacks a C-terminal ER-retention sequence. The mature membrane-bound protein can both oxidize and reduce disulfide bonds and acts selectively on membrane-associated polypeptides. [provided by RefSeq, Jan 2017]

thioredoxin-related transmembrane protein 3

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The canonical protein encoded by this gene has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, one transmembrane domain and a C-terminal ER-retention sequence. This gene is expressed in many tissues but has its highest expression in heart and skeletal muscle. It is expressed in the retinal neuroepithelium and lens epithelium in the developing murine eye and haploinsufficiency of this gene in humans and zebrafish is associated with microphthalmia. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2017]

thioredoxin-related transmembrane protein 2

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, one transmembrane domain and a C-terminal ER-retention sequence. This protein is enriched on the mitochondria-associated-membrane of the ER via palmitoylation of two of its cytosolically exposed cysteines. [provided by RefSeq, Jan 2017]

transmembrane protein 188 pseudogene

transmembrane protein 86A

Enables alkenylglycerophosphocholine hydrolase activity. Predicted to be involved in lipid metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 86B

Enables D-lysine 5,6-aminomutase activity; alkenylglycerophosphocholine hydrolase activity; and identical protein binding activity. Involved in ether lipid metabolic process. Located in cytoplasm and membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 45A

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 45B

Predicted to be involved in innate immune response. Predicted to be located in Golgi apparatus; endosome membrane; and lysosomal membrane. [provided by Alliance of Genome Resources, Mar 2025]

glycoprotein (transmembrane) nmb

The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

transmembrane protein 155

Enables transmembrane transporter binding activity. Predicted to be involved in mesendoderm development. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 156

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 158 (gene/pseudogene)

Constitutive activation of the Ras pathway triggers an irreversible proliferation arrest reminiscent of replicative senescence. Transcription of this gene is upregulated in response to activation of the Ras pathway, but not under other conditions that induce senescence. The encoded protein is similar to a rat cell surface receptor proposed to function in a neuronal survival pathway. An allelic polymorphism in this gene results in both functional and non-functional (frameshifted) alleles; the reference genome represents the functional allele. [provided by RefSeq, Jul 2015]

transmembrane protein 159

Involved in lipid droplet formation. Located in endoplasmic reticulum membrane and lipid droplet. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane (C-terminal) protease, serine 12

Predicted to enable serine-type endopeptidase activity. Predicted to be involved in acrosome assembly and positive regulation of sperm capacitation. Predicted to act upstream of or within binding activity of sperm to zona pellucida and protein processing. Predicted to be located in acrosomal vesicle. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protease, serine 13

This gene encodes a member of the type II transmembrane serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Transmembrane serine proteases are regulated by protease inhibitors and known to function in development, homeostasis, infection, and tumorigenesis. This protein facilitates entry of viruses into host cells by proteolytically cleaving and activating viral envelope glycoproteins. [provided by RefSeq, Aug 2021]

transmembrane protease, serine 15

This gene encodes an enzyme that converts the pancreatic proenzyme trypsinogen to trypsin, which activates other proenzymes including chymotrypsinogen and procarboxypeptidases. The precursor protein is cleaved into two chains that form a heterodimer linked by a disulfide bond. This protein is a member of the trypsin family of peptidases. Mutations in this gene cause enterokinase deficiency, a malabsorption disorder characterized by diarrhea and failure to thrive. [provided by RefSeq, Jul 2008]

interferon induced transmembrane protein pseudogene

interferon induced transmembrane protein 3 pseudogene

transmembrane epididymal protein 2, pseudogene

interferon induced transmembrane protein 10

Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protease, serine 11C, pseudogene

Predicted to enable serine-type endopeptidase activity. Predicted to be involved in self proteolysis. Predicted to be located in dendrite; perikaryon; and plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 213

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 210

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 215

Predicted to act upstream of or within negative regulation of retinal cell programmed cell death and sprouting angiogenesis. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

interferon induced transmembrane protein pseudogene

leucine zipper-EF-hand containing transmembrane protein 1

This gene encodes a protein that is localized to the inner mitochondrial membrane. The protein functions to maintain the mitochondrial tubular shapes and is required for normal mitochondrial morphology and cellular viability. Mutations in this gene cause Wolf-Hirschhorn syndrome, a complex malformation syndrome caused by the deletion of parts of the distal short arm of chromosome 4. Related pseudogenes have been identified on chromosomes 8, 15 and 19. [provided by RefSeq, Oct 2009]

GPS, PLAT and transmembrane domain-containing protein FLJ00285-like

transmembrane protein 88

Predicted to enable PDZ domain binding activity. Involved in negative regulation of canonical Wnt signaling pathway; protein localization to plasma membrane; and protein stabilization. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 81

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 80

Predicted to be involved in non-motile cilium assembly. Predicted to be located in cilium and membrane. Predicted to be active in ciliary transition zone. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 8A

Predicted to enable calcium-dependent phospholipase A2 activity and calcium-independent phospholipase A2 activity. Predicted to be involved in lipid metabolic process. Located in extracellular exosome and lysosomal membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 8C

Involved in myoblast fusion. Located in plasma membrane. Implicated in Carey-Fineman-Ziter syndrome. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 8B

Involved in cell-matrix adhesion. Located in cell surface and plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 87B

This gene encodes a protein that may interact with human papillomavirus type 18 E6 oncogene. The protein is also likely to be involved in endosome-to-trans-Golgi network retrograde transport. The gene is expressed in adult and fetal tissues, including brain and heart. This gene is a component of the 2q13 deletion syndrome. Mutations in this gene may be associated with congenital heart defects. [provided by RefSeq, Aug 2016]

transmembrane protein 87A

Involved in cellular response to mechanical stimulus and detection of mechanical stimulus involved in sensory perception of touch. Acts upstream of or within retrograde transport, endosome to Golgi. Located in Golgi cisterna membrane; plasma membrane; and ruffle. [provided by Alliance of Genome Resources, Mar 2025]

interferon induced transmembrane protein 9 pseudogene

transmembrane protein 52B

Located in extracellular exosome. [provided by Alliance of Genome Resources, Mar 2025]

interferon induced transmembrane protein 3 pseudogene

transmembrane protein 97 pseudogene 1

transmembrane protein 184A

Predicted to enable heparin binding activity and transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to act upstream of or within germ-line sex determination; regulation of protein localization; and regulation of secretion. Predicted to be located in cytoplasmic vesicle; perinuclear region of cytoplasm; and plasma membrane. Predicted to be active in early endosome membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 184B

Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 184C

Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 222

Located in dendrite. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 223

Enables mitochondrial ribosome binding activity. Involved in mitochondrial cytochrome c oxidase assembly. Located in mitochondrion. Is active in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 220

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 221

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 183A pseudogene

leucine-rich repeats and transmembrane domains 1

Predicted to enable Roundabout binding activity and heparin binding activity. Predicted to be involved in axon guidance and negative chemotaxis. Predicted to act upstream of or within positive regulation of synapse assembly. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane emp24-like trafficking protein 10 (yeast)

This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8. [provided by RefSeq, Jul 2008]

interferon induced transmembrane protein pseudogene

transmembrane protein 167B

Involved in constitutive secretory pathway. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 167A

Involved in constitutive secretory pathway. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane and tetratricopeptide repeat containing 4 pseudogene

glycoprotein A33 (transmembrane)

The glycoprotein encoded by this gene is a cell surface antigen that is expressed in greater than 95% of human colon cancers. The open reading frame encodes a 319-amino acid polypeptide having a putative secretory signal sequence and 3 potential glycosylation sites. The predicted mature protein has a 213-amino acid extracellular region, a single transmembrane domain, and a 62-amino acid intracellular tail. The sequence of the extracellular region contains 2 domains characteristic of the CD2 subgroup of the immunoglobulin (Ig) superfamily. [provided by RefSeq, Jul 2008]

transmembrane protein 132C

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

teneurin transmembrane protein 3

This gene encodes a member of the teneurin transmembrane protein family. The encoded protein may be involved in the regulation of neuronal development including development of the visual pathway. Mutations in this gene have been associated with microphthalmia and developmental dysplasia of the hip. [provided by RefSeq, Jan 2023]

teneurin transmembrane protein 2

Enables cell adhesion molecule binding activity and signaling receptor binding activity. Involved in retrograde trans-synaptic signaling by trans-synaptic protein complex. Located in cell-cell junction and plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

teneurin transmembrane protein 1

The protein encoded by this gene belongs to the tenascin family and teneurin subfamily. It is expressed in the neurons and may function as a cellular signal transducer. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

teneurin transmembrane protein 4

The protein encoded by this gene plays a role in establishing proper neuronal connectivity during development. Defects in this gene have been associated with hereditary essential tremor-5. [provided by RefSeq, Oct 2016]

six transmembrane epithelial antigen of the prostate 1

This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines. The gene product is predicted to be a six-transmembrane protein, and was shown to be a cell surface antigen significantly expressed at cell-cell junctions. [provided by RefSeq, Jul 2008]

prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)

The product of this gene belongs to the family of prolyl 4-hydroxylases. This protein is a prolyl hydroxylase that may be involved in the degradation of hypoxia-inducible transcription factors under normoxia. It plays a role in adaptation to hypoxia and may be related to cellular oxygen sensing. Alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

transmembrane protein 39B

Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 39A

Involved in negative regulation of autophagosome assembly; negative regulation of autophagosome maturation; and positive regulation of viral genome replication. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Mar 2025]

POM121 transmembrane nucleoporin-like 13, pseudogene

serine-rich and transmembrane domain containing 1

Located in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 126A pseudogene

transmembrane channel-like 4

Enables voltage-gated chloride channel activity. Predicted to be involved in sensory perception of salty taste. Located in extracellular exosome. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane channel-like 6

Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 10 transmembrane domains and 2 leucine zipper motifs. [provided by RefSeq, Jul 2008]

transmembrane channel-like 7

Predicted to enable ion channel inhibitor activity and mechanosensitive monoatomic ion channel activity. Predicted to be involved in sensory perception of mechanical stimulus. Predicted to be located in plasma membrane. Predicted to be active in neuronal cell body. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane channel-like 1

This gene is considered a member of a gene family predicted to encode transmembrane proteins. The specific function of this gene is unknown; however, it is known to be required for normal function of cochlear hair cells. Mutations in this gene have been associated with progressive postlingual hearing loss and profound prelingual deafness. [provided by RefSeq, Jul 2008]

transmembrane channel-like 2

This gene encodes a transmembrane protein that is necesssary for mechanotransduction in cochlear hair cells of the inner ear. Mutations in this gene may underlie hereditary disorders of balance and hearing. [provided by RefSeq, Aug 2015]

transmembrane channel-like 3

Predicted to enable mechanosensitive monoatomic ion channel activity. Predicted to be involved in monoatomic ion transmembrane transport. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane channel-like 8

Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane domains and 3 leucine zipper motifs. [provided by RefSeq, Jul 2008]

cysteine-rich transmembrane module containing 1

Located in extracellular exosome. [provided by Alliance of Genome Resources, Mar 2025]

interferon induced transmembrane protein 4 pseudogene

transmembrane protein 132B pseudogene

transmembrane and coiled-coil domains 5B, pseudogene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane and coiled-coil domains 5A

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 200C

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

cysteine-rich transmembrane module containing 1 pseudogene

transmembrane protein 125

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 127

This gene encodes a transmembrane protein with four predicted transmembrane domains. The protein is associated with a subpopulation of vesicular organelles corresponding to early endosomal structures, with the Golgi, and with lysosomes, and may participate in protein trafficking between these structures. Mutations in this gene and several other genes cause pheochromocytomas. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2022]

transmembrane protein 121

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 123

This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death. [provided by RefSeq, Jul 2008]

transmembrane protein 129, E3 ubiquitin protein ligase

Enables ubiquitin protein ligase activity. Involved in protein polyubiquitination; retrograde protein transport, ER to cytosol; and ubiquitin-dependent protein catabolic process. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 128

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 35

Enables acetylcholine receptor regulator activity. Involved in chaperone-mediated protein complex assembly and positive regulation of protein localization to cell surface. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 14E

Predicted to be involved in regulation of heme biosynthetic process. Predicted to be located in membrane. Predicted to be active in mitochondrial membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 143

Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Located in mitochondrion. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 140

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 89

Located in nucleus. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 82

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

osteoclast stimulatory transmembrane protein

The protein encoded by this gene is orthologous to the mouse osteoclast stimulatory transmembrane protein (OCSTAMP), which is a membrane-anchored cell surface receptor that promotes nucleation of osteoclasts. The mouse protein is also involved in bone resorption and osteoclast differentiation. [provided by RefSeq, Feb 2017]

transmembrane phosphatase with tensin homology pseudogene 1

POM121 transmembrane nucleoporin-like 8 pseudogene

transmembrane protein 132C pseudogene

transmembrane protein 211

Predicted to be active in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 217

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 216

This locus encodes a transmembrane domain-containing protein. Mutations at this locus have been associated with Meckel-Gruber Syndrome Type 2, and Joubert Syndrome 2, also known as Cerebello-oculorenal Syndrome 2. [provided by RefSeq, Aug 2010]

transmembrane protein 214

Predicted to be involved in apoptotic process. Located in several cellular components, including Golgi apparatus; cytoplasmic microtubule; and endoplasmic reticulum. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 219

Predicted to be involved in apoptotic process. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 218

Predicted to be located in cilium and membrane. Implicated in Joubert syndrome. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 78

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 79

Enables identical protein binding activity. Predicted to be involved in several processes, including epithelial cell maturation; establishment of skin barrier; and positive regulation of epidermis development. Predicted to act upstream of or within cornification; cuticle development; and hair follicle morphogenesis. Predicted to be located in Golgi apparatus; lysosome; and membrane. Predicted to be active in lysosomal membrane and trans-Golgi network membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 70

This gene likely encodes a mitochondrial membrane protein. The encoded protein may play a role in biogenesis of mitochondrial ATP synthase. Mutations in this gene have been associated with neonatal mitochondrial encephalocardiomyopathy due to ATP synthase deficiency. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010]

transmembrane protein 71

Located in mitochondrion. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 72

This gene encodes a transmembrane protein which may be expressed specifically in the kidney. [provided by RefSeq, Sep 2016]

transmembrane protein 74

Predicted to enable transmembrane transporter binding activity. Involved in macroautophagy. Predicted to be located in cytoplasmic vesicle; plasma membrane; and vacuolar membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 75

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 132B pseudogene

transmembrane protein 167A pseudogene

cysteine rich transmembrane BMP regulator 1 (chordin-like)

This gene encodes a transmembrane protein containing six cysteine-rich repeat domains and an insulin-like growth factor-binding domain. The encoded protein may play a role in tissue development though interactions with members of the transforming growth factor beta family, such as bone morphogenetic proteins. [provided by RefSeq, Nov 2010]

T cell receptor associated transmembrane adaptor 1

Predicted to enable transmembrane receptor protein tyrosine kinase adaptor activity. Acts upstream of or within negative regulation of receptor recycling; negative regulation of transport; and positive regulation of signal transduction. Located in centriolar satellite; mitotic spindle; and plasma membrane. Part of T cell receptor complex. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 63A

Enables mechanosensitive monoatomic ion channel activity. Predicted to be involved in surfactant secretion. Located in bounding membrane of organelle; centriolar satellite; and plasma membrane. Implicated in hypomyelinating leukodystrophy 19. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 63C

Enables calcium-activated cation channel activity. Involved in monoatomic cation transport. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in plasma membrane. Implicated in hereditary spastic paraplegia 87. Biomarker of focal segmental glomerulosclerosis. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 63B

Enables mechanosensitive monoatomic cation channel activity. Predicted to be involved in sensory perception of sound and surfactant secretion. Located in actin cytoskeleton; cytoplasmic vesicle membrane; and plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 191B

sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B

This gene encodes a member of the semaphorin protein family which regulates axon growth during development of the nervous system. The encoded protein has a characteristic Sema domain near the N-terminus, through which semaphorins bind to plexin, and five thrombospondin type 1 repeats in the C-terminal region of the protein. The protein product may be cleaved and exist as a secreted molecule (PMID: 19463192). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A

This gene belongs to the semaphorin gene family that encodes membrane proteins containing a semaphorin domain and several thrombospondin type-1 repeats. Members of this family are involved in axonal guidance during neural development. This gene has been implicated as an autism susceptibility gene.[provided by RefSeq, Jan 2010]

thioredoxin-related transmembrane protein 2 pseudogene 1

transmembrane protein 126B pseudogene

interferon induced transmembrane protein 3 pseudogene

transmembrane protein 251 pseudogene

kringle containing transmembrane protein 1

This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Mutations in this gene result in ectodermal dysplasia. This protein has also been found to be a functional receptor for Coxsackievirus A10 and may be an alternative entry receptor for SARS-CoV-2. [provided by RefSeq, Nov 2021]

cleft lip and palate associated transmembrane protein 1

Predicted to enable GABA receptor binding activity. Predicted to be involved in regulation of T cell differentiation in thymus. Located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 262

Predicted to be located in motile cilium and plasma membrane. Predicted to be part of CatSper complex. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 198

Involved in positive regulation of canonical Wnt signaling pathway. Located in cytoplasmic vesicle and plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 177

Involved in mitochondrial respiratory chain complex II assembly. Located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 174

Predicted to be involved in phosphate ion homeostasis. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 175

Enables arachidonate binding activity; potassium ion leak channel activity; and proton channel activity. Involved in lysosomal lumen pH elevation; potassium ion transmembrane transport; and proton transmembrane transport. Located in endosome membrane and lysosome. Is active in lysosomal membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 171

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 100

Involved in BMP signaling pathway. Located in several cellular components, including endoplasmic reticulum; perikaryon; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 191B

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 191C

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 191A (pseudogene)

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

V-set and transmembrane domain containing 2 like

Involved in negative regulation of neuron apoptotic process. Located in cytoplasm and extracellular region. [provided by Alliance of Genome Resources, Mar 2025]

V-set and transmembrane domain containing 2A

Predicted to enable identical protein binding activity. Involved in several processes, including positive regulation of brown fat cell differentiation; positive regulation of lipid storage; and positive regulation of white fat cell proliferation. Predicted to be located in extracellular region. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Mar 2025]

V-set and transmembrane domain containing 2B

Predicted to be active in membrane. [provided by Alliance of Genome Resources, Mar 2025]

leucine zipper-EF-hand containing transmembrane protein 1, pseudogene 1

transmembrane 4 L six family member 20

The protein encoded by this gene is a member of the four-transmembrane L6 superfamily. Members of this family function in various cellular processes including cell proliferation, motility, and adhesion via their interactions with integrins. In human brain tissue, this gene is expressed at high levels in the parietal lobe, occipital lobe, hippocampus, pons, white matter, corpus callosum, and cerebellum. Knockout of the homologous gene in mouse results in a neurobehavioral phenotype with suggested enhanced motor coordination. A deletion mutation in the human gene is associated with specific language impairment-5. [provided by RefSeq, Jul 2016]

transmembrane protein 258 pseudogene

transmembrane protein 183A pseudogene

transmembrane protein 151B

Predicted to be active in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 151A

Located in endoplasmic reticulum and membrane. Implicated in episodic kinesigenic dyskinesia 3. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane 4 L six family member 1

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface antigen and is highly expressed in different carcinomas. [provided by RefSeq, Jul 2008]

transmembrane 4 L six family member 4

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that can regulate cell proliferation.[provided by RefSeq, Mar 2011]

transmembrane 4 L six family member 5

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is highly similar in sequence and structure to transmembrane 4 superfamily member 1. It may play a role in cell proliferation, and overexpression of this protein may be associated with the uncontrolled growth of tumour cells. [provided by RefSeq, Jul 2008]

transmembrane protein 248

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 249

Predicted to be located in sperm principal piece. Predicted to be part of CatSper complex. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 244

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 245

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 246

Enables glycosyltransferase activity. Involved in GPI anchor biosynthetic process. Located in Golgi membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 240

This gene encodes a transmembrane-domain containing protein found in the brain and cerebellum. Mutations in this gene result in spinocerebellar ataxia 21. [provided by RefSeq, Dec 2014]

transmembrane protein 243, mitochondrial

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

leucine rich transmembrane and O-methyltransferase domain containing

This locus represents naturally occurring readthrough transcription between the neighboring LRRC51 (leucine-rich repeat containing 51) and TOMT (transmembrane O-methyltransferase) genes on chromosome 11. The readthrough transcript encodes a fusion protein that shares sequence identity with each individual gene product. Multiple reports implicate mutations in this gene in nonsyndromic deafness.[provided by RefSeq, Feb 2021]

transmembrane and tetratricopeptide repeat containing 4

This gene encodes a transmembrane protein that belongs to family of proteins containing an N-terminal transmembrane domain and a C-terminal tetratricopeptide repeat (TPR) domain. TPR domains mediate protein-protein interactions in various cellular processes, such as synaptic vesicle fusion, protein folding, and protein translocation. A pseudogene of this gene has been defined on chromosome 5. [provided by RefSeq, Apr 2017]

transmembrane and tetratricopeptide repeat containing 3

This gene encodes a protein that belongs to the transmembrane and tetratricopeptide repeat-containing protein family. [provided by RefSeq, May 2010]

transmembrane and tetratricopeptide repeat containing 1

Enables dolichyl-phosphate-mannose-protein mannosyltransferase activity. Involved in protein O-linked mannosylation. Predicted to be located in endoplasmic reticulum and membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 97 pseudogene 2

cystic fibrosis transmembrane conductance regulator pseudogene 1

transmembrane protein 176A

Predicted to act upstream of or within negative regulation of dendritic cell differentiation. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 176B

Predicted to be involved in negative regulation of dendritic cell differentiation. Predicted to be located in nuclear membrane. [provided by Alliance of Genome Resources, Mar 2025]

vezatin, adherens junctions transmembrane protein

This gene encodes a transmembrane protein which has been localized to adherens junctions and shown to bind to myosin VIIA. Examination of expression of this gene in gastric cancer tissues have shown that expression is decreased which appears to be related to hypermethylation of the promoter. Expression of this gene may also be inhibited by binding of a specific microRNA to a target sequence in the 3' UTR of the transcripts. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011]

transmembrane protein 120B

Predicted to be involved in fat cell differentiation and protein heterooligomerization. Predicted to be located in membrane and nucleus. Predicted to be active in nuclear inner membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 120A

Enables coenzyme A binding activity. Involved in antiviral innate immune response; fat cell differentiation; and protein complex oligomerization. Located in endoplasmic reticulum and plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

kringle containing transmembrane protein 2

This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor. A similar protein in mouse functions interacts with with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

transmembrane protein 248 pseudogene 1

leucine rich repeat transmembrane neuronal 4

Predicted to enable heparan sulfate proteoglycan binding activity. Predicted to be involved in regulation of synapse assembly. Predicted to act upstream of or within AMPA glutamate receptor clustering; positive regulation of synapse assembly; and regulation of presynaptic membrane organization. Predicted to be located in postsynaptic membrane. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in several cellular components, including GABA-ergic synapse; photoreceptor ribbon synapse; and postsynaptic density membrane. [provided by Alliance of Genome Resources, Mar 2025]

leucine rich repeat transmembrane neuronal 1

Predicted to be involved in regulation of postsynaptic density assembly and regulation of presynapse assembly. Predicted to act upstream of or within several processes, including long-term synaptic potentiation; negative regulation of receptor internalization; and positive regulation of synapse assembly. Located in endoplasmic reticulum and growth cone. Is active in GABA-ergic synapse and postsynaptic specialization membrane. [provided by Alliance of Genome Resources, Mar 2025]

leucine rich repeat transmembrane neuronal 3

Involved in regulation of presynapse assembly. Acts upstream of or within positive regulation of amyloid-beta formation. Is active in glutamatergic synapse. [provided by Alliance of Genome Resources, Mar 2025]

leucine rich repeat transmembrane neuronal 2

Predicted to enable neurexin family protein binding activity. Predicted to be involved in regulation of postsynaptic density assembly. Predicted to act upstream of or within several processes, including long-term synaptic potentiation; negative regulation of receptor internalization; and positive regulation of synapse assembly. Is active in GABA-ergic synapse and postsynaptic specialization membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 173

This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D

Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphorin domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. This gene encodes a class 6 vertebrate transmembrane semaphorin that demonstrates alternative splicing. Several transcript variants have been identified and expression of the distinct encoded isoforms is thought to be regulated in a tissue- and development-dependent manner. [provided by RefSeq, Nov 2010]

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B

This gene encodes a member of the semaphorin family, a group of proteins characterized by the presence of a conserved semaphorin (sema) domain. Whereas some semaphorins are transmembrane proteins, others are secreted. Semaphorins play a major role in axon guidance. The protein encoded by this gene may be involved in both peripheral and central nervous system development. [provided by RefSeq, Jul 2008]

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C

This gene encodes a member of the semaphorin family. Semaphorins represent important molecular signals controlling multiple aspects of the cellular response that follows CNS injury, and thus may play an important role in neural regeneration. [provided by RefSeq, May 2010]

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A

Predicted to enable identical protein binding activity; signaling receptor binding activity; and transmembrane signaling receptor activity. Involved in cellular response to vascular endothelial growth factor stimulus; negative regulation of cell adhesion involved in sprouting angiogenesis; and negative regulation of signal transduction. Predicted to be located in axon and membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

interferon induced transmembrane protein 3

Interferon-induced transmembrane (IFITM) proteins are a family of interferon induced antiviral proteins. The family contains five members, including IFITM1, IFITM2 and IFITM3 and belong to the CD225 superfamily. The protein encoded by this gene restricts cellular entry by diverse viral pathogens, such as influenza A virus, Ebola virus and Sars-CoV-2. [provided by RefSeq, Nov 2021]

interferon induced transmembrane protein 1

Interferon-induced transmembrane (IFITM) proteins are a family of interferon induced antiviral proteins. The family contains five members, including IFITM1, IFITM2 and IFITM3 that belong to the CD225 superfamily. The protein encoded by this gene restricts cellular entry by diverse viral pathogens, such as influenza A virus, Ebola virus and Sars-CoV-2. [provided by RefSeq, Nov 2021]

transmembrane protein 69 pseudogene

POM121 transmembrane nucleoporin C

Predicted to enable nuclear localization sequence binding activity. Predicted to be a structural constituent of nuclear pore. Predicted to be involved in RNA export from nucleus and protein import into nucleus. Located in nuclear membrane and nucleoplasm. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 27

This gene encodes a type 1 transmembrane protein that is important for trafficking amino acid transporters to the apical brush border of proximal tubules. The encoded protein binds to amino acid transporters and regulates their expression on the plasma membrane. It also plays a role in controlling insulin exocytosis by regulating formation of the SNARE (soluble N-ethylmaleimide-sensitive-factor attachment protein receptor) complex in pancreatic beta cells. The extracellular domain of the encoded protein may be cleaved and shed from the plasma membrane specifically in pancreatic beta cells. [provided by RefSeq, Jun 2013]

transmembrane protein 26

This gene encodes a protein containing multiple transmembrane helices. It is a selective surface protein marker of brite/beige adipocytes, which may coexist with classical brown adipocytes in brown adipose tissue. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]

transmembrane protein 25

Predicted to be involved in negative regulation of excitatory postsynaptic potential and regulation of protein stability. Predicted to be located in late endosome and lysosome. [provided by Alliance of Genome Resources, Mar 2025]

POM121 transmembrane nucleoporin pseudogene

lymphocyte transmembrane adaptor 1

Enables SH2 domain binding activity and protein kinase binding activity. Involved in several processes, including B cell activation; negative regulation of MAPK cascade; and negative regulation of T cell activation. Located in Golgi apparatus; cytosol; and plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 225

Predicted to enable protein phosphatase 1 binding activity and protein phosphatase inhibitor activity. Predicted to be involved in negative regulation of phosphatase activity. Predicted to be located in inner acrosomal membrane and outer acrosomal membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 256 pseudogene 1

lysosomal protein transmembrane 5

This gene encodes a transmembrane receptor that is associated with lysosomes. The encoded protein, also known as E3 protein, may play a role in hematopoiesis. [provided by RefSeq, Feb 2009]

transmembrane protease, serine 11A

Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region and plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protease, serine 11B

Enables serine-type peptidase activity. Predicted to be involved in proteolysis. Located in plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protease, serine 11D

This gene encodes a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. It is a type II integral membrane protein and has 29-38% identity in the sequence of the catalytic region with human hepsin, enteropeptidase, acrosin, and mast cell tryptase. The noncatalytic region has little similarity to other known proteins. This protein may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. This protein facilitates entry of viruses into host cells by proteolytically cleaving and activating viral envelope glycoproteins. [provided by RefSeq, Aug 2021]

transmembrane protease, serine 11E

Predicted to enable serine-type peptidase activity. Involved in cognition. Predicted to be located in extracellular region and membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protease, serine 11F

Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within establishment of skin barrier. Located in cell surface. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 212

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 14D (pseudogene)

Predicted to be involved in regulation of heme biosynthetic process. Predicted to be located in membrane. Predicted to be active in mitochondrial membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 14C

Predicted to be involved in regulation of heme biosynthetic process. Predicted to act upstream of or within erythrocyte differentiation; mitochondrial transport; and nitrogen compound transport. Located in mitochondrion. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 14B

Enables identical protein binding activity. Involved in cerebral cortex development; neural precursor cell proliferation; and regulation of G1/S transition of mitotic cell cycle. Predicted to be located in membrane. Predicted to be active in mitochondrial membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 14A

Involved in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. Located in endoplasmic reticulum membrane and mitochondrial membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 147

Enables ribosome binding activity. Involved in multi-pass transmembrane protein insertion into ER membrane and protein localization to nuclear inner membrane. Located in nuclear membrane. Part of multi-pass translocon complex. Is active in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 145

Predicted to be involved in G protein-coupled receptor signaling pathway and response to pheromone. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 144

Predicted to enable carbohydrate transmembrane transporter activity. Predicted to be involved in carbohydrate transmembrane transport. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 141

Located in mitochondrion. [provided by Alliance of Genome Resources, Mar 2025]

interferon induced transmembrane protein pseudogene

transmembrane protein 194A

Involved in nuclear membrane organization. Predicted to be located in nuclear inner membrane. Predicted to be active in nuclear envelope. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane 9 superfamily member 2 pseudogene

transmembrane protein 59-like

This gene encodes a predicted type-I membrane glycoprotein. The encoded protein may play a role in functioning of the central nervous system. [provided by RefSeq, Jul 2008]

interferon induced transmembrane protein 2

Interferon-induced transmembrane (IFITM) proteins are a family of interferon induced antiviral proteins. The family contains five members, including IFITM1, IFITM2 and IFITM3 and belong to the CD225 superfamily. The protein encoded by this gene restricts cellular entry by diverse viral pathogens, such as influenza A virus, Ebola virus and Sars-CoV-2. [provided by RefSeq, Nov 2021]

transmembrane protein 229A

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 229B

Predicted to act upstream of or within macrophage activation and response to bacterium. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane 6 superfamily member 1

Predicted to be located in endomembrane system; lysosome; and membrane. Predicted to be active in lysosomal membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane 6 superfamily member 2

Enables identical protein binding activity. Involved in regulation of lipid metabolic process. Located in endoplasmic reticulum membrane and endoplasmic reticulum-Golgi intermediate compartment membrane. [provided by Alliance of Genome Resources, Mar 2025]

secreted and transmembrane 1

This gene encodes a transmembrane and secreted protein with characteristics of a type 1a transmembrane protein. It is found in a perinuclear Golgi-like pattern and thought to be involved in hematopoietic and/or immune system processes. [provided by RefSeq, Jul 2008]

transmembrane protein 98

This gene encodes a transmembrane protein. A missense mutation in this gene result in Nanophthalmos 4 (NNO4). Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2014]

transmembrane protein 99

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 92

Located in nucleoplasm. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 91

Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be active in intracellular membrane-bounded organelle and membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 97

TMEM97 is a conserved integral membrane protein that plays a role in controlling cellular cholesterol levels (Bartz et al., 2009 [PubMed 19583955]).[supplied by OMIM, Aug 2009]

transmembrane protein 95

Involved in fusion of sperm to egg plasma membrane involved in single fertilization. Predicted to be located in cytoplasmic vesicle and sperm plasma membrane. Predicted to be active in acrosomal membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane inner ear

This gene encodes a transmembrane inner ear protein. Studies in mouse suggest that this gene is required for normal postnatal maturation of sensory hair cells in the cochlea, including correct development of stereocilia bundles. This gene is one of multiple genes responsible for recessive non-syndromic deafness (DFNB), also known as autosomal recessive nonsyndromic hearing loss (ARNSHL), the most common form of congenitally acquired inherited hearing impairment. [provided by RefSeq, Mar 2009]

transmembrane protein 88B

Predicted to be involved in negative regulation of canonical Wnt signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

CKLF-like MARVEL transmembrane domain containing 7

This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene acts as a tumor suppressor that regulates G1/S transition in the cell cycle, and epidermal growth factor receptor/protein kinase B signaling during tumor pathogenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]

transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene 5

transmembrane protein C16orf54

proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)

Enables WW domain binding activity. Predicted to be involved in blood coagulation. Located in plasma membrane. Biomarker of cholangiocarcinoma. [provided by Alliance of Genome Resources, Mar 2025]

proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane)

This gene encodes a protein which contains a vitamin K-dependent carboxylation/gamma-carboxyglutamic domain. The encoded protein is a member of a family of vitamin K-dependent transmembrane proteins which contain a glutamate-rich extracellular domain. [provided by RefSeq, Aug 2011]

transmembrane protein 261 pseudogene 1

POM121 transmembrane nucleoporin-like 6 pseudogene

thioredoxin-related transmembrane protein 1 pseudogene

thioredoxin-related transmembrane protein 1 pseudogene

transmembrane protein 239

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 238

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 235

Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in apical plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 234

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 237

The protein encoded by this gene is a tetraspanin protein that is thought to be involved in WNT signaling. Defects in this gene are a cause of Joubert syndrome-14. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

transmembrane protein 236

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 231

This gene encodes a transmembrane protein, which is a component of the B9 complex involved in the formation of the diffusion barrier between the cilia and plasma membrane. Mutations in this gene cause Joubert syndrome (JBTS). Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2013]

transmembrane protein 230

This gene encodes a multi-pass transmembrane protein that belongs to the TMEM134/TMEM230 protein family. The encoded protein localizes to secretory and recycling vesicle in the neuron and may be involved in synaptic vesicles trafficking and recycling. Mutations in this gene may be linked to familial Parkinson's disease. [provided by RefSeq, Mar 2017]

transmembrane protein 233

Located in plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 232

Predicted to be involved in flagellated sperm motility and spermatid cytoplasm removal during spermiation of flagellated sperm. Predicted to act upstream of or within maintenance of protein complex location. Predicted to be located in membrane. Predicted to be active in outer dense fiber. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane and coiled-coil domains 1

This locus encodes a transmembrane protein. Mutations at this locus have been associated with craniofacial dysmorphism, skeletal anomalies, and cognitive disability. Mutations at this locus have also been associated with open angle glaucoma blindness. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]

transmembrane and coiled-coil domains 2

Located in nucleus. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane and coiled-coil domains 4

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane and coiled-coil domains 6

Predicted to enable nuclear import signal receptor activity. Predicted to be involved in protein import into nucleus. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

leucine-rich repeat, immunoglobulin-like and transmembrane domains 2

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

leucine-rich repeat, immunoglobulin-like and transmembrane domains 3

This gene encodes a protein that has a fibronectin type III domain and a C-terminal transmembrane domain, as well as a leucine-rich repeat domain and immunoglobulin-like domain near the N-terminus. The encoded protein may regulate fibroblast growth factor receptors and affect the modification of these receptors, which are glycosylated differently in the Golgi and endoplasmic reticulum. Mutations in this gene are associated with congenital stationary night blindness, type 1F. [provided by RefSeq, May 2013]

leucine-rich repeat, immunoglobulin-like and transmembrane domains 1

Predicted to be involved in visual perception. Predicted to be located in dendrite; endoplasmic reticulum; and membrane. Predicted to be active in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 11

Involved in mitochondrion organization. Located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 17

Involved in non-motile cilium assembly. Predicted to be located in ciliary membrane. Predicted to be part of MKS complex. Predicted to be active in ciliary transition zone. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 18

Predicted to enable DNA binding activity. Involved in cell migration. Located in nuclear membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 19

Predicted to be active in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 194B

Predicted to be located in nuclear inner membrane. Predicted to be active in nuclear envelope. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 200A

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

interferon induced transmembrane protein 3 pseudogene

transmembrane phosphatase with tensin homology

This gene encodes a PTEN-related tyrosine phosphatase which may play a role in the signal transduction pathways of the endocrine or spermatogenic function of the testis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

transmembrane protein 184C pseudogene

transmembrane protein 9

Involved in intracellular pH reduction; positive regulation of canonical Wnt signaling pathway; and proton-transporting V-type ATPase complex assembly. Located in bounding membrane of organelle; intercellular bridge; and mitotic spindle. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 2

This gene encodes a type II transmembrane protein that belongs to the interferon-induced transmembrane (IFITM) protein superfamily. The encoded protein functions as a cell surface hyaluronidase that cleaves extracellular high molecular weight hyaluronan into intermediate size fragments before internalization and degradation in the lysosome. It also has an interferon-mediated antiviral function in humans through activation of the JAK STAT signaling pathway. The activation of this gene by transcription factor SOX4 in breast cancer cells has been shown to mediate the pathological effects of SOX4 on cancer progression. Naturally occurring mutations in this gene are associated with autosomal recessive non-syndromic hearing loss. [provided by RefSeq, Mar 2017]

transmembrane protein 5

This gene encodes a type II transmembrane protein that is thought to have glycosyltransferase function. Mutations in this gene result in cobblestone lissencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]

transmembrane protein 38A

Predicted to enable potassium channel activity. Predicted to be involved in regulation of release of sequestered calcium ion into cytosol. Predicted to act upstream of or within several processes, including cellular response to caffeine; monoatomic cation transmembrane transport; and regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion. Located in extracellular exosome. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 38B

This gene encodes an intracellular monovalent cation channel that functions in maintenance of intracellular calcium release. Mutations in this gene may be associated with autosomal recessive osteogenesis. [provided by RefSeq, Oct 2012]

proline-rich transmembrane protein 4

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

proline-rich transmembrane protein 1

Enables identical protein binding activity. Predicted to be involved in several processes, including long-term synaptic depression; protein localization to cell surface; and regulation of AMPA receptor activity. Predicted to act upstream of or within several processes, including learning or memory; long-term synaptic potentiation; and synapse organization. Predicted to be located in plasma membrane and synaptic vesicle membrane. Predicted to be active in glutamatergic synapse and postsynaptic density membrane. [provided by Alliance of Genome Resources, Mar 2025]

proline-rich transmembrane protein 3

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

proline-rich transmembrane protein 2

This gene encodes a transmembrane protein containing a proline-rich domain in its N-terminal half. Studies in mice suggest that it is predominantly expressed in brain and spinal cord in embryonic and postnatal stages. Mutations in this gene are associated with episodic kinesigenic dyskinesia-1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)

This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. The encoded protein functions as a chloride channel, making it unique among members of this protein family, and controls ion and water secretion and absorption in epithelial tissues. Channel activation is mediated by cycles of regulatory domain phosphorylation, ATP-binding by the nucleotide-binding domains, and ATP hydrolysis. Mutations in this gene cause cystic fibrosis, the most common lethal genetic disorder in populations of Northern European descent. The most frequently occurring mutation in cystic fibrosis, DeltaF508, results in impaired folding and trafficking of the encoded protein. Multiple pseudogenes have been identified in the human genome. [provided by RefSeq, Aug 2017]

POM121 transmembrane nucleoporin-like 10, pseudogene

transmembrane protein 183A

Predicted to be involved in regulation of protein stability. Predicted to be located in membrane. Predicted to be part of SCF ubiquitin ligase complex. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 183B

This locus was thought to represent a pseudogene of chromosome 1 open reading frame 37 because it is intronless and retains a polyA tail at the 3' end. It does however contain a complete open reading frame that subsequent research has demonstrated to be transcribed in a limited number of human tissues. The encoded protein may represent a transmembrane protein associated with cell membranes and be involved in cell-cell or cell-environment interactions. [provided by RefSeq, Jul 2010]

transmembrane protein 41A

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 41B

Enables phospholipid scramblase activity. Involved in autophagosome assembly and intracellular lipid transport. Located in mitochondria-associated endoplasmic reticulum membrane contact site. Is active in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 231 pseudogene

transmembrane protein 111 pseudogene

transmembrane protein 179

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 56

Predicted to be involved in lipid homeostasis. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 178A

Predicted to be involved in negative regulation of osteoclast differentiation and regulation of cytosolic calcium ion concentration. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 30C

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane and coiled-coil domain family 1 pseudogene

transmembrane protein 119

Involved in positive regulation of bone mineralization; positive regulation of osteoblast differentiation; and positive regulation of osteoblast proliferation. Located in plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 110

Enables calcium channel regulator activity. Involved in activation of store-operated calcium channel activity and store-operated calcium entry. Located in cortical endoplasmic reticulum; endoplasmic reticulum membrane; and endoplasmic reticulum-plasma membrane contact site. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 114

This gene encodes a glycosylated transmembrane protein that plays a role in lens and eye development. Mutations in this gene, including a t(16;22)(p13.3;q11.2) translocation, are associated with congenital and juvenile cataract disorders. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]

transmembrane protein 115

Enables identical protein binding activity. Involved in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Located in Golgi cisterna membrane; Golgi transport complex; and nucleus. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 116

Predicted to be involved in signal transduction. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 117

Involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress. Located in endoplasmic reticulum and plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 170B

Involved in negative regulation of canonical Wnt signaling pathway. Located in plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 170A

Involved in endoplasmic reticulum tubular network organization; nuclear envelope organization; and nuclear pore complex assembly. Located in endoplasmic reticulum membrane and nuclear envelope. [provided by Alliance of Genome Resources, Mar 2025]

POM121 transmembrane nucleoporin-like 14, pseudogene

transmembrane protein 230 pseudogene

transmembrane protein 132B pseudogene

transmembrane protein FLJ37396

GRB2-binding adaptor protein, transmembrane

Predicted to be involved in B cell homeostasis and B cell proliferation involved in immune response. Located in Golgi apparatus and plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 126A pseudogene

transmembrane protein 265

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 263

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 260

Enables dolichyl-phosphate-mannose-protein mannosyltransferase activity. Involved in protein maturation. Is active in endoplasmic reticulum membrane. Implicated in T-cell non-Hodgkin lymphoma; non-Hodgkin lymphoma; and stomach cancer. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 261

Involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 190

Predicted to enable identical protein binding activity. Predicted to be involved in hematopoietic progenitor cell differentiation. Located in nucleus. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 192

Enables protein homodimerization activity. Located in several cellular components, including late endosome; lysosomal membrane; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 196

Involved in several processes, including negative regulation of cell growth; negative regulation of cell migration; and positive regulation of apoptotic process. Located in cytoplasm. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 199

The protein encoded by this gene has been observed to localize to the endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC) and coat protein complex I (COPI) in some human cells. The encoded protein shares some homology with the yeast protein Vma12. Defects in this gene are a cause of congenital disorder of glycosylation, type IIp. [provided by RefSeq, Mar 2016]

transmembrane protein 44

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 47

This gene encodes a member of the PMP22/EMP/claudin protein family. The encoded protein is localized to the ER and the plasma membrane. In dogs, transcripts of this gene exist at high levels in the brain. [provided by RefSeq, Jul 2008]

transmembrane protein 40

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 43

This gene belongs to the TMEM43 family. Defects in this gene are the cause of familial arrhythmogenic right ventricular dysplasia type 5 (ARVD5), also known as arrhythmogenic right ventricular cardiomyopathy type 5 (ARVC5). Arrhythmogenic right ventricular dysplasia is an inherited disorder, often involving both ventricles, and is characterized by ventricular tachycardia, heart failure, sudden cardiac death, and fibrofatty replacement of cardiomyocytes. This gene contains a response element for PPAR gamma (an adipogenic transcription factor), which may explain the fibrofatty replacement of the myocardium, a characteristic pathological finding in ARVC. [provided by RefSeq, Oct 2008]

transmembrane protein 42

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane epididymal protein 1

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protease, serine 9

The protein encoded by this gene is a membrane-bound type II serine polyprotease that is cleaved to release three different proteases. Two of the proteases are active and can be inhibited by serine protease inhibitors, and one is thought to be catalytically inactive. This gene enhances the invasive capability of pancreatic cancer cells and may be involved in cancer progression. [provided by RefSeq, Jul 2016]

transmembrane protease, serine 2

This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. This protein also facilitates entry of viruses into host cells by proteolytically cleaving and activating viral envelope glycoproteins. Viruses found to use this protein for cell entry include Influenza virus and the human coronaviruses HCoV-229E, MERS-CoV, SARS-CoV and SARS-CoV-2 (COVID-19 virus). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2020]

transmembrane protease, serine 3

This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a serine protease domain, a transmembrane domain, an LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified by its association with both congenital and childhood onset autosomal recessive deafness. This gene is expressed in fetal cochlea and many other tissues, and is thought to be involved in the development and maintenance of the inner ear or the contents of the perilymph and endolymph. This gene was also identified as a tumor-associated gene that is overexpressed in ovarian tumors. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]

transmembrane protease, serine 4

This gene encodes a member of the serine protease family. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified as a gene overexpressed in pancreatic carcinoma. The encoded protein is membrane bound with a N-terminal anchor sequence and a glycosylated extracellular region containing the serine protease domain. The protein has been found to promote SARS-CoV-2 entry into host cells. [provided by RefSeq, Aug 2021]

transmembrane protease, serine 5

This gene encodes a protein that belongs to the serine protease family. Serine proteases are known to be involved in many physiological and pathological processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

transmembrane protease, serine 6

The protein encoded by this gene is a type II transmembrane serine proteinase that is found attached to the cell surface. The encoded protein may be involved in matrix remodeling processes in the liver. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

transmembrane protease, serine 7

Predicted to enable serine-type peptidase activity. Predicted to be involved in proteolysis. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A pseudogene

transmembrane protein 126A

The protein encoded by this gene is a mitochondrial membrane protein of unknown function. Defects in this gene are a cause of optic atrophy type 7 (OPA7). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

transmembrane protein 126B

This gene encodes a mitochondrial transmembrane protein which is a component of the mitochondrial complex I assembly complex. The encoded protein serves as an assembly factor that is required for formation of the membrane arm of the complex. It interacts with NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 13. Naturally occurring mutations in this gene are associated with isolated complex I deficiency. A pseudogene of this gene has been defined on chromosome 9. [provided by RefSeq, Apr 2017]

transmembrane and immunoglobulin domain containing 1

Predicted to enable cell-cell adhesion mediator activity and protein homodimerization activity. Involved in several processes, including negative regulation of apoptotic process; regulation of cell migration; and regulation of membrane permeability. Located in cytosol; mitochondrion; and plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

POM121 transmembrane nucleoporin-like 7

POM121 transmembrane nucleoporin-like 2

Predicted to enable nuclear localization sequence binding activity. Predicted to be a structural constituent of nuclear pore. Predicted to be involved in RNA export from nucleus and protein import into nucleus. Predicted to be part of nuclear pore. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene 2

transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene 3

transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene 1

transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene 6

transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene 4

POM121 transmembrane nucleoporin-like 3, pseudogene

transmembrane protein 106B

Enables ATPase binding activity. Involved in dendrite morphogenesis and lysosome localization. Located in endosome and lysosomal membrane. Implicated in hypomyelinating leukodystrophy 16. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 106C

Predicted to be located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 106A

Predicted to be involved in several processes, including glycoprotein biosynthetic process; positive regulation of intracellular signal transduction; and positive regulation of macromolecule biosynthetic process. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A

This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010]

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B

Predicted to enable chemorepellent activity; neuropilin binding activity; and semaphorin receptor binding activity. Predicted to be involved in several processes, including axon guidance; neural crest cell migration; and semaphorin-plexin signaling pathway. Predicted to be located in membrane and synapse. Predicted to be active in glutamatergic synapse and postsynaptic density membrane. [provided by Alliance of Genome Resources, Mar 2025]

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C

Predicted to enable chemorepellent activity; neuropilin binding activity; and semaphorin receptor binding activity. Involved in muscle cell differentiation and positive regulation of stress-activated MAPK cascade. Located in extracellular space. [provided by Alliance of Genome Resources, Mar 2025]

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D

Enables identical protein binding activity; semaphorin receptor binding activity; and transmembrane signaling receptor activity. Involved in several processes, including ossification involved in bone maturation; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and regulation of neuron projection development. Located in plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F

This gene encodes a transmembrane class IV semaphorin family protein, which plays a role in neural development. This gene may be involved in neurogenesis in prostate cancer, the development of neurofibromas, and breast cancer tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G

Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

transmembrane and coiled-coil domains 3

This gene encodes a member of the monovalent cation:proton antiporter 2 (CPA2) family of transporter proteins. Members of this family typically couple the export of monovalent cations, such as potassium or sodium, to the import of protons across cellular membranes. Mutations in this gene have been identified in patients with a rare inherited vision defect, cornea guttata with anterior polar cataract. [provided by RefSeq, Mar 2017]

transmembrane protein 38A pseudogene

transmembrane protein 183A pseudogene

transmembrane protein, adipocyte asscociated 1

Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within embryonic cleavage and negative regulation of mitotic cell cycle phase transition. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 185A pseudogene 1

transmembrane emp24 protein transport domain containing 11, pseudogene

transmembrane protein 94

Enables P-type magnesium transporter activity. Involved in magnesium ion transport from cytosol to endoplasmic reticulum. Is active in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane 131 like

Involved in negative regulation of canonical Wnt signaling pathway and negative regulation of immature T cell proliferation in thymus. Located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 275

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

PMIS2 transmembrane protein

Predicted to act upstream of or within binding activity of sperm to zona pellucida. Predicted to be active in intracellular membrane-bounded organelle and membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 276

Predicted to enable zinc ion binding activity. Predicted to be located in membrane; nuclear envelope; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 271

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane O-methyltransferase

This gene encodes a catechol-O-methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to a hydroxyl group of catechols and is essential for auditory and vestibular function. Mutations in this gene have been associated with nonsyndromic deafness. Readthrough transcription is observed across this gene and the adjacent leucine-rich repeat containing 51 gene. A third locus (GeneID:220074) is defined to represent the readthrough transcripts. [provided by RefSeq, Feb 2021]

transmembrane protein 267

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 35A

Enables acetylcholine receptor regulator activity. Involved in chaperone-mediated protein complex assembly and positive regulation of protein localization to cell surface. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Mar 2025]

endosomal transmembrane epsin interactor 1

Enables ubiquitin ligase activator activity. Involved in CXCL12-activated CXCR4 signaling pathway and negative adaptation of signaling pathway. Located in endosome membrane and plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 268

Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

endosomal transmembrane epsin interactor 3

This gene is located near the gene for the lysosomal enzyme glucosylceramidase; a deficiency in this enzyme is associated with Gaucher disease. The encoded protein has been identified as a potential binding partner of a WW domain-containing protein which is involved in apoptosis and tumor suppression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

transmembrane protein 35B

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

endosomal transmembrane epsin interactor 2

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 250

Predicted to enable GTPase activity and molecular adaptor activity. Involved in positive regulation of cell population proliferation and positive regulation of viral process. Located in cytoplasm and nucleoplasm. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 266

Enables protein homodimerization activity. Predicted to be involved in transmembrane transport. Located in cytosol; dendrite; and plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 121B

transmembrane protein 273

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane BAX inhibitor motif containing 7, pseudogene

transmembrane protein 270

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 225B

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 272

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 269

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

serine rich and transmembrane domain containing 2

Predicted to be located in membrane. Predicted to be active in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 238 like

Involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Mar 2025]

short transmembrane mitochondrial protein 1

Involved in mitochondrial cytochrome c oxidase assembly. Located in mitochondrion. Is active in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Mar 2025]

proline rich transmembrane protein 1B

Predicted to be active in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 217B

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane and death domain 1

Predicted to be involved in signal transduction. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

small transmembrane regulator of ion transport 1

Predicted to enable enzyme activator activity. Predicted to be involved in regulation of calcium ion transport and regulation of striated muscle contraction. Predicted to act upstream of or within positive regulation of ATPase-coupled calcium transmembrane transporter activity and positive regulation of calcium ion import. Predicted to be located in sarcoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 278

Predicted to be involved in negative regulation of canonical Wnt signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

leucine rich repeat transmembrane protein 3

short transmembrane mitochondrial protein 1-like

From Reactome Pathways 2024

proteins participating in the Disorders of transmembrane transporters pathway from the Reactome Pathways 2024 dataset.

From GAD Gene-Disease Associations

genes associated with the disease cocaine-related disorders; opioid-related disorders; substance-related disorders in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term transporters in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the SLC41 divalent cation transporters, integral membrane domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From KEGG Pathways

proteins participating in the abc transporters general pathway from the KEGG Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Organic anion transporters pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Sodium-coupled sulphate, di- and tri-carboxylate transporters pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Na+/Cl- dependent neurotransmitter transporters pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Orphan transporters pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Inositol transporters pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Na+-dependent glucose transporters pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Mitochondrial ABC transporters pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Metal ion SLC transporters pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the ABCA transporters in lipid homeostasis pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Amine compound SLC transporters pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Proton-coupled neutral amino acid transporters pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Facilitative Na+-independent glucose transporters pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Bicarbonate transporters pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Zinc transporters pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Bile salt and organic anion SLC transporters pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Amino acid and oligopeptide SLC transporters pathway from the Reactome Pathways dataset.

From WikiPathways Pathways 2024

proteins participating in the Fatty acid transporters pathway from the WikiPathways Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the ABC transporters in lipid homeostasis pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Bicarbonate transporters pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Inositol transporters pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Metal ion SLC transporters pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Mitochondrial ABC transporters pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Na+/Cl- dependent neurotransmitter transporters pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Organic anion transporters pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Proton-coupled neutral amino acid transporters pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Sodium-coupled sulphate, di- and tri-carboxylate transporters pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Zinc transporters pathway from the Reactome Pathways 2024 dataset.

From KEGG Pathways 2026

proteins participating in the ABC transporters pathway from the KEGG Pathways 2026 dataset.

From GAD Gene-Disease Associations

genes associated with the disease alcohol-related disorders; cocaine-related disorders; in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

From GAD Gene-Disease Associations

genes associated with the disease speech disorders; substance-related disorders in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

From GAD Gene-Disease Associations

genes associated with the disease alcoholism; opioid-related disorders; substance-related disorders in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

From GAD Gene-Disease Associations

genes associated with the disease alcoholism; cocaine-related disorders; heroin dependence; substance-related disorders in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

From GAD Gene-Disease Associations

genes associated with the disease blood coagulation disorders; puerperal disorders; sinus thrombosis, intracranial in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

From GAD Gene-Disease Associations

genes associated with the disease hearing loss, sensorineural; learning disorders; melas syndrome; migraine disorders; mitochondrial diseases; sensorineural hearing loss in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

From GAD Gene-Disease Associations

genes associated with the disease craniofacial abnormalities; growth disorders; learning disorders; syndrome in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

From GAD Gene-Disease Associations

genes associated with the disease articulation disorders; disorders in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

From GAD Gene-Disease Associations

genes associated with the disease articulation disorders; dyslexia, acquired; language disorders; noonan syndrome; turner's phenotype, karyotype normal in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

From GAD Gene-Disease Associations

genes associated with the disease alzheimer disease; alzheimer's disease; disorders of excessive somnolence; memory disorders in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

From GAD Gene-Disease Associations

genes associated with the disease blood coagulation disorders; blood coagulation disorders, inherited; recurrence; thromboembolism; thrombophilia; venous thrombosis in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

From GAD Gene-Disease Associations

genes associated with the disease personality disorders; eating disorders in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

From GAD Gene-Disease Associations

genes associated with the disease learning disorders; memory disorders; mental retardation in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

From GAD Gene-Disease Associations

genes associated with the disease fatigue; sleep disorders; sleep initiation and maintenance disorders in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

From GAD Gene-Disease Associations

genes associated with the disease migraine disorders; substance-related disorders in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

From GAD Gene-Disease Associations

genes associated with the disease cystic fibrosis; growth disorders; nutrition disorders in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

From GAD Gene-Disease Associations

genes associated with the disease brain injuries; cerebrovascular disorders; migraine disorders in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

From GAD Gene-Disease Associations

genes associated with the disease apnea; apoplexy; blood coagulation disorders; brain ischemia; cerebrovascular disorders; hypotony, muscle; muscle hypotonia; protein c deficiency; seizures; stroke; thrombosis in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

From ClinVar Gene-Phenotype Associations

genes associated with the FLNB-Related Disorders phenotype from the curated ClinVar Gene-Phenotype Associations dataset.

From ClinVar Gene-Phenotype Associations

genes associated with the NSDHL-Related Disorders phenotype from the curated ClinVar Gene-Phenotype Associations dataset.

From ClinVar Gene-Phenotype Associations

genes associated with the Epilepsy, X-linked, with variable learning disabilities and behavior disorders phenotype from the curated ClinVar Gene-Phenotype Associations dataset.

From ClinVar Gene-Phenotype Associations

genes associated with the WFS1-Related Disorders phenotype from the curated ClinVar Gene-Phenotype Associations dataset.

From ClinVar Gene-Phenotype Associations

genes associated with the MYH9 related disorders phenotype from the curated ClinVar Gene-Phenotype Associations dataset.

From CTD Gene-Disease Associations

genes/proteins associated with the disease Child Development Disorders, Pervasive from the curated CTD Gene-Disease Associations dataset.

From CTD Gene-Disease Associations

genes/proteins associated with the disease Opioid-Related Disorders from the curated CTD Gene-Disease Associations dataset.

From CTD Gene-Disease Associations

genes/proteins associated with the disease Hemorrhagic Disorders from the curated CTD Gene-Disease Associations dataset.

From CTD Gene-Disease Associations

genes/proteins associated with the disease Language Disorders from the curated CTD Gene-Disease Associations dataset.

From CTD Gene-Disease Associations

genes/proteins associated with the disease Child Behavior Disorders from the curated CTD Gene-Disease Associations dataset.

From CTD Gene-Disease Associations

genes/proteins associated with the disease Movement Disorders from the curated CTD Gene-Disease Associations dataset.

From CTD Gene-Disease Associations

genes/proteins associated with the disease Chronobiology Disorders from the curated CTD Gene-Disease Associations dataset.

From CTD Gene-Disease Associations

genes/proteins associated with the disease Consciousness Disorders from the curated CTD Gene-Disease Associations dataset.

From CTD Gene-Disease Associations

genes/proteins associated with the disease Olfaction Disorders from the curated CTD Gene-Disease Associations dataset.

From CTD Gene-Disease Associations

genes/proteins associated with the disease Mood Disorders from the curated CTD Gene-Disease Associations dataset.

From CTD Gene-Disease Associations

genes/proteins associated with the disease Alcohol-Related Disorders from the curated CTD Gene-Disease Associations dataset.

From CTD Gene-Disease Associations

genes/proteins associated with the disease Alcohol-Induced Disorders, Nervous System from the curated CTD Gene-Disease Associations dataset.

From CTD Gene-Disease Associations

genes/proteins associated with the disease Cognition Disorders from the curated CTD Gene-Disease Associations dataset.

From CTD Gene-Disease Associations

genes/proteins associated with the disease Iron Metabolism Disorders from the curated CTD Gene-Disease Associations dataset.

From CTD Gene-Disease Associations

genes/proteins associated with the disease DNA Repair-Deficiency Disorders from the curated CTD Gene-Disease Associations dataset.

From CTD Gene-Disease Associations

genes/proteins associated with the disease Anxiety Disorders from the curated CTD Gene-Disease Associations dataset.

From CTD Gene-Disease Associations

genes/proteins associated with the disease Phobic Disorders from the curated CTD Gene-Disease Associations dataset.

From CTD Gene-Disease Associations

genes/proteins associated with the disease Fetal Alcohol Spectrum Disorders from the curated CTD Gene-Disease Associations dataset.

From CTD Gene-Disease Associations

genes/proteins associated with the disease Somatoform Disorders from the curated CTD Gene-Disease Associations dataset.

From CTD Gene-Disease Associations

genes/proteins associated with the disease 46, XY Disorders of Sex Development from the curated CTD Gene-Disease Associations dataset.

From CTD Gene-Disease Associations

genes/proteins associated with the disease Mental Disorders from the curated CTD Gene-Disease Associations dataset.

From CTD Gene-Disease Associations

genes/proteins associated with the disease Affective Disorders, Psychotic from the curated CTD Gene-Disease Associations dataset.

From CTD Gene-Disease Associations

genes/proteins associated with the disease Paranoid Disorders from the curated CTD Gene-Disease Associations dataset.

From CTD Gene-Disease Associations

genes/proteins associated with the disease Learning Disorders from the curated CTD Gene-Disease Associations dataset.

From CTD Gene-Disease Associations

genes/proteins associated with the disease Histiocytic Disorders, Malignant from the curated CTD Gene-Disease Associations dataset.

From CTD Gene-Disease Associations

genes/proteins associated with the disease Growth Disorders from the curated CTD Gene-Disease Associations dataset.

From CTD Gene-Disease Associations

genes/proteins associated with the disease Stress Disorders, Post-Traumatic from the curated CTD Gene-Disease Associations dataset.

From CTD Gene-Disease Associations

genes/proteins associated with the disease Vision Disorders from the curated CTD Gene-Disease Associations dataset.

From CTD Gene-Disease Associations

genes/proteins associated with the disease Respiration Disorders from the curated CTD Gene-Disease Associations dataset.

From CTD Gene-Disease Associations

genes/proteins associated with the disease Taste Disorders from the curated CTD Gene-Disease Associations dataset.

From CTD Gene-Disease Associations

genes/proteins associated with the disease Hearing Disorders from the curated CTD Gene-Disease Associations dataset.

From CTD Gene-Disease Associations

genes/proteins associated with the disease Photosensitivity Disorders from the curated CTD Gene-Disease Associations dataset.

From CTD Gene-Disease Associations

genes/proteins associated with the disease Cocaine-Related Disorders from the curated CTD Gene-Disease Associations dataset.

From CTD Gene-Disease Associations

genes/proteins associated with the disease Peroxisome biogenesis disorders from the curated CTD Gene-Disease Associations dataset.

From CTD Gene-Disease Associations

genes/proteins associated with the disease Myeloproliferative Disorders from the curated CTD Gene-Disease Associations dataset.

From CTD Gene-Disease Associations

genes/proteins associated with the disease Disorders of Excessive Somnolence from the curated CTD Gene-Disease Associations dataset.

From CTD Gene-Disease Associations

genes/proteins associated with the disease Temporomandibular Joint Disorders from the curated CTD Gene-Disease Associations dataset.

From CTD Gene-Disease Associations

genes/proteins associated with the disease Substance-Related Disorders from the curated CTD Gene-Disease Associations dataset.

From CTD Gene-Disease Associations

genes/proteins associated with the disease Schizophrenia and Disorders with Psychotic Features from the curated CTD Gene-Disease Associations dataset.

From CTD Gene-Disease Associations

genes/proteins associated with the disease Sleep Initiation and Maintenance Disorders from the curated CTD Gene-Disease Associations dataset.

From CTD Gene-Disease Associations

genes/proteins associated with the disease Somatosensory Disorders from the curated CTD Gene-Disease Associations dataset.

From CTD Gene-Disease Associations

genes/proteins associated with the disease Ciliary Motility Disorders from the curated CTD Gene-Disease Associations dataset.