Name

Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles Dataset

From Allen Brain Atlas

mRNA expression profiles for 6 adult human brain tissue samples spanning ~300 brain structures

Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles Dataset

From Allen Brain Atlas

mRNA expression profiles for adult mouse brain tissues spanning ~2000 anatomically defined brain structures

Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray Dataset

From Allen Brain Atlas

mRNA expression profiles for human brain tissue samples spanning 27 time points and 26 brain structures

Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq Dataset

From Allen Brain Atlas

mRNA expression profiles for human brain tissue samples spanning 31 time points and 26 brain structures

Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles Dataset

From Allen Brain Atlas

mRNA expression profiles for 4 human prenatal brain tissue samples spanning 4 time points and ~300 brain structures

BioGPS Cell Line Gene Expression Profiles Dataset

From BioGPS

mRNA expression profiles for the NCI-60 panel of cancer cell lines

BioGPS Human Cell Type and Tissue Gene Expression Profiles Dataset

From BioGPS

mRNA expression profiles for human tissues and cell types

BioGPS Mouse Cell Type and Tissue Gene Expression Profiles Dataset

From BioGPS

mRNA expression profiles for mouse tissues and cell types

CCLE Cell Line Gene Expression Profiles Dataset

From Cancer Cell Line Encyclopedia

mRNA microarray expression profiles for cancer cell lines

GDSC Cell Line Gene Expression Profiles Dataset

From Genomics of Drug Sensitivity in Cancer

mRNA microarray expression profiles for cancer cell lines

GTEx Tissue Gene Expression Profiles Dataset (Archived)

From Genotype Tissue Expression

Gene expression profiles for tissues from GTEx by RNA-seq

GTEx Tissue Sample Gene Expression Profiles Dataset

From Genotype Tissue Expression

RNA-seq gene expression profiles for tissue samples from GTEx

Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles Dataset

From Heiser et al., PNAS, 2011

mRNA expression profiles for breast cancer cell lines measured by microarray

HPA Cell Line Gene Expression Profiles Dataset

From Human Protein Atlas

RNA-seq gene expression profiles for cell lines from HPA

HPA Tissue Gene Expression Profiles Dataset

From Human Protein Atlas

RNA-seq gene expression profiles for tissues from HPA

HPA Tissue Protein Expression Profiles Dataset

From Human Protein Atlas

Semiquantitative protein expression profiles for tissues

HPA Tissue Sample Gene Expression Profiles Dataset

From Human Protein Atlas

RNA-seq gene expression profiles for tissue samples from HPA

HPM Cell Type and Tissue Protein Expression Profiles Dataset

From Human Proteome Map

Protein expression profiles for tissues and cell types

Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles Dataset

From Klijn et al., Nat. Biotechnol., 2015

RNA-seq gene expression profiles for cancer cell lines

MSigDB Cancer Gene Co-expression Modules Dataset

From Molecular Signatures Database

Computational signatures of genes co-expressed with cancer related genes

ProteomicsDB Cell Type and Tissue Protein Expression Profiles Dataset

From Proteomics Database

Protein expression profiles for tissues and cell types reprocessed from many proteomics datasets

Roadmap Epigenomics Cell and Tissue Gene Expression Profiles Dataset

From Roadmap Epigenomics

mRNA expression profiles for primary cell types and tissues

TISSUES Curated Tissue Protein Expression Evidence Scores Dataset (Archived)

From TISSUES

Protein tissue expression evidence scores by manual literature curation

TISSUES Experimental Tissue Protein Expression Evidence Scores Dataset (Archived)

From TISSUES

Protein tissue expression evidence scores by integrating experimental data

TISSUES Text-mining Tissue Protein Expression Evidence Scores Dataset (Archived)

From TISSUES

Gene-tissue co-occurrence scores from text-mining biomedical abstracts

KnockTF Gene Expression Profiles with Transcription Factor Perturbations Dataset

From knockTF

Gene expression profiles for cell lines or tissues following transcription factor perturbation (knockdown/knockout)

GTEx Tissue Gene Expression Profiles 2023 Dataset

From Genotype Tissue Expression

Gene expression profiles for tissues from GTEx by RNA-seq

NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles Dataset

From Novartis Institutes for Biomedical Research

Drug perturbation signatures created by profiling 4343 small molecules in the U2-OS cell line with the DRUG-seq platform

TISSUES Curated Tissue Protein Expression Evidence Scores 2025 Dataset

From TISSUES

Protein tissue expression evidence scores by manual literature curation

TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 Dataset

From TISSUES

Protein tissue expression evidence scores by integrating experimental data

TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 Dataset

From TISSUES

Gene-tissue co-occurrence scores from text-mining biomedical abstracts

Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles Dataset

From Allen Brain Atlas

mRNA expression profiles for dementia and traumatic brain injuries (TBI) from aging brain tissue

GEO Signatures of Differentially Expressed Genes for Diseases Dataset

From Gene Expression Omnibus

mRNA expression profiles for cell lines or tissues following disease perturbation

GEO Signatures of Differentially Expressed Genes for Gene Perturbations Dataset

From Gene Expression Omnibus

mRNA expression profiles for cell lines or tissues following genetic perturbation (knockdown, knockout, over-expression, mutation)

GEO Signatures of Differentially Expressed Genes for Kinase Perturbations Dataset

From Gene Expression Omnibus

mRNA expression profiles for cell lines or tissues following kinase perturbation (inhibition, activation, knockdown, knockout, over-expression, mutation)

GEO Signatures of Differentially Expressed Genes for Small Molecules Dataset

From Gene Expression Omnibus

mRNA expression profiles for cell lines or tissues following small molecule perturbation

GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations Dataset

From Gene Expression Omnibus

mRNA expression profiles for cell lines or tissues following transcription factor perturbation (inhibition, activation, knockdown, knockout, over-expression, mutation)

GEO Signatures of Differentially Expressed Genes for Viral Infections Dataset

From Gene Expression Omnibus

mRNA expression profiles for cell lines or tissues following viral infection

GTEx eQTL Dataset (Archived)

From Genotype Tissue Expression

Significance values for all gene-SNP pairs testing likelihood that SNP affects gene expression

GTEx Tissue-Specific Aging Signatures Dataset

From Genotype Tissue Expression

Tissue-specific aging signatures createed from GTEx RNA-seq gene expression profiles

GTEx eQTL 2025 Dataset

From Genotype Tissue Expression

Significance values for all gene-SNP pairs testing likelihood that SNP affects gene expression

HLA-DQB1 Gene

major histocompatibility complex, class II, DQ beta 1

HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]

HLA-DQB3 Gene

major histocompatibility complex, class II, DQ beta 3

Predicted to be involved in adaptive immune response and antigen processing and presentation of peptide or polysaccharide antigen via MHC class II. Predicted to be located in endosome membrane and lysosomal membrane. Predicted to be part of MHC class II protein complex. [provided by Alliance of Genome Resources, Mar 2025]

HLA-DQB2 Gene

major histocompatibility complex, class II, DQ beta 2

HLA-DQB2 belongs to the family of HLA class II beta chain paralogs. Class II molecules are heterodimers consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. They play a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). Polymorphisms in the alpha and beta chains specify the peptide binding specificity, and typing for these polymorphisms is routinely done for bone marrow transplantation. However this gene, HLA-DQB2, is not routinely typed, as it is not thought to have an effect on transplantation. There is conflicting evidence in the literature and public sequence databases for the protein-coding capacity of HLA-DQB2. Because there is evidence of transcription and an intact ORF, HLA-DQB2 is represented in Entrez Gene and in RefSeq as a protein-coding locus. [provided by RefSeq, Oct 2010]

HLA-DMB Gene

major histocompatibility complex, class II, DM beta

HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]

HLA-K Gene

major histocompatibility complex, class I, K (pseudogene)

HLA-J Gene

major histocompatibility complex, class I, J (pseudogene)

This major histocompatibility complex gene represents a transcribed pseudogene, possibly derived from HLA-A. [provided by RefSeq, May 2010]

HLA-L Gene

major histocompatibility complex, class I, L (pseudogene)

Predicted to be involved in antigen processing and presentation of peptide antigen via MHC class I. Predicted to be located in lumenal side of endoplasmic reticulum membrane and phagocytic vesicle membrane. Predicted to be part of MHC class I protein complex. [provided by Alliance of Genome Resources, Mar 2025]

HLA-B Gene

major histocompatibility complex, class I, B

HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008]

HLA-A Gene

major histocompatibility complex, class I, A

HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen so that they can be recognized by cytotoxic T cells. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. More than 6000 HLA-A alleles have been described. The HLA system plays an important role in the occurrence and outcome of infectious diseases, including those caused by the malaria parasite, the human immunodeficiency virus (HIV), and the severe acute respiratory syndrome coronavirus (SARS-CoV). The structural spike and the nucleocapsid proteins of the novel coronavirus SARS-CoV-2, which causes coronavirus disease 2019 (COVID-19), are reported to contain multiple Class I epitopes with predicted HLA restrictions. Individual HLA genetic variation may help explain different immune responses to a virus across a population.[provided by RefSeq, Aug 2020]

HLA-G Gene

major histocompatibility complex, class I, G

HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]

HLA-F Gene

major histocompatibility complex, class I, F

This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. [provided by RefSeq, Jul 2008]

HLA-DOA Gene

major histocompatibility complex, class II, DO alpha

HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level. [provided by RefSeq, Jul 2008]

HLA-DOB Gene

major histocompatibility complex, class II, DO beta

HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]

HLA-DQA2 Gene

major histocompatibility complex, class II, DQ alpha 2

This gene belongs to the HLA class II alpha chain family. The encoded protein forms a heterodimer with a class II beta chain. It is located in intracellular vesicles and plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (B lymphocytes, dendritic cells, macrophages) and are used to present antigenic peptides on the cell surface to be recognized by CD4 T-cells. [provided by RefSeq, Jun 2010]

HLA-F-AS1 Gene

HLA-F antisense RNA 1

HLA-H Gene

major histocompatibility complex, class I, H (pseudogene)

This major histocompatibility complex gene represents a transcribed pseudogene, possibly derived from HLA-A. This gene displays extensive variation. [provided by RefSeq, May 2010]

HLA-N Gene

major histocompatibility complex, class I, N (pseudogene)

HLA-C Gene

major histocompatibility complex, class I, C

HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. About 6000 HLA-C alleles have been described. The HLA system plays an important role in the occurrence and outcome of infectious diseases, including those caused by the malaria parasite, the human immunodeficiency virus (HIV), and the severe acute respiratory syndrome coronavirus (SARS-CoV). The structural spike and the nucleocapsid proteins of the novel coronavirus SARS-CoV-2, which causes coronavirus disease 2019 (COVID-19), are reported to contain multiple Class I epitopes with predicted HLA restrictions. Individual HLA genetic variation may help explain different immune responses to a virus across a population.[provided by RefSeq, Aug 2020]

HLA-E Gene

major histocompatibility complex, class I, E

HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. [provided by RefSeq, Jul 2008]

HLA-Z Gene

major histocompatibility complex, class I, Z (pseudogene)

HLA-Y Gene

major histocompatibility complex, class I, Y (pseudogene)

HLA-X Gene

major histocompatibility complex, class I, X (pseudogene)

HLA-S Gene

major histocompatibility complex, class I, S (pseudogene)

HLA-P Gene

major histocompatibility complex, class I, P (pseudogene)

HLA-W Gene

major histocompatibility complex, class I, W (pseudogene)

HLA-V Gene

major histocompatibility complex, class I, V (pseudogene)

HLA-U Gene

major histocompatibility complex, class I, U (pseudogene)

HLA-T Gene

major histocompatibility complex, class I, T (pseudogene)

HLA-DMA Gene

major histocompatibility complex, class II, DM alpha

HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. [provided by RefSeq, Jul 2008]

HLA-DPA1 Gene

major histocompatibility complex, class II, DP alpha 1

HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq, Jul 2008]

HLA-DPA3 Gene

major histocompatibility complex, class II, DP alpha 3 (pseudogene)

HLA-DPA2 Gene

major histocompatibility complex, class II, DP alpha 2 (pseudogene)

HLA-DRB8 Gene

major histocompatibility complex, class II, DR beta 8 (pseudogene)

HLA-DRB9 Gene

major histocompatibility complex, class II, DR beta 9 (pseudogene)

Predicted to be involved in antigen processing and presentation and immune response. Predicted to be located in membrane. Predicted to be part of MHC class II protein complex. [provided by Alliance of Genome Resources, Mar 2025]

HLA-DRB2 Gene

major histocompatibility complex, class II, DR beta 2 (pseudogene)

Predicted to be involved in adaptive immune response and antigen processing and presentation of peptide or polysaccharide antigen via MHC class II. Predicted to be located in endosome membrane and lysosomal membrane. Predicted to be part of MHC class II protein complex. [provided by Alliance of Genome Resources, Mar 2025]

HLA-DRB3 Gene

major histocompatibility complex, class II, DR beta 3

HLA-DRB3 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. There are multiple pseudogenes of this gene. [provided by RefSeq, Feb 2020]

HLA-DRB1 Gene

major histocompatibility complex, class II, DR beta 1

HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and some alleles have increased frequencies associated with certain diseases or conditions. For example, DRB1*1302 has been related to acute and chronic hepatitis B virus persistence. There are multiple pseudogenes of this gene. [provided by RefSeq, Jul 2020]

HLA-DRB6 Gene

major histocompatibility complex, class II, DR beta 6 (pseudogene)

HLA-DRB7 Gene

major histocompatibility complex, class II, DR beta 7 (pseudogene)

Predicted to be involved in antigen processing and presentation and immune response. Predicted to be located in membrane. Predicted to be part of MHC class II protein complex. [provided by Alliance of Genome Resources, Mar 2025]

HLA-DRB4 Gene

major histocompatibility complex, class II, DR beta 4

HLA-DRB4 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. There are multiple pseudogenes of this gene. [provided by RefSeq, Feb 2020]

HLA-DRB5 Gene

major histocompatibility complex, class II, DR beta 5

HLA-DRB5 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. There are multiple pseudogenes of this gene. [provided by RefSeq, Feb 2020]

HLA-DPB1 Gene

major histocompatibility complex, class II, DP beta 1

HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq, Jul 2008]

HLA-DPB2 Gene

major histocompatibility complex, class II, DP beta 2 (pseudogene)

HLA-DRA Gene

major histocompatibility complex, class II, DR alpha

HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. This molecule is expressed on the surface of various antigen presenting cells such as B lymphocytes, dendritic cells, and monocytes/macrophages, and plays a central role in the immune system and response by presenting peptides derived from extracellular proteins, in particular, pathogen-derived peptides to T cells. The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. [provided by RefSeq, Aug 2020]

HLA-DQB1-AS1 Gene

HLA-DQB1 antisense RNA 1

HCG18 Gene

HLA complex group 18 (non-protein coding)

HCG4P11 Gene

HLA complex group 4 pseudogene 11

HCG4 Gene

HLA complex group 4 (non-protein coding)

HCG9 Gene

HLA complex group 9 (non-protein coding)

This gene lies within the MHC class I region on chromosome 6p21.3. This gene is believed to be non-coding, but its function has not been determined. [provided by RefSeq, Jul 2009]

HCG25 Gene

HLA complex group 25 (non-protein coding)

HCG27 Gene

HLA complex group 27 (non-protein coding)

LOC649783 Gene

HLA class II histocompatibility antigen-like

HCG21 Gene

HLA complex group 21 (non-protein coding)

HCG20 Gene

HLA complex group 20 (non-protein coding)

HCG23 Gene

HLA complex group 23 (non-protein coding)

HCG22 Gene

HLA complex group 22

Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Mar 2025]

RFX4 Gene

regulatory factor X, 4 (influences HLA class II expression)

This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X3, and X5. It has been shown to interact with itself as well as with regulatory factors X2 and X3, but it does not interact with regulatory factor X1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011]

RFX5 Gene

regulatory factor X, 5 (influences HLA class II expression)

A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS; MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to a deficiency in RFX, a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX (Steimle et al., 1995). RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of only two have been determined. [provided by RefSeq, Jul 2008]

RFX1 Gene

regulatory factor X, 1 (influences HLA class II expression)

This gene encodes a member of the regulatory factor X (RFX) family of transcription factors, which are characterized by a winged-helix DNA-binding domain. The encoded transcription factor contains an N-terminal activation domain and a C-terminal repression domain, and may activate or repress target gene expression depending on cellular context. This transcription factor has been shown to regulate a wide variety of genes involved in immunity and cancer, including the MHC class II genes and genes that may be involved in cancer progression. This gene exhibits altered expression in glioblastoma and the autoimmune disease systemic lupus erythematosis (SLE). [provided by RefSeq, Jul 2016]

RFX2 Gene

regulatory factor X, 2 (influences HLA class II expression)

This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. This protein can bind to cis elements in the promoter of the IL-5 receptor alpha gene. Two transcript variants encoding different isoforms have been described for this gene, and both variants utilize alternative polyadenylation sites. [provided by RefSeq, Jul 2008]

RFX3 Gene

regulatory factor X, 3 (influences HLA class II expression)

This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2013]

HCG9P5 Gene

HLA complex group 9 pseudogene 5

HCG9P3 Gene

HLA complex group 9 pseudogene 3

HCG9P2 Gene

HLA complex group 9 pseudogene 2

LOC644456 Gene

IK cytokine, down-regulator of HLA II pseudogene

3.8-1.4 Gene

HLA complex group 26 (non-protein coding) pseudogene

3.8-1.5 Gene

HLA complex group 26 (non-protein coding) pseudogene

3.8-1.2 Gene

HLA complex group 26 (non-protein coding) pseudogene

HCG4P1 Gene

HLA complex group 4 pseudogene 1

HCG4P2 Gene

HLA complex group 4 pseudogene 2

HCG4P3 Gene

HLA complex group 4 pseudogene 3

HCG4P4 Gene

HLA complex group 4 pseudogene 4

HCG4P5 Gene

HLA complex group 4 pseudogene 5

HCG4P7 Gene

HLA complex group 4 pseudogene 7

HCG4P8 Gene

HLA complex group 4 pseudogene 8

HCG4P9 Gene

HLA complex group 4 pseudogene 9

HCG24 Gene

HLA complex group 24 (non-protein coding)

HCG26 Gene

HLA complex group 26 (non-protein coding)

HCG15 Gene

HLA complex group 15 (non-protein coding)

HCG11 Gene

HLA complex group 11 (non-protein coding)

HCG19P Gene

HLA complex group 19 pseudogene

NRCLP2 Gene

Narcolepsy, HLA-associated

HCG9P1 Gene

HLA complex group 9 pseudogene 1

HCG16 Gene

HLA complex group 16 (non-protein coding)

HCG14 Gene

HLA complex group 14 (non-protein coding)

HCG17 Gene

HLA complex group 17 (non-protein coding)

HCG13P Gene

HLA complex group 13 pseudogene

HCP5B Gene

HLA complex P5B (non-protein coding)

LOC105369230 Gene

HLA class II histocompatibility antigen, DRB1-7 beta chain

HCP5 Gene

HLA complex P5 (non-protein coding)

LOC100507703 Gene

HLA class I histocompatibility antigen, A-69 alpha chain-like

3.8-1.3 Gene

HLA complex group 26 (non-protein coding) pseudogene

IK Gene

IK cytokine, down-regulator of HLA II

The protein encoded by this gene was identified by its RED repeat, a stretch of repeated arginine, glutamic acid and aspartic acid residues. The protein localizes to discrete dots within the nucleus, excluding the nucleolus. Its function is unknown. This gene maps to chromosome 5; however, a pseudogene may exist on chromosome 2. [provided by RefSeq, Jul 2008]

HCG4B Gene

HLA complex group 4B (non-protein coding)

HCG8 Gene

HLA complex group 8

LOC7795 Gene

Methylation modifier for class I HLA

hla-dqa1 differential expression Gene Set

From GAD Gene-Disease Associations

genes associated with the disease hla-dqa1 differential expression in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

defective dr beta 4 chain expression to the hla-drb1 gene Gene Set

From GAD Gene-Disease Associations

genes associated with the disease defective dr beta 4 chain expression to the hla-drb1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

differential plasma lipoprotein response to simvastatin Gene Set

From GAD Gene-Disease Associations

genes associated with the disease differential plasma lipoprotein response to simvastatin in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

differential expansion rates of small abdominal aortic aneurysms Gene Set

From GAD Gene-Disease Associations

genes associated with the disease differential expansion rates of small abdominal aortic aneurysms in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

differential Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term differential in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Differential Threshold Gene Set

From HuGE Navigator Gene-Phenotype Associations

genes associated with the Differential Threshold phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Differential aging in older adults (frontal cortex) Gene Set

From GWAS Catalog SNP-Phenotype Associations 2025

genes associated with the Differential aging in older adults (frontal cortex) phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.

Differential aging (frontal cortex) Gene Set

From GWAS Catalog SNP-Phenotype Associations 2025

genes associated with the Differential aging (frontal cortex) phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.

hla genes Gene Set

From GAD Gene-Disease Associations

genes associated with the disease hla genes in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

hla-associated diseases Gene Set

From GAD Gene-Disease Associations

genes associated with the disease hla-associated diseases in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

ankylosing spondylitis independent of hla-b27 Gene Set

From GAD Gene-Disease Associations

genes associated with the disease ankylosing spondylitis independent of hla-b27 in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

hla-dr2 specificity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease hla-dr2 specificity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

hla Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term hla in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

hla-a specific inhibitory mhc class i receptor activity Gene Set

From GO Molecular Function Annotations 2015

genes performing the hla-a specific inhibitory mhc class i receptor activity molecular function from the curated GO Molecular Function Annotations 2015 dataset.

hla-b specific inhibitory mhc class i receptor activity Gene Set

From GO Molecular Function Annotations 2015

genes performing the hla-b specific inhibitory mhc class i receptor activity molecular function from the curated GO Molecular Function Annotations 2015 dataset.

hla-a specific activating mhc class i receptor activity Gene Set

From GO Molecular Function Annotations 2015

genes performing the hla-a specific activating mhc class i receptor activity molecular function from the curated GO Molecular Function Annotations 2015 dataset.

Hypersomnia (HLA-DQB1*06:02 negative) Gene Set

From GWAS Catalog SNP-Phenotype Associations

genes associated with the Hypersomnia (HLA-DQB1*06:02 negative) phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations dataset.

increased proportion of hla dr+ and cd57+ t cells Gene Set

From HPO Gene-Disease Associations

genes associated with the increased proportion of hla dr+ and cd57+ t cells phenotype by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset.

HLA-C Gene Set

From MSigDB Cancer Gene Co-expression Modules

co-expressed genes for HLA-C from the MSigDB Cancer Gene Co-expression Modules dataset.

HLA-DPA1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for HLA-DPA1 from the Pathway Commons Protein-Protein Interactions dataset.

HLA-DQB1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for HLA-DQB1 from the Pathway Commons Protein-Protein Interactions dataset.

HLA-B Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for HLA-B from the Pathway Commons Protein-Protein Interactions dataset.

HLA-DRB1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for HLA-DRB1 from the Pathway Commons Protein-Protein Interactions dataset.

HLA-DRB4 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for HLA-DRB4 from the Pathway Commons Protein-Protein Interactions dataset.

HLA-DRB5 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for HLA-DRB5 from the Pathway Commons Protein-Protein Interactions dataset.

HLA-DQB2 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for HLA-DQB2 from the Pathway Commons Protein-Protein Interactions dataset.

HLA-DRA Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for HLA-DRA from the Pathway Commons Protein-Protein Interactions dataset.

HLA-H Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for HLA-H from the Pathway Commons Protein-Protein Interactions dataset.

HLA-A Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for HLA-A from the Pathway Commons Protein-Protein Interactions dataset.

HLA-F Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for HLA-F from the Pathway Commons Protein-Protein Interactions dataset.

HLA-E Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for HLA-E from the Pathway Commons Protein-Protein Interactions dataset.

HLA-DPB1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for HLA-DPB1 from the Pathway Commons Protein-Protein Interactions dataset.

HLA-DOA Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for HLA-DOA from the Pathway Commons Protein-Protein Interactions dataset.

HLA-DOB Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for HLA-DOB from the Pathway Commons Protein-Protein Interactions dataset.

HLA-DRB3 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for HLA-DRB3 from the Pathway Commons Protein-Protein Interactions dataset.

HLA-DQA2 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for HLA-DQA2 from the Pathway Commons Protein-Protein Interactions dataset.

HLA-DMB Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for HLA-DMB from the Pathway Commons Protein-Protein Interactions dataset.

HLA-DMA Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for HLA-DMA from the Pathway Commons Protein-Protein Interactions dataset.

HLA-C Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for HLA-C from the Pathway Commons Protein-Protein Interactions dataset.

HLA-G Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for HLA-G from the Pathway Commons Protein-Protein Interactions dataset.

Increased Proportion Of Hla Dr+ T Cells Gene Set

From DisGeNET Gene-Phenotype Associations

genes associated with the phenotype Increased Proportion Of Hla Dr+ T Cells in GWAS and other genetic association datasets from the DisGeNET Gene-Phenotype Associations dataset.

HLA-A specific activating MHC class I receptor activity Gene Set

From GO Molecular Function Annotations 2023

genes performing the HLA-A specific activating MHC class I receptor activity molecular function from the curated GO Molecular Function Annotations 2023 dataset.

HLA-E specific inhibitory MHC class Ib receptor activity Gene Set

From GO Molecular Function Annotations 2023

genes performing the HLA-E specific inhibitory MHC class Ib receptor activity molecular function from the curated GO Molecular Function Annotations 2023 dataset.

HLA-B specific inhibitory MHC class I receptor activity Gene Set

From GO Molecular Function Annotations 2023

genes performing the HLA-B specific inhibitory MHC class I receptor activity molecular function from the curated GO Molecular Function Annotations 2023 dataset.

HLA-C specific inhibitory MHC class I receptor activity Gene Set

From GO Molecular Function Annotations 2023

genes performing the HLA-C specific inhibitory MHC class I receptor activity molecular function from the curated GO Molecular Function Annotations 2023 dataset.

HLA-A specific inhibitory MHC class I receptor activity Gene Set

From GO Molecular Function Annotations 2023

genes performing the HLA-A specific inhibitory MHC class I receptor activity molecular function from the curated GO Molecular Function Annotations 2023 dataset.

HLA-A Gene Set

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the HLA-A gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

HLA-DMA Gene Set

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the HLA-DMA gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

HLA-DMB Gene Set

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the HLA-DMB gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

HLA-DOA Gene Set

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the HLA-DOA gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

HLA-DOB Gene Set

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the HLA-DOB gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

HLA-DPA1 Gene Set

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the HLA-DPA1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

HLA-DQA2 Gene Set

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the HLA-DQA2 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

HLA-DQB2 Gene Set

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the HLA-DQB2 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

HLA-DRA Gene Set

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the HLA-DRA gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

HLA-DRB1 Gene Set

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the HLA-DRB1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

HLA-DRB5 Gene Set

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the HLA-DRB5 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

Human - Tonsil - L2 - C1Q HLA macrophages Gene Set

From HuBMAP Azimuth Cell Type Annotations

genes associated with the Human - Tonsil - L2 - C1Q HLA macrophages cell type from the HuBMAP Azimuth Cell Type Annotations dataset.

HLA-A specific activating MHC class I receptor activity Gene Set

From GO Molecular Function Annotations 2025

genes performing the HLA-A specific activating MHC class I receptor activity molecular function from the curated GO Molecular Function Annotations 2025 dataset.

HLA-E specific inhibitory MHC class Ib receptor activity Gene Set

From GO Molecular Function Annotations 2025

genes performing the HLA-E specific inhibitory MHC class Ib receptor activity molecular function from the curated GO Molecular Function Annotations 2025 dataset.

HLA-B specific inhibitory MHC class I receptor activity Gene Set

From GO Molecular Function Annotations 2025

genes performing the HLA-B specific inhibitory MHC class I receptor activity molecular function from the curated GO Molecular Function Annotations 2025 dataset.

HLA-C specific inhibitory MHC class I receptor activity Gene Set

From GO Molecular Function Annotations 2025

genes performing the HLA-C specific inhibitory MHC class I receptor activity molecular function from the curated GO Molecular Function Annotations 2025 dataset.

HLA-A specific inhibitory MHC class I receptor activity Gene Set

From GO Molecular Function Annotations 2025

genes performing the HLA-A specific inhibitory MHC class I receptor activity molecular function from the curated GO Molecular Function Annotations 2025 dataset.

Type 1 diabetes in high risk HLA genotype individuals (time to event) Gene Set

From GWAS Catalog SNP-Phenotype Associations 2025

genes associated with the Type 1 diabetes in high risk HLA genotype individuals (time to event) phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.

Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) Gene Set

From GWAS Catalog SNP-Phenotype Associations 2025

genes associated with the Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.

Hypersomnia (HLA-DQB1*06:02 negative) Gene Set

From GWAS Catalog SNP-Phenotype Associations 2025

genes associated with the Hypersomnia (HLA-DQB1*06:02 negative) phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.

Alloimmunization response to pregnancy (HLA class I) Gene Set

From GWAS Catalog SNP-Phenotype Associations 2025

genes associated with the Alloimmunization response to pregnancy (HLA class I) phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.

HLA-A*0201 RESTRICTED TERT(572Y)/TERT(572) PEPTIDES VACCINE VX-001 Gene Set

From DGIdb Drug Targets 2026

interacting proteins for the HLA-A*0201 RESTRICTED TERT(572Y)/TERT(572) PEPTIDES VACCINE VX-001 drug from theDGIdb Drug Targets 2026 dataset.

PMC9454148-mmc2.pdf-4-HLA-AIER2_EGR1_KDM5D_EGR1 Gene Set

From Rummagene Transcription Factor Associations 2026

target genes of the PMC9454148-mmc2.pdf-4-HLA-AIER2_EGR1_KDM5D_EGR1 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

HLA-A Gene Set

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the HLA-A gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

HLA-DRB1 Gene Set

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the HLA-DRB1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

HLA-DQB1 Gene Set

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the HLA-DQB1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

HLA-C Gene Set

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the HLA-C gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

HLA-DOA Gene Set

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the HLA-DOA gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

HLA-B Gene Set

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the HLA-B gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

HLA-E Gene Set

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the HLA-E gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

double stranded rna induced gene expression Gene Set

From Biocarta Pathways

proteins participating in the double stranded rna induced gene expression pathway from the Biocarta Pathways dataset.

gata3 participate in activating the th2 cytokine genes expression Gene Set

From Biocarta Pathways

proteins participating in the gata3 participate in activating the th2 cytokine genes expression pathway from the Biocarta Pathways dataset.

control of gene expression by vitamin d receptor Gene Set

From Biocarta Pathways

proteins participating in the control of gene expression by vitamin d receptor pathway from the Biocarta Pathways dataset.

fmlp induced chemokine gene expression in hmc-1 cells Gene Set

From Biocarta Pathways

proteins participating in the fmlp induced chemokine gene expression in hmc-1 cells pathway from the Biocarta Pathways dataset.

basic mechanism of action of ppara pparb(d) and pparg and effects on gene expression Gene Set

From Biocarta Pathways

proteins participating in the basic mechanism of action of ppara pparb(d) and pparg and effects on gene expression pathway from the Biocarta Pathways dataset.

fosb gene expression and drug abuse Gene Set

From Biocarta Pathways

proteins participating in the fosb gene expression and drug abuse pathway from the Biocarta Pathways dataset.

oxidative stress induced gene expression via nrf2 Gene Set

From Biocarta Pathways

proteins participating in the oxidative stress induced gene expression via nrf2 pathway from the Biocarta Pathways dataset.

hepatic gsta1/gsta2 expression Gene Set

From GAD Gene-Disease Associations

genes associated with the disease hepatic gsta1/gsta2 expression in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

reduced gene expression and lower plasma levels of beta2-glycoprotein i Gene Set

From GAD Gene-Disease Associations

genes associated with the disease reduced gene expression and lower plasma levels of beta2-glycoprotein i in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

rna expression of carboxylesterases 1 and 2. Gene Set

From GAD Gene-Disease Associations

genes associated with the disease rna expression of carboxylesterases 1 and 2. in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

hepatic cyp3a4 expression Gene Set

From GAD Gene-Disease Associations

genes associated with the disease hepatic cyp3a4 expression in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

cd14 expression Gene Set

From GAD Gene-Disease Associations

genes associated with the disease cd14 expression in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

reduced expression of the apolipoprotein a-i gene and resolution of disputed paternity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease reduced expression of the apolipoprotein a-i gene and resolution of disputed paternity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

cell-surface b7 expression; cytokine production Gene Set

From GAD Gene-Disease Associations

genes associated with the disease cell-surface b7 expression; cytokine production in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

cyp3a5 expression Gene Set

From GAD Gene-Disease Associations

genes associated with the disease cyp3a5 expression in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

psa mrna expression Gene Set

From GAD Gene-Disease Associations

genes associated with the disease psa mrna expression in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

increased expression of the g gamma and a gamma globin Gene Set

From GAD Gene-Disease Associations

genes associated with the disease increased expression of the g gamma and a gamma globin in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

leptin expression Gene Set

From GAD Gene-Disease Associations

genes associated with the disease leptin expression in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

low expression of nb1 Gene Set

From GAD Gene-Disease Associations

genes associated with the disease low expression of nb1 in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

pon1 expression Gene Set

From GAD Gene-Disease Associations

genes associated with the disease pon1 expression in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

global gene expression Gene Set

From GAD Gene-Disease Associations

genes associated with the disease global gene expression in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

p-glycoprotein expression, placental Gene Set

From GAD Gene-Disease Associations

genes associated with the disease p-glycoprotein expression, placental in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

anril expression Gene Set

From GAD Gene-Disease Associations

genes associated with the disease anril expression in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

AIRE_KO_GDS2274_245_mouse_Medullary thymic epithelial cells (with low CD80 expression) Gene Set

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the AIRE_KO_GDS2274_245_mouse_Medullary thymic epithelial cells (with low CD80 expression) gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

AIRE_KO_GDS2274_246_mouse_Medullary thymic epithelial cells (with high CD80 expression) Gene Set

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the AIRE_KO_GDS2274_246_mouse_Medullary thymic epithelial cells (with high CD80 expression) gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

AICD_Induced expression / Over-expression_GDS1979_288_human_SHEP-SF neuroblastoma Gene Set

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the AICD_Induced expression / Over-expression_GDS1979_288_human_SHEP-SF neuroblastoma gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

positive regulation of gene expression, epigenetic Gene Set

From GO Biological Process Annotations 2015

genes participating in the positive regulation of gene expression, epigenetic biological process from the curated GO Biological Process Annotations 2015 dataset.

posttranscriptional regulation of gene expression Gene Set

From GO Biological Process Annotations 2015

genes participating in the posttranscriptional regulation of gene expression biological process from the curated GO Biological Process Annotations 2015 dataset.

positive regulation of rhodopsin gene expression Gene Set

From GO Biological Process Annotations 2015

genes participating in the positive regulation of rhodopsin gene expression biological process from the curated GO Biological Process Annotations 2015 dataset.

regulation of gene expression, epigenetic Gene Set

From GO Biological Process Annotations 2015

genes participating in the regulation of gene expression, epigenetic biological process from the curated GO Biological Process Annotations 2015 dataset.

mrna localization resulting in posttranscriptional regulation of gene expression Gene Set

From GO Biological Process Annotations 2015

genes participating in the mrna localization resulting in posttranscriptional regulation of gene expression biological process from the curated GO Biological Process Annotations 2015 dataset.

circadian regulation of gene expression Gene Set

From GO Biological Process Annotations 2015

genes participating in the circadian regulation of gene expression biological process from the curated GO Biological Process Annotations 2015 dataset.

gene expression Gene Set

From GO Biological Process Annotations 2015

genes participating in the gene expression biological process from the curated GO Biological Process Annotations 2015 dataset.

negative regulation of gene expression, epigenetic Gene Set

From GO Biological Process Annotations 2015

genes participating in the negative regulation of gene expression, epigenetic biological process from the curated GO Biological Process Annotations 2015 dataset.

regulation of rhodopsin gene expression Gene Set

From GO Biological Process Annotations 2015

genes participating in the regulation of rhodopsin gene expression biological process from the curated GO Biological Process Annotations 2015 dataset.

regulation of gene expression by genetic imprinting Gene Set

From GO Biological Process Annotations 2015

genes participating in the regulation of gene expression by genetic imprinting biological process from the curated GO Biological Process Annotations 2015 dataset.

modulation by virus of host gene expression Gene Set

From GO Biological Process Annotations 2015

genes participating in the modulation by virus of host gene expression biological process from the curated GO Biological Process Annotations 2015 dataset.

negative regulation of gene expression Gene Set

From GO Biological Process Annotations 2015

genes participating in the negative regulation of gene expression biological process from the curated GO Biological Process Annotations 2015 dataset.

regulation of gene expression Gene Set

From GO Biological Process Annotations 2015

genes participating in the regulation of gene expression biological process from the curated GO Biological Process Annotations 2015 dataset.

signal transduction involved in regulation of gene expression Gene Set

From GO Biological Process Annotations 2015

genes participating in the signal transduction involved in regulation of gene expression biological process from the curated GO Biological Process Annotations 2015 dataset.

positive regulation of gene expression Gene Set

From GO Biological Process Annotations 2015

genes participating in the positive regulation of gene expression biological process from the curated GO Biological Process Annotations 2015 dataset.

PCA3 expression level Gene Set

From GWAS Catalog SNP-Phenotype Associations

genes associated with the PCA3 expression level phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations dataset.

decreased facial expression Gene Set

From HPO Gene-Disease Associations

genes associated with the decreased facial expression phenotype by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset.

abnormal platelet membrane protein expression Gene Set

From HPO Gene-Disease Associations

genes associated with the abnormal platelet membrane protein expression phenotype by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset.

loss of facial expression Gene Set

From HPO Gene-Disease Associations

genes associated with the loss of facial expression phenotype by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset.

sleepy facial expression Gene Set

From HPO Gene-Disease Associations

genes associated with the sleepy facial expression phenotype by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset.

disturbance of facial expression Gene Set

From HPO Gene-Disease Associations

genes associated with the disturbance of facial expression phenotype by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset.

reduced lymphocyte surface expression of cd43 (sialophorin) Gene Set

From HPO Gene-Disease Associations

genes associated with the reduced lymphocyte surface expression of cd43 (sialophorin) phenotype by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset.

abnormal facial expression Gene Set

From HPO Gene-Disease Associations

genes associated with the abnormal facial expression phenotype by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset.

fixed facial expression Gene Set

From HPO Gene-Disease Associations

genes associated with the fixed facial expression phenotype by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset.

Limb expression 1 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Limb expression 1 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

abnormal mhc ii cell surface expression on macrophages Gene Set

From MPO Gene-Phenotype Associations

gene mutations causing the abnormal mhc ii cell surface expression on macrophages phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

abnormal epigenetic regulation of gene expression Gene Set

From MPO Gene-Phenotype Associations

gene mutations causing the abnormal epigenetic regulation of gene expression phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

[creatine kinase, brain type, ectopic expression of] Gene Set

From OMIM Gene-Disease Associations

genes associated with the [creatine kinase, brain type, ectopic expression of] phenotype from the curated OMIM Gene-Disease Associations dataset.

{gene expression, variation in, qtl} Gene Set

From OMIM Gene-Disease Associations

genes associated with the {gene expression, variation in, qtl} phenotype from the curated OMIM Gene-Disease Associations dataset.

gene-expression-regulation Gene Set

From Phosphosite Textmining Biological Term Annotations

proteins co-occuring with the biological term gene-expression-regulation in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

Activation of gene expression by SREBF (SREBP) Gene Set

From Reactome Pathways 2014

proteins participating in the Activation of gene expression by SREBF (SREBP) pathway from the Reactome Pathways dataset.

L13a-mediated translational silencing of Ceruloplasmin expression Gene Set

From Reactome Pathways 2014

proteins participating in the L13a-mediated translational silencing of Ceruloplasmin expression pathway from the Reactome Pathways dataset.

ChREBP activates metabolic gene expression Gene Set

From Reactome Pathways 2014

proteins participating in the ChREBP activates metabolic gene expression pathway from the Reactome Pathways dataset.

Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells Gene Set

From Reactome Pathways 2014

proteins participating in the Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells pathway from the Reactome Pathways dataset.

Nef mediated downregulation of CD28 cell surface expression Gene Set

From Reactome Pathways 2014

proteins participating in the Nef mediated downregulation of CD28 cell surface expression pathway from the Reactome Pathways dataset.

YAP1- and WWTR1 (TAZ)-stimulated gene expression Gene Set

From Reactome Pathways 2014

proteins participating in the YAP1- and WWTR1 (TAZ)-stimulated gene expression pathway from the Reactome Pathways dataset.

Regulation of gene expression in beta cells Gene Set

From Reactome Pathways 2014

proteins participating in the Regulation of gene expression in beta cells pathway from the Reactome Pathways dataset.

Epigenetic regulation of gene expression Gene Set

From Reactome Pathways 2014

proteins participating in the Epigenetic regulation of gene expression pathway from the Reactome Pathways dataset.

Pre-NOTCH Expression and Processing Gene Set

From Reactome Pathways 2014

proteins participating in the Pre-NOTCH Expression and Processing pathway from the Reactome Pathways dataset.

Regulation of gene expression by Hypoxia-inducible Factor Gene Set

From Reactome Pathways 2014

proteins participating in the Regulation of gene expression by Hypoxia-inducible Factor pathway from the Reactome Pathways dataset.

Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells Gene Set

From Reactome Pathways 2014

proteins participating in the Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells pathway from the Reactome Pathways dataset.

REV-ERBA represses gene expression Gene Set

From Reactome Pathways 2014

proteins participating in the REV-ERBA represses gene expression pathway from the Reactome Pathways dataset.

PPARA activates gene expression Gene Set

From Reactome Pathways 2014

proteins participating in the PPARA activates gene expression pathway from the Reactome Pathways dataset.

Nef mediated downregulation of MHC class I complex cell surface expression Gene Set

From Reactome Pathways 2014

proteins participating in the Nef mediated downregulation of MHC class I complex cell surface expression pathway from the Reactome Pathways dataset.

Negative epigenetic regulation of rRNA expression Gene Set

From Reactome Pathways 2014

proteins participating in the Negative epigenetic regulation of rRNA expression pathway from the Reactome Pathways dataset.

Regulation of gene expression in early pancreatic precursor cells Gene Set

From Reactome Pathways 2014

proteins participating in the Regulation of gene expression in early pancreatic precursor cells pathway from the Reactome Pathways dataset.

PERK regulates gene expression Gene Set

From Reactome Pathways 2014

proteins participating in the PERK regulates gene expression pathway from the Reactome Pathways dataset.

RORA activates circadian gene expression Gene Set

From Reactome Pathways 2014

proteins participating in the RORA activates circadian gene expression pathway from the Reactome Pathways dataset.

SIRT1 negatively regulates rRNA Expression Gene Set

From Reactome Pathways 2014

proteins participating in the SIRT1 negatively regulates rRNA Expression pathway from the Reactome Pathways dataset.

Gene Expression Gene Set

From Reactome Pathways 2014

proteins participating in the Gene Expression pathway from the Reactome Pathways dataset.

BMAL1:CLOCK,NPAS2 activates circadian gene expression Gene Set

From Reactome Pathways 2014

proteins participating in the BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway from the Reactome Pathways dataset.

NoRC negatively regulates rRNA expression Gene Set

From Reactome Pathways 2014

proteins participating in the NoRC negatively regulates rRNA expression pathway from the Reactome Pathways dataset.

Mitochondrial Gene Expression(Mus musculus) Gene Set

From WikiPathways Pathways 2014

proteins participating in the Mitochondrial Gene Expression(Mus musculus) pathway from the WikiPathways Pathways 2014 dataset.

Mitochondrial Gene Expression(Homo sapiens) Gene Set

From WikiPathways Pathways 2014

proteins participating in the Mitochondrial Gene Expression(Homo sapiens) pathway from the WikiPathways Pathways 2014 dataset.

Reduced Facial Expression Gene Set

From DisGeNET Gene-Disease Associations

genes associated with the disease Reduced Facial Expression in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Abnormal Facial Expression Gene Set

From DisGeNET Gene-Disease Associations

genes associated with the disease Abnormal Facial Expression in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Decreased Facial Expression Gene Set

From DisGeNET Gene-Phenotype Associations

genes associated with the phenotype Decreased Facial Expression in GWAS and other genetic association datasets from the DisGeNET Gene-Phenotype Associations dataset.

Abnormal Muscle Fiber Protein Expression Gene Set

From DisGeNET Gene-Phenotype Associations

genes associated with the phenotype Abnormal Muscle Fiber Protein Expression in GWAS and other genetic association datasets from the DisGeNET Gene-Phenotype Associations dataset.

Reduced Mhc Ii Surface Expression Gene Set

From DisGeNET Gene-Phenotype Associations

genes associated with the phenotype Reduced Mhc Ii Surface Expression in GWAS and other genetic association datasets from the DisGeNET Gene-Phenotype Associations dataset.

Abnormal Muscle Fiber Dystrophin Expression Gene Set

From DisGeNET Gene-Phenotype Associations

genes associated with the phenotype Abnormal Muscle Fiber Dystrophin Expression in GWAS and other genetic association datasets from the DisGeNET Gene-Phenotype Associations dataset.

Sleepy Facial Expression Gene Set

From DisGeNET Gene-Phenotype Associations

genes associated with the phenotype Sleepy Facial Expression in GWAS and other genetic association datasets from the DisGeNET Gene-Phenotype Associations dataset.

Loss Of Facial Expression Gene Set

From DisGeNET Gene-Phenotype Associations

genes associated with the phenotype Loss Of Facial Expression in GWAS and other genetic association datasets from the DisGeNET Gene-Phenotype Associations dataset.

Disturbance Of Facial Expression Gene Set

From DisGeNET Gene-Phenotype Associations

genes associated with the phenotype Disturbance Of Facial Expression in GWAS and other genetic association datasets from the DisGeNET Gene-Phenotype Associations dataset.

Fixed Facial Expression Gene Set

From DisGeNET Gene-Phenotype Associations

genes associated with the phenotype Fixed Facial Expression in GWAS and other genetic association datasets from the DisGeNET Gene-Phenotype Associations dataset.

Reduced Lymphocyte Surface Expression Of Cd43 Gene Set

From DisGeNET Gene-Phenotype Associations

genes associated with the phenotype Reduced Lymphocyte Surface Expression Of Cd43 in GWAS and other genetic association datasets from the DisGeNET Gene-Phenotype Associations dataset.

positive regulation of gene expression Gene Set

From GO Biological Process Annotations 2023

genes participating in the positive regulation of gene expression biological process from the curated GO Biological Process Annotations 2023 dataset.

negative regulation of gene expression Gene Set

From GO Biological Process Annotations 2023

genes participating in the negative regulation of gene expression biological process from the curated GO Biological Process Annotations 2023 dataset.

gene expression Gene Set

From GO Biological Process Annotations 2023

genes participating in the gene expression biological process from the curated GO Biological Process Annotations 2023 dataset.

negative regulation of gene expression, epigenetic Gene Set

From GO Biological Process Annotations 2023

genes participating in the negative regulation of gene expression, epigenetic biological process from the curated GO Biological Process Annotations 2023 dataset.

regulation of gene expression Gene Set

From GO Biological Process Annotations 2023

genes participating in the regulation of gene expression biological process from the curated GO Biological Process Annotations 2023 dataset.

post-transcriptional regulation of gene expression Gene Set

From GO Biological Process Annotations 2023

genes participating in the post-transcriptional regulation of gene expression biological process from the curated GO Biological Process Annotations 2023 dataset.

epigenetic regulation of gene expression Gene Set

From GO Biological Process Annotations 2023

genes participating in the epigenetic regulation of gene expression biological process from the curated GO Biological Process Annotations 2023 dataset.

regulation of gene expression by genomic imprinting Gene Set

From GO Biological Process Annotations 2023

genes participating in the regulation of gene expression by genomic imprinting biological process from the curated GO Biological Process Annotations 2023 dataset.

maternal-to-zygotic transition of gene expression Gene Set

From GO Biological Process Annotations 2023

genes participating in the maternal-to-zygotic transition of gene expression biological process from the curated GO Biological Process Annotations 2023 dataset.

negative regulation of gene expression via CpG island methylation Gene Set

From GO Biological Process Annotations 2023

genes participating in the negative regulation of gene expression via CpG island methylation biological process from the curated GO Biological Process Annotations 2023 dataset.

mRNA localization resulting in post-transcriptional regulation of gene expression Gene Set

From GO Biological Process Annotations 2023

genes participating in the mRNA localization resulting in post-transcriptional regulation of gene expression biological process from the curated GO Biological Process Annotations 2023 dataset.

positive regulation of gene expression via CpG island demethylation Gene Set

From GO Biological Process Annotations 2023

genes participating in the positive regulation of gene expression via CpG island demethylation biological process from the curated GO Biological Process Annotations 2023 dataset.

mitochondrial gene expression Gene Set

From GO Biological Process Annotations 2023

genes participating in the mitochondrial gene expression biological process from the curated GO Biological Process Annotations 2023 dataset.

regulation of mitochondrial gene expression Gene Set

From GO Biological Process Annotations 2023

genes participating in the regulation of mitochondrial gene expression biological process from the curated GO Biological Process Annotations 2023 dataset.

abnormal MHC II cell surface expression on macrophages Gene Set

From MGI Mouse Phenotype Associations 2023

gene mutations causing the abnormal MHC II cell surface expression on macrophages phenotype in transgenic mice from the MGI Mouse Phenotype Associations 2023 dataset.

abnormal epigenetic regulation of gene expression Gene Set

From MGI Mouse Phenotype Associations 2023

gene mutations causing the abnormal epigenetic regulation of gene expression phenotype in transgenic mice from the MGI Mouse Phenotype Associations 2023 dataset.

4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression Gene Set

From WikiPathways Pathways 2024

proteins participating in the 4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression pathway from the WikiPathways Pathways 2024 dataset.

Mitochondrial gene expression Gene Set

From WikiPathways Pathways 2024

proteins participating in the Mitochondrial gene expression pathway from the WikiPathways Pathways 2024 dataset.

Model for regulation of MSMP expression in cancer cells and its proangiogenic role in ovarian tumors Gene Set

From WikiPathways Pathways 2024

proteins participating in the Model for regulation of MSMP expression in cancer cells and its proangiogenic role in ovarian tumors pathway from the WikiPathways Pathways 2024 dataset.

Selective expression of chemokine receptors during T cell polarization Gene Set

From WikiPathways Pathways 2024

proteins participating in the Selective expression of chemokine receptors during T cell polarization pathway from the WikiPathways Pathways 2024 dataset.

Activation of gene expression by SREBF (SREBP) Gene Set

From Reactome Pathways 2024

proteins participating in the Activation of gene expression by SREBF (SREBP) pathway from the Reactome Pathways 2024 dataset.

B-WICH complex positively regulates rRNA expression Gene Set

From Reactome Pathways 2024

proteins participating in the B-WICH complex positively regulates rRNA expression pathway from the Reactome Pathways 2024 dataset.

BMAL1:CLOCK,NPAS2 activates circadian gene expression Gene Set

From Reactome Pathways 2024

proteins participating in the BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway from the Reactome Pathways 2024 dataset.

ChREBP activates metabolic gene expression Gene Set

From Reactome Pathways 2024

proteins participating in the ChREBP activates metabolic gene expression pathway from the Reactome Pathways 2024 dataset.

ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Gene Set

From Reactome Pathways 2024

proteins participating in the ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression pathway from the Reactome Pathways 2024 dataset.

Epigenetic regulation of gene expression Gene Set

From Reactome Pathways 2024

proteins participating in the Epigenetic regulation of gene expression pathway from the Reactome Pathways 2024 dataset.

Epigenetic regulation of gene expression by MLL3 and MLL4 complexes Gene Set

From Reactome Pathways 2024

proteins participating in the Epigenetic regulation of gene expression by MLL3 and MLL4 complexes pathway from the Reactome Pathways 2024 dataset.

Estrogen-dependent gene expression Gene Set

From Reactome Pathways 2024

proteins participating in the Estrogen-dependent gene expression pathway from the Reactome Pathways 2024 dataset.

Expression and Processing of Neurotrophins Gene Set

From Reactome Pathways 2024

proteins participating in the Expression and Processing of Neurotrophins pathway from the Reactome Pathways 2024 dataset.

Expression and translocation of olfactory receptors Gene Set

From Reactome Pathways 2024

proteins participating in the Expression and translocation of olfactory receptors pathway from the Reactome Pathways 2024 dataset.

Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Gene Set

From Reactome Pathways 2024

proteins participating in the Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation pathway from the Reactome Pathways 2024 dataset.

Gene expression (Transcription) Gene Set

From Reactome Pathways 2024

proteins participating in the Gene expression (Transcription) pathway from the Reactome Pathways 2024 dataset.

L13a-mediated translational silencing of Ceruloplasmin expression Gene Set

From Reactome Pathways 2024

proteins participating in the L13a-mediated translational silencing of Ceruloplasmin expression pathway from the Reactome Pathways 2024 dataset.

MITF-M-dependent gene expression Gene Set

From Reactome Pathways 2024

proteins participating in the MITF-M-dependent gene expression pathway from the Reactome Pathways 2024 dataset.

MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Gene Set

From Reactome Pathways 2024

proteins participating in the MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis pathway from the Reactome Pathways 2024 dataset.

MTF1 activates gene expression Gene Set

From Reactome Pathways 2024

proteins participating in the MTF1 activates gene expression pathway from the Reactome Pathways 2024 dataset.

NPAS4 regulates expression of target genes Gene Set

From Reactome Pathways 2024

proteins participating in the NPAS4 regulates expression of target genes pathway from the Reactome Pathways 2024 dataset.

NR1D1 (REV-ERBA) represses gene expression Gene Set

From Reactome Pathways 2024

proteins participating in the NR1D1 (REV-ERBA) represses gene expression pathway from the Reactome Pathways 2024 dataset.

NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis Gene Set

From Reactome Pathways 2024

proteins participating in the NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis pathway from the Reactome Pathways 2024 dataset.

NR1H2 & NR1H3 regulate gene expression linked to lipogenesis Gene Set

From Reactome Pathways 2024

proteins participating in the NR1H2 & NR1H3 regulate gene expression linked to lipogenesis pathway from the Reactome Pathways 2024 dataset.

NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose Gene Set

From Reactome Pathways 2024

proteins participating in the NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose pathway from the Reactome Pathways 2024 dataset.

NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis Gene Set

From Reactome Pathways 2024

proteins participating in the NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis pathway from the Reactome Pathways 2024 dataset.

NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake Gene Set

From Reactome Pathways 2024

proteins participating in the NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake pathway from the Reactome Pathways 2024 dataset.

NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Gene Set

From Reactome Pathways 2024

proteins participating in the NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux pathway from the Reactome Pathways 2024 dataset.

Nef mediated downregulation of CD28 cell surface expression Gene Set

From Reactome Pathways 2024

proteins participating in the Nef mediated downregulation of CD28 cell surface expression pathway from the Reactome Pathways 2024 dataset.

Nef mediated downregulation of MHC class I complex cell surface expression Gene Set

From Reactome Pathways 2024

proteins participating in the Nef mediated downregulation of MHC class I complex cell surface expression pathway from the Reactome Pathways 2024 dataset.

Negative epigenetic regulation of rRNA expression Gene Set

From Reactome Pathways 2024

proteins participating in the Negative epigenetic regulation of rRNA expression pathway from the Reactome Pathways 2024 dataset.

NoRC negatively regulates rRNA expression Gene Set

From Reactome Pathways 2024

proteins participating in the NoRC negatively regulates rRNA expression pathway from the Reactome Pathways 2024 dataset.

PERK regulates gene expression Gene Set

From Reactome Pathways 2024

proteins participating in the PERK regulates gene expression pathway from the Reactome Pathways 2024 dataset.

PPARA activates gene expression Gene Set

From Reactome Pathways 2024

proteins participating in the PPARA activates gene expression pathway from the Reactome Pathways 2024 dataset.

PTK6 Expression Gene Set

From Reactome Pathways 2024

proteins participating in the PTK6 Expression pathway from the Reactome Pathways 2024 dataset.

Positive epigenetic regulation of rRNA expression Gene Set

From Reactome Pathways 2024

proteins participating in the Positive epigenetic regulation of rRNA expression pathway from the Reactome Pathways 2024 dataset.

Pre-NOTCH Expression and Processing Gene Set

From Reactome Pathways 2024

proteins participating in the Pre-NOTCH Expression and Processing pathway from the Reactome Pathways 2024 dataset.

RORA activates gene expression Gene Set

From Reactome Pathways 2024

proteins participating in the RORA activates gene expression pathway from the Reactome Pathways 2024 dataset.

RUNX1 regulates expression of components of tight junctions Gene Set

From Reactome Pathways 2024

proteins participating in the RUNX1 regulates expression of components of tight junctions pathway from the Reactome Pathways 2024 dataset.

Regulation of CDH11 Expression and Function Gene Set

From Reactome Pathways 2024

proteins participating in the Regulation of CDH11 Expression and Function pathway from the Reactome Pathways 2024 dataset.

Regulation of CDH19 Expression and Function Gene Set

From Reactome Pathways 2024

proteins participating in the Regulation of CDH19 Expression and Function pathway from the Reactome Pathways 2024 dataset.

Regulation of Expression and Function of Type II Classical Cadherins Gene Set

From Reactome Pathways 2024

proteins participating in the Regulation of Expression and Function of Type II Classical Cadherins pathway from the Reactome Pathways 2024 dataset.

Regulation of HMOX1 expression and activity Gene Set

From Reactome Pathways 2024

proteins participating in the Regulation of HMOX1 expression and activity pathway from the Reactome Pathways 2024 dataset.

Regulation of MECP2 expression and activity Gene Set

From Reactome Pathways 2024

proteins participating in the Regulation of MECP2 expression and activity pathway from the Reactome Pathways 2024 dataset.

Regulation of NFE2L2 gene expression Gene Set

From Reactome Pathways 2024

proteins participating in the Regulation of NFE2L2 gene expression pathway from the Reactome Pathways 2024 dataset.

Regulation of NPAS4 gene expression Gene Set

From Reactome Pathways 2024

proteins participating in the Regulation of NPAS4 gene expression pathway from the Reactome Pathways 2024 dataset.

Regulation of RUNX1 Expression and Activity Gene Set

From Reactome Pathways 2024

proteins participating in the Regulation of RUNX1 Expression and Activity pathway from the Reactome Pathways 2024 dataset.

Regulation of RUNX2 expression and activity Gene Set

From Reactome Pathways 2024

proteins participating in the Regulation of RUNX2 expression and activity pathway from the Reactome Pathways 2024 dataset.

Regulation of RUNX3 expression and activity Gene Set

From Reactome Pathways 2024

proteins participating in the Regulation of RUNX3 expression and activity pathway from the Reactome Pathways 2024 dataset.

Regulation of TP53 Expression Gene Set

From Reactome Pathways 2024

proteins participating in the Regulation of TP53 Expression pathway from the Reactome Pathways 2024 dataset.

Regulation of TP53 Expression and Degradation Gene Set

From Reactome Pathways 2024

proteins participating in the Regulation of TP53 Expression and Degradation pathway from the Reactome Pathways 2024 dataset.

Regulation of expression of SLITs and ROBOs Gene Set

From Reactome Pathways 2024

proteins participating in the Regulation of expression of SLITs and ROBOs pathway from the Reactome Pathways 2024 dataset.

Regulation of gene expression by Hypoxia-inducible Factor Gene Set

From Reactome Pathways 2024

proteins participating in the Regulation of gene expression by Hypoxia-inducible Factor pathway from the Reactome Pathways 2024 dataset.

Regulation of gene expression in beta cells Gene Set

From Reactome Pathways 2024

proteins participating in the Regulation of gene expression in beta cells pathway from the Reactome Pathways 2024 dataset.

Regulation of gene expression in early pancreatic precursor cells Gene Set

From Reactome Pathways 2024

proteins participating in the Regulation of gene expression in early pancreatic precursor cells pathway from the Reactome Pathways 2024 dataset.

Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells Gene Set

From Reactome Pathways 2024

proteins participating in the Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells pathway from the Reactome Pathways 2024 dataset.

Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells Gene Set

From Reactome Pathways 2024

proteins participating in the Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells pathway from the Reactome Pathways 2024 dataset.

SIRT1 negatively regulates rRNA expression Gene Set

From Reactome Pathways 2024

proteins participating in the SIRT1 negatively regulates rRNA expression pathway from the Reactome Pathways 2024 dataset.

TGFBR3 expression Gene Set

From Reactome Pathways 2024

proteins participating in the TGFBR3 expression pathway from the Reactome Pathways 2024 dataset.

Transcriptional and post-translational regulation of MITF-M expression and activity Gene Set

From Reactome Pathways 2024

proteins participating in the Transcriptional and post-translational regulation of MITF-M expression and activity pathway from the Reactome Pathways 2024 dataset.

YAP1- and WWTR1 (TAZ)-stimulated gene expression Gene Set

From Reactome Pathways 2024

proteins participating in the YAP1- and WWTR1 (TAZ)-stimulated gene expression pathway from the Reactome Pathways 2024 dataset.

positive regulation of gene expression Gene Set

From GO Biological Process Annotations 2025

genes participating in the positive regulation of gene expression biological process from the curated GO Biological Process Annotations 2025 dataset.

negative regulation of gene expression Gene Set

From GO Biological Process Annotations 2025

genes participating in the negative regulation of gene expression biological process from the curated GO Biological Process Annotations 2025 dataset.

gene expression Gene Set

From GO Biological Process Annotations 2025

genes participating in the gene expression biological process from the curated GO Biological Process Annotations 2025 dataset.

negative regulation of gene expression, epigenetic Gene Set

From GO Biological Process Annotations 2025

genes participating in the negative regulation of gene expression, epigenetic biological process from the curated GO Biological Process Annotations 2025 dataset.

regulation of gene expression Gene Set

From GO Biological Process Annotations 2025

genes participating in the regulation of gene expression biological process from the curated GO Biological Process Annotations 2025 dataset.

positive regulation of gene expression via chromosomal CpG island demethylation Gene Set

From GO Biological Process Annotations 2025

genes participating in the positive regulation of gene expression via chromosomal CpG island demethylation biological process from the curated GO Biological Process Annotations 2025 dataset.

post-transcriptional regulation of gene expression Gene Set

From GO Biological Process Annotations 2025

genes participating in the post-transcriptional regulation of gene expression biological process from the curated GO Biological Process Annotations 2025 dataset.

epigenetic regulation of gene expression Gene Set

From GO Biological Process Annotations 2025

genes participating in the epigenetic regulation of gene expression biological process from the curated GO Biological Process Annotations 2025 dataset.

negative regulation of gene expression via chromosomal CpG island methylation Gene Set

From GO Biological Process Annotations 2025

genes participating in the negative regulation of gene expression via chromosomal CpG island methylation biological process from the curated GO Biological Process Annotations 2025 dataset.

positive regulation of gene expression, epigenetic Gene Set

From GO Biological Process Annotations 2025

genes participating in the positive regulation of gene expression, epigenetic biological process from the curated GO Biological Process Annotations 2025 dataset.

maternal-to-zygotic transition of gene expression Gene Set

From GO Biological Process Annotations 2025

genes participating in the maternal-to-zygotic transition of gene expression biological process from the curated GO Biological Process Annotations 2025 dataset.

mRNA localization resulting in post-transcriptional regulation of gene expression Gene Set

From GO Biological Process Annotations 2025

genes participating in the mRNA localization resulting in post-transcriptional regulation of gene expression biological process from the curated GO Biological Process Annotations 2025 dataset.

mitochondrial gene expression Gene Set

From GO Biological Process Annotations 2025

genes participating in the mitochondrial gene expression biological process from the curated GO Biological Process Annotations 2025 dataset.

epigenetic programming of gene expression Gene Set

From GO Biological Process Annotations 2025

genes participating in the epigenetic programming of gene expression biological process from the curated GO Biological Process Annotations 2025 dataset.

regulation of mitochondrial gene expression Gene Set

From GO Biological Process Annotations 2025

genes participating in the regulation of mitochondrial gene expression biological process from the curated GO Biological Process Annotations 2025 dataset.

Abnormal muscle fiber dystrophin expression Gene Set

From ClinVar Gene-Phenotype Associations 2025

genes associated with the Abnormal muscle fiber dystrophin expression phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset.

Chromatin organization and gene expression regulators Gene Set

From CM4AI U2OS Cell Map Protein Localization Assemblies

proteins comprising Chromatin organization and gene expression regulators assembly using integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.

Regulation of cell cycle and gene expression Gene Set

From CM4AI U2OS Cell Map Protein Localization Assemblies

proteins comprising Regulation of cell cycle and gene expression assembly using integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.

Regulation of gene expression and mRNA processing - 2 Gene Set

From CM4AI U2OS Cell Map Protein Localization Assemblies

proteins comprising Regulation of gene expression and mRNA processing - 2 assembly using integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.

Regulation of gene expression and cell cycle progression Gene Set

From CM4AI U2OS Cell Map Protein Localization Assemblies

proteins comprising Regulation of gene expression and cell cycle progression assembly using integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.

Regulation of gene expression and signal transduction Gene Set

From CM4AI U2OS Cell Map Protein Localization Assemblies

proteins comprising Regulation of gene expression and signal transduction assembly using integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.

Regulation of gene expression and mRNA processing Gene Set

From CM4AI U2OS Cell Map Protein Localization Assemblies

proteins comprising Regulation of gene expression and mRNA processing assembly using integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.

Regulation of gene expression and protein quality control Gene Set

From CM4AI U2OS Cell Map Protein Localization Assemblies

proteins comprising Regulation of gene expression and protein quality control assembly using integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.

Regulation of gene expression and protein modification Gene Set

From CM4AI U2OS Cell Map Protein Localization Assemblies

proteins comprising Regulation of gene expression and protein modification assembly using integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.

Nuclear transport and gene expression regulation Gene Set

From CM4AI U2OS Cell Map Protein Localization Assemblies

proteins comprising Nuclear transport and gene expression regulation assembly using integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.

Regulation of gene expression and signal transduction in immune and stress responses Gene Set

From CM4AI U2OS Cell Map Protein Localization Assemblies

proteins comprising Regulation of gene expression and signal transduction in immune and stress responses assembly using integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.

Regulation of gene expression and chromatin remodeling Gene Set

From CM4AI U2OS Cell Map Protein Localization Assemblies

proteins comprising Regulation of gene expression and chromatin remodeling assembly using integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.

Regulation of gene expression and cellular stress response Gene Set

From CM4AI U2OS Cell Map Protein Localization Assemblies

proteins comprising Regulation of gene expression and cellular stress response assembly using integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.

Regulation of gene expression and chromosomal stability Gene Set

From CM4AI U2OS Cell Map Protein Localization Assemblies

proteins comprising Regulation of gene expression and chromosomal stability assembly using integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.

Regulation of Gene Expression and Nuclear Transport Gene Set

From CM4AI U2OS Cell Map Protein Localization Assemblies

proteins comprising Regulation of Gene Expression and Nuclear Transport assembly using integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.

Regulation of Gene Expression and Protein Ubiquitination Gene Set

From CM4AI U2OS Cell Map Protein Localization Assemblies

proteins comprising Regulation of Gene Expression and Protein Ubiquitination assembly using integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.

Regulation of Cytoskeletal Dynamics and Gene Expression Gene Set

From CM4AI U2OS Cell Map Protein Localization Assemblies

proteins comprising Regulation of Cytoskeletal Dynamics and Gene Expression assembly using integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.

Glucocorticoid receptor gene expression in B-cell precursor acute lymphoblastic leukaemia Gene Set

From GWAS Catalog SNP-Phenotype Associations 2025

genes associated with the Glucocorticoid receptor gene expression in B-cell precursor acute lymphoblastic leukaemia phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.

PCA3 expression level Gene Set

From GWAS Catalog SNP-Phenotype Associations 2025

genes associated with the PCA3 expression level phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.

Interleukin-6 gene expression levels in non-alcoholic fatty liver disease x mastiha supplementation interaction Gene Set

From GWAS Catalog SNP-Phenotype Associations 2025

genes associated with the Interleukin-6 gene expression levels in non-alcoholic fatty liver disease x mastiha supplementation interaction phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.

TNF-alpha gene expression levels in non-alcoholic fatty liver disease x mastiha supplementation interaction Gene Set

From GWAS Catalog SNP-Phenotype Associations 2025

genes associated with the TNF-alpha gene expression levels in non-alcoholic fatty liver disease x mastiha supplementation interaction phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.

PD-L1 expression and PD-1 checkpoint pathway in cancer Gene Set

From KEGG Pathways 2026

proteins participating in the PD-L1 expression and PD-1 checkpoint pathway in cancer pathway from the KEGG Pathways 2026 dataset.